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Prof. Dr. Rolf-Detlef Treede

We investigate the coding of actual or potential tissue damaging stimuli (noxious stimuli) in primary nociceptive neurons and the subsequent signal processing in the nociceptive system. We use electrophysiology and live cell imaging in cellular systems, electrophysiology and behavioral testing in rodent models of neuropathic pain and back pain, as well as psychophysics, electrophysiology and functional imaging in healthy subjects and in patients with chronic pain or diseases of the nervous system. The aim of this work is the mechanism-based classification of chronic pain and the validation of biomarkers for the detection of these mechanisms.

The focus of our work is on

  1. Quantification of pain behaviour and psychological comorbidities (anxiety, depression, sleep disorder) in rodent models of chronic back pain and neuropathic pain.

  2. Phenotyping of patients with chronic neuropathic pain, mechanism-based classification of pain patients, modelling of pain mechanisms in human surrogate models.

  3. Interaction of pain and stress in healthy subjects, patients with back pain and patients with spinal cord injuries.
Sensitivity profiles of patients with chronic peripheral neuropathic pain show three phenotype clusters (from Baron et al. 2017). A: training data set, B: validation data set

National and international joint research projects

DFG Sonderforschungsbereiche

  • SFB1158 „Heidelberg Pain Consortium"
    Förderkennzeichen:     1158/2; Teilprojekt S01
    Laufzeit:                     01.07.2019 – 30.06.2023
    Kurzbezeichnung:        Standarisierung und Entwicklung neuer humaner und muriner Schmerzmodelle und Methoden (Human-Tiermodell Tandem)

  • Förderkennzeichen:     1158/2; Teilprojekt B09
    Laufzeit:                     01.07.2019 – 30.06.2023
    Kurzbezeichnung:        Regulatorische Schaltkreise des Gehirns als Grundlage der bidirektionalen Interaktion zwischen chronischen Schmerzen und Depression

Graduiertenkollegs

  • GRK 1874 "Diabetic Microvascular Complications" (DIAMICOM)
    Work Package 4 – Diabetic Neuropathy, MD SP15 “Identification of tissue specific changes within the nociceptive system in diabetic peripheral neuropathy – characterizing pain in zebra fish
    Laufzeit:                      2013 – 2021

Weitere Verbundprojekte

  • DFG FOR 2690 "Translational Pruritus Research" (PruSearch)
    Förderkennzeichen:      MA1251/10-2
    Laufzeit:                      01.09.2018 – 30.08.2021
    Kurzbezeichnung:         Translationale Pruritusforschung (PRUSEARCH): Zentrale Informationsinfrastruktur, Bioinformatik und Physische Biomaterial Bank

  • EU (H2020-JTI-IMI2-2016-10-two-stage)
    Förderkennzeichen      777500
    Laufzeit                      01.04.2018 – 31.03.2022
    Kurzbezeichnung:        IMI-PainCare

Selected publications

  1. Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice AS, Segerdahl M, Serra J, Sindrup S, Sommer C, Tölle T, Vollert J, Treede RD (2017) Peripheral Neuropathic Pain: A mechanism-related organizing principle based on sensory profiles. Pain 2016 Nov 3. [Epub ahead of print]
  2. Caspani O, Reitz MC, Ceci A, Kremer A, Treede RD (2014) Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats. Pharmacol Biochem Behav 124, 290-296
  3. Henrich F, Magerl W, Klein T, Greffrath W, Treede RD (2015) Capsaicin-sensitive C- and A-fibre nociceptors control long-term potentiation-like pain amplification in humans. Brain 138, 2505-2520.
  4. Hoheisel U, Reuter R, de Freitas MF, Treede RD, Mense S (2013) Injection of nerve growth factor into a low back muscle induces long-lasting latent hypersensitivity in rat dorsal horn neurons. Pain 154, 1953-1960
  5. Klein T, Magerl W, Hopf HC, Sandkühler J, Treede RD (2004) Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans. J Neurosci 24, 938-946
  6. Michaux GP, Magerl W, Anton F, Treede RD (2012) Experimental characterization of the effects of acute stresslike doses of hydrocortisone in human neurogenic hyperalgesia models. Pain 153, 420-428.
  7. Schuh-Hofer S, Wodarski R, Pfau DB, Caspani O, Magerl W, Kennedy JD, Treede RD (2013) One night of total sleep deprivation promotes a state of generalized hyperalgesia: a surrogate pain model to study the relationship of insomnia and pain. Pain 154, 1613-1621
  8. Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70: 1630-1635.
  9. Tesarz J, Eich W, Treede RD, Gerhardt A (2016) Altered pressure pain thresholds and increased wind-up in adult patients with chronic back pain with a history of childhood maltreatment: a quantitative sensory testing study. Pain 157: 1799-1809.
  10. Zhang J, Hoheisel U, Klein T, Magerl W, Mense S, Treede RD (2016) High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents. J Neurophysiol 115, 692-700

Contact

Medical Faculty Mannheim
Heidelberg University

Ludolf-Krehl-Str. 13-17
68167 Mannheim
Phone: +49 621/383-9926
E-Mail: rolf-detlef.treede@medma.uni-heidelberg.de

 

Photo Credits: #1 FGV-Zentrum, Med. Fakultät Mannheim

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