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Publications

Recent publications: https://pubmed.ncbi.nlm.nih.gov/?term=Dobreva+Gergana&sort=date

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S. “Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling.” J Hepatol. 2020 Sep 9:S0168-8278(20)33608-4.

Chelladurai P, Dabral S, Basineni SR, Chen CN, Schmoranzer M, Bender N, Feld C, Nötzold RR, Dobreva G, Wilhelm J, Jungblut B, Zhao L, Bauer UM, Seeger W, Pullamsetti SS. “Isoform-specific characterization of class I histone deacetylases and their therapeutic modulation in pulmonary hypertension.” Sci Rep. 2020 Jul 30;10(1):12864.

Mossel DM, Moganti K, Riabov V, Weiss C, Kopf S, Cordero J, Dobreva G, Rots MG, Klüter H, Harmsen MC, Kzhyshkowska J. “Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions.” Front Immunol. 2020 Jun 2;11:1071.

Chaudhry SR, Kinfe TM, Lamprecht A, Niemelä M, Dobreva G, Hänggi D, Muhammad S. “Elevated level of cerebrospinal fluid and systemic chemokine CCL5 is a predictive biomarker of clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH).” Cytokine. 2020 Sep;133:155142.

Garvalov BK, Muhammad S, Dobreva G. “Lamin B1 in cancer and aging.” Aging (Albany NY). 2019 Sep 20;11(18):7336-7338.

Malek Mohammadi M, Abouissa A, Azizah I, Xie Y, Cordero J, Shirvani A, Gigina A, Engelhardt M, Trogisch FA, Geffers R, Dobreva G, Bauersachs J, Heineke J. “Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation.” JCI Insight. 2019 Jul 23;5(16):e128336.

Scharf GM, Kilian K, Cordero J, Wang Y, Grund A, Hofmann M, Froese N, Wang X, Kispert A, Kist R, Conway SJ, Geffers R, Wollert KC, Dobreva G, Bauersachs J, Heineke J. “Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation.” JCI Insight. 2019 Jul 16;5(15):e126721.

Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, Mehta A, Wujak L, Cabrera-Fuentes H, Chao CM, Braubach P, Bellusci S, Seeger W, Günther A, Preissner KT, Wygrecka M, Savai R, Papy-Garcia D, Dobreva G, Heikenwalder M, Savai-Pullamsetti S, Braun T, Barreto G. “Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis.” Nat Commun. 2019 May 20;10(1):2229.

Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G. “Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.” Cell Res. 2019 Jun;29(6):486-501.

Jia Y, Vong JS, Asafova A, Garvalov BK, Caputo L, Cordero J, Singh A, Boettger T, Günther S, Fink L, Acker T, Barreto G, Seeger W, Braun T, Savai R, Dobreva G. “Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET.” J Exp Med. 2019 Jun 3;216(6):1377-1395.

Klett H, Jürgensen L, Most P, Busch M, Günther F, Dobreva G, Leuschner F, Hassel D, Busch H, Boerries M. “Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration.” Biomolecules. 2018 Dec 28;9(1):11.

Singh I, Contreras A, Cordero J, Rubio K, Dobersch S, Günther S, Jeratsch S, Mehta A, Krüger M, Graumann J, Seeger W, Dobreva G, Braun T, Barreto G. “MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization.” Nat Genet. 2018 Jul;50(7):990-1001.

Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T. “Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.” J Clin Invest. 2017 Jun 1;127(6):2235-2248.

Witzel HR, Cheedipudi S, Gao R, Stainier DY, Dobreva G. “Isl2b regulates anterior second heart field development in zebrafish.” Sci Rep. 2017,7:41043.

Mehta A, Cordero J, Dobersch S, Romero-Olmedo AJ, Savai R, Bodner J, Chao CM, Fink L, Guzmán-Díaz E, Singh I, Dobreva G, Rapp UR, Günther S, Ilinskaya ON, Bellusci S, Dammann RH, Braun T, Seeger W, Gattenlöhner S, Tresch A, Günther A, Barreto G. “Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.” EMBO Mol Med. 2016, 8(12):1380-1389.

Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. “The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.” Cell Stem Cell 2015, 17(3):287-99

Dobreva G, Braun T. “The transcriptional landscape of regenerating newborn mouse hearts.” Circ Res 2015, 116(5):767-9

Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M,  Dirschinger R, Yanchun G, Kühl S, Sinnecker D, Lipp P, Laugwitz KL, Kühl M,  Moretti A. “Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity.” Stem Cells 2015, 33(4): 1113-1129

Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK. “Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.” Cereb Cortex 2015, 25(10): 3406-19

Cheedipudi S, Genolet O, Dobreva G. “Epigenetic inheritance of cell fates during embryonic development.” Front Genet 2014, 5:19.

Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S. “Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.” Circ Res 2013, 113(7):856-62

Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK. “A network of genetic repression and derepression specifies projection fates in the developing neocortex.” Proc Natl Acad Sci U S A 2012, 109(47):19071-8

Witzel H, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G. “The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity” Dev Cell 2012, 23(1):58-70

Dobreva G, Braun T. “When silence is broken: polycomb group proteins in heart development.” Circ Res 2012, 110(3):372-4

Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R. “Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner” Cell Stem Cell 2010, 7(4):496-507

Dobreva G, Braun T. “The yin and yang of polycomb repression in regenerating muscle” Cell Stem Cell  2010, 7(4):422-4

Alcamo EA, Chirivella L, Dautzenberg M, Dobreva G, Fariñas I, Grosschedl R, and McConnell SK. “Satb2 regulates callosal projection neuron identity in the developing cerebral cortex” Neuron 2008, 57(3):364-77

Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, and Grosschedl R. ”SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation” Cell 2006, 125(5):971-86

Kieslinger M, Folberth S, Dobreva G, Dorn T, Croci L, Erben R, Conzales G, and Grosschedl R. “EBF2 regulates osteoblast-dependent differentiation of osteoclasts” Dev Cell 2005, 9(6):757-67

Dobreva G, Dambacher J, and Grosschedl R. “SUMO modification of a novel MAR-binding protein, SATB2, regulates immunoglobulin µ gene expression” Genes Dev 2003, 17(24): 3048-61

Bodem J*, Dobreva G*, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H, Vingron M, and Grummt I. "TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p" EMBO Reports  2000, 1(2):171-5 *J. Bodem and G. Dobreva contributed equally to this work.

Boyanovski B, Russeva M, Dobreva G, Ganev V, Mladenova A, Peicheva V, Nikolov K, and Baleva M. "Protein C Activity in Patients with Antiphospholipid Syndrome" Journal of Clinical Rheumatology 2000, 6:239-243

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