Forschungsarbeit
Aktuelle
klinische Studien
Chirurgie:
Prof. Dr. S. Post / Prof.
Dr. M. Schwarzbach / Dr. J. Weiss / Dr. R. Bönninghoff / Dr.
R. Proßt / Dr. K. Nowak
Nephrologie:
Prof. Dr.
P. Schnülle / Priv.-Doz. Dr. Birck / Priv.-Doz. B. Yard / Dr. P.
Brinkkoetter / Dr. S. Krzossok / Dr. U. Goettmann
Urologie:
Prof. Dr. M. Michel / Dr. T.
Knoll
Anaesthesie:
Priv.-Doz. Dr. G. Beck / Dr.
V. Buhmann / Neysan Rafat (über Graduiertenkolleg)
Radiologie
Priv.-Doz. Dr. W. Neff / Dr.
A. Werner
Pathologie
Prof. Dr. R. Waldherr /
Priv.-Doz. Dr. W.E. Back
Top
1: Prosst RL,
Fernandez ED, Neff W, Braun C, Neufang T, Post S.
.Evaluation
of MR-angiography for preoperative assessment of living kidney donors.
Clin Transplant
2005; 19 (4): 522-526.
2: Gottmann U,
Notheisen A, Brinkkoetter PT, Yard BA, Waldherr R, Schnuelle P,
van der Woude FJ,
Braun C.
Influence
of donor pretreatment with dopamine on allogeneic kidney
transplantation after prolonged cold storage in rats.
Transplantation. 2005 May 27;79(10):1344-50.
3: van der Woude FJ,
Schnuelle P, Yard BA.
Preconditioning
strategies to limit graft immunogenicity and cold ischemic
organ injury.
J
Investig Med. 2004 Jul;52(5):323-9. Review.
Top
4: Krzossok S, Birck
R, Koeppel H, Schnulle P, Waldherr R, van der Woude FJ,
Braun C.
Treatment of proteinuria with low-molecular-weight heparin after renal
transplantation.
Transpl Int. 2004 Sep;17(8):468-72. Epub 2004 Aug 21.
5: Schaub M, Ploetz
CJ, Gerbaulet D, Fang L, Kranich P, Stadlbauer TH, Goettman
U, Yard BA, Braun C,
Schnuelle P, van der Woude FJ.
Effect
of dopamine on inflammatory status in kidneys of brain-dead rats.
Transplantation. 2004 May 15;77(9):1333-40.
6: Busauschina A,
Schnuelle P, van der Woude FJ.
Cyclosporine
nephrotoxicity.
Transplant Proc. 2004 Mar;36(2 Suppl):229S-233S. Review.
7: Schnuelle P,
Yard BA, Braun C, Dominguez-Fernandez E, Schaub M, Birck R,
Sturm J, Post S, van der Woude FJ.
Impact of donor dopamine on immediate graft function after kidney
transplantation.
Am J
Transplant. 2004 Mar;4(3):419-26.
Top
8: Yard B, Beck G,
Schnuelle P, Braun C, Schaub M, Bechtler M, Gottmann U,
Xiao
Y, Breedijk A, Wandschneider S, Losel R, Sponer G, Wehling M, van der Woude
FJ.
Prevention of cold-preservation injury of cultured endothelial cells by
catecholamines and related compounds.
Am J
Transplant. 2004 Jan;4(1):22-30.
9: Gottmann U,
Oltersdorf J, Schaub M, Knoll T, Back WE, van der Woude FJ,
Braun C.
Oxidative
stress in chronic renal allograft nephropathy in rats: effects of
long-term treatment with carvedilol, BM 91.0228, or alpha-tocopherol.
J
Cardiovasc Pharmacol. 2003 Sep;42(3):442-50.
10: Knoll T,
Oltersdorf J, Gottmann U, Schaub M, Michel MS, Kirchengast M, van
der Woude FJ,
Rohmeiss P, Braun C.
Influence
of acute selective endothelin-receptor-A blockade on renal
hemodynamics in a rat model of chronic allograft rejection.
Transpl Int. 2003 Jun;16(6):425-9. Epub 2003 Mar 26.
11:
Davidson J, Wilkinson A, Dantal J, Dotta F, Haller H, Hernandez D, Kasiske
BL,
Kiberd B, Krentz A, Legendre C, Marchetti P, Markell M, van der Woude FJ,
Wheeler DC; International Expert Panel.
New-onset diabetes after transplantation: 2003 International consensus
guidelines. Proceedings of an international expert panel meeting. Barcelona,
Spain, 19 February 2003.
Transplantation. 2003 May 27;75(10 Suppl):SS3-24. Review. No abstract
available.
Top
12: Schmitt WH, van
der Woude FJ.
Organ
transplantation in the vasculitides.
Curr
Opin Rheumatol. 2003 Jan;15(1):22-8. Review.
13: Niemann-Masanek
U, Mueller A, Yard BA, Waldherr R, van der Woude FJ.
B7-1
(CD80) and B7-2 (CD 86) expression in human tubular epithelial cells in
vivo
and in vitro.
Nephron. 2002;92(3):542-56.
14: Bruijn JA, van
der Woude FJ.
Tacrolimus
and ciclosporin microemulsion in renal transplantation.
Lancet. 2002 Sep 7;360(9335):800; author reply 800-1. No abstract available.
15:
Kapper S, Beck G, Riedel S, Prem K, Haak M, van der Woude FJ, Yard BA.
Modulation of chemokine production and expression of adhesion molecules in
renal tubular epithelial and endothelial cells by catecholamines.
Transplantation. 2002 Jul 27;74(2):253-60.
16:
van der Woude FJ.
Kidney transplantation and ANCA-associated vasculitis.
Cleve Clin J Med. 2002;69 Suppl 2:SII143-5. Review. No abstract available.
PMID:
12086254 [PubMed - indexed for MEDLINE]
Top
17:
van der Woude FJ.
Graft immunogenicity revisited: relevance of tissue-specific immunity, brain
death and donor pretreatment.
Nephron. 2002 Jun;91(2):181-7. Review. No abstract available.
18: Schnuelle P,
van der Heide JH, Tegzess A, Verburgh CA, Paul LC, van der
Woude FJ, de Fijter JW.
Open randomized trial comparing early withdrawal of either cyclosporine or
mycophenolate mofetil in stable renal transplant recipients initially treated
with
a triple drug regimen.
J Am
Soc Nephrol. 2002 Feb;13(2):536-43.
19: Schnuelle P,
Berger S, de Boer J, Persijn G, van der Woude FJ.
Effects
of catecholamine application to brain-dead donors on graft survival in
solid organ transplantation.
Transplantation. 2001 Aug 15;72(3):455-63.
20: Braun C,
Schultz M, Fang L, Schaub M, Back WE, Herr D, Laux V, Rohmeiss P,
Schnuelle P, van der
Woude FJ.
Treatment
of chronic renal allograft rejection in rats with a
low-molecular-weight heparin (reviparin).
Transplantation. 2001 Jul 27;72(2):209-15.
Top
21: Rabe J,
Schnulle P, Diehl SJ, Lorenz D, van Der Woude FJ, Georgi M.
Unclear
radiographic pulmonary changes in a patient who recently underwent
renal transplantation.
Nephrol Dial Transplant. 2001 Jul;16(7):1490-2. No abstract available.
22: Schnuelle P,
Berger S, de Boer J, Persijn G, van der Woude FJ.
Donor
employment of vasopressors and its impact on allograft survival after
transplantation.
Transplant Proc. 2001 Feb-Mar;33(1-2):1282-3. No abstract available.
23: Braun C,
Schultz M, Schaub M, Fang L, Back WE, Herr D, Laux V, Schnuelle P,
Rohmeiss P, van der
Woude FJ.
Effect
of treatment with low-molecular-weight heparin on chronic renal
allograft rejection in rats.
Transplant Proc. 2001 Feb-Mar;33(1-2):363-5. No abstract available.
24: Lorenz D,
Neufang T, Post S.
Hand
assisted laparoscopic nephrectomy for live donor organ harvesting. Initial
results. Chirurg 2001, May 72 (5):588-592.
25: Berger SP,
Hunger M, Yard BA, Schnuelle P, Van Der Woude FJ.
Dopamine
induces the expression of heme oxygenase-1 by human endothelial cells
in
vitro.
Kidney Int. 2000 Dec;58(6):2314-9.
Top
26: Braun C,
Conzelmann T, Vetter S, Schaub M, Back WE, Kirchengast M, Tullius
SG, Schnulle P, van
der Woude FJ, Rohmeiss P.
Treatment
with a combined endothelin A/B-receptor antagonist does not prevent
chronic renal allograft rejection in rats.
J
Cardiovasc Pharmacol. 2000 Oct;36(4):428-37.
27: Braun C, Vetter
S, Conzelmann T, Schaub M, Kirchengast M, van der Woude FJ,
Rohmeiss P.
Improved recovery following posttransplant acute renal failure in rat renal
isografts with an oral endothelin-A receptor antagonist.
Exp
Nephrol. 2000 Jul-Oct;8(4-5):283-90.
28: Mueller A,
Schnuelle P, Waldherr R, van der Woude FJ.
Impact
of the Banff '97 classification for histological diagnosis of rejection
on
clinical outcome and renal function parameters after kidney transplantation.
Transplantation. 2000 Mar 27;69(6):1123-7.
29: Braun C,
Conzelmann T, Vetter S, Schaub M, Back WE, Yard B, Kirchengast M,
Tullius SG, Schnulle
P, van der Woude FJ, Rohmeiss P.
Prevention
of chronic renal allograft rejection in rats with an oral endothelin
A
receptor antagonist.
Transplantation. 1999 Sep 27;68(6):739-46.
Top
30: Schnuelle P,
Lorenz D, Mueller A, Trede M, Van Der Woude FJ.
Donor
catecholamine use reduces acute allograft rejection and improves graft
survival after cadaveric renal transplantation.
Kidney Int. 1999 Aug;56(2):738-46.
31:
Yard BA, Lorentz CP, Herr D, van der Woude FJ.
Sulfation-dependent
down-regulation of interferon-gamma-induced major
histocompatibility complex class I and II and intercellular adhesion
molecule-1
expression on tubular and endothelial cells by glycosaminoglycans.
Transplantation. 1998 Nov 15;66(9):1244-50.
32: Schnuelle P,
Lorenz D, Trede M, Van Der Woude FJ.
Impact
of renal cadaveric transplantation on survival in end-stage renal
failure: evidence for reduced mortality risk compared with hemodialysis during
long-term follow-up.
J Am
Soc Nephrol. 1998 Nov;9(11):2135-41.
33: Schnulle P, van
der Woude FJ.
[Mycophenolate
mofetil in comparison with other immunosuppressive drugs]
Internist (Berl). 1998 Aug;39(8):879-86. Review. German. No abstract
available.
34: Schnuelle P,
van der Woude FJ.
Should
A2 kidneys be transplanted into B or O recipients?
Lancet. 1998 Jun 6;351(9117):1675-6. No abstract available.
Top
35: van der Woude
FJ, Hollander AA.
Rejection
after kidney transplantation: new concepts, new therapeutic options.
Transplant Proc. 1998 Aug;30(5):2419-24. Review. No abstract available.
36:
Wever PC, Boonstra JG, Laterveer JC, Hack CE, van der Woude FJ, Daha MR,
ten
Berge IJ.
Mechanisms of lymphocyte-mediated cytotoxicity in acute renal allograft
rejection.
Transplantation. 1998 Jul 27;66(2):259-64.
37: Deckers JG,
Daha MR, Van der Kooij SW, Van der Woude FJ.
Epithelial-
and endothelial-cell specificity of renal graft infiltrating T
cells.
Clin
Transplant. 1998 Aug;12(4):285-91.
38: Arend SM,
Mallat MJ, Westendorp RJ, van der Woude FJ, van Es LA.
Patient
survival after renal transplantation; more than 25 years follow-up.
Nephrol Dial Transplant. 1997 Aug;12(8):1672-9.
39:
Deckers JG, Boonstra JG, Van der Kooij SW, Daha MR, Van der Woude FJ.
Tissue-specific characteristics of cytotoxic graft-infiltrating T cells
during
renal allograft rejection.
Transplantation. 1997 Jul 15;64(1):178-81.
Top
40: Koning OH,
Ploeg RJ, van Bockel JH, Groenewegen M, van der Woude FJ,
Persijn GG, Hermans J.
Risk factors for delayed graft function in cadaveric kidney transplantation:
a
prospective study of renal function and graft survival after preservation with
University of Wisconsin solution in multi-organ donors. European Multicenter
Study Group.
Transplantation. 1997 Jun 15;63(11):1620-8.
41: Hollander AA,
Hene RJ, Hermans J, van Es LA, van der Woude FJ.
Late
prednisone withdrawal in cyclosporine-treated kidney transplant patients:
a
randomized study.
J Am
Soc Nephrol.
1997 Feb;8(2):294-301.
42: Boonstra JG,
van der Pijl JW, Smets YF, Lemkes HH, Ringers J, van Es LA,
van der Woude FJ,
Bruijn JA.
Interstitial
and vascular pancreas rejection in relation to graft survival.
Transpl Int.
1997;10(6):451-6.
43: van der Woude
FJ.
Prevention
and treatment of late graft dysfunction.
Kidney Blood Press Res. 1997;20(3):170-2. Review. No abstract available.
Top
´44: Hollander AA,
de Waal LP, van Bockel HJ, Jonker M, Claas FH, van der Voort
Maarschalk MF,
Bruijn JA, van der Woude FJ.
No
tolerance induction with cryopreserved bone marrow cells after allogeneic
kidney transplantation and antilymphocyte globulin in rhesus monkeys.
Transpl Int. 1997;10(3):249-50. No abstract available.
45: Bouma GJ,
Hollander DA, van der Meer-Prins EM, van Bree SP, van Rood JJ,
van der Woude FJ,
Claas FH.
In
vitro sensitivity to prednisolone may predict kidney rejection after steroid
withdrawal.
Transplantation.
1996 Nov 27;62(10):1422-9.
46: Arend SM,
Westendorp RG, Kroon FP, van't Wout JW, Vandenbroucke JP, van Es
LA, van der Woude FJ.
Rejection
treatment and cytomegalovirus infection as risk factors for
Pneumocystis carinii pneumonia in renal transplant recipients.
Clin
Infect Dis. 1996 Jun;22(6):920-5.
47:
Prodjosudjadi W, Daha MR, Gerritsma JS, Florijn KW, Barendregt JN, Bruijn
JA, van der Woude FJ,
van Es LA.
Increased
urinary excretion of monocyte chemoattractant protein-1 during acute
renal allograft rejection.
Nephrol Dial Transplant. 1996 Jun;11(6):1096-103.
Top
48:
Kooijmans-Coutinho MF, Hermans J, Schrama E, Ringers J, Daha MR, Bruijn JA,
van
der Woude FJ.
Interstitial rejection, vascular rejection, and diffuse thrombosis of renal
allografts. Predisposing factors, histology, immunohistochemistry, and
relation
to
outcome.
Transplantation. 1996 May 15;61(9):1338-44.
49:
Bouwes Bavinck JN, Crijns M, Vermeer BJ, van der Woude FJ, Claas FH,
Pfister H, Green A, Bergman W.
Chronic sun exposure and age are inversely associated with nevi in adult
renal
transplant recipients.
J
Invest Dermatol. 1996 May;106(5):1036-41.
50: van Saase JL,
Mallat MJ, van der Woude FJ, van Bockel JH, van Es LA.
[Results
of kidney transplantation in Leiden, 1966-1994, and prognostic
factors]
Ned
Tijdschr Geneeskd. 1996 Apr 13;140(15):827-32. Dutch.
51:
Bouwes Bavinck JN, Hardie DR, Green A, Cutmore S, MacNaught A, O'Sullivan
B, Siskind V, Van
Der Woude FJ, Hardie IR.
The
risk of skin cancer in renal transplant recipients in Queensland,
Australia. A follow-up study.
Transplantation. 1996 Mar 15;61(5):715-21.
Top
52:
Kooijmans-Coutinho MF, Rischen-Vos J, Hermans J, Arndt JW, van der Woude
FJ.
Dietary fish oil in renal transplant recipients treated with cyclosporin-A:
no
beneficial effects shown.
J Am
Soc Nephrol. 1996 Mar;7(3):513-8.
53:
Timmerman JJ, van der Woude FJ, van Gijlswijk-Janssen DJ, Verweij CL, van
Es
LA, Daha MR.
Differential expression of complement components in human fetal and adult
kidneys.
Kidney Int. 1996 Mar;49(3):730-40.
54: van der Woude
FJ, Deckers JG, Mallat MJ, Yard BA, Schrama E, van Saase JL,
Daha
MR.
Tissue antigens in tubulointerstitial and vascular rejection.
Kidney Int Suppl. 1995 Dec;52:S11-3.
Review.
55:
de Jong-Tieben LM, Berkhout RJ, Smits HL, Bouwes Bavinck JN, Vermeer BJ,
van
der Woude FJ, ter Schegget J.
High frequency of detection of epidermodysplasia verruciformis-associated
human
papillomavirus DNA in biopsies from malignant and premalignant skin lesions
from
renal transplant recipients.
J
Invest Dermatol. 1995 Sep;105(3):367-71.
Top
56: Bavinck JN,
Tieben LM, Van der Woude FJ, Tegzess AM, Hermans J, ter
Schegget J, Vermeer BJ.
Prevention of skin cancer and reduction of keratotic skin lesions during
acitretin therapy in renal transplant recipients: a double-blind,
placebo-controlled study.
J
Clin Oncol. 1995 Aug;13(8):1933-8.
57: Hollander AA,
van der Woude FJ, Cohen AF.
Effect
of grapefruit juice on blood cyclosporin concentration.
Lancet. 1995 Jul 8;346(8967):123; author reply 123-4. No abstract available.
58: van Saase JL,
van der Woude FJ, Thorogood J, Hollander AA, van Es LA,
Weening JJ, van Bockel JH, Bruijn JA.
The
relation between acute vascular and interstitial renal allograft rejection
and
subsequent chronic rejection.
Transplantation. 1995 May 15;59(9):1280-5.
59:
Bouma GJ, van der Meer-Prins EM, van der Woude FJ, van Rood JJ, Claas FH.
Relevance of pretransplant donor-specific T cell allorepertoire for human
kidney graft survival.
Transplantation. 1995 Apr 15;59(7):969-76.
Top
60: Hollander AA,
van Saase JL, Kootte AM, van Dorp WT, van Bockel HJ, van Es
LA, van der Woude FJ.
Beneficial
effects of conversion from cyclosporin to azathioprine after kidney
transplantation.
Lancet. 1995 Mar 11;345(8950):610-4.
61:
Koning OH, van Bockel JH, van der Woude FJ, Persijn GG, Hermans J, Ploeg
RJ.
Risk factors for delayed graft function in University of Wisconsin solution
preserved kidneys from multiorgan donors. European Multicenter Study Group on
Organ Preservation.
Transplant Proc. 1995 Feb;27(1):752-3. No abstract available.
62:
Kooijmans-Coutinho MF, Bruijn JA, Hermans J, Schindler R, Frei U, Schrama
E, van Es LA, Daha
MR, van der Woude FJ.
Evaluation
by histology, immunohistology and PCR of protocollized renal
biopsies 1 week post-transplant in relation to subsequent rejection episodes.
Nephrol Dial Transplant. 1995;10(6):847-54.
63:
van der Woude FJ.
Mycophenolate
mofetil (RS 61443): nothing new under the sun or an important
break-through in the field of transplantation?
Nephrol Dial Transplant. 1995;10(7):1112-5. Review. No abstract available.
Top
1: Boonstra JG,
Wever PC, Laterveer JC, Bruijn JA, van der Woude FJ, ten Berge
IJ,
Daha MR.
Apoptosis of acinar cells in pancreas allograft rejection.
Transplantation. 1997 Oct 27;64(8):1211-3.
2:
Boonstra JG, Deckers JG, Laterveer JC, Price V, van Es LA, Bruijn JA, Daha
MR,
van der Woude FJ.
Pancreas and kidney allograft-infiltrating cells in simultaneous
pancreas-kidney transplantation.
Transplantation. 1997 May 27;63(10):1470-5.
Top
3:
Kroes AC, van der Pijl JW, van Tol MJ, van Krieken JH, Falk KI, Gratama JW,
van
der Woude FJ.
Rapid occurrence of lymphoproliferative disease after pancreas-kidney
transplantation performed during acute primary Epstein-Barr virus infection.
Clin
Infect Dis. 1997 Mar;24(3):339-43.
4:
van der Pijl JW, Srivastava N, Denouel J, Burggraaf J, Schoemaker RC, van
der Woude FJ, Cohen
AF.
Pharmacokinetics
of the conventional and microemulsion formulations of
cyclosporine in pancreas-kidney transplant recipients with gastroparesis.
Transplantation.
1996 Aug 27;62(4):456-62.
5: de la Fuente RB,
van der Pijl JW, Ringers J, Zwartendijk J, van der Woude
FJ.
Ballooning of the duodenal segment after a pancreas-kidney transplantation.
J
Urol. 1996 Apr;155(4):1384. No abstract available.
6: Van der Pijl JW,
Smets YF, de la Fuente R, Ringers J, Lemkes HH, van der
Woude FJ.
Urologic infections and problems after 50 simultaneous pancreas-kidney
transplantations.
Transplant Proc. 1995 Dec;27(6):3105. No abstract available.
Top
7: Smets YF, van
der Pijl JW, van Dissel JT, Ringers J, Lemkes HH, van der
Woude FJ.
Major bacterial and fungal infections after 50 simultaneous pancreas-kidney
transplantations.
Transplant Proc. 1995 Dec;27(6):3089-90. No abstract available.
8:
Boonstra JG, Bruijn JA, Hermans J, Lemkes HH, Ringers J, van der Pijl H,
van der Woude FJ.
The
incidence of interstitial and vascular kidney rejection after
pancreas-kidney
transplantation.
J Am
Soc Nephrol. 1995 May;5(11):1918-25.
9:
Hollander AA, van Rooij J, Lentjes GW, Arbouw F, van Bree JB, Schoemaker
RC, van Es LA, van
der Woude FJ, Cohen AF.
The
effect of grapefruit juice on cyclosporine and prednisone metabolism in
transplant patients.
Clin
Pharmacol Ther. 1995 Mar;57(3):318-24.
1.
Pilotstudie zur AB0-inkompatiblen Lebendnierentransplantation
Studienkoordinatoren: Priv.Doz. Dr. P. Schnülle / Prof. Dr. F.J. van der Woude
2.
Prospektiv randomisierte Studie zur Evaluierung einer Spenderkonditionierung
mit Dopamin auf den Verlauf nach Nierentransplantation
Studienkoordinator: Priv.Doz. Dr. P. Schnülle in Kooperation mit der Deutschen
Stiftung Organtransplantation (Region-Baden-Wuerttemberg und Bayern) sowie
EUROTRANSPLANT
3.
Randomisierte klinische Studie zur Evaluierung einer Cyclosporin A freien
Dauerimmunsuppression mit Mycophenolat Mofetil (MMF)
Studienkoordinator: Priv.Doz. Dr. P. Schnülle / Prof. Dr. F.J. van der Woude
in Kooperation mit der den Transplantationszentren Leiden (Niederlande) und
Groningen (Niederlande) (abgeschlossen, Ergebnisse siehe JASM 2002)
