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Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned (23)Na/(1)H resonator systems

F. Wetterling, S. Ansar and E. Handwerker

Phys Med Biol, 57 (21), pp.6929-6946

A double-tuned (23)Na/(1)H resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. (1)H-diffusion-, (1)H perfusion, (1)H T(2)-, (1)H arterial blood flow- and (23)Na spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal (23)Na was detected in hypoperfused stroke tissue which exhibited a low (1)H apparent diffusion coefficient (ADC) and no changes in (1)H T(2) relaxation time during transient ischemia, while (23)Na increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned (1)H/(23)Na birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear (23)Na/(1)H MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high (23)Na at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear (23)Na/(1)H MRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue.

Contact: Dr. Frank Zöllner last modified: 18.03.2019
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