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Selected publications

  • Kroll lab
    1. She J, Yuan Z, Wu Y, Chen J, Kroll J. Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Mol Metab. doi: 10.1016/j.molmet.2017.11.006, 2018
    2. Wiggenhauser LM, Kohl K, Dietrich N, Hammes HP, Kroll J. Studying diabetes through the eyes of a fish: Microdissection, visualization and analysis of the adult tg(fli:EGFP) zebrafish retinal vasculature. J Vis Exp, doi: 10.3791/56674, 2017.
    3. Sharma KR, Heckler K, Stoll SJ, Hillebrands JL, Kynast K, Herpel E, Porubsky S, Elger M, Hadaschik B, Bieback K, Hammes HP, Nawroth PP, Kroll J. ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Sci Rep. Nov 16;6:37172. doi: 10.1038/srep37172, 2016.
    4. Schaeker K, Bartsch S, Patry C, Cramer‐Stoll S, Hillebrands JL, Wieland T, Kroll J. The bipartite Rac1 guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (Elmo1/Dock180) protects endothelial cells from apoptosis in blood vessel development. J Biol Chem 290: 6408‐ 6418, 2015.
    5. Jörgens K, Stoll SJ, Pohl J, Fleming TH, Sticht C, Nawroth PP, Hammes HP, Kroll J. High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signalling cascade. Diabetes 64(1):213‐25, 2015.
    6. Kiesow K, Bennewitz K, Miranda LG, Stoll SJ, Hartenstein B, Angel P, Kroll J*, Schorpp‐Kistner M*. Junb controls lymphatic vascular development in zebrafish via miR‐182. Sci Rep. 13;5:15007, 2015.
    7. Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DYR, Srivastava D. miR‐10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting VEGF signaling. Circ. Res. 111: 1421‐33, 2012. Urbich C, Kaluza D, Frömel T, Knau A, Bennewitz, K, Boon R, Bonauer A, Döbele C, Böckel JN, Hergenreider E, Zeiher AM, Kroll J, Fleming I, and Dimmeler S. MicroRNA‐27a/b controls repulsion and angiogenesis by targeting semaphorin 6A in endothelial cells. Blood 119:1607‐1616, 2012.
    8. Kaluza D, Kroll J, Gesierich S, Yao TP, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, and Urbich C. Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J 30: 4142–4156, 2011.
    9. Stoll SJ, Bartsch S, Augustin HG, and Kroll J. The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. Circ Res 108: 1367‐1377, 2011.
    10. Epting D, Wendik B, Bennewitz K, Dietz CT, Driever W, and Kroll J. The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish. Circ Res 107: 45‐55, 2010.
  • Dobreva lab
    1. Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T. “ Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. ” J Clin Invest. 2017 Jun 1;127(6):2235-2248.
    2. Witzel HR, Cheedipudi S, Gao R, Stainier DY, Dobreva G. “Isl2b regulates anterior second heart field development in zebrafish.” Sci Rep. 2017,7:41043.
    3. Mehta A, Cordero J, Dobersch S, Romero-Olmedo AJ, Savai R, Bodner J, Chao CM, Fink L, Guzmán-Díaz E, Singh I, Dobreva G, Rapp UR, Günther S, Ilinskaya ON, Bellusci S, Dammann RH, Braun T, Seeger W, Gattenlöhner S, Tresch A, Günther A, Barreto G. “Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.” EMBO Mol Med. 2016, 8(12):1380-1389.
    4. Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. “The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.” Cell Stem Cell 2015, 17(3):287-99
    5. Dobreva G, Braun T. “The transcriptional landscape of regenerating newborn mouse hearts.” Circ Res 2015, 116(5):767-9
    6. Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M,  Dirschinger R, Yanchun G, Kühl S, Sinnecker D, Lipp P, Laugwitz KL, Kühl M,  Moretti A. “Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity.” Stem Cells 2015, 33(4): 1113-1129
    7. Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK. “Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.” Cereb Cortex 2015, 25(10): 3406-19
    8. Cheedipudi S, Genolet O, Dobreva G. “Epigenetic inheritance of cell fates during embryonic development.” Front Genet 2014, 5:19.
    9. Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S. “Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.” Circ Res 2013, 113(7):856-62
    10. Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK. “A network of genetic repression and derepression specifies projection fates in the developing neocortex.” Proc Natl Acad Sci U S A 2012, 109(47):19071-8

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