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Echocardiography is a robust and reproducible non-invasive approach of assessing cardiovascular function in vivo. Our research group within the ECAS builds on more than 10 years of hands-on experience in murine echocardiography. In our research projects, we use cardiac ultrasound imaging in all stages of cardiac disease as state-of-the-art functional diagnosis tool. Assessed parameters start with systolic function (e.g. left-ventricular ejection fraction) and anatomy (e.g. ventricular dimensions and wall thickness), and lead via diastolic function, speckle-tracking echocardiography and right-ventricular imaging to infant, neonatal and even embryonal stages. One of our research aims is to develop existing echocardiography approaches further and establish new analytical standards in constant exchange with experts from Fujifilm VisualSonics and Purdue University.
Depending on your manuscript or project idea, we will record ultrasound images, assist or conduct the data acquisition and, if requested, give advice in design and structure of experimental groups and cohorts.
Important: In terms of the animal protection law, echocardiography needs to be announced to the regional council and the operating personnel needs to be listed (i.e., us). Depending on the study volume, an extension or new animal proposal will be necessary; however, we will support you in writing.
- Cardiovascular image acquisition
- Specific image analysis
- Guidance in study design for echocardiographic measurements depending on the project hypothesis
Fujifilm VisualSonics Vevo 3100 System
frequency up to 70 MHz, resolution down to 30 µm
Vevo Imaging Station
including Anesthesia System, Mouse Handling Table with ECG measurement, THM unit ready for third party connection (e.g. DSI, Millar – not provided) and body temperature control
MX400, MX550D and MX700 transducer
covering small rats and large mice, small mice or infant, neonatal and embryonal mice, respectively
Vevo license package
including 1D, 2D Analysis, Doppler imaging, LV tracing and VevoStrain Analysis Suite
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