Publications

2021

Barysch SV, Stankovic-Valentin N, Miedema T, Karaca S, Doppel J, Nait Achour T, Vasudeva A, Wolf L, Sticht C, Urlaub H, Melchior F. Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling. EMBO Rep. 2021 Jan 22:e49651. doi: 10.15252/embr.201949651. Epub ahead of print. PMID:33480129.

Chen J, Fleming T, Katz S, Dewenter M, Hofmann K, Saadatmand A, Kronlage M, Werner MP, Pokrandt B, Schreiter F, Lin J, Katz D, Morgenstern J, Elwakiel A, Sinn P, Gröne HJ, Hammes HP, Nawroth PP, Isermann B, Sticht C, Brügger B, Katus HA, Hagenmueller M, Backs J. CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy. Diabetes. 2021 Feb;70(2):616-626. doi: 10.2337/db19-0659. Epub 2020 Nov 25. PMID: 33239449.

Olsavszky V, Sticht C, Schmid CD, Winkler M, Wohlfeil SA, Olsavszky A, Schledzewski K, Géraud C, Goerdt S, Leibing T, Koch PS. Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells. Gene. 2021 Feb 5;768:145284. doi: 10.1016/j.gene.2020.145284. Epub 2020 Oct 31. PMID: 33130055.

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S. Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 2021 Feb;74(2):380-393. doi: 10.1016/j.jhep.2020.08.033. Epub 2020 Sep 9. PMID: 32916216.

2020

Daniele C, Nardozi D, Torelli A, Khan AUM, Gretz N. Transcutaneous Measurement of Glomerular Filtration Rate in Rodents. Methods Mol Biol. 2020;2067:129-137. doi: 10.1007/978-1-4939-9841-8_9. PMID: 31701449.

Bär I, Ast V, Meyer D, König R, Rauner M, Hofbauer LC, Müller JP. Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks. Cells. 2020 Nov 9;9(11):2443. doi: 10.3390/cells9112443. PMID: 33182501; PMCID: PMC7697865

Brenna C, Khan AUM, Picascia T, Sun Q, Heuveline V, Gretz N. New technical approaches for 3D morphological imaging and quantification of measurements. Anat Rec (Hoboken). 2020 Oct;303(10):2702-2715. doi: 10.1002/ar.24463. Epub 2020 Jun 12. PMID: 32533657.

Loeffler MA, Hu J, Kirchner M, Wei X, Xiao Y, Albrecht T, De La Torre C, Sticht C, Banales JM, Vogel MN, Pathil-Warth A, Mehrabi A, Hoffmann K, Rupp C, Köhler B, Springfeld C, Schirmacher P, Ji J, Roessler S, Goeppert B. MiRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR-451a/ATF2 axis. J Pathol. 2020 Nov;252(3):239-251. doi: 10.1002/path.5514. Epub 2020 Sep 15. PMID: 32710569.

Gamez C, Schneider-Wald B, Schuette A, Mack M, Hauk L, Khan AUM, Gretz N, Stoffel M, Bieback K, Schwarz ML. Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results. PLoS One. 2020 Jan 10;15(1):e0227553. Doi: 10.1371/journal.pone.0227553. PMID: 31923210; PMCID: PMC6953860.

Sun Q, Picascia T, Khan AUM, Brenna C, Heuveline V, Schmaus A, Sleeman JP, Gretz N. Application of ethyl cinnamate based optical tissue clearing and expansion microscopy combined with retrograde perfusion for 3D lung imaging. Exp Lung Res. 2020 Oct 12:1-16. doi: 10.1080/01902148.2020.1829183. Epub ahead of print. PMID: 33043719.

S. Luiken, A. Fraas, M. Bieg, R. Sugiyanto, B. Goeppert, S. Singer, C. Ploeger, G. Warsow, J.U. Marquardt, C. Sticht, C. De La Torre, S. Pusch, A. Mehrabi, N. Gretz, M. Schlesner, R. Eils, P. Schirmacher, T. Longerich, S. Roessler, NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis, Oncogene, 39 (2020) 3128-3144

Marquard S, Thomann S, Weiler SME, Bissinger M, Lutz T, Sticht C, Tóth M, de la Torre C, Gretz N, Straub BK, Marquardt J, Schirmacher P, Breuhahn K. Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis. Cell Commun Signal. 2020 Oct 23;18(1):166. doi: 10.1186/s12964-020-00634-6. PMID: 33097058; PMCID: PMC7583285.

Lou B, Boger M, Bennewitz K, Sticht C, Kopf S, Morgenstern J, Fleming T, Hell R, Yuan Z, Nawroth PP, Kroll J. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biol. 2020 Oct;37:101723. doi: 10.1016/j.redox.2020.101723. Epub 2020 Sep 16. PMID: 32980661; PMCID: PMC7519378.

2019

Huang J, Brenna C, Khan AUM, Daniele C, Rudolf R, Heuveline V, Gretz N. A cationic near infrared fluorescent agent and ethyl-cinnamate tissue clearing protocol for vascular staining and imaging. Sci Rep. 2019 Jan 24;9(1):521. doi: 10.1038/s41598-018-36741-1. PMID: 30679514; PMCID: PMC6345820.

Wei T, Weiler SME, Tóth M, Sticht C, Lutz T, Thomann S, De La Torre C, Straub B, Merker S, Ruppert T, Marquardt J, Singer S, Gretz N, Schirmacher P, Breuhahn K. YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells. Oncogene. 2019 Jul;38(27):5541-5550. doi: 10.1038/s41388-019-0801-y. Epub 2019 Apr 1. PMID: 30936457.

Saadatmand AR, Sramek V, Weber S, Finke D, Dewenter M, Sticht C, Gretz N, Wüstemann T, Hagenmueller M, Kuenzel SR, Meyer-Roxlau S, Kramer M, Sossalla S, Lehmann LH, Kämmerer S, Backs J, El-Armouche A. CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22282-22287. doi: 10.1073/pnas.1816521116. Epub 2019 Oct 16. PMID: 31619570; PMCID: PMC6825262.

2018

Khan AUM, Torelli A, Wolf I, Gretz N. AutoCellSeg: robust automatic colony forming unit (CFU)/cell analysis using adaptive image segmentation and easy-to-use post-editing techniques. Sci Rep. 2018 May 8;8(1):7302. doi: 10.1038/s41598-018-24916-9. PMID: 29739959; PMCID: PMC5940850.

Sticht C, De La Torre C, Parveen A, Gretz N. miRWalk: An online resource for prediction of microRNA binding sites. PLoS One. 2018 Oct 18;13(10):e0206239. doi: 10.1371/journal.pone.0206239. PMID: 30335862; PMCID: PMC6193719.

González-Vallinas M, Rodríguez-Paredes M, Albrecht M, Sticht C, Stichel D, Gutekunst J, Pitea A, Sass S, Sánchez-Rivera FJ, Lorenzo-Bermejo J, Schmitt J, De La Torre C, Warth A, Theis FJ, Müller NS, Gretz N, Muley T, Meister M, Tschaharganeh DF, Schirmacher P, Matthäus F, Breuhahn K. Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients. Mol Cancer Res. 2018 Mar;16(3):390-402. doi: 10.1158/1541-7786.MCR-17-0334. Epub 2018 Jan 12. PMID: 29330288.

Arnold C, Feldner A, Zappe M, Komljenovic D, De La Torre C, Ruzicka P, Hecker M, Neuhofer W, Korff T. Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J. 2019 Mar;33(3):3364-3377. doi: 10.1096/fj.201801594R. Epub 2018 Nov 1. PMID: 30383452.

Yuan X, Li J, Coulouarn C, Lin T, Sulpice L, Bergeat D, De La Torre C, Liebe R, Gretz N, Ebert MPA, Dooley S, Weng HL. SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance. Br J Cancer. 2018 Nov;119(11):1358-1366. doi: 10.1038/s41416-018-0338-9. Epub 2018 Nov 13. PMID: 30420613; PMCID: PMC6265288.

2017

Müller SM, Wang S, Telman W, Liebthal M, Schnitzer H, Viehhauser A, Sticht C, Delatorre C, Wirtz M, Hell R, Dietz KJ. The redox-sensitive module of cyclophilin 20-3, 2-cysteine peroxiredoxin and cysteine synthase integrates sulfur metabolism and oxylipin signaling in the high light acclimation response. Plant J. 2017 Sep;91(6):995-1014. doi: 10.1111/tpj.13622. Epub 2017 Aug 3. PMID: 28644561.

Khan AU, Mikut R, Reischl M. A New Feedback-Based Method for Parameter Adaptation in Image Processing Routines. PLoS One. 2016 Oct 20;11(10):e0165180. doi: 10.1371/journal.pone.0165180. PMID: 27764213; PMCID: PMC5072585.

Khan AU, Mikut R, Reischl M. A Benchmark Data Set to Evaluate the Illumination Robustness of Image Processing Algorithms for Object Segmentation and Classification. PLoS One. 2015 Jul 20;10(7):e0131098. Doi: 10.1371/journal.pone.0131098. PMID: 26191792; PMCID: PMC4508044.

Becker A, Klapczynski A, Kuch N, Arpino F, Simon-Keller K, De La Torre C, Sticht C, van Abeelen FA, Oversluizen G, Gretz N. Gene expression profiling reveals aryl hydrocarbon receptor as a possible target for photobiomodulation when using blue light. Sci Rep. 2016 Sep 27;6:33847. doi: 10.1038/srep33847. PMID: 27669902; PMCID: PMC5037386.