NEWS


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miRWalk2.0 is released for public use (Click Here).


How to cite miRWalk database?

Dweep, H., Sticht, C., Pandey, P., Gretz, N., miRWalk - database: prediction of possible miRNA binding sites by "walking" the genes of 3 genomes, Journal of Biomedical Informatics, 44: 839-7, 2011. (JBI PubMed)

miRWalk Citations :

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March/29/2011 - Last Update

The Predicted Target module is updated with the lastest versions of 3rd party programs and the Validated Target module is last upated on 15th March 2013.

ABOUT


miRWalk is a comprehensive database that provides information on miRNA from Human, Mouse and Rat on their predicted as well as validated binding sites on their target genes.
miRWalk is different from existing miRNA resources as:
(i) A newly developed algorithm "miRWalk" has been used to produce the predicted miRNA binding sites on the complete sequence of all known genes (including all transcripts and mitochondrial genes) of Human, Mouse and Rat based on a comparision of identified miRNA binding sites with the 8 established miRNA-target prediction program is presented.
(ii) In addition, it provides predicted miRNA binding sites on genes associated with 449 human biological pathways and 2356 OMIM disorders and
(iii) Furthermore, it presents information on experimentally validated miRNA interaction information associated with genes, pathways, diseases, organs, OMIM disorders, cell lines and literature on miRNAs. In addition, it hosts the information on proteins known to be involved in miRNA processing.

The miRWalk database consists of two modules.

The Predicted Targets module hosts miRNA-target interactions information on the complete sequence of all known genes of Human, Mouse and Rat including all the transcripts and mitochondrial genes. Along with the miRNA targets, is presented interaction information produced by 8 established miRNA targets prediction programs. In addition, it provides predicted miRNA target interaction information on genes linked to 449 human biological pathways and 2356 OMIM disorders. This module is last updated on 15th March 2011.

The Validated Targets module hosts experimentally verified miRNA interaction information associated with genes, pathways, organs, diseases, cell lines, OMIM disorders and literature on miRNAs. This module is last updated on 15th March 2011. In addition, it provides the information on proteins known to be involved in miRNA processing.


Prediction Programs Diana-microT miRanda miRDB PICTAR PITA RNA22 RNAhybrid Targetscan
Version Or Date   Version 3.0   August 2010 release   April 2009   March 2007   August 2008   May 2008   Version 2.1   Verion 5.1  


It covers the following features:-
1. MiRNA-targets interactions information produced by using miRWalk algorithm on the complete sequence (promoter, 5' UTR, CDS and 3' UTR) of all known genes of Human, Mouse and Rat including all transcripts.
2. MiRNA-targets interactions information produced by 8 established miRNA prediction programs on 3' UTRs of all known genes of Human, Mouse and Rat i.e. RNA22miRandamiRDBTargetScanRNAhybridPITAPICTAR, and Diana-microT.
3. Predicted miRNA-target interactions information on genes linked with 449 human biological pathways and 2356 OMIM disorders.
4. Predicted miRNA-target interactions information on 3 complete mitochonrial genomes i.e. Human, Mouse and Rat.
5. Experimentally Verified miRNA interactions information associated with genes, pathways, organs, diseases and transcription factors.
6. It also hosts validated miRNA interactions information on cell lines.
7. Moreover, It also provides the information on proteins known to be involved in miRNA processing.


Summary of the targets per miRNA by miRWalk on Promoter, 5 UTR, CDS and 3 UTR of all genes of Human, Mouse and Rat


Species/Regions Human (No. of Targets per miRNA) Mouse (No. of Targets per miRNA) Rat (No. of Targets per miRNA)
Promoter   7932   8098   6111  
5' UTR   211   170   118  
CDS   1752   1742   1289  
3' UTR   1315   1172   587