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Investigation of water diffusion effect on the signal relaxation in presence of a stochastic cylinder network: A phantom study

M. Sohlin, J. Sedlacik, J. Reichenbach and L. Schad

Proceedings 16th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Toronto,, p.1427

A signal decay model valid in the static dephasing regime is commonly used to map the oxygen extraction fraction (OEF) in the brain. In this work, the model was examined in a phantom study under non-static conditions, i.e. small vessel radius. Our measurements show that water diffusion must be taken into account to obtain proper OEF values for small vessel diameters. Both methods become unstable when more than two fit parameters are used, this can be a severe problem in vivo. Furthermore, using T2 as a fit parameter in the static model seems to give misleading results.

Contact: Prof. Dr. Frank Zöllner last modified: 20.03.2019
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