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Dissolved hyperpolarized xenon-129 MRI in human kidneys.

J. Chacon-Caldera, A. Maunder, M. Rao, G. Norquay, O. Rodgers, M. Clemence, C. Puddu, L. Schad and J. Wild

Magn Reson Med, 83 (1), pp.262-270

To assess the feasibility of using dissolved hyperpolarized xenon-129 ( Xe) MRI to study renal physiology in humans at 3 T. Using a flexible transceiver RF coil, dynamic and spatially resolved Xe spectroscopy was performed in the abdomen after inhalation of hyperpolarized Xe gas with 3 healthy male volunteers. A transmit-only receive-only RF coil array was purpose-built to focus RF excitation and enhance sensitivity for dynamic imaging of Xe uptake in the kidneys using spoiled gradient echo and balanced steady-state sequences. Using spatially resolved spectroscopy, different magnitudes of signal from Xe dissolved in red blood cells and tissue/plasma could be identified in the kidneys and the aorta. The spectra from both kidneys showed peaks with similar amplitudes and chemical shift values. Imaging with the purpose-built coil array was shown to provide more than a 3-fold higher SNR in the kidneys when compared with surrounding tissues, while further physiological information from the dissolved Xe in the lungs and in transit to the kidneys was provided with the transceiver coil. The signal of dissolved hyperpolarized Xe could be imaged with both tested sequences for about 40 seconds after inhalation. The uptake of Xe dissolved in the human kidneys was measured with spectroscopic and imaging experiments, demonstrating the potential of hyperpolarized Xe MR as a novel, noninvasive technique to image human kidney tissue perfusion.

Contact: Dr. Frank Zöllner last modified: 18.11.2019
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