miRWalk
is a comprehensive database that provides information on miRNA from Human, Mouse and Rat on their predicted as well as validated binding sites on their target genes.
miRWalk is different from existing miRNA resources as:
(i) A newly developed algorithm "miRWalk" has been used to produce the predicted miRNA binding sites on the complete sequence of all known genes (including all transcripts and mitochondrial genes)
of Human, Mouse and Rat based on a comparision of identified miRNA binding sites with the 8 established miRNA-target prediction program is presented.
(ii) In addition, it provides predicted miRNA binding sites on genes associated with 449 human biological pathways and 2356 OMIM disorders and
(iii) Furthermore, it presents information on experimentally validated miRNA interaction information associated with genes, pathways, diseases, organs, OMIM disorders,
cell lines and literature on miRNAs. In addition, it hosts the information on proteins known to be involved in miRNA processing.
The miRWalk database consists of two modules.
The Predicted Targets module hosts miRNA-target interactions information on the complete sequence of
all known genes of Human, Mouse and Rat including all the transcripts and mitochondrial genes.
Along with the miRNA targets, is presented interaction information produced by 8 established miRNA targets prediction programs.
In addition, it provides predicted miRNA target interaction information on genes linked to 449 human biological pathways and 2356 OMIM disorders.
This module is last updated on 15th March 2011.
The Validated Targets module hosts experimentally verified miRNA interaction information associated with genes, pathways, organs, diseases,
cell lines, OMIM disorders and literature on miRNAs. This module is last updated on 15th March 2011.
In addition, it provides the information on proteins known to be involved in miRNA processing.
| Prediction Programs |
Diana-microT |
miRanda |
miRDB |
PICTAR |
PITA |
RNA22 |
RNAhybrid |
Targetscan |
| Version Or Date |
Version 3.0 |
August 2010 release |
April 2009 |
March 2007 |
August 2008 |
May 2008 |
Version 2.1 |
Verion 5.1 |
It covers the following features:-
1. MiRNA-targets interactions information produced by using miRWalk algorithm on the complete sequence (promoter, 5' UTR, CDS and 3' UTR) of all known genes of Human, Mouse and Rat including all transcripts.
2. MiRNA-targets interactions information produced by 8 established miRNA prediction programs on 3' UTRs of all known genes of Human, Mouse and Rat i.e.
RNA22,
miRanda,
miRDB,
TargetScan,
RNAhybrid,
PITA,
PICTAR, and
Diana-microT.
3. Predicted miRNA-target interactions information on genes linked with 449 human biological pathways and 2356 OMIM disorders.
4. Predicted miRNA-target interactions information on 3 complete mitochonrial genomes i.e. Human, Mouse and Rat.
5. Experimentally Verified miRNA interactions information associated with genes, pathways, organs, diseases and transcription factors.
6. It also hosts validated miRNA interactions information on cell lines.
7. Moreover, It also provides the information on proteins known to be involved in miRNA processing.
