University of Heidelberg
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Interleaved gradient echo planar (IGEPI) and phase contrast CINE-PC flow measurements in the renal artery

M. Bock, S. Schoenberg, L. Schad, M. Knopp, M. Essig and G. van Kaick

J Magn Reson Imaging, 8 (4), pp.889-895

ECG-gated phase contrast (CINE-PC) flow measurements in the renal artery help to differentiate between low- and high-grade stenoses. Because conventional CINE-PC acquisitions with high temporal resolution require acquisition times of several minutes, respiratory motion results in a systematic overestimation of renal artery flow. With the use of an interleaved gradient echo-planar technique (IGEPI), total measurement times can be shortened to about 30 seconds, while a high spatial and temporal resolution is maintained. In this study, an IGEPI CINE-PC flow measurement pulse sequence with 16 gradient echoes was compared with a non-breathheld conventional CINE-PC technique. Flow-time curves were measured in volunteers and in patients with suspected renal artery stenosis. With IGEPI CINE-PC, mean flow velocity, vessel cross-sectional area, and mean blood flow were substantially lower by 90\% to 25\%. Contrast-enhanced 3D MR angiography was used to compare stenosis grading based on flow-time curve patterns with morphologic grading. With IGEPI CINE-PC, all high-grade stenoses (n = 5) were detected, whereas only 66\% (n = 3) were found with conventional CINE-PC.

Contact: Dr. Frank Zöllner last modified: 14.01.2019
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