University of Heidelberg
Faculty of Medicine Mannheim
University Hospital Mannheim
News
These pages are still under constructions and will be available soon! Please check again later!
Note


If you have questions concerning a specific publication please use this form with subject 'information about publications' and giving the full citation in the message body.

Links
Home > Publications > Abstract >

Tissue contrast in MRI owing to intermolecular multiple-quantum coherences (iMQC)

S. Kirsch and P. Bachert

Z Med Phys, 16 (3), pp.188-198

Dipole-dipole interactions in 1H NMR of liquids permit a new tissue contrast in MR imaging (MRI). For this purpose, the CRAZED (COSY Revamped by Asymmetric Z-gradient Echo Detection) sequence which simply consists of two radiofrequency pulses of delay tau and a magnetic field gradient pulse of strength G, is applied to create intermolecular multiple-quantum coherences of dipolar-coupled ensembles of water protons with spatial distance d = pi/(gammaGtau). As a consequence, the measured signal originates from "sources" that have a tunable dimension. CRAZED was first applied to MR imaging at 1.5 T by Zhong et al. To study the contrast properties and influence of sequence parameters of this technique, we implemented different sequences of this type on a clinical 1.5-T whole-body tomograph. The sequences were optimized in experiments with agar gel phantoms. We obtained images with dipolar contrast from the brain of healthy volunteers. The gradient system enabled correlation distances d in the range of 0.05 mm to 1 mm.

Contact: Dr. Frank Zöllner last modified: 21.05.2019
to top of page