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Combination of DCE and DSC MRI: Added value in the study of tumor vascularization

M. Heilmann, S. Sourbron, C. Walczak, A. Biffar, J. Vautier, M. Peller and A. Volk

Proceedings 16th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Toronto,, p.446

Combination of DCE and DSC MRI was realized by simultaneous measurement of T1 and T2* kinetics. In a subcutaneous xenograft model implanted in nude mice examined at 4.7T, a 6 kDa CA was suitable for assessing heterogeneous capillary permeability by measuring Ktrans, whereas a 0.5kDa CA yielded perfusion weighted Ktrans values. Furthermore, a description of R2*(t) in the presence of CA leakage was proposed yielding the parameters κ20 and κ21. They are thought to be related to intra-voxel cellular distribution and vascular architecture. Combined DCE-DSC MRI holds potential to improve tumor characterization.

Contact: Prof. Dr. Frank Zöllner last modified: 22.05.2019
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