University of Heidelberg
Faculty of Medicine Mannheim
University Hospital Mannheim
These pages are still under constructions and will be available soon! Please check again later!

If you have questions concerning a specific publication please use this form with subject 'information about publications' and giving the full citation in the message body.

Collaborate Research Projects
Home > Publications > Abstract >

MR tomography of lung metastases with rapid gradient echo sequences. Initial results in diagnostic applications

M. Knopp, T. Hess, L. Schad, H. Bischoff, G. Weisser, S. Blüml and G. van Kaick

Radiologe, 34 (10), pp.581-587

Rapid gradient echo sequences enable MR imaging (MRI) of pulmonary metastases with acquisition times of less than 1 s per slice. By optimization of this technique, density, T1- and T2-weighted images can be obtained (FLASH: TR 6.5 ms, TE2 = 3 ms, alpha = 10 degrees; T1w-Turbo-FLASH: TI 200 ms, TR 6.5 ms, TE2 = 3 ms, alpha = 10 degrees; T2w-Turbo-FLASH: TE1 = 50 ms, TR = 6.5 ms, TE2 = 3.5 ms; alpha = 10 degrees). In a prospective study 25 patients in whom pulmonary metastases were suspected were examined with three techniques in all three anatomical planes prior to surgery. All lung metastases revealed a high signal intensity on the FLASH as well as the T2w-Turbo-FLASH images, whereas vascular structures revealed a low signal intensity on the T2-weighted Turbo-FLASH images. Analysis regarding detection and correct number of lung metastases per patient with MRI compared with the histology revealed (n = 25): sensitivity of 82\%, specificity 67\%, positive predictive value of 95\% and negative predictive value of 33\%. While MRI does not currently have any diagnostic advantages over CT, the excellent differentiation of parenchymal lesions and vascular structures without the use of contrast medium and the variability of imaging planes are significant methodological advantages.

Contact: Dr. Frank Zöllner last modified: 30.11.2020
to top of page