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23Na-MRI contrasts for application in muscular sodium channel diseases

A. Nagel, M. Weber, C. Matthies, J. Dinkel, K. Jurkatt-Rott, F. Lehmann-Horn and L. Schad

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Honolulu,, p.555

Three different 23Na-MRI contrasts were applied and compared with regard to the information they provide about the compartments from which the 23Na signal originates. In particular, a T1-weighted, a concentration-weighted contrast, and an inversion recovery sequence, the latter of which suppresses the 23Na fluid signal were used. It was shown that the 23Na-IR sequence is well suitable to visualize an intracellular sodium accumulation, caused by provocation of the lower leg muscles in patients with hypokalemic periodic paralysis, a muscular sodium channelopathy. This is substantiated by the fact, that the total sodium concentration stays constant after provocation.

Contact: Prof. Dr. Frank Zöllner last modified: 30.11.2020
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