Sie befinden sich hier




Barke A, Korwisi B, Casser HR, Fors EA, Geber C, Schug SA, Stubhaug A, Ushida T, Wetterling T, Rief W, Treede RD. Pilot field testing of the chronic pain classification for ICD-11: the results of ecological coding. BMC Public Health. 2018 Nov 7;18(1):1239

Berlit S, Lis S, Häfner K, Kleindienst N, Baumgärtner U, Treede RD, Sütterlin M, Schmahl C. Changes in birth-related pain perception impact of neurobiological and psycho-social factors. Arch Gynecol Obstet, 2018, 297:591-59

De Azambuja G, Hortscht U, Hoheisel U, Oliveira-Fusaro M.C., Mense S, Treede RD. Short‐term swimming exercise attenuates the sensitization of dorsal horn neurons in rats with NGF‐induced low back pain. Eur J Pain.2018 Sep;22(8):1409-1418

Eichhorn N, Treede RD, Schuh-Hofer S. The Role of Sex in Sleep Deprivation Related Changes of Nociception and Conditioned Pain Modulation. Neuroscience. 2018 Sep 1;387:191-200.

Eitner L, Özgül ÖS, Enax-Krumova EK, Vollert J, Maier C, Höffken O. Conditioned pain modulation using painful cutaneous electrical stimulation or simply habituation? Eur J Pain. 2018 Aug;22(7):1281-1290.

Kopf S, Groener JB, Kender Z, Fleming T, Bischoff S, Jende J, Schumann C, Ries S, Bendszus M, Schuh-Hofer S, Treede RD, Nawroth PP. Deep phenotyping neuropathy: An underestimated complication in patients with pre-diabetes and type 2 diabetes associated with albuminuria. Diabetes Res Clin Pract. 2018 Dec;146:191-201

Knopp KL, Stenfors C, Baastrup C, Bannon AW, Calvo M, Caspani O, Currie G, Finnerup NB, Huang W, Kennedy JD, Lefevre I, Machin I, Macleod M, Rees H, Rice ASC, Rutten K, Segerdahl M, Serra J, Wodarski R, Berge OG, Treede RD. Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium.
Scand J Pain. 2015 Apr 1;7(1):58-70

Magerl W, Hansen N, Treede RD, Klein T. The human pain system exhibits higher-order plasticity (metaplasticity). Neurobiol Learn Mem. 2018 Oct;154:112-120

Naoum J, Kleindienst N, Baumgärtner U, Willis F, Mancke F, Treede RD, Bohus M, Schmahl C. Effects of a Painful Stimulus on Stress Regulation in Male Patients With Borderline Personality Disorder: A Pilot Study. J Pers Disord. 2018 Jul 23:1-19

Nawroth PP, Bendszus M, Pham M, Jende J, Heiland S, Ries S, Schumann C, Schmelz M, Schuh-Hofer S, Treede RD, Kuner R, Oikonomou D, Groener JB, Kopf S. The Quest for more Research on Painful Diabetic Neuropathy. Neuroscience. 2018 Sep 1;387:28-37

Nuñez-Badinez P, Sepúlveda H, Diaz E, Greffrath W, Treede RD, Stehberg J, Montecino M, van Zundert B. Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia. J Cell Biochem. 2018 May;119(5):3922-3935

Pallavi P, Pretze M, Caballero J, Li Y, Hofmann BB, Stamellou E, Klotz S, Wängler C, Wängler B, Loesel R, Roth S, Theisinger B, Moerz H, Binzen U, Greffrath W, Treede RD, Harmsen MC, Krämer BK, Hafner M, Yard BA, Kälsch AI. Analyses of Synthetic N-Acyl Dopamine Derivatives Revealing Different Structural Requirements for Their Anti-inflammatory and Transient-Receptor-Potential-Channel-of-the-Vanilloid-Receptor-Subfamily-Subtype-1 (TRPV1)-Activating Properties. J Med Chem. 2018 Apr 12;61(7):3126-3137.

Ploner M, Magerl W, Schmelz M, Albrecht P J., Rice, F L. Emerging Techniques in the Diagnosis of Neuropathic Pain. Pain. 2018, Refresher Course 17th World Congress on Pain, IASP Press. 2018, p. 169-186

Schilder A, Magerl W, Klein T, Treede RD. Assessment of pain quality reveals distinct differences between nociceptive innervation of low back fascia and muscle in humans. Pain Rep. 2018 May 30;3(3):e662. eCollection 2018 May.

Schuh-Hofer S, Eichhorn N, Grinevich V, Treede RD. Sleep Deprivation Related Changes of Plasma Oxytocin in Males and Female Contraceptive Users Depend on Sex and Correlate Differentially With Anxiety and Pain Hypersensitivity. Front Behav Neurosci. 2018 Aug 2;12:161. eCollection 2018.

Schuh-Hofer S, Fischer J, Unterberg A, Treede RD, Ahmadi R. Spinal cord stimulation modulates descending pain inhibition and temporal summation of pricking pain in patients with neuropathic pain.
Acta Neurochir (Wien). 2018 Dec;160(12):2509-2519

Schwarzer A, Kaisler M, Kipping K, Seybold D, Rausch V, Maier C, Vollert J. Opioid intake prior to admission is not increased in elderly patients with low-energy fractures: A case-control study in a German hospital population. Eur J Pain. 2018 Oct;22(9):1651-1661

Tampin B, Vollert J, Schmid AB. Sensory profiles are comparable in patients with distal and proximal entrapment neuropathies, while the pain experience differs. Curr Med Res Opin. 2018 Nov;34(11):1899-1906.

Thiaucourt M, Shabes P, Schloss N, Sack M, Baumgärtner U, Schmahl C, Ende G. Posterior Insular GABA Levels Inversely Correlate with the Intensity of Experimental Mechanical Pain in Healthy Subjects. Neuroscience. 2018 Sep 1;387:116-122.

Treede RD. The International Association for the Study of Pain definition of pain: as valid in 2018 as in 1979, but in need of regularly updated footnotes. Pain Rep. 2018 Mar 5;3(2):e643.

Tuschy B, Berlit S, Stützer P, Lis S, Schmahl C, Baumgärtner U, Sütterlin M. Evaluation of psychosocial and biological parameters in women seeking for a caesarean section and women who are aiming for vaginal delivery: a cross-sectional study. Arch Gynecol Obstet. 2018 Apr;297(4):897-905

Vollert J, Magerl W, Baron R, Binder A, Enax-Krumova EK, Geisslinger G, Gierthmühlen J, Henrich F, Hüllemann P, Klein T, Lötsch J, Maier C, Oertel B, Schuh-Hofer S, Tölle TR, Treede RD. Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. Pain. 2018 Jun;159(6):1090-1102.

Willis F, Kuniss S, Kleindienst N, Lis S, Naoum J, Jungkunz M, Neukel C, Bohus M, Treede RD, Baumgärtner U, Schmahl C. Stress reactivity and pain-mediated stress regulation in remitted patients with borderline personality disorder. Brain Behav. 2018 Jan 26;8(2):e00909.

Üçeyler N, Vollert J, Broll B, Riediger N, Langjahr M, Saffer N, Schubert AL, Siedler G, Sommer C. Sensory profiles and skin innervation of patients with painful and painless neuropathies. Pain. 2018 Sep;159(9):1867-1876.


Dembla S, Behrendt M, Mohr F, Goecke C, Sondermann J, Schneider FM, Stab J, Enzeroth R, Leitner M, Nunez-Badinez P, Philipp M, Greffrath W, Bünemann M, Oliver D, Zakharian E, Schmidt M, Oberwinkler J.. Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels. eLife. 2017; 6: e26280. Published online 2017 Aug 15.

Jakobs M, Schuh-Hofer S, Unterberg A, Ahmadi R  Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain  J Vis Exp. 2017 May 10;(123)

Pallegama RW, Ariyasinghe S, Perera ED, Treede RD. Influence of Catastrophizing and Personality Traits on Recalled Ratings of Acute Pain Experience in Healthy Young Adults. Pain Med. 2017 Jan 1;18(1):49-60

Zhang J, Mense S, Treede RD, Hoheisel U. Prevention and reversal of latent sensitization of dorsal horn neurons by glial blockers in a model of low back pain in male rats. J Neurophysiol. 2017 Oct 1;118(4):2059-2069.

Willis F, Kuniss S, Kleindienst N, Naoum J, Reitz S, Boll S, Bohus M, Treede RD, Baumgärtner U, Schmahl C. The role of nociceptive input and tissue injury on stress regulation in borderline personality disorder.  Pain. 2017 Mar;158(3):479-487.

Vollert J, Maier C, Attal N, Bennett DLH, Bouhassira D, Enax-Krumova EK, Finnerup NB, Freynhagen R, Gierthmühlen J, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Magerl W, Ramirez JD, Rice ASC, Schuh-Hofer S, Segerdahl M, Serra J, Shillo PR, Sindrup S, Tesfaye S, Themistocleous AC, Tölle TR, Treede RD, Baron R. Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations. Pain. 2017 Aug;158(8):1446-1455.

Nuñez-Badinez P, Sepúlveda H, Diaz E, Greffrath W, Treede RD, Stehberg J, Montecino M, van Zundert B. Variable transcriptional responsiveness of the P2 × 3 receptor gene during CFA-induced inflammatory hyperalgesia. J Cell Biochem. 2017 Dec 8. doi: 10.1002/jcb.26534. [Epub ahead of print]

Nawroth PP, Bendszus M, Pham M, Jende J, Heiland S, Ries S, Schumann C, Schmelz M, Schuh-Hofer S, Treede RD, Kuner R, Oikonomou D, Groener JB, Kopf S. The quest for more research on painful diabetic neuropathy. Neuroscience. 2017 Sep 20. pii: S0306-4522(17)30667-X.

Magerl W, Treede RD (2017) Physiologie von Nozizeption und Schmerz. In: Kröner-Herwig B, Frettlöh J, Klinger R, Nilges P (Eds.) Schmerzpsychotherapie, 8th Ed. Heidelberg, Springer, pp. 31-72.

Kaiser U, Treede RD, Sabatowski R. Multimodal pain therapy in chronic noncancer pain-gold standard or need for further clarification?  Pain. 2017 Oct;158(10):1853-185

Groener JB, Cheko, R, Kender Z, Oikonomou D, Kuner R, Magerl W, Treede RD, Jende J ME, Skin auto-fluorescence and impairment in thermal sensory testing in diabetes mellitus type 2. 2017 Diabetologie und Stoffwechsel 12(S 01)S1-S84. DOI 10.1055/s-0037-1601793.

Gerhardt A, Eich W, Treede RD, Tesarz J. Conditioned pain modulation in patients with nonspecific chronic back pain with chronic local pain, chronic widespread pain, and fibromyalgia.  Pain. 2017 Mar;158(3):430-439.

Franz S, Schuld C, Wilder-Smith EP, Heutehaus L, Lang S, Gantz S, Schuh-Hofer S, Treede RD, Bryce TN, Wang H, Weidner N. Spinal Cord Injury Pain Instrument and painDETECT questionnaire: Convergent construct validity in individuals with Spinal Cord Injury. Eur J Pain. 2017 Nov;21(10):1642-1656

Eichhorn N, Treede RD, Schuh-Hofer S. The role of sex in sleep deprivation related changes of nociception and conditioned pain modulation. Neuroscience. 2017 Oct 1. pii: S0306-4522(17)30697-8.

Davis KD, Flor H, Greely HT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD. Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations. Nat Rev Neurol. 2017 Oct;13(10):624-638.

Berlit S, Lis S, Häfner K, Kleindienst N, Baumgärtner U, Treede RD, Sütterlin M, Schmahl C. Changes in birth-related pain perception impact of neurobiological and psycho-social factors. Arch Gynecol Obstet. 2017 Dec 1.

Baron R, Treede RD, Birklein F, Cegla T, Freynhagen R, Heskamp ML, Kern KU, Maier C, Rolke R, Seddigh S, Sommer C, Ständer S, Maihöfner C. Treatment of painful radiculopathies with capsaicin 8% cutaneous patch.  Curr Med Res Opin. 2017 Aug;33(8):1401-1411.

Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice AS, Segerdahl M, Serra J, Sindrup S, Sommer C, Tölle T, Vollert J, Treede RD (2017) Peripheral Neuropathic Pain: A mechanism-related organizing principle based on sensory profiles. Pain 2017 Feb; 158(2):261-272.


Zhang J, Hoheisel U, Klein T, Magerl W, Mense S, Treede RD (2016) High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents. J Neurophysiol 115: 692-700.

Magerl W (2016) Ursache neuropathischer Schmerzen: Mikroglia und Monozyten (Kommentar). Journal Club Schmerzmedizin 5: 215.

Magerl W (2016) Schmerzpatienten tut Kälte früher weh (Kommentar). Journal Club Schmerzmedizin 5: 214.

Magerl W (2016) Partielle Konditionierung erzeugt Nocebo-Hyperalgesie (Kommentar). Journal Club Schmerzmedizin 5: 28.

Baron R, Binder A, Attal N, Casale R, Dickenson AH, Treede RD. Neuropathic low back pain in clinical practice. Eur J Pain. 2016;20(6):861-73.

Cruccu G, Finnerup NB, Jensen TS, Scholz J, Sindou M, Svensson P, Treede RD, Zakrzewska JM, Nurmikko T. Trigeminal neuralgia: New classification and diagnostic grading for practice and research. Neurology. 2016;87(2):220-8.

Dusch M, van der Ham J, Weinkauf B, Benrath J, Rukwied R, Ringkamp M, Schmelz M, Treede RD, Baumgärtner U. Laser-evoked potentials mediated by mechano-insensitive nociceptors in human skin. Eur J Pain. 2016;20(5):845-54.

 Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DL, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice AS, Serra J, Smith BH, Treede RD, Jensen TS. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016;157(8):1599-606.

Gerhardt A, Eich W, Janke S, Leisner S, Treede RD, Tesarz J. Chronic Widespread Back Pain is Distinct From Chronic Local Back Pain: Evidence From Quantitative Sensory Testing, Pain Drawings, and Psychometrics. Clin J Pain. 2016;32(7):568-79.

Hu B, Doods H, Treede RD, Ceci A. Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain. Neurosci Lett. 2016;619:162-167.

 Jakobs M, Unterberg A, Treede RD, Schuh-Hofer S, Ahmadi R. Subcutaneous trigeminal nerve field stimulation for refractory trigeminal pain: a cohort analysis. Acta Neurochir (Wien). 2016 Sep;158(9):1767-74.

Klotz S, Pallavi P, Tsagogiorgas C, Zimmer F, Zöllner FG, Binzen U, Greffrath W, Treede RD, Walter J, Harmsen MC, Krämer BK, Hafner M, Yard BA, Hoeger S. N-octanoyl dopamine treatment exerts renoprotective properties in acute kidney injury but not in renal allograft recipients. Nephrol Dial Transplant. 2016;31(4):564-73.

Mainka T, Malewicz NM, Baron R, Enax-Krumova EK, Treede RD, Maier C. Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain. Eur J Pain. 2016;20(1):116-29.

McDonnell A, Schulman B, Ali Z, Dib-Hajj SD, Brock F, Cobain S, Mainka T, Vollert J, Tarabar S, Waxman SG. Inherited erythromelalgia due to mutations in SCN9A: natural history, clinical phenotype and somatosensory profile. Brain. 2016;139(Pt 4):1052-65.

Piegang BN, Tigoufack IB, Ngnokam D, Achounna AS, Watcho P, Greffrath W, Treede RD, Nguelefack TB. Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities. BMC Complement Altern Med. 2016;16(1):97.

Reitz MC, Hrncic D, Treede RD, Caspani O. A comparative behavioural study of mechanical hypersensitivity in 2 pain models in rats and humans. Pain. 2016;157(6):1248-58.

Schilder A, Magerl W, Hoheisel U, Klein T, Treede RD. Electrical high-frequency stimulation of the human thoracolumbar fascia evokes long-term potentiation-like pain amplification. Pain. 2016;157(10):2309-17.

Schuh-Hofer S, Schäfer-Voß S, Treede RD. Schlaf und Schmerz _ Sleep and Pain. Akt Neurol 2016; 43(04): 249-255.

Shabes P, Schloss N, Magerl W, Schmahl C, Treede RD, Baumgärtner U. A novel human surrogate model of noninjurious sharp mechanical pain. Pain. 2016;157(1):214-224.

Tesarz J, Eich W, Treede RD, Gerhardt A. Altered pressure pain thresholds and increased wind-up in adult patients with chronic back pain with a history of childhood maltreatment: a quantitative sensory testing study. Pain. 2016;157(8):1799-809.

Treede RD: Entstehung der Schmerzchronifizierung. In: Casser H-R, Hasenbring M, Becker A, Baron R (Hrsg.). Rückenschmerzen und Nackenschmerzen, pp 27-38, Springer-Verlag Berlin Heidelberg (2016).

Treede RD. Gain control mechanisms in the nociceptive system. Pain. 2016;157(6):1199-204.

Uhrig MK, Trautmann N, Baumgärtner U, Treede RD, Henrich F, Hiller W, Marschall S. Emotion Elicitation: A Comparison of Pictures and Films. Front Psychol. 2016;7:180.

Upadhyay J, Granitzka J, Bauermann T, Baumgärtner U, Breimhorst M, Treede RD, Birklein F. Detection of central circuits implicated in the formation of novel pain memories. J Pain Res. 2016;9:671-681.

Van den Born JC, Hammes HP, Greffrath W, van Goor H, Hillebrands JL; DFG GRK International Research Training Group 1874 Diabetic Microvascular Complications (DIAMICOM). Gasotransmitters in Vascular Complications of Diabetes. Diabetes. 2016;65(2):331-45.

Vollert J, Attal N, Baron R, Freynhagen R, Haanpää M, Hansson P, Jensen TS, Rice AS, Segerdahl M, Serra J, Sindrup SH, Tölle TR, Treede RD, Maier C. Quantitative sensory testing using DFNS protocol in Europe: an evaluation of heterogeneity across multiple centers in patients with peripheral neuropathic pain and healthy subjects. Pain. 2016;157(3):750-8.

Vollert J, Kramer M, Barroso A, Freynhagen R, Haanpää M, Hansson P, Jensen TS, Kuehler BM, Maier C, Mainka T, Reimer M, Segerdahl M, Serra J, Solà R, Tölle TR, Treede RD, Baron R. Symptom profiles in the painDETECT Questionnaire in patients with peripheral neuropathic pain stratified according to sensory loss in quantitative sensory testing. Pain. 2016;157(8):1810-8.

Wodarski R, Delaney A, Ultenius C, Morland R, Andrews N, Baastrup C, Bryden LA, Caspani O, Christoph T, Gardiner NJ, Huang W, Kennedy JD, Koyama S, Li D, Ligocki M, Lindsten A, Machin I, Pekcec A, Robens A, Rotariu SM, Vo S, Segerdahl M, Stenfors C, Svensson CI, Treede RD, Uto K, Yamamoto K, Rutten K, Rice AS. Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study. Pain. 2016;157(10):2350-65.

Zhang J, Hoheisel U, Klein T, Magerl W, Mense S, Treede RD. High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents. J Neurophysiol. 2016;115(2):692-700.


Gierthmühlen J, Enax-Krumova EK, Attal N, Bouhassira D, Cruccu G, Finnerup NB, Haanpää M, Hansson P, Jensen TS, Freynhagen R, Kennedy JD, Mainka T, Rice AS, Segerdahl M, Sindrup SH, Serra J, Tölle T, Treede RD, Baron R, Maier C. Who is healthy? Aspects to consider when including healthy volunteers in QST-based studies-a consensus statement by the EUROPAIN and NEUROPAIN consortia. Pain. 2015;156(11);263:91-101.&subject=Reprint

Goursaud S, Schäfer S, Dumont AO, Vergouts M, Gallo A, Desmet N, Deumens R, Hermans E. The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis. Exp Neurol. 2015;263:91-101.

Henrich F, Magerl W, Klein T, Greffrath W, Treede RD. Capsaicin-sensitive C- and A-fibre nociceptors control long-term potentiation-like pain amplification in humans. Brain. 2015;138(Pt 9):2505-20.

Hoheisel U, Mense S. Inflammation of the thoracolumbar fascia excites and sensitizes rat dorsal horn neurons. Eur J Pain. 2015;19:419-428.

Hoheisel U, Rosner J, Mense S. Innervation changes induced by inflammation of the rat thoracolumbar fascia. Neuroscience. 2015;300:351-359.

Hoheisel U, Vogt MA, Palme R, Gass P, Mense S. Immobilization stress sensitizes rat dorsal horn neurons having input from the low back. Eur J Pain. 2015;19(6):861-70.

Horschitz S, Matthäus F, Groß A, Rosner J, Galach M, Greffrath W, Treede RD, Utikal J, Schloss P, Meyer-Lindenberg A. Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons. Stem Cell Res. 2015;15(1):30-41

Kamerman PR, Wadley AL, Davis KD, Hietaharju A, Jain P, Kopf A, Meyer AC, Raja SN, Rice AS, Smith BH, Treede RD, Wiffen PJ. World Health Organization essential medicines lists: where are the drugs to treat neuropathic pain? Pain. 2015;156(5):793-7.

Lomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U, Lutz B. Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacology. 2015;40(2):488-501.

Maurer K, Binzen U, Mörz H, Treede RD, Greffrath W. [Direct inhibition of TRPV1 by acetylsalicylic acid : New effect of an old drug]. Schmerz. 2015;29(2):223-6.

Meents JE, Hoffmann J, Chaplan SR, Neeb L, Schuh-Hofer S, Wickenden A, Reuter U.. Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. J Headache Pain. 2015;16:57.

Meyer-Frießem CH, Haag LM, Schmidt-Wilcke T, Magerl W, Pogatzki-Zahn EM, Tegenthoff M, Zahn PK. Transcutaneous spinal DC stimulation reduces pain sensitivity in humans. Neurosci Lett. 2015;589C:153-158.

Mouraux A, Iannetti GD, Baumgärtner U, Treede RD: Evoked Potentials in Relation to Pain Perception. In: A.Vania Apkarian (Ed.). The Brain Adapting with Pain, pp 205-220, IASP Press, Philadelphia (2015).

Reitz S, Kluetsch R, Niedtfeld I, Knorz T, Lis S, Paret C, Kirsch P, Meyer-Lindenberg A, Treede RD, Baumgärtner U, Bohus M, Schmahl C. Incision and stress regulation in borderline personality disorder: neurobiological mechanisms of self-injurious behaviour. Br J Psychiatry. 2015;207(2):165-72.

Ries C, Müller M, Wegmann K, Pfau DB, Müller LP, Burkhart KJ. Is an extension of the safe zone possible without jeopardizing the proximal radioulnar joint when performing a radial head plate osteosynthesis? J Shoulder Elbow Surg. 2015;24(10):1627-34.

Schlereth T, Heiland A, Breimhorst M, Féchir M, Kern U, Magerl W, Birklein F. Association between pain, central sensitization and anxiety in postherpetic neuralgia. Eur J Pain. 2015;19(2):193-201.

Schmahl C, Baumgärtner U. Pain in Borderline Personality Disorder. Mod Trends Pharmacopsychiatri. 2015;30:166-175.

Schuh-Hofer S, Baumgärtner U, Treede RD. Effect of sleep deprivation on the electrophysiological signature of habituation to noxious laser stimuli. Eur J Pain. 2015;19(8):1197-209.

Tesarz J, Gerhardt A, Leisner S, Janke S, Treede RD, Eich W. Distinct quantitative sensory testing profiles in nonspecific chronic back pain subjects with and without psychological trauma. Pain. 2015;156(4):577-86.

Treede RD. Deutsche Schmerzgesellschaft - erfolgreich in Deutschland und der Welt. Schmerz. 2015;29(5):465.

Treede RD, Baumgärtner U: Monitoring Brain Electrical and Magnetic Activity for Assessing Pain: Advantages and Limitations. In: A.Vania Apkarian (Ed.). The Brain Adapting with Pain, pp 45-51, IASP Press, Philadelphia (2015).

Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA, Kaasa S, Kosek E, Lavand?homme P, Nicholas M, Perrot S, Scholz J, Schug S, Smith BH, Svensson P, Vlaeyen JW, Wang SJ. A classification of chronic pain for ICD-11. Pain. 2015;156(6):1003-7.

Treede RD, Zenz M. [Long-term application of opioids in chronic noncancer pain (LONTS 2) : Urgently required new guidelines]. Schmerz. 2015;29(1):5-7.

van den Broeke EN, Mouraux A, Groneberg AH, Pfau DB, Treede RD, Klein T. Characterizing pinprick-evoked brain potentials before and after experimentally induced secondary hyperalgesia. J Neurophysiol. 2015;114(5):2672-2681.

Vollert J, Mainka T, Baron R, Enax-Krumova EK, Hüllemann P, Maier C, Pfau DB, Tölle T, Treede RD. Quality assurance for Quantitative Sensory Testing laboratories: development and validation of an automated evaluation tool for the analysis of declared healthy samples. Pain. 2015;156(12):2423-2430.

Weinkauf B, Deising S, Obreja O, Hoheisel U, Mense S, Schmelz M, Rukwied R. Comparison of nerve growth factor-induced sensitization pattern in lumbar and tibial muscle and fascia. Muscle Nerve. 2015;52(2):265-72.

Wodarski R, Schuh-Hofer S, Yurek DA, Wafford KA, Gilmour G, Treede RD, Kennedy JD. Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat. Eur J Pain. 2015;19(4):554-66.

Yarnitsky D, Bouhassira D, Drewes AM, Fillingim RB, Granot M, Hansson P, Landau R, Marchand S, Matre D, Nilsen KB, Stubhaug A, Treede RD, Wilder-Smith OH. Recommendations on practice of conditioned pain modulation (CPM) testing. Eur J Pain. 2015;19(6):805-6.


Magerl W (2014) Genetische Faktoren bei chronischen Schmerzsyndromen (Kommentar). Journal Club Schmerzmedizin 3: 209.

Caspani O, Reitz MC, Ceci A, Kremer A, Treede RD. Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats. Pharmacol Biochem Behav. 2014;124C:290-296.

Dusch M, Bräscher AK, Kopf A, Treede RD, Benrath J. [Medical educational evaluation of the German Pain Congress 2012 : In the context of the CanMEDS physician competency framework]. Schmerz. 2014;28(5):520-7.

Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD. Response to letter to the Editor. Pain. 2014;155(5):1045-6.

Gewandter JS, Dworkin RH, Turk DC, McDermott MP, Baron R, Gastonguay MR, Gilron I, Katz NP, Mehta C, Raja SN, Senn S, Taylor C, Cowan P, Desjardins P, Dimitrova R, Dionne R, Farrar JT, Hewitt DJ, Iyengar S, Jay GW, Kalso E, Kerns RD, Leff R, Leong M, Petersen KL, Ravina BM, Rauschkolb C, Rice AS, Rowbotham MC, Sampaio C, Sindrup SH, Stauffer JW, Steigerwald I, Stewart J, Tobias J, Treede RD, Wallace M, White RE. Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations. Pain. 2014;155(9):1683-1695.

Herrmann-Lingen C, Brunner E, Hildenbrand S, Loew TH, Raupach T, Spies C,Treede RD, Vahl CF, Wenz HJ. Evaluation of medical research performance - position paper of the Association of the Scientific Medical Societies in Germany (AWMF). Ger Med Sci. 2014 Jun 26;12:Doc11.

Hoheisel U, Taguchi T, Mense S: Nociception – die Fascia thoracolumbalis als sensorisches Organ. In: Schleip R, Findley TW, Chaitow L, Huijing PA (Eds.). Lehrbuch Faszien, pp 69-74, Urban & Fischer Verlag, München (2014).

Jürgens TP, Sawatzki A, Henrich F, Magerl W, May A. An improved model of heat-induced hyperalgesia-repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. PLoS One. 2014;9(6):e99507.

Kopf A, Dusch M, Alt-Epping B, Petzke F, Treede RD. [Pain medicine as a cross-sectional subject in German medical schools : An opportunity for general pain management]. Schmerz. 2014;28(4):405-13.

Kopf A, Rittner H, Sabatowski R, Treede RD. für die Adhoc-Kommission "Studienordnung" der Deutschen Schmerzgesellschaft Kerncurriculum Schmerzmedizin für die Lehre für das Querschnittfach 14 Schmerzmedizin nach der neuen ärztlichen Approbationsordnung Deusche Schmerzgesellschaft, 2. aktual. Aufl. 2014, Berlin.

Madsen CS, Finnerup NB, Baumgärtner U. Assessment of small fibers using evoked potentials. Scandinavian Journal of Pain. 2014;5:111–118.

Mainka T, Bischoff FS, Baron R, Krumova EK, Nicolas V, Pennekamp W Treede RD, Vollert J, Westermann A, Maier C. Comparison of muscle and joint pressure-pain thresholds in patients with complex regional pain syndrome and upper limb pain of other origin. Pain. 2014;155(3):591-7.

Maurer K, Binzen U, Mörz H, Bugert P, Schedel A, Treede RD, Greffrath W. Acetylsalicylic acid enhances tachyphylaxis of repetitive capsaicin responses in TRPV1-GFP expressing HEK293 cells. Neurosci Lett. 2014;563C:101-106.

Mücke M, Cuhls H, Radbruch L, Baron R, Maier C, Tölle T Treede RD, Rolke R. [Quantitative sensory testing]. Schmerz. 2014;28(6):635-48.

Pfau DB, Krumova EK, Treede RD, Baron R, Toelle T, Birklein F, Eich W, Geber C, Gerhardt A, Weiss T, Magerl W, Maier C. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Reference data for the trunk and application in patients with chronic postherpetic neuralgia. Pain. 2014;155(5):1002-15.

Pfau DB, Stiasny-Kolster K, Oertel WH, Treede RD, Magerl W. Response to letter to the editor. Pain. 2014;155(1):200-1.

Piano V, Verhagen S, Schalkwijk A, Hekster Y, Kress H, Lanteri-Minet M, Burgers J, Treede RD, Engels Y, Vissers K. Treatment for neuropathic pain in patients with cancer: comparative analysis of recommendations in national clinical practice guidelines from European countries. Pain Pract. 2014;14(1):1-7.

Schäfer AG, Hall TM, Rolke R, Treede RD, Lüdtke K, Mallwitz J, Briffa KN. Low back related leg pain: An investigation of construct validity of a new classification system. J Back Musculoskelet Rehabil. 2014;27(4):409-18.

Schäfer S, Berger JV, Deumens R, Goursaud S, Hanisch UK, Hermans E. Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury. J Neuroinflammation. 2014;11(1):157.

Schilder A, Hoheisel U, Magerl W, Benrath J, Klein T, Treede RD. Sensory findings after stimulation of the thoracolumbar fascia with hypertonic saline suggest its contribution to low back pain. Pain. 2014;155(2):222-31.

Schilder A, Hoheisel U, Magerl W, Benrath J, Klein T, Treede RD. [Deep tissue and back pain : Stimulation of the thoracolumbar fascia with hypertonic saline]. Schmerz. 2014;28(1):90-2.

Tesarz J, Gerhardt A, Treede RD, Eich W. [Pain perception in athletes : Characteristic features in pain processing by athletes compared to non-athletes]. Schmerz. 2014;28(2):184-7.

Wegmann K, Lappen S, Pfau DB, Neiss WF, Müller LP, Burkhart KJ. Course of the radial nerve in relation to the center of rotation of the elbow--the need for a rational safe zone for lateral pin placement. J Hand Surg Am. 2014;39(6):1136-40


Backonja MM, Attal N, Baron R, Bouhassira D, Drangholt M, Dyck PJ, Edwards RR, Freeman R, Gracely R, Haanpaa MH, Hansson P, Hatem SM, Krumova EK, Jensen TS, Maier C, Mick G, Rice AS, Rolke R, Treede RD, Serra J, Toelle T, Tugnoli V, Walk D, Walalce MS, Ware M, Yarnitsky D, Ziegler D. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain. 2013;154(9):1807-19.

Dusch M, Benrath J, Fischer J, Schmelz M, Fritz H, Klüter H, Thiel M, Treede RD. [Cross-sectional field 14 pain medicine : Implementation of the German Pain Society (DGSS) core curriculum in the model study course MaReCuM]. Schmerz. 2013;27(4):387-94.

Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD. Interventional management of neuropathic pain: NeuPSIG recommendations. Pain. 2013 Nov;154(11):2249-61.

Finnerup NB, Scholz J, Attal N, Baron R, Haanpää M, Hansson P, Raja SN, Rice AS, Rief W, Rowbotham MC, Simpson DM,Treede RD. Neuropathic pain needs systematic classification. Eur J Pain. 2013;17(7):953-956.

Gaul C, Ettlin D, Pfau DB. Anhaltender idiopathischer Gesichtsschmerz und atypische Odontalgie. Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, Volume 107, Issues 4–5, 2013, Pages 309-313.

Geber C, Breimhorst M, Burbach B, Egenolf C, Baier B, Fechir M, Koerber J, Treede RD, Vogt T, Birklein F. Pain in chemotherapy-induced neuropathy - More than neuropathic? Pain. 2013;154(12):2877-87.

Geber C, Treede RD, Magerl W. Response to letter by Werner et al. Pain. 2013; 154(1):176-8.

Gustorff B, Sycha T, Lieba-Samal D, Rolke R, Treede RD, Magerl W. The pattern and time course of somatosensory changes in the human UVB sunburn model reveal the presence of peripheral and central sensitization. Pain. 2013; 154(4):586-97.

Held SM, Rolke R, Treede RD, Schmieder K, Karimi Z, Sudhaus SC, Hasenbring MI. Pain-Related Endurance, Fear-Avoidance and Somatosensory Sensitivity as Correlates of Clinical Status after Lumbar Disc Surgery. The Open Pain Journal. 2013;6:165-175.

Hoheisel U, Reuter R, de Freitas MF, Treede RD, Mense S. Injection of nerve growth factor into a low back muscle induces long-lasting latent hypersensitivity in rat dorsal horn neurons. Pain. 2013;154(10):1953-60.

Iannetti GD, Baumgärtner U, Tracey I, Treede RD, Magerl W. Pinprick-evoked brain potentials: a novel tool to assess central sensitization of nociceptive pathways in humans. J Neurophysiol. 2013;110(5):1107-16.

Matre D, Olsen MB, Jacobsen LM, Klein T, Gjerstad J. Induction of the perceptual correlate of human long-term potentiation (LTP) is associated with the 5-HTT genotype. Brain Res. 2013;1491:54-9.

Mense S, Hoheisel U. Shock wave treatment improves nerve regeneration in the rat. Muscle Nerve. 2013;47(5):702-10.

Mochizuki H, Baumgärtner U, Kamping S, Ruttorf M, Schad LR, Flor H, Kakigi R, Treede RD. Cortico-subcortical activation patterns for itch and pain imagery. Pain. 2013;154(10):1989-98.

Pellkofer HL, Havla J, Hauer D, Schelling G, Azad SC, Kuempfel T, Magerl W, Huge V. The Major Brain Endocannabinoid 2-AG Controls Neuropathic Pain and Mechanical Hyperalgesia in Patients with Neuromyelitis Optica. PLoS One. 2013;8(8):e71500.

Piano V, Verhagen S, Schalkwijk A, Burgers J, Kress H, Treede RD, Hekster Y, Lanteri-Minet M, Engels Y, Vissers K. Diagnosing neuropathic pain in patients with cancer: comparative analysis of recommendations in national guidelines from European countries. Pain Pract. 2013 Jul;13(6):433-9.

Puta C, Schulz B, Schoeler S, Magerl W, Gabriel B, Gabriel HH, Miltner WH, Weiss T. Somatosensory abnormalities for painful and innocuous stimuli at the back and at a site distinct from the region of pain in chronic back pain patients. PLoS One. 2013;8(3):e58885.

Reinhardt T, Kleindienst N, Treede RD, Bohus M, Schmahl C. Individual Modulation of Pain Sensitivity under Stress. Pain Med. 2013;14(5):676-85.

Rolke R, Rolke S, Vogt T, Birklein F, Geber C, Treede RD, Letzel S, Voelter-Mahlknecht S. Hand-arm vibration syndrome: Clinical characteristics, conventional electrophysiology and quantitative sensory testing. Clin Neurophysiol. 2013;124(8):1680-1688.

Schuh-Hofer S, Treede RD. Physiologie und Pathophysiologie des Schmerzes. In: Interventionelle Neurophysiologie. Claßen J, Schnitzler A (Herausgeber). Stuttgart: Thieme; 2013. S. 142-151.

Schuh-Hofer S, Wodarski R, Pfau DB, Caspani O, Magerl W, Kennedy JD, Treede RD. One night of total sleep deprivation promotes a state of generalized hyperalgesia: A surrogate pain model to study the relationship of insomnia and pain. Pain. 2013;154(9):1613-21.

Stiasny-Kolster K, Pfau DB, Oertel WH, Treede RD, Magerl W. Hyperalgesia and functional sensory loss in restless legs syndrome. Pain. 2013;154(8):1457-63.

Tesarz J, Gerhardt A, Treede RD, Eich W. Authors' response. Pain. 2013;154(12):2888-90

Tesarz J, Gerhardt A, Schommer K, Treede RD, Eich W. Alterations in endogenous pain modulation in endurance athletes: An experimental study using quantitative sensory testing and the cold-pressor task. Pain. 2013;154(7):1022-9.

Tesarz J, Hoheisel U, Mense S. Tetrodotoxin-resistant fibres and spinal Fos expression: differences between input from muscle and skin. Exp Brain Res. 2013; 224(4):571-80.

Treede RD, Wagner T, Kern KU, Husstedt IW, Arendt G, Birklein F, Cegla T, Freynhagen R, Gockel HH, Heskamp ML, Jager H, Joppich R, Maier C, Leffler A, Nagelein HH, Rolke R, Seddigh S, Sommer C, Stander S, Wasner G, Baron R.. Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain. Curr Med Res Opin. 2013;29(5):527-38.

Zu Eulenburg P, Baumgärtner U, Treede RD, Dieterich M. Interoceptive and multimodal functions of the operculo-insular cortex: Tactile, nociceptive and vestibular representations. Neuroimage. 2013;83C:75-86.


Attal N, Bennett D, Treede RD. Neuropathic pain update: from basic mechanisms to clinical management. In: Tracey I, editor. Pain 2012: refresher courses, 14th World Congress on Pain. Seattle: IASP Press; 2012. p. 85-107.

Baumgärtner U, Greffrath W, Treede RD. Contact heat and cold, mechanical, electrical and chemical stimuli to elicit small fiber-evoked potentials: Merits and limitations for basic science and clinical use. Neurophysiol Clin. 2012;42(5):267-80.

Blankenburg M, Kraemer N, Hirschfeld G, Krumova EK, Maier C, Hechler T, Aksu F, Magerl W, Reinehr T, Wiesel T, Zernikow B. Childhood diabetic neuropathy: functional impairment and non-invasive screening assessment. Diabet Med. 2012; 29(11):1425-1432.

Bryce TN, Biering-Sørensen F, Finnerup NB, Cardenas DD, Defrin R, Lundeberg T, Norrbrink C, Richards JS, Siddall P, Stripling T, Treede RD, Waxman SG, Widerström-Noga E, Yezierski RP, Dijkers M. International Spinal Cord Injury Pain Classification: part I. Background and description. Spinal Cord. 2012; 50(6):413-7.

Bryce TN, Biering-Sørensen F, Finnerup NB, Cardenas DD, Defrin R, Ivan E, Lundeberg T, Norrbrink C, Richards JS, Siddall P, Stripling T, Treede RD, Waxman SG, Widerström-Noga E, Yezierski RP, Dijkers M. International Spinal Cord Injury Pain (ISCIP) Classification: Part 2. Initial validation using vignettes. Spinal Cord. 2012; 50(6):404-12.

Busch V, Magerl W, Kern U, Haas J, Hajak G, Eichhammer P. The effect of deep and slow breathing on pain perception, autonomic activity, and mood processing-an experimental study. Pain Med. 2012; 13(2):215-28.

Gierthmühlen J, Maier C, Baron R, Tölle T, Treede RD, Birbaumer N, Huge V, Koroschetz J, Krumova EK, Lauchart M, Maihöfner C, Richter H, Westermann A; the German Research Network on Neuropathic Pain (DFNS) study group. Sensory signs in complex regional pain syndrome and peripheral nerve injury. Pain. 2012; 153(4):765-774.

Greenspan JD, Treede RD, Lenz FA. 'Pseudo-neglect' in CRPS is closer to 'anti-neglect' than to classical hemi-neglect? Pain. 2012; 153(11):2157-8

Gröne E, Crispin A, Fleckenstein J, Irnich D, Treede RD, Lang PM. Test order of quantitative sensory testing facilitates mechanical hyperalgesia in healthy volunteers. J Pain. 2012; 13(1):73-80.

Haanpää M, Treede RD. Capsaicin for Neuropathic Pain: Linking Traditional Medicine and Molecular Biology. Eur Neurol. 2012; 68(5):264-275.

Hirschfeld G, Zernikow B, Kraemer N, Hechler T, Aksu F, Krumova E, Maier C, Magerl W, Blankenburg M. Development of Somatosensory Perception in Children: A Longitudinal QST-Study. Neuropediatrics. 2012; 43(1):10-6.

Hoheisel, U., Taguchi, T., Mense, S. Nociception: The thoracolumbar fascia as a sensory organ. In: Fascia in Manual Therapy. Schleip, Findley, Chaitow, Huijing (Eds.), Churchill Livingstone Elsevier, Edinburgh (2012), pp 95-101.

Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice AS, Treede RD. Response to letters by Oaklander et al. and Horowitz. Pain. 2012; 153(4):935-6.

Jung DC, Baumgärtner U, Treede RD. Schmerzmessung beim Menschen_Pain measurement in humans. Neurophysiol. Lab. 34 (2012) 149-173.

Magerl W, Burkart D, Fernandez A, Schmidt LG, Treede RD. Persistent antinociception through repeated self-injury in patients with borderline personality disorder. Pain. 2012; 153(3):575-84.

Michaux GP, Magerl W, Anton F, Treede RD. Experimental characterization of the effects of acute stresslike doses of hydrocortisone in human neurogenic hyperalgesia models. Pain. 2012; 153(2):420-8.

Pfau DB, Geber C, Birklein F, Treede RD. Quantitative sensory testing of neuropathic pain patients: potential mechanistic and therapeutic implications. Curr Pain Headache Rep. 2012; 16(3):199-206.

Puta C, Schulz B, Schoeler S, Magerl W, Gabriel B, Gabriel HH, Miltner WH, Weiss T. Enhanced sensitivity to punctate painful stimuli in female patients with chronic low back pain. BMC Neurol. 2012; 12(1):98.

Raja SN, Treede RD. Testing the Link between Sympathetic Efferent and Sensory Afferent Fibers in Neuropathic Pain. Anesthesiology. 2012; 117(1):173-7.

Rief W, Kaasa S, Jensen R, Perrot S, Vlaeyen JW, Treede RD, Vissers KC. New proposals for the international classification of diseases-11 revision of pain diagnoses. J Pain. 2012; 13(4): 305-16.

Schmahl C, Ludäscher P, Greffrath W, Kraus A, Valerius G, Schulze TG, Treutlein J, Rietschel M, Smolka MN, Bohus M. COMT val158met Polymorphism and Neural Pain Processing. PLoS One. 2012; 7(1):e23658.

S.Schuh-Hofer, Treede RD. Definition und Pathophysiologie neuropathischer Schmerzen. Nervenheilkunde 2012; 31: 115-122.

Svensson P, Drangsholt M, Pfau DB, List T.. Neurosensory testing of orofacial pain in the dental clinic. J Am Dent Assoc. 2012; 143(8):e37-9.

Treede RD: Was ist Schmerz? - Definition. In: Schmerzmedizin - 1000 Fragen. Bernateck et al., Thieme, Stuttgart (2012): Kap.2.1, S.18-20.

Treede RD. Assay sensitivity in clinical trials with chronic pain patients. Pain. 2012; 153(6):1136-7.

Treede RD. Peripheral and Central Mechanisms of Neuropathic Pain. In: Neuropathic Pain: Mechanisms, Diagnosis and Treatment. Simpson, McArthur, Dworkin (Eds.), Oxford University Press, New York (2012), pp 14-24.

Tsagogiorgas C, Wedel J, Hottenrott M, Schneider MO, Binzen U, Greffrath W, Treede RD, Theisinger B, Theisinger S, Waldherr R, Krämer BK, Thiel M, Schnuelle P, Yard BA, Hoeger S. N-octanoyl-Dopamine Is an Agonist at the Capsaicin Receptor TRPV1 and Mitigates Is Chemia-Induced Acute Kidney Injury in Rat. PLoS One. 2012; 7:e43525.


Attal N, Bouhassira D, Baron R, Dostrovsky J, Dworkin RH, Finnerup N, Gourlay G, Haanpaa M, Raja S, Rice AS, Simpson D, Treede RD. Assessing symptom profiles in neuropathic pain clinical trials: Can it improve outcome? Eur J Pain. 2011; 15(5):441-3

Bachmann CG, Nitsche MA, Pfingsten M, Gersdorff N, Harder C, Baier PC, Antal A, Treede RD, Paulus W, Happe S. Diurnal time course of heat pain perception in healthy humans. Neurosci Lett. 2011; 489(2):122-5.

Baumgärtner U, Vogel H, Ohara S, Treede RD, Lenz F. Dipole source analyses of laser evoked potentials obtained from subdural grid recordings from primary somatic sensory cortex. J Neurophysiol. 2011; 106(2):722-30.

Bekkering GE, Soares-Weiser K, Reid K, Kessels AG, Dahan A, Treede RD, Kleijnen J. Can morphine still be considered to be the standard for treating chronic pain? A systematic review including pair-wise and network meta-analyses. Curr Med Res Opin. 2011; 27(7):1477-91.

Binder A, May D, Baron R, Maier C, Tölle TR, Treede RD, Berthele A, Faltraco F, Flor H, Gierthmühlen J, Haenisch S, Huge V, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Uçeyler N, Ufer M, Wasner G, Zhu J, Cascorbi I. Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients. PLoS ONE. 2011; 6(3):e17387

Blankenburg M, Meyer D, Hirschfeld G, Kraemer N, Hechler T, Aksu F, Krumova EK, Magerl W, Maier C, Zernikow B.. Developmental and sex differences in somatosensory perception-a systematic comparison of 7- versus 14-year-olds using quantitative sensory testing. Pain. 2011; 152(11):2625-31.

Blumenstiel K, Gerhardt A, Rolke R, Bieber C, Tesarz J, Friederich HC, Eich W, Treede RD. Quantitative Sensory Testing Profiles in Chronic Back Pain Are Distinct From Those in Fibromyalgia. Clin J Pain. 2011; 27(8):682-690.

Felden L, Walter C, Harder S, Treede RD, Kayser H, Drover D, Geisslinger G, Lötsch J. Comparative clinical effects of hydromorphone and morphine: a meta-analysis. Br J Anaesth. 2011;107(3):319-28.

Fißmer I, Klein T, Magerl W, Treede RD, Zahn PK, Pogatzki-Zahn EM. Modality-specific Somatosensory Changes in a Human Surrogate Model of Postoperative Pain. Anesthesiology. 2011; 115(2):387-397.

Geber C, Baumgärtner U, Fechir M, Vogt T, Birklein F, Treede RD. Comparison of LEP and QST and their contribution to standard sensory diagnostic assessment of spinal lesions: a pilot study. Neurol Sci. 2011; 32(3):401-10.

Geber C, Klein T, Azad S, Birklein F, Gierthmühlen J, Huge V, Lauchart M, Nitzsche D, Stengel M, Valet M, Baron R, Maier C, Tölle T, Treede RD. Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): A multi-centre study. Pain. 2011; 152(3):548-56.

Grundmann L, Rolke R, Nitsche MA, Pavlakovic G, Happe S, Treede RD, Paulus W, Bachmann CG.. Effects of transcranial direct current stimulation of the primary sensory cortex on somatosensory perception. Brain Stimul. 2011;4(4):253-60.

Haanpää M, Attal N, Backonja M, Baron R, Bennett M, Bouhassira D, Cruccu G, Hansson P, Haythornthwaite JA, Iannetti GD, Jensen TS, Kauppila T, Nurmikko TJ, Rice AS, Rowbotham M, Serra J, Sommer C, Smith BH, Treede RD. NeuPSIG guidelines on neuropathic pain assessment. Pain 2011; 152(1):14-27.

Hoheisel U, Taguchi T, Treede RD, Mense S. Nociceptive input from the rat thoracolumbar fascia to lumbar dorsal horn neurones. Eur J Pain. 2011; 15:810-815.

Hopfner F, Schormair B, Knauf F, Berthele A, Tolle TR, Baron R, Maier C, Treede RD, Binder A, Sommer C, Maihoefner C, Kunz W, Zimprich F, Heemann U, Pfeufer A, Nabauer M, Kaab S, Nowak B, Gieger C, Lichtner P, Trenkwalder C, Oexle K, Winkelmann J. Novel SCARB2 mutation in Action Myoclonus-Renal Failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features. BMC Neurol. 2011;11(1):134.

Huge V, Lauchart M, Magerl W, Beyer A, Moehnle P, Kaufhold W, Schelling G, Azad SC. Complex interaction of sensory and motor signs and symptoms in chronic CRPS. PLoS One. 2011; 6(4):e18775.

Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice AS, Treede RD. A new definition of neuropathic pain. Pain. 2011;152(10):2204-5.

Magerl W, Leonhardt C, Lautenbacher S. Schmerz und Schlafstörungen. In: Der niedergelassene Arzt. 2011; 11:69-71

Magerl W und Treede RD. Physiologie von Nozizeption und Schmerz in: Kröner-Herwig, B.; Frettlöh, J.; Klinger, R.; Nilges, P. (Hrsg.) Schmerzpsychotherapie: Grundlagen - Diagnostik - Krankheitsbilder - Behandlung 7. Aufl. 2011; Kapitel 3, Springer, Heidelberg, pp. 29-75

Mueller-Schwefe G, Freytag A, H Er A, Schiffhorst G, Becker A, Casser HR, Glaeske G, Thoma R, Treede RD. Healthcare utilization of back pain patients: results of a claims data analysis. J Med Econ. 2011; 14(6):816-23.

Neeb L, Hellen P, Boehnke C, Hoffmann J, Schuh-Hofer S, Dirnagl U, Reuter U. IL-1? Stimulates COX-2 Dependent PGE(2) Synthesis and CGRP Release in Rat Trigeminal Ganglia Cells. PLoS One.2011;6(3):e17360.

Pergolizzi J, Alon E, Baron R, Bonezzi C, Dobrogowski J, Gálvez R, Jensen T, Kress HG, Marcus MA, Morlion B, Perrot S, Treede RD. Tapentadol in the management of chronic low back pain: a novel approach to a complex condition? J Pain Res. 2011;4:203-10.

Pfau DB, Klein T, Putzer D, Pogatzki-Zahn EM, Treede RD, Magerl W. Analysis of hyperalgesia time courses in humans after painful electrical high-frequency stimulation identifies a possible transition from early to late LTP-like pain plasticity. Pain. 2011;152(7):1532-9.

Tesarz J, Hoheisel U, Wiedenhöfer B, Mense S. Sensory innervation of the thoracolumbar fascia in rats and humans. Neuroscience. 2011 ;194:302-308.

Treede RD. Entstehung der Schmerzchronifizierung. In: Baron R, Koppert W, Strumpf M, Willweber-Strumpf A (Hrsg), Praktische Schmerztherapie, 2. Aufl. 2011, Kapitel 1, pp. 3-13

Treede RD. Quantitative sensorische Testung (QST). In: Baron R, Koppert W, Strumpf M, Willweber-Strumpf A (Hrsg), Praktische Schmerztherapie, 2. Aufl. 2011, Kapitel 9, Springer, Heidelberg, pp. 89-96

Treede RD. Elektrophysiologische Messverfahren. In: Baron R, Koppert W, Strumpf M, Willweber-Strumpf A (Hrsg), Praktische Schmerztherapie, 2. Aufl. 2011, Kapitel 10, Springer, Heidelberg, pp. 97-104

Tronnier V, Baron R, Birklein F, Eckert S, Harke H, Horstkotte D, Hügler P, Hüppe M, Kniesel B, Maier C, Schütze G, Thoma R, Treede RD, Vadokas V; für die Arbeitsgruppe zur Erstellung der S3-Leitlinie. [Epidural spinal cord stimulation for therapy of chronic pain : Summary of the S3 guidelines]. Schmerz. 2011; 25(5):484-92. German.

Westermann A, Rönnau AK, Krumova E, Regeniter S, Schwenkreis P, Rolke R, Treede RD, Richter H, Maier C. Pain-associated Mild Sensory Deficits Without Hyperalgesia in Chronic Non-neuropathic Pain. Clin J Pain. 2011; 27(9):782-9.


Bachmann CG, Muschinsky S, Nitsche MA, Rolke R, Magerl W, Treede RD, Paulus W, Happe S (2010). Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory percepts. Clin Neurophysiol. 121(12):2083-9.

Bachmann CG, Rolke R, Scheidt U, Stadelmann C, Sommer M, Pavlakovic G, Happe S, Treede RD, Paulus W (2010). Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndrome. Brain.133(Pt 3):762-70.

Baumgärtner U (2010). [Nociceptive system : Nociceptors, fiber types, spinal pathways, and projection areas]. Schmerz. 24(2):105-13. German.

Baumgärtner U, Iannetti GD, Zambreanu L, Stoeter P, Treede RD, Tracey I (2010). Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: a high-resolution fMRI study. J Neurophysiol. 104(5):2863-72.

Baumgärtner U, Vogel H, Ohara S, Treede RD, Lenz FA (2010). Dipole Source Analyses of Early Median Nerve SEP Components Obtained From Subdural Grid Recordings. J Neurophysiol. 104(6):3029-41.

Beissner F, Brandau A, Henke C, Felden L, Baumgärtner U, Treede RD, Oertel BG, Lötsch J (2010). Quick Discrimination of A(delta) and C Fiber Mediated Pain Based on Three Verbal Descriptors. PLoS One. 5(9). pii: e12944.

Blankenburg M, Boekens H, Hechler T, Maier C, Krumova E, Scherens A, Magerl W, Aksu F, Zernikow B (2010). Reference values for quantitative sensory testing in children and adolescents: Developmental and gender differences of somatosensory perception. Pain. 149(1):76-88.

Cruccu G, Sommer C, Anand P, Attal N, Baron R, Garcia-Larrea L, Haanpää M, Jensen TS, Serra J, Treede RD (2010). EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol. 17(8):1010-8.

Dworkin RH, O'Connor AB, Audette J, Baron R, Gourlay GK, Haanpää ML, Kent JL, Krane EJ, Lebel AA, Levy RM, Mackey SC, Mayer J, Miaskowski C, Raja SN, Rice AS, Schmader KE, Stacey B, Stanos S, Treede RD, Turk DC, Walco GA, Wells CD (2010). Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 85(3 Suppl):S3-14.

Freytag A, Schiffhorst G, Thoma R, Strick K, Gries C, Becker A, Treede RD, Müller-Schwefe G, Casser HR, Luley C, Höer A, Ujeyl M, Gothe H, Kugler J, Glaeske G, Häussler B (2010). [Identification and grouping of pain patients according to claims data]. Schmerz. 24(1):12-22. German.

Greenspan JD, Treede RD, Tasker RR, Lenz FA (2010). Central Pain States. In Fishman SM, BallantyneJC, Rathmell JP (Herausgeber), Bonica's Management of Pain. Philadelphia, Lippincott Williams & Wilkins: Chapter 28, pp 357-374.

Haanpää M, Treede RD (2010). Diagnosis and Classification of Neuropathic Pain. In: Ballantyne J.C.(Editor), Pain Clinical Updates. Seattle, IASP: Volume 18(7), pp 18-27.

Huge V, Lauchart M, Magerl W, Schelling G, Beyer A, Thieme D, Azad SC (2010). Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain. Eur J Pain. 14(4):387-94.

Lorenz J, Baumgärtner U (2010). Apparative Diagnostik. In: Standel T, Schulte am Esch J, Treede RD, Schäfer M, Bardenheuer HJ (Hrsg), Schmerztherapie, 2. Aufl., Kapitel 3, Thieme, Stuttgart, pp. 87-95

Lucius H, Treede RD (2010). [The new code F45.41.] Schmerz. 24(4):383-4. German.

Magerl W, Krumova EK, Baron R, Tölle T, Treede RD, Maier C (2010). Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data. Pain. 151(3):598-605.

Maier C, Baron R, Tölle TR, Binder A, Birbaumer N, Birklein F, Gierthmühlen J, Flor H, Geber C, Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Schwarz A, Sommer C, Tronnier V, Uçeyler N, Valet M, Wasner G, Treede RD (2010). Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain. 150(3):439-450.

Martin J, Heymann A, Bäsell K, Baron R, Biniek R, Bürkle H, Dall P, Dictus C, Eggers V, Eichler I, Engelmann L, Garten L, Hartl W, Haase U, Huth R, Kessler P, Kleinschmidt S, Koppert W, Kretz FJ, Laubenthal H, Marggraf G, Meiser A, Neugebauer E, Neuhaus U, Putensen C, Quintel M, Reske A, Roth B, Scholz J, Schröder S, Schreiter D, Schüttler J, Schwarzmann G, Stingele R, Tonner P, Tränkle P, Treede RD, Trupkovic T, Tryba M, Wappler F, Waydhas C, Spies C (2010). Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care - short version. Ger Med Sci. 8:Doc02.

Mueller C, Klega A, Buchholz HG, Rolke R, Magerl W, Schirrmacher R, Schirrmacher E, Birklein F, Treede RD, Schreckenberger M (2010). Basal opioid receptor binding is associated with differences in sensory perception in healthy human subjects: A [(18)F]diprenorphine PET study. Neuroimage.49(1):731-7.

Pogatzki-Zahn EM, Treede RD (2010). Physiologie und Pathophysiologie des Schmerzes. In: Van Aken HK, Wulf H (Hrsg.), Lokalanästhesie, Regionalanästhesie, Regionale Schmerztherapie, 3. Auflage, Kapitel 2, Thieme, Stuttgart, pp. 10-53.

Reuss S, Disque-Kaiser U, Binzen U, Greffrath W, Peschke E (2010). 'TRPing' Synaptic Ribbon Function in the Rat Pineal Gland: Neuroendocrine Regulation Involves the Capsaicin Receptor TRPV1. Neuroendocrinology. 92(2):133-142.

Rief W, Kaasa S, Jensen R, Perrot S, Vlaeyen JW, Treede RD, Vissers KC (2010). The need to revise pain diagnoses in ICD-11. Pain. 149(2):169-70.

Schulte E, Hermann K, Berghöfer A, Hagmeister H, Schuh-Hofer S, Schenk M, Kopf A, Vilain M, Martus P, Willich SN, Boemke W (2010). Referral practices in patients suffering from non-malignant chronic pain. Eur J Pain. 14(3):308.e1-308.e10.

Tiede W, Magerl W, Baumgärtner U, Durrer B, Ehlert U, Treede RD (2010). Sleep restriction attenuates amplitudes and attentional modulation of pain-related evoked potentials, but augments pain ratings in healthy volunteers. Pain. 148(1):36-42.

Treede RD, Müller-Schwefe G, Thoma R (2010). [Coding chronic pain in ICD-10.] Schmerz. 24(3):207-8. German.

Walco GA, Dworkin RH, Krane EJ, LeBel AA, Treede RD (2010). Neuropathic pain in children: Special considerations. Mayo Clin Proc. 85(3 Suppl):S33-41.


Agostinho CM, Scherens A, Richter H, Schaub C, Rolke R, Treede RD, Maier C (2009). Habituation and short-term repeatability of thermal testing in healthy human subjects and patients with chronic non-neuropathic pain. Eur J Pain. 13: 779-785.

Baumgärtner U, Treede RD(2009). Are there nociceptive-specific brain potentials? J Neurophysiol. 102(5):3073-4; author reply 3075-6. No abstract available.

Chacur M, Lambertz D, Hoheisel U, Mense S (2009). Role of spinal microglia in myositis-induced central sensitisation: an immunohistochemical and behavioural study in rats. Eur J Pain. 13(9):915-23.

Csifcsak G, Nitsche MA, Baumgärtner U, Paulus W, Treede RD, Antal A.(2009). Electrophysiological correlates of reduced pain perception after theta-burst stimulation. Neuroreport. 20(12):1051-5.

Eberle T, Doganci B, Krämer HH, Geber C, Fechir M, Magerl W, Birklein F (2009). Warm and cold complex regional pain syndromes: differences beyond skin temperature? Neurology. 72(6):505-12.

Geber C, Baumgärtner U, Schwab R, Müller H, Stoeter P, Dieterich M, Sommer C, Birklein F, Treede RD (2009). Revised Definition of Neuropathic Pain and Ist Grading System: An Open Case Series Illustrating Ist Use in Clinical Practice. The American Journal of Medicine 122: S3-S12.

Geber C, Scherens A, Pfau D, Nestler N, Zenz M, Tölle T, Baron R, Treede RD, Maier C (2009). Zertifizierungsrichtlinien für QST-Labore. Schmerz. 23(1):65-9. German.

Greffrath W, Schwarz ST, Büsselberg D, Treede RD (2009). Heat-induced action potential discharges in nociceptive primary sensory neurons of rats. J Neurophysiol.102:424-436.

Haanpää ML, Backonja M-M, Bennett MI, Bouhassira D, Cruccu G, Hansson PT, Jensen TS, Kauppila T, Rice ASC, MB, BS, MD, FRCA, FFPMRCA, Smith BH, Treede RD, Baron R (2009). Assessment of Neuropathic Pain in Primery Care. The American Journal of Medicine 122: S13-S21.

Hu B, Doods H, Treede RD, Ceci A (2009). Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833. Pain. 143(3):206-12.

Jantsch HH, Gawlitza M, Geber C, Baumgärtner U, Krämer HH, Magerl W, Treede RD, Birklein F (2009). Explicit episodic memory for sensory-discriminative components of capsaicin-induced pain: Immediate and delayed ratings. Pain. 143(1-2):97-105.

Jung P, Baumgärtner U, Stoeter P, Treede RD (2009). Structural and Functional Asymmetry in the Human Parietal Opercular Cortex. J Neurophysiol. 101(6):3246-57.

Kobayashi K, Winberry J, Liu CC, Treede RD, Lenz FA (2009). A painful cutaneous laser stimulus evokes responses from single neurons in the human thalamic principal somatic sensory nucleus ventral caudal - Vc. J Neurophysiol. 101(5):2210-7.

Kraus A, Geuze E, Schmahl C, Greffrath W, Treede RD, Bohus M, Vermetten E (2009). Differentiation of pain ratings in combat-related posttraumatic stress disorder. Pain. 143(3):179-85.

Ludäscher P, Greffrath W, Schmahl C, Kleindienst N, Kraus A, Baumgärtner U, Magerl W, Treede RD, Bohus M (2009). A cross-sectional investigation of discontinuation of self-injury and normalizing pain perception in patients with borderline personality disorder. Acta Psychiatr Scand. 120(1):62-70.

Pfau DB, Rolke R, Nickel R, Treede RD, Daublaender M (2009). Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and fibromyalgia syndrome. Pain. 147(1-3):72-83.

Pogatzki-Zahn EM, Strumpf M, Treede RD (2009). Der Fall „Scott Reuben“. Schmerz. 23(3):229-30.

Rief W, Treede RD, Schweiger U, Henningsen P, Rüddel H, Nilges P(2009). Neue Schmerzdiagnose in der deutschen ICD-10-Version. Nervenarzt. 80(3): 340-2.

Roeska K, Ceci A, Treede RD, Doods H (2009). Effect of high trait anxiety on mechanical hypersensitivity in male rats. Neurosci Lett. 464(3):160-4.

Tölle TR, Treede RD, Zenz M (2009). [To give or not to give, that is not the question here! : Longterm administration of opioids for non-tumor pain (LONTS).] Schmerz. 23(5):437-9. German. No abstract available.

Treede RD(2009). Vom Tiermodell zur Diabeteskomplikation. Diabetologe 5:344-349.


Birklein F, Depmeier C, Rolke R, Hansen C, Rautenstrauss B, Prawitt D, Magerl W (2008). A family-based investigation of cold pain tolerance. Pain. 138(1):111-8.

Chizh BA, Greenspan JD, Casey KL, Nemenov MI, Treede RD (2008). Identifying biological markers of activity in human nociceptive pathways to facilitate analgesic drug development. Pain. 140(2):249-53.

Cruccu G, Aminoff MJ, Curio G, Guerit JM, Kakigi R, Mauguiere F, Rossini PM, Treede RD, Garcia-Larrea L(2008). Recommendations for the clinical use of somatosensory-evoked potentials. Clin Neurophysiol. 119(8):1705-19.

de Tommaso M,Baumgärtner U, Sardaro M, Difruscolo O, Serpino C, Treede RD (2008). Effects of distraction versus spatial discrimination on laser-evoked potentials in migraine. Headache. 48(3):408-16.

Freynhagen R, Rolke R, Baron R, Tölle TR, Rutjes AK, Schu S, Treede RD (2008). Pseudoradicular and radicular low-back pain - A disease continuum rather than different entities? Rebuttal: Reply to the letter "Cheese and Chalk? Missing the real anatomy" by Breck McKay. Pain. 137(1):230-231.

Freynhagen R, Rolke R, Rutjes AK,Baron R, Tölle TR, Schu S, Treede RD (2008). Pseudoradicular and radicular low-back pain--a disease continuum rather than different entities? Answers from quantitative sensory testing. Pain 135(1-2): 65-74.

Geber C, Magerl W, Fondel R, Fechir M, Rolke R, Vogt T, Treede RD, Birklein F (2008). Numbness in clinical and experimental pain - A cross-sectional study exploring the mechanisms of reduced tactile function. Pain. 139(1):73-8.

Huge V, Lauchart M, Förderreuther S, Kaufhold W, Valet M, Azad SC, Beyer A, Magerl W (2008). Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I). PLoS ONE. 3(7):e2742.

Jung P,Baumgärtner U, Magerl W, Treede RD (2008). Hemispheric asymmetry of hand representation in human primary somatosensory cortex and handedness. Clin Neurophysiol. 119(11):2579-86.

Klauenberg S, Maier C, Assion HJ, Hoffmann A, Krumova EK, Magerl W, Scherens A, Treede RD, Juckel G (2008). Depression and changed pain perception: hints for a central disinhibition mechanism. Pain. 140(2):332-43.

Klein T, Magerl W, Hanschmann A, Althaus M, Treede RD (2008). Antihyperalgesic and analgesic properties of the N-methyl-d-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia. Eur J Pain. 12(1):17-29.

Klein T, Magerl W, Treede RD, E. M. Pogatzki-Zahn (2008). Physiologie u.Pathophysiologie des postoperativen Schmerzes. In E.M.Pogatzki-Zahn, H.K.Van Aken, P.K.Zahn (Herausgeber), Postoperative Schmerztherapie, Stuttgart: Thieme, S. 7-25

Klein T, Stahn S, Magerl W, Treede RD (2008). The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation. Pain. 139(3):507-19.

Loeser JD, Treede RD (2008). The Kyoto protocol of IASP Basic Pain Terminology. Pain. 137(3):473-7.

Loeser JD, Treede RD (2008). Reply to the letter-to-the-editor by Devor. Pain. 140:520-21.

Maag R, Baron R, Treede RD (2008). 1.2.6 Quantitative sensorische Testung (QST) in klinischer Forschung und Praxis. In: Kress HG (Hrsg), Aktuelle Schmerztherapie, 7. Ergänzungslieferung 6/08, Ecomed, Landsberg, pp. 1-14

Maag R, Binder A, Maier C, Scherens A, Toelle T, Treede RD, Baron R (2008). Detection of a Characteristic Painful Neuropathy in Fabry Disease: A Pilot Study. Pain Med. 9(8):1217-23

Roeska K, Doods H, Arndt K, Treede RD, Ceci A (2008). Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. Pain. 139(2):349-57

Rolke R,Freynhagen R, Rutjes AK, Baron R, Tölle TR, Schu S, Treede RD (2008). Pseudoradicular and radicular low-back pain - A disease continuum rather than different entities? Reply to the letters by Leffler and Hansson and by Van Boxem et al. Pain 135(3):313-315

Rolke R, Freynhagen R, Rutjes AK, Baron R, Tölle TR, Schu S, Treede RD (2008). Pseudoradicular and radicular low-back pain - A disease continuum rather than different entities? Rebuttal: Reply to the letter by M. Schiltenwolf and M. Akbar. Pain 138: 688-690.

Schoeffel D, Casser HR, Bach M, Kress HG, Likar R, Locher H, Steinleitner W, Strohmeier M, Brunner H, Treede RD Zieglgänsberger W, Sandkühler J (2008). Risikoabschätzung in der Schmerztherapie. Schmerz. 22(5):594-603.

Treede RD (2008). Highly localized inhibition of pain via long-term depression (LTD). Clin Neurophysiol. 119:1703-04.

Treede RD (2008). The Adequate Stimulus. In Bushnell M.C., Basbaum A.I.(Herausgeber), The senses: A Comprehensive Reference; Volume 5:Pain. Amsterdam Elsevier: pp 1-3.

Treede RD (2008). Placebo in der Therapie (Pro und Contra). In Psychologie heute 35 (11): 77

Treede RD (2008). Woher kommt der Schmerz? In: Rotary Magazin, Serie Hirnforschung: Nozizeption. S. 52-55

Treede RD, Apkarian AV (2008). Nociceptive Processing in the Cerebral Cortex. In Bushnell M.C., Basbaum A. I.(Herausgeber), The senses: A Comprehensive Reference; Volume 5:Pain. Amsterdam Elsevier: pp 670-691.

Treede RD, Baron R (2008). How to detect a sensory abnormality. Eur J Pain. 12(4):395-6.

Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J (2008). Neuropathic pain. Redefinition and a grading system for clinical and research purposes. Neurology. 70(18):1630-5.


Baron R, Treede RD (2007). Diagnose neuropathischer Schmerzen. Dtsch Med Wochenschr. 132(41):2139-44.

Bast T, Wright T, Boor R, Harting I, Feneberg R, Rupp A, Hoechstetter K, Rating D, Baumgärtner U (2007). Combined EEG and MEG analysis of early somatosensory evoked activity in children and adolescents with focal epilepsies. Clin Neurophysiol. 118(8):1721-35.

Bernateck M, Rolke R, Birklein F, Treede RD, Fink M, Karst M (2007). Successful intravenous regional block with low-dose tumor necrosis factor-alpha antibody infliximab for treatment of complex regional pain syndrome 1. Anesth Analg. 105(4):1148-51.

Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS, Kalso EA, Loeser JD, Miaskowski C, Nurmikko TJ, Portenoy RK, Rice AS, Stacey BR, Treede RD, Turk DC, Wallace MS (2007). Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain. 132(3):237-51.

Fischbach T, Greffrath W, Nawrath H, Treede RD (2007). Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive DRG neurons of rat. J Neurophysiol. 98(2):929-38.

Geber C, Fondel R, Kramer HH, Rolke R, Treede RD, Sommer C, Birklein F (2007). Psychophysics, Flare, and Neurosecretory Function in Human Pain Models: Capsaicin Versus Electrically Evoked Pain. J Pain. 8(6):503-14.

Greffrath W, Baumgärtner U, Treede RD (2007). Peripheral and central components of habituation of heat pain perception and evoked potentials in humans. Pain. 132(3):301-11.

Hansen N, Klein T, Magerl W, Treede RD (2007) Psychophysical evidence for long-term potentiation of C-fiber and A&dgr;-fiber pathways in humans by analysis of pain descriptors. J Neurophysiol.97(3):2559-63.

Klein T, Magerl W, Nickel U, Hopf HC, Sandkuhler J, Treede RD (2007) Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system. Neuropharmacology. 52(2):655-61.

Klein T, Magerl W, Treede RD (2007). Forget about your chronic pain. Pain. 132(1-2):16-7.

Lang S, Klein T, Magerl W, Treede RD (2007). Modality-specific sensory changes in humans after the induction of long-term potentiation (LTP) in cutaneous nociceptive pathways. Pain. 128(3):254-63.

Schmahl C, Bohus M, Esposito F, Treede RD, Di Salle F, Greffrath W, Ludaescher P, Jochims A, Scheffler K, Hennig J, Seifritz E (2007). Reply to:On determining sensivity to pain in borderline personality disorder. Arch.Gen.Psychiatry 64:748-749.

Tölle TR, Baron R, Treede RD (2007). Neuropathische Schmerzen messbar machen. DFNS Schmerztherapie DZKF 3/4:58-62.

Treede RD (2007). Entstehung der Schmerzchronifizierung. In: Praktische Schmerztherapie, edited by R. Baron and M. Strumpf, Springer, pp 3-12.

Treede RD (2007). Quantitative sensorische Testung (QST). In: Praktische Schmerztherapie, edited by R. Baron and M. Strumpf, Springer, pp 75-82.

Treede RD (2007). Elektrophysiologische Messverfahren. In: Praktische Schmerztherapie, edited by R. Baron and M. Strumpf, Springer, pp 83-90.

Treede RD (2007). Allodynia. In: Encyclopedia of Pain, edited by R. F. Schmidt and W. D. Willis, Berlin, Heidelberg, NewYork:Springer, pp 49-52.

Treede RD (2007). Hyperalgesia. In: Encyclopedia of Pain, edited by R. F. Schmidt and W. D. Willis, Berlin, Heidelberg, NewYork:Springer, pp 919-923.

Treede RD (2007). Das Somatosensorische System. In: Physiologie des Menschen, edited by R. F. Schmidt and F.Lang, Berlin, Heidelberg, NewYork:Springer, pp 296-323.

Treede RD, Baumgärtner U, Lenz FA (2007). Nociceptive processing in the secondary somatosensory cortex. In: Encyclopedia of Pain, edited by R. F. Schmidt and W. D. Willis, Berlin, Heidelberg, NewYork:Springer, pp 1376-1379.

Veldhuijzen DS, Greenspan JD, Kim JH, Coghill RC, Treede RD, Ohara S, Lenz FA (2007). Imaging central pain syndromes. Curr Pain Headache Rep. 11(3):183-9.


Anderson WS, O'Hara S, Lawson HC, Treede RD, Lenz FA (2006). Plasticity of pain-related neuronal activity in the human thalamus. Prog Brain Res. 157: 353-64.

Ashina S, Bendtsen L, Ashina M, Magerl W, Jensen R (2006). Generalized hyperalgesia in patients with chronic tension-type headache. Cephalalgia. 26(8):940-8.

Baumgärtner U, Buchholz HG, Bellosevich A, Magerl W, Siessmeier T, Rolke R, Hohnemann S, Piel M, Rosch F, Wester HJ, Henriksen G, Stoeter P, Bartenstein P, Treede RD, Schreckenberger M (2006). High opiate receptor binding potential in the human lateral pain system. Neuroimage. 30(3):692-9.

Baumgärtner U, Tiede W, Treede RD, Craig AD (2006). Laser-evoked potentials are graded and somatotopically organized anteroposteriorly in the operculo-insular cortex of anesthetized monkeys. J Neurophysiol. 96(5):2802-8.

Bendtsen L, Treede RD (2006) Sensitization of myofascial pain pathways in tension-type headaches. In: The Headaches, edited by J. Olesen, P. Goadsby, N. Ramadan, P. Tfelt-Hansen, and K. M. A. Welch, Philadelphia: Lippincott Williams & Wilkins, pp 637-641.

Bentley DE, Baumgärtner U, Watson A, Barrett G, Kulkarni B, Youell PD, Schlereth T, Jones AKP, Treede R-D (2006). The Time Course of Sensory and Affective Pain Processing: Evidence from Laser-Evoked Potentials. In: Proceedings of the 11th World Congress on Pain. Flor H, Kalso E, Dostrovsky J, eds. IASP Press, Seattle, pp 397-405.

Binzen U, Greffrath W, Hennessy S, Bausen M, Saaler-Reinhardt S, Treede RD (2006). Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. Neuroscience. 142(2):527-39.

Bond M, Breivik H, Jensen TS, Scholten W, Soyannwo O, and Treede RD (2006). Pain associated with neurological disorders. In: Neurological disorders: public health challenges, edited by J. A. Aarli, T. Dua, A. Janca, and A. Muscetta, Genf:WHO, pp 127-139.

Firner M, Greffrath W, Treede RD (2006). Phosphorylation of extracellular signal-related protein kinase is required for rapid facilitation of heat-induced currents in rat dorsal root ganglion neurons. Neuroscience. 2006 Nov 17;143(1):253-63.

Gold MS, Chessell I, Devor M, Dray A, Gereau RW, Kane SA, Koltzenburg M, Louis JC, Ringkamp M, Treede RD (2006). Peripheral nervous system targets: rapporteur report. In: Emerging Strategies for the Treatment of Neuropathic Pain, edited by J. N. Campbell, A. I. Basbaum, A. Dray, R. Dubner, R. H. Dworkin, and C. N. Sang, Seattle:IASP Press, pp 3-36.

Greffrath W (2006). Der Capsaicinrezeptor. Ein TRP zur Transduktion schmerzhafter Reize Schmerz. 20(3):219-25.

Hauck M, Baumgärtner U, Hille E, Hille S, Lorenz J, Quante M (2006). Evidence for early activation of primary motor cortex and SMA after electrical lower limb stimulation using EEG source reconstruction. Brain Res. 1125:17-25.

Jochims A, Ludascher P, Bohus M, Treede RD, Schmahl C (2006). Schmerzverarbeitung bei Borderline-Persönlichkeitsstörung, Fibromyalgie und Posttraumatischer Belastungsstörung. Schmerz. 20(2):140-50.

Klein T, Magerl W, Treede RD (2006). Perceptual correlate of nociceptive long-term potentiation (LTP) in humans shares the time course of early-LTP. J Neurophysiol. 96(6):3551-5.

Klossika I, Flor H, Kamping S, Bleichhardt G, Trautmann N, Treede RD, Bohus M, Schmahl C (2006). Emotional modulation of pain: a clinical perspective. Pain. 124(3):264-8.

Lang PM, Schober GM, Rolke R, Wagner S, Hilge R, Offenbacher M, Treede RD, Hoffmann U, Irnich D (2006). Sensory neuropathy and signs of central sensitization in patients with peripheral arterial disease. Pain. 124(1-2):190-200.

Magerl W, Klein T (2006). Experimental human models of neuropathic pain. Beitrag in: Handbook of Clinical Neurology. Herausgeber: Cervero G, Jensen TS, Elsevier Amsterdam, 81. Aufl. S.503-516.

Rolke R, Baron R, Maier C, Tolle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Botefur IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihofner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B (2006). Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain. 123(3):231-43.

Rolke R, Birklein F, Magerl W, Treede RD (2006). Schmerz: Physiologische Grundlagen und klinische Aspekte. Qintessenz. 57(9):983-990.

Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, Birklein F, Treede RD (2006). Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain. 10(1):77-88.

Schmahl C, Bohus M, Esposito F, Treede RD, Di Salle F, Greffrath W, Ludaescher P, Jochims A, Lieb K, Scheffler K, Hennig J, Seifritz E (2006). Neural correlates of antinociception in borderline personality disorder. Arch Gen Psychiatry. 63(6):659-67.

Treede RD (2006). Discussion summary: Neurobiology of neuropathic pain. In: From Basic Pain Mechanisms to Headache, edited by J. Olesen and T. S. Jensen, Oxford: Oxford University Press, pp 76-77.

Treede RD (2006). Mechanisms of cutaneous hyperalgesia. In: From Basic Pain Mechanisms to Headache, edited by J. Olesen and T. S. Jensen, Oxford: Oxford University Press, p. 135-140.

Treede RD (2006). Pain and hyperalgesia: definitions and theories. In: Handbook of Clinical Neurology; Vol. 81, edited by F. Cervero and T. S. Jensen, Amsterdam: Elsevier, p. 3-10.

Treede RD (2006). Psychophysical Models for neuropathic pain. In: Emerging Strategies for the Treatment of Neuropathic Pain, edited by J. N. Campbell, A. I. Basbaum, A. Dray, R. Dubner, R. H. Dworkin, and C. N. Sang, Seattle: IASP Press, 2006, pp 427-442.

Treede RD (2006). Assessment of pain as an emotion in animals and in humans. Exp Neurol. 197(1):1-3.

Treede RD, Klein T, Magerl W (2006). Pain memory and central sensitization in humans. In: Emerging strategies for the treatment of neuropathic pain, edited by J. N. Campbell, A. I. Basbaum, A. Dray, R. Dubner, R. H. Dworkin, and C. N. Sang, Seattle: IASP Press, p. 251-267.

Treede RD, Lenz FA (2006). Passing lanes and slow lanes into the nociceptive network of the human brain. Pain. 123(3):223-5.


Apkarian, A. V., Bushnell, C., Treede, R.-D., & Zubieta, J.-K. (2005). Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 9:463-484.

Ashina S, Babenko L, Jensen R, Ashina M, Magerl W, & Bendtsen L (2005). Increased muscular and cutaneous pain sensitivity in cephalic region in patients with chronic tension-type headache. Eur J Neurol 12:543-549.

Baumgärtner, U., Cruccu, G., Iannetti, G. D., & Treede, R. D. (2005). Laser guns and hot plates. Pain 116:1-3.

Bushnell MC, Treede R-D (2005). Clinical nerve function studies and imaging. In Charlton JE, editor. Core Curriculum for Professional Education in Pain. SSettle: IASP Press, pp 41-44.

Hagenacker, T., Splettstoesser, F., Greffrath, W., Treede, R. D., & Büsselberg, D. (2005). Capsaicin differentially modulates voltage-activated calcium channel currents in dorsal root ganglion neurones of rats. Brain Research 1062:74-85.

Klein, T., Magerl, W., Rolke, R., & Treede, R.-D. (2005). Human surrogate models of neuropathic pain. Pain 115:227-233.

Özcan, M., Baumgärtner, U., Vucurevic, G., Stoeter, P., & Treede, R. D. (2005). Spatial resolution of fMRI in the human parasylvian cortex: comparison of somatosensory and auditory activation. Neuroimage 25:877-887.

Rolke R, Andrews Campbell K, Magerl W, Treede RD (2005) Deep pain thresholds in the distal limbs of healthy human subjects. Eur J Pain. 9:39-48.

Schreckenberger, M., Siessmeier, T., Viertmann, A., Landvogt, C., Buchholz, H. G., Rolke, R., Treede, R. D., Bartenstein, P., & Birklein, F. (2005). The unpleasantness of tonic pain is encoded by the insular cortex. Neurology 64:1175-1183.

Treede, R.-D. (2005). Funktionsprüfung der nozizeptiven Bahnen durch SEP nach schmerzhaften Laser-Hitzereizen. In: Evozierte Potentiale, eds. Stöhr, M., Dichgans, J., Buettner, U. W., & Hess, C. W., pp. 600-621. Springer, Berlin.


Bentley DE, Watson A, Treede R-D, Barrett G, Youell PD, Kulkarni B, Jones AKP (2004) Differential effects on the laser evoked potential of selectively attending to pain localisation versus pain unpleasantness. Clin Neurophysiol 115: 1846-1856.

Greffrath W, Magerl W, Disque-Kaiser U, Martin E, Reuss S, Boehmer G (2004) Contribution of Ca2+-activated K+ channels to hyperpolarizing after-potentials and discharge pattern in rat supraoptic neurones. J Neuroendocrinol 16: 577-588.

Klein T, Magerl W, Hopf HC, Sandkühler J, Treede R-D (2004) Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans. J Neurosci 24:964-971

Magerl W, Treede R-D (2004) Secondary tactile hypoesthesia: a novel type of pain-induced somatosensory plasticity in human subjects. Neuroscience Letters 361:136-139

Meyer RA, Treede RD (2004) Mechanisms of secondary hyperalgesia: a role for myelinated nociceptors in punctate hyperalgesia. In: Hyperalgesia: Molecular Mechanisms and Clinical Implications (Brune K, Handwerker HO, eds), pp 143-155. Seattle: IASP Press.

Ohara S, Crone NE, Weiss N, Treede RD, Lenz FA (2004) Cutaneous painful laser stimuli evoke responses recorded directly from primary somatosensory cortex in awake humans. J Neurophysiol 91: 2734-2746.

Ohara S, Crone NE, Weiss N, Vogel H, Treede RD, Lenz FA (2004) Attention to pain is processed at multiple cortical sites in man. Exp Brain Res 156: 513-517.

Ohara S, Crone NE, Weiss N, Treede R-D, Lenz FA (2004) Amplitudes of laser evoked potential recorded from primary somatosensory, parasylvian and medial frontal cortex are graded with stimulus intensity. Pain 110: 318-328.

Schmahl C, Greffrath W, Baumgärtner U, Schlereth T, Magerl W, Philipsen A, Lieb K, Bohus M, Treede RD (2004) Differential nociceptive deficits in patients with borderline personality disorder and self-injurious behavior: laser-evoked potentials, spatial discrimination of noxious stimuli, and pain ratings. Pain 110: 470-479.

Stiasny-Kolster K, Magerl W, Oertel WH, Möller JC, Treede R-D (2004) Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome. Brain 127: 773-782.

Treede R-D (2004) Nozizeption und Schmerz. In: Neurobiologie und Philosophie zum Schmerz (Bromm B, Pawlik K , eds), pp 63-74. Göttingen: Vandenhoeck & Ruprecht.

Treede R-D, Handwerker HO, Baumgärtner U, Meyer RA, Magerl W (2004) Hyperalgesia and allodynia: taxonomy, assessment, and mechanisms. In: Hyperalgesia: Molecular Mechanisms and Clinical Implications (Brune K, Handwerker HO, eds), pp 1-15. Seattle: IASP Press.

Valeriani M, Barba C, Le Pera D, Restuccia D, Colicchio G, Tonali P, Gagliardo O, <nobr>Treede R-D</nobr> (2004) Different neuronal contribution to N20 somatosensory evoked potential and to CO(2) laser evoked potentials: an intracerebral recording study. Clin Neurophysiol 115:211-216


Greffrath W, Binzen U, Schwarz S, Saaler-Reinhardt S, Treede R-D (2003) Co-expression of heat sensitive vanilloid receptor subtypes in rat dorsal root ganglion neurons. Neuroreport 14:2251-2255

Jung P, Baumgärtner U, Bauermann T, Magerl W, Gawehn J, Stoeter P, Treede R-D (2003) Asymmetry in the human primary somatosensory cortex and handedness. Neuroimage 19:913-923

Klein T, Magerl W, Mantzke U, Hopf H-C, Sandkühler J, Treede R-D (2003) Perceptual correlates of long-term potentiation in the spinal cord. In: (eds) Dostrovsky J, Carr D, and Koltzenburg M Proceedings of the 10th World Congress on Pain. Progress in Pain Research and Management, Vol. 24 IASP Press, Seattle, Seattle, pp 407-415

Magerl W, Treede RD (2003) Secondary tactile hypoesthesia: a novel type of pain-induced somatosensory plasticity in human subjects. Neurosci Lett 361: 136-139.

Schlereth T, Baumgärtner U, Magerl W, Stoeter P, Treede R-D (2003) Left-hemisphere dominance in early nociceptive processing in the human parasylvian cortex. Neuroimage 20:441-454

Spiegel J, Hansen C, Baumgärtner U, Hopf HC, Treede R-D (2003) Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis. Clin Neurophysiol 114:992-1002

Treede R-D (2003) Neurophysiological studies of pain pathways in peripheral and central nervous system disorders. J Neurol 250:1152-1161

Treede R-D (2003) Pain and the somatosensory cortex. In: (eds) Bountra C, Munglani R, and Schmidt W Pain: Current understanding, emerging therapies, and novel approaches to drug discovery Marcel Dekker, New York-Basel, pp 87-99

Treede R-D, Lorenz J, Baumgärtner U (2003) Clinical usefulness of laser-evoked potentials. Neurophysiologie Clinique 33:303-314

Treede R-D, Magerl W (2003) Zentrale nozizeptive Neurone und Bahnen. In: (eds) Egle UT, Hoffmann SO, Lehmann KA, and Nix WA Handbuch Chronischer Schmerz Schattauer, Stuttgart, pp 34-44

Treede R-D, Rolke R, Magerl W (2003) Reply to letter by Cohen and Quintner. Pain 104:712-714

Vogel H, Port JD, Lenz FA, Solaiyappan M, Krauss G, Treede R-D (2003) Dipole source analysis of laser-evoked subdural potentials recorded from parasylvian cortex in humans. J Neurophysiol 89:3051-3060


Baumgärtner U, Magerl W, Klein T, Hopf HC, Treede R-D (2002) Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain. Pain 96:141-151.

Greffrath W, Nemenov MI, Schwarz S, Baumgärtner U, Vogel H, Arendt-Nielsen L, Treede R-D (2002) Inward currents in primary nociceptive neurons of the rat and pain sensations in humans elicited by infrared diode laser pulses. Pain 99:145-155.

Greffrath W, Kirschstein T, Nawrath H, Treede, R-D (2002) Acetylsalicylic acid reduces heat responses in rat nociceptive primary sensory neurons -- evidence for a new mechanism of action. Neurosci Lett 320:61-64.

Lenz FA, Treede, R-D (2002) Attention, novelty, and pain. Pain 99:1-3.

Treede R-D (2002) Spinothalamic and thalamocortical nociceptive pathways. J Pain 3:109-112.

Treede R-D, Rolke R, Andrews K, Magerl W (2002) Pain elicited by blunt pressure: neurobiological basis and clinical relevance. Pain 98:235-240.


Drzezga A, Darsow U, Treede R-D, Siebner H, Frisch M, Munz F, Weilke F, Ring J, Schwaiger M, Bartenstein P. (2001) Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O PET-studies. Pain 92:295-305.

Fitzek S, Baumgärtner U, Fitzek C, Magerl W, Urban P, Thömke F, Marx J, Treede R-D, Stoeter P, Hopf HC (2001) Mechanisms and predictors of chronic facial pain in lateral medullary infarction, Ann Neurol 49:493-500.

Greffrath W, Kirschstein T, Nawrath H, Treede R-D (2001) Changes in cytosolic calcium in response to noxious heat and their relationship to vanilloid receptors in rat dorsal root ganglion neurons, Neurosci 104:539-550.

Magerl W, Fuchs P N, Meyer R A, Treede R-D (2001) Roles of capsaicin-insensitive nociceptors in pain and secondary hyperalgesia, Brain, 124:1754-1764

Schlereth T, Magerl W, Treede R-D (2001) Spatial discrimination thresholds for pain and touch in human hairy skin, Pain, 92:187-194.

Sonnenborg FA, Andersen OK, Arendt-Nielsen L, Treede R-D (2001) Withdrawal reflex organisation to electrical stimulation of the dorsal foot in humans, Exp Brain Res:136:303-312.

Treede R-D (2001) Neural basis of pain. In: Smelser NJ, Baltes PB. (Eds.), International Encyclopedia of the Social & Behavioral Sciences, Elsevier, Amsterdam-Paris-New York, pp. 11000-11005.

Treede R-D (2001) Physiologische Grundlagen der Schmerzentstehung und Schmerztherapie. In: Zenz M, Jurna I. (Eds.), Lehrbuch der Schmerztherapie, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, pp. 39-63


Buchner H, Richrath P, Grünholz J, Noppeney U, Waberski TD, Gobbelé R, Willmes K and Treede R-D (2000) Differential effects of pain and spatial attention on digit representation in the human primary somatosensory cortex. Neuroreport 11:1289-1293.

Jørum E, Warncke T, Ziegler EA, Magerl W, Fuchs PN, Meyer RA, Treede RD (2000) Secondary hyperalgesia to punctate stimuli is mediated by A-fiber nociceptors. In: Devor M, Rowbotham M, Wiesenfeld-Hallin Z (eds) Procedings of the 9th World Congress on pain, Progr Pain Res Management, Vol 16, IASP Press, Seattle, pp 215-223

Lenz FA, Krauss G, Treede R-D, Lee J-I, Boatman D, Crone N, Minahan R, Port J, Rios M (2000) Different generators in human temporal-parasylvian cortex account for subdural laser-evoked potentials, auditory-evoked potentials, and event-related potentials. Neurosci Lett 279:153-156.

Reinert A, Treede RD, Bromm B (2000) The pain inhibiting pain effect: an electrophysiological study in humans. Brain Res 862:103-110

Schwarz S, Greffrath W, Büsselberg D, Treede R-D (2000) Inactivation and tachyphylaxis of heat-evoked inward currents in nociceptive primary sensory neurones of rats. J Physiol 528: 539-549

Spiegel J, Hansen C, Treede RD (2000) Clincal evaluation criteria for the assessment of impaired pain sensitivity by thulium-laser evoked potentials. Clin Neurophysiol 111:725-735

Treede R-D, Apkarian AV, Bromm B, Greenspan JD, Lenz FA (2000) Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus. Pain 87: 113-119

Treede R-D, Kenshalo DR, Gracely RH, Jones AKP (2000) Reply to Eccleston and Crombez, Reply to Hooper (The cortical representation of pain). Pain 84:443-444.

Treede R-D, Magerl W (2000) Multiple mechanisms of secondary hyperalgesia. In: Sandkühler J, Bromm B, Gebhart GF (eds) Nervous system plasticity and chronic pain, Prog Brain Res 129, Elsevier, Amsterdam, 331-341


Kirschstein T, Greffrath W, Büsselberg D, Treede R-D (1999) Inhibition of rapid heat responses in nociceptive primary sensory neurons of the rat by vanilloid receptor antagonists. J Neurophysiol 82:2853-2860.

Magerl W, Ali Z, Ellrich J, Meyer RA, Treede R-D (1999) C- and Ad-fiber components of heat-evoked cerebral potentials in healthy human subjects. Pain 82:127-137.

Rios M, Treede R, Lee J, Lenz FA (1999) Direct evidence of nociceptive input to human anterior cingulate gyrus and parasylvian cortex. Curr Rev Pain 3:256-264.

Spiegel J, Tintera J, Gawehn P, Stoeter P, Treede R-D (1999) Functional MRI of human primary somatosensory and motor cortex during median nerve stimulation. Clin Neurophysiol 110:47-52.

Treede R-D (1999) Physiologische Grundlagen des Knochenschmerzes. Osteologie 8:195-200.

Treede R-D (1999) Hitzeschmerz der Haut - Einfluss der a -Adrenorezeptoren. Schmerz 13:407-408.

Treede R-D (1999) Transduction and transmission properties of primary nociceptive afferents. Russ J Physiol 85:205-211.

Treede R-D, Kenshalo DR, Gracely RH, Jones AKP (1999) The cortical representation of pain. Pain 79:105-111.

Treede R-D, Vogel H, Rios M, Krauss G, Lesser RP, Lenz FA (1999) Pain related evoked potentials from parasylvian cortex in humans. Electroenceph Clin Neurophysiol Suppl.49:250-254.

Urban PP, Hansen C, Baumgärtner U, Fitzek S, Marx J, Fitzek C, Treede R-D, Hopf HC (1999) Abolished laser-evoked potentials and normal blink reflex in midlateral medullary infarction. J Neurol 246:347-352.

Ziegler EA, Magerl W, Meyer RA, Treede R-D (1999) Secondary hyperalgesia to punctate mechanical stimuli: Central sensitization to A-fibre nociceptor input. Brain 122:2245-2257.


Baumgärtner U, Vogel H, Ellrich J, Gawehn J, Stoeter P, Treede RD (1998) Brain electrical source analysis of primary cortical components of the tibial nerve somatosensory evoked potential using regional sources. Electroenceph Clin Neurophysiol 108:588-599.

Ellrich J, Treede R-D (1998) Convergence of nociceptive and non-nociceptive input onto spinal reflex pathways to the tibialis anterior muscle in man. Acta Physiol Scand 163:391-401.

Ellrich J, Treede R-D (1998) Characterization of blink reflex interneurons by activation of diffuse noxious inhibitory controls in man. Brain Res 803:161-168.

Ellrich J, Andersen OK, Treede R-D, Arendt-Nielsen L (1998) Convergence of nociceptive and non-nociceptive input onto the medullary dorsal horn in man. Neuroreport 9:3213-3217.

Ellrich J, Steffens H, Treede R-D, Schomburg ED (1998) The Hoffmann reflex of human plantar foot muscles. Muscle Nerve 21:732-738.

Magerl W, Wilk SH, Treede R-D (1998) Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans. Pain 74:257-268.

Treede R-D (1998) Pathophysiologie und Diagnostik von sensiblen Störungen bei Patienten mit sympathikusabhängigen Schmerzen. Schmerz 12:250-260.

Treede R-D (1998) Chronischer neuropathischer Schmerz: Klinik und Pathophysiologie beim Menschen. Tierlaboratorium 21:107-116.

Treede R-D, Magerl W, Baumgärtner U (1998) Laser evoked potentials for assessment of nociceptive pathways in humans. Towards a rational experimental and clinical use. Pain Forum 7:191-195.

Treede R-D, Meyer RA, Campbell JN (1998) Myelinated mechanically insensitive afferents from monkey hairy skin: heat response properties. J Neurophysiol 80:1082-1093.


Hansen C, Hopf HC, Treede R-D (1996) Paradoxical heat sensation in patients with multiple sclerosis. Evidence for a supraspinal integration of temperature sensation. Brain 119:1729-1736.

Hansen HC, Treede R-D, Lorenz J, Kunze K, Bromm B (1996) Recovery from brainstem lesions involving the nociceptive pathways: comparison of clinical findings with laser-evoked potentials. J Clin Neurophysiol 13:330-338.

Magerl W, Treede R-D (1996) Heat-evoked vasodilatation in human hairy skin: axon reflexes due to low-level activity of nociceptive afferents. J Physiol 497:837-848.

Magerl W, Koltzenburg M, Schmitz JM, Handwerker HO (1996) Asymmetry and time-course of cutaneous sympathetic reflex responses following sustained excitation of chemosensitive nociceptors in humans. J Autonom Nerv Syst 57:63-72.

Siedenberg R, Treede R-D (1996) Laser-evoked potentials: exogenous and endogenous components. Electroenceph Clin Neurophysiol 100:240-249.

Spiegel J, Hansen C, Treede R-D (1996) Laser-evoked potentials after painful hand and foot stimulation in humans: evidence for generation of the middle-latency component in the secondary somatosensory cortex. Neurosci Lett 216:179-182.

Treede R-D (1996) Assessment of thin-fiber and anterolateral-tract function with laser evoked potentials. In: Recent Advances in Clinical Neurophysiology (Kimura J, Shibasaki H eds), pp 323-327. Amsterdam: Elsevier Sci.

Treede R-D (1996) Funktionsprüfung der nozizeptiven Bahnen durch SEP nach schmerzhaften Laser-Hitzereizen. In: Evozierte Potentiale (Stöhr M, Dichgans J, Buettner UW, Hess CW, Altenmüller E eds), pp 655-676. Berlin-Heidelberg: Springer-Verlag.

Treede R-D (1996) Funktionsprüfung nozizeptiver Bahnen durch SEP nach schmerzhaften Laser-Reizen. Z EEG-EMG 27:16-18.


Cole JD, Merton WL, Barrett G, Katifi HA, Treede R-D (1995) Evoked potentials in a subject with a large-fibre sensory neuropathy below the neck. Can J Physiol Pharmacol 73:234-245.

Hansen C, Treede R-D (1995) Laser-evozierte Potentiale: Eine neue klinisch-neurophysiologische Untersuchungsmethode für die Schmerzbahnen. EEG-Labor 17:76-85.

Heyer G, Magerl W (1995) Skin reactions and sensations induced by intradermal injection of substance P into compound 48/80 pretreated skin. In: Wound Healing and Skin Physiology (Altmeyer P, Hoffmann K, El Gammal S, Hutchinson S eds), pp 335-344. Berlin-Heidelberg: Springer-Verlag.

Tillman D-B, Treede R-D, Meyer RA, Campbell JN (1995) Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: estimates of receptor depth and threshold. J Physiol 485:753-765.

Tillman D-B, Treede R-D, Meyer RA, Campbell JN (1995) Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: correlation with pain threshold in humans. J Physiol 485:767-774.

Treede R-D (1995) Peripheral acute pain mechanisms. Ann Med 27:213-216.

Treede R-D, Kunde V (1995) Middle-latency somatosensory evoked potentials after stimulation of the radial and median nerves: component structure and scalp topography. J Clin Neurophysiol 12:291-301.

Treede R-D, Magerl W (1995) Modern concepts of pain and hyperalgesia: beyond the polymodal C-nociceptor. News Physiol Sci 10:216-228.

Treede R-D, Lorenz J, Kunze K, Bromm B (1995) Assessment of nociceptive pathways with laser-evoked potentials in normal subjects and patients. In: Pain and the Brain: From Nociception to Cognition (Bromm B, Desmedt JE eds), pp 377-391. New York: Raven Press.

Treede R-D, Meyer RA, Raja SN, Campbell JN (1995) Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J Physiol 483:747-758.


Magerl W, Koltzenburg M, Meyer-Jürgens D, Handwerker HO (1994) The somatotopic organization of nociceptor-induced vascular response pattern reflects central nociceptive processing in humans. In: Proceedings of the 7th World Congress on Pain. Progress in Pain Research and Management, Vol. 2 (Gebhart GF, Hammond DL, Jensen TS eds), pp 843-856. Seattle: IASP Press.

Treede R-D (1994) Evoked potentials related to pain. In: Touch, Temperature, and Pain in Health and Disease: Mechanisms and Assessments. Progress in Pain Research and Management, Vol. 3 (Boivie J, Hansson P, Lindblom U eds), pp 473-489. Seattle: IASP Press.

Treede R-D (1994) Principles of central nervous system monitoring in humans. In: Central Nervous System Monitoring in Anesthesia and Intensive Care (Schulte am Esch J, Kochs E eds), pp 19-26. Berlin-Heidelberg-New York: Springer-Verlag.

Treede R-D, Meyer RA, Lesser RP (1994) Similarity of threshold temperatures for first pain sensation, laser-evoked potentials and nociceptor activation. In: Proceedings of the 7th World Congress on Pain. Progress in Pain Research and Management, Vol. 2 (Gebhart GF, Hammond DL, Jensen TS eds), pp 857-865. Seattle: IASP Press.


Meyer RA, Raja SN, Treede R-D, Davis KD, Campbell JN (1992) Neural mechanisms of sympathetically maintained pain. In: Reflex Sympathetic Dystrophy: Pathophysiological Mechanisms and Clinical Implications (Jänig W, Schmidt RF eds), pp 57-66. Weinheim: Verlag Chemie.

Meyer RA, Treede R-D, Raja SN, Campbell JN (1992) Peripheral versus central mechanisms for secondary hyperalgesia. Is the controversy resolved? APS Journal 1:127-131.

Tarkka IM, Treede R-D, Bromm B (1992) Sensory and movement-related cortical potentials in nociceptive and auditory reaction time tasks. Acta Neurol Scand 86:359-364.

Treede R-D (1992) Vasodilator flare due to activation of superficial cutaneous afferents in humans: heat-sensitive versus histamine-sensitive fibers. Neurosci Lett 141:169-172.

Treede R-D, Davis KD, Campbell JN, Raja SN (1992) The plasticity of cutaneous hyperalgesia during sympathetic ganglion blockade in patients with neuropathic pain. Brain 115:607-621.

Treede R-D, Meyer RA, Raja SN, Campbell JN (1992) Peripheral and central mechanisms of cutaneous hyperalgesia. Prog Neurobiol 38:397-421.

Treede R-D, Hansen HC, Kunze K, Bromm B (1992) Neurophysiologische Beurteilung der Schmerzbahnen bei Patienten mit Hirnstammläsionen. In: Verhandlungen der Deutschen Gesellschaft für Neurologie, Vol. 7, 65. Jahrestagung Saarbrücken (Schimrigk K, Haaß A, Hamann G eds), pp 609-610.


Bromm B, Treede RD (1991). Laser-evoked cerebral potentials in the assessment of cutaneous pain sensitivity in normal subjects and patients. Rev Neurol (Paris). 1991;147(10):625-43.

Davis KD, Treede RD, Raja SN, Meyer RA, Campbell JN (1991). Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain. Pain. 1991 Dec;47(3):309-17.

Meyer RA, Davis KD, Cohen RH, Treede RD, Campbell JN (1991). Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey. Brain Res. 1991 Oct 11;561(2):252-61.

Meyer RA, Cohen RH, Davis KD, Treede RD, and Campbell JN (1991). Evidence for cutaneous afferents that are insensitive to mechanical stimuli. In: Proceedings of the VIth World Congress on Pain, edited by M. R. Bond, J. E. Charlton, and C. J. Woolf, Amsterdam:Elsevier Science Publishers, 1991, p. 71-75.

Raja SN, Treede RD, Davis KD, Campbell JN (1991). Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain. Anesthesiology. 1991 Apr;74(4):691-8.

Treede RD, Lankers J, Frieling A, Zangemeister WH, Kunze K, Bromm B (1991). Cerebral potentials evoked by painful, laser stimuli in patients with syringomyelia. Brain. 1991 Aug;114 ( Pt 4):1595-607.

Treede RD, Raja SN, Davis KD, Meyer RA, and Campbell JN (1991). Evidence that peripheral alpha-adrenergic receptors mediate sympathetically maintained pain. In: Proceedings of the Vth World Congress on Pain, edited by M. R. Bond, J. E. Charlton, and C. J. Woolf, Amsterdam:Elsevier Science Publishers, 1991, p. 377-382.

Treede RD and Bromm B (1991). Neurophysiological approaches to the study of spinothalamic tract function in humans. In: Pain and Central Nervous System Disease: The Central Pain Syndromes, edited by K. L. Casey, New York:Raven Press, 1991, p. 117-127.


Kochs E, Treede RD, Schulte am Esch J, Bromm B (1990). Modulation of pain-related somatosensory evoked potentials by general anesthesia. Anesth Analg. 1990 Sep;71(3):225-30.

Kochs E, Schulte am Esch J, Treede RD, and Bromm B (1990). Evoked cerebral responses to painful stimulation during general anesthesia. In: Advances in Pain Research and Therapy, Vol. 13, edited by S. Lipton, New York:Raven Press, 1990, p. 99-105.

Treede RD, Meyer RA, Davis KD, Campbell JN (1990). Intradermal injections of bradykinin or histamine cause a flare-like vasodilatation in monkey. Evidence from laser Doppler studies. Neurosci Lett. 1990 Jul 31;115(2-3):201-6.

Treede RD, Meyer RA, Campbell JN (1990). Comparison of heat and mechanical receptive fields of cutaneous C-fiber nociceptors in monkey. J Neurophysiol. 1990 Nov;64(5):1502-13.


Bromm B, Scharein E, Treede RD (1988). Analgesic effect of acetylsalicylic acid and lithium as measured with the CO2-laser stimulator. Pharmacopsychiatry. 1988 Mar;21(2):109-11.

Treede RD, Meier W, Kunze K, Bromm B (1988). Ultralate cerebral potentials as correlates of delayed pain perception: observation in a case of neurosyphilis. J Neurol Neurosurg Psychiatry. 1988 Oct;51(10):1330-3.

Treede RD, Kief S, Hölzer T, Bromm B (1988). Late somatosensory evoked cerebral potentials in response to cutaneous heat stimuli. Electroencephalogr Clin Neurophysiol. 1988 Nov;70(5):429-41.

Treede RD and Bromm B (1988). Differenzierung verschiedener Komponenten des Schmerzes durch evozierte zerebrale Potentiale. Hamburger Ärzteblatt 42:144-147, 1988.

Treede RD (1988). Evozierte cerebrale Potentiale nach Hitzereizen als Grundlage für die nicht-invasive Objektivierung der Hautsensibilität, Hamburg:Habilitationsschrift (Physiologie), 1988.

Treede RD, Kief S, Hölzer T and Bromm B (1988). Late somatosensory evoked cerebral potentials in response to cutaneous heat stimuli. Electroenceph.Clin.Neurophysiol. 70:429-441, 1988.

Treede RD and Bromm B (1988). Reliability and validity of ultra-late cerebral potentials in response to C-fibre activation in man. In: Proceedings of the Vth World Congress on Pain, edited by R. Dubner, G. F. Gebhart, and M. R. Bond, Amsterdam:Elsevier Science Publishers BV, 1988, p. 567-573.


Bromm B, Treede RD (1987). Human cerebral potentials evoked by CO2 laser stimuli causing pain. Exp Brain Res. 1987;67(1):153-62.

Bromm B, Treede RD (1987). Pain related cerebral potentials: late and ultralate components. Int J Neurosci. 1987 Mar;33(1-2):15-23.

Kochs E, Treede RD, Roewer N, Bromm B and Schulte am Esch J (1987). Überwachung des zentralen Nervensystems mit Hilfe evozierter Potentiale. In: Die Inhalationsnarkose, edited by H. Schwilden and H. Stoeckel, Stuttgart:Thieme-Verlag, 1987, p. 151-164.

Treede RD (1987). C-Faser Aktivität und evozierte cerebrale Potentiale beim Menschen. In: Physiologie aktuell. Band III, edited by B. Bromm and H. P. Koepchen, Stuttgart:Gustav-Fischer-Verlag, 1987, p. 167-175.


Kochs E, Treede RD, Schulte am Esch J (1986). Increase in somatosensory evoked potentials during anesthesia induction with etomidate Anaesthesist. 1986 Jun;35(6):359-64. German.

Kochs E, Treede RD and Schulte am Esch J (1986). Evozierte Potentiale unter Narkoseeinleitung mit Midazolam in Kombination mit Etomidate bzw. Thiopental. In: Benzodiazepine in Anästhesie und Intensivmedizin, edited by J. Schulte am Esch, Basel:Editiones Roche, 1986, p. 153-164.


Chen AC, Treede RD, Bromm B (1985). Tonic pain inhibits phasic pain: evoked cerebral potential correlates in man. Psychiatry Res. 1985 Apr;14(4):343-51.

Chen AC, Treede RD (1985). The McGill Pain Questionnaire in the assessment of phasic and tonic experimental pain: behavioral evaluation of the 'pain inhibiting pain' effect. Pain. 1985 May;22(1):67-79.

Kochs E, Treede RD and Schulte am Esch J (1985). Beeinflussung somatosensorisch evozierter Potentiale durch Etomidat. In: Kardiovaskuläre Erkrankungen und Nervensystem, Neurotoxikologie, Probleme des Hirntodes, edited by H. Gänshirt, P. Berlit, and G. Haack, Berlin: Springer-Verlag, 1985, p. 520-524.


Bromm B, Jahnke MT, Treede RD (1984). Responses of human cutaneous afferents to CO2 laser stimuli causing pain. Exp Brain Res. 1984;55(1):158-66.

Bromm B, Treede RD (1984). Nerve fibre discharges, cerebral potentials and sensations induced by CO2 laser stimulation. Hum Neurobiol. 1984;3(1):33-40.

Biehl R, Treede RD and Bromm B (1984). Pain ratings of short radiant heat pulses. In: Pain Measurement in Man. Neurophysiological Correlates of Pain, edited by B. Bromm, Amsterdam:Elsevier Science Publishers B.V., 1984, p. 397-408.

Chen ACN, Treede RD and Bromm B (1984). Modulation of pain evoked cerebral potential by concurrent subacute pain. In: Pain Measurement in Man: Neurophysiological Correlates of Pain, edited by B. Bromm, Amsterdam:Elsevier Press, 1984, p. 301-310.

Kochs E, Treede RD and Schulte am Esch J (1984). Verhalten von somatosensorisch evozierten Potentialen unter Narkoseinleitung mit Etomidat. Biomed.Technik Suppl. 29:163-164, 1984.

Treede RD, Jahnke MT and Bromm B (1984). Functional properties of CO2 laser activated nociceptive fibers in an intact human skin nerve. In: Pain Measurement in Man: Neurophysiological Correlates of Pain, edited by B. Bromm, Amsterdam:Elsevier Press, 1984, p. 65-78.


Bromm B and Treede RD (1981). Nociceptive reflexes and pain sensation in man. Pain 10:408-410, 1981.

Treede RD (1981). Vergleichende Messung des subjektiven Empfindungsstärke und physiologischer Reaktionen auf elektrische Schmerzreize. Aufbau einer Methode und erste Ergebnisse. Dissertation. Physiologisches Institut, Hamburg. 1-68, 1981.


Treede RD (1979). Famulatur bei einem Werkarzt. Hamburger Ärzteblatt 9:401-403, 1979.