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RF Methods and Imaging

Group Leader: Jorge Chacón Caldera, Dr. Sc. Hum. / Matthias Malzacher, M.Sc. 


Research Profile

The aim of our group is to develop Radio-Frequency (RF) methods for Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) as well as EM simulations for RF safety in the RF and the LF regime. Special focus is set on high resolution proton MRI of kidneys as pre-clinical tool at 3 T and 9.4 T, improvement of Signal-to-Noise-Ratio (SNR)for X-nuclei MRI in the human body at 3 T and for preclinical research at 9.4 T as well as EM simulations for whole body SAR calculations and peripheral nerve stimulations.

    ex-vivo mouse kidney

    Cationized-Ferritin Ex-vivo mouse kidney scanned at 9.4 T with a cryogenically cooled quadrature coil (Bruker BioSpin GmbH, Germany). 25 µm isotropic resolution.


    EM simulations of E field distortions by a detuned 24 channel head coil using different detuning concepts at 3T.

    Sodium/Proton Body Resonator

    3 channel Rx array for chlorine MRI at 9.4 T.
                                                                                                        


    3 different stacked receive-only coils to a 3 coil base Rx array to enhance prostate MRI at 3T.      

     









 

Current research projects

  • High resolution imaging of glomeruli in ex-vivo rodent kidneys at 9.4 and 3T
  • 35Cl/23Na/1H RF resonator systems for preclinical imaging at 9.4T
  • EM-field simulations of novel coil concepts and MRI safety assessment for RF and LF problems
  • Human abdominal, spine and head RF resonators for X-nuclei imaging
  • Organ-dedicated RF resonators
Group members

Interested in joining our group for an internship, Bachelorthesis or Masterthesis? Please contact: Jorge Chacon Caldera

Colaborations


Equipment

  • Scanners: 
    • 0.5T portable MRI system (Pure Devices GmbH, Germany)
    • 1 and  9.4T pre-clinical MRI Systems (Bruker BioSpin GmbH, Germany)
    • 1.5 and 3T clinical MRI systems (Siemens Healtcare GmbH, Germany)
  • RF laboratory (equipped with 2 NWA)
  • EM simulation software (CST - Computer Simulation Technology AG, Germany)
Recent publications

  • M. Malzacher, R. HuJ. Chacon-Caldera and L. Schad.
    Reducing signal-to-noise ratio degradation due to coil coupling in a receiver array
    for 35CL MRI at 9.4 T: A comparison of matching and decoupling strategies.

    Concept Magn Reson B, in press (2018).
  • J. Chacon-Caldera, A. Fischer, M. Malzacher, Y. Vetter, M. Davids, M. Flöser, C. Stumpf and L. Schad.
    Evaluation of stacked resonators to enhance the performance of a surface
    receive-only arr
    ay for prostate MRI at 3 Tesla.
    Magn Reson Imaging, 53 , p.164-172 (2018).
  • M. Malzacher, M. Davids, L. Schad and J. Chacon-Caldera.
    Evaluating the effects of receive-only arrays in specific absorption rate
    simulations at 3 and 7 T.

    Magn Reson Imaging, 53 , p.7-13 (2018).
  • M. Davids, B. Guérin, M. Malzacher, L. Schad and L. Wald.
    Predicting Magnetostimulation Thresholds in the Peripheral
    Nervous System using Realistic Body Models.

    Sci Rep-Uk, 7, p.5316 (2017).
  • J. Chacon-Caldera, M. Malzacher and L. Schad.
    Partially orthogonal resonators for magnetic resonance imaging.
    Sci Rep-Uk, 7, p.42347 (2017).
  • J. Chacón-Caldera, S. Geraci, P. Krämer, L. Cullen-McEwen, J. Bertram, N. Gretz and L. Schad.
    Fast glomerular quantification of whole ex vivo mouse kidneys using Magnetic Resonance Imaging at 9.4 Tesla.
    Z Med Phys, 26 (1), pp.54-62 (2016).
  • M. Malzacher, R. Kalayciyan, S. Konstandin, S. Haneder and L. Schad.
    Sodium-23 MRI of whole spine at 3 Tesla using a 5-channel receive-only phased-array and a whole-body transmit resonator.
    Z Med Phys, 26 (1), p.95–100 (2016).
Contact: Jorge Chacón Caldera, M.Sc. last modified: 19.10.2018
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