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Peer reviewed original research articles:

  1. Kubitschke, M., Mueller, M., Wallhorn, L., Pulin, M., Mittag, M., Pollok, S., Ziebarth, T., Bremshey, S., Gerdey, J., Claussen, K.C., Renken, K., Gross, J., Meyer, N., Wiegert, J.S., Reiner, A., Fuhrmann, M., Masseck, O.A. (2022) sDarken: Next generation genetically encoded fluorescent sensors for serotonin. Accepted at Nat Commun Preprint:
  2. Duerst, C., Wiegert, J.S., Schulze, C., Helassa, N., Török, K., Oertner, T.G. (2020). The vesicular release probability sets the strength of individual Schaffer collateral synapses. Nat Commun 13(1), 6126
  3. Stuedemann, T., Roessinger, J., Manthey, C., Geertz, B., Srikantharajah, R., von Bibra, C.C., Shibamiya, A., Koehne, M., Wiehler, A., Wiegert, J.S., Eschenhagen, T., Weinberger, F. (2021). Contractile force of transplanted cardiomyocytes contributes to heart function after injury. Circulation, 146(15):1159-1169.
  4. Rodriguez-Rozada, S., Wietek, J., Tenedini, F. M., Sauter, K., Hegemann, P., Soba, P., & Wiegert, J.S. (2022). Aion is a bistable anion-conducting channelrhodopsin that provides temporally extended and reversible neuronal silencing. Commun Biol, 5, Article number: 687 (2022).
  5. Wagdi, A., Malan, D., Sathyanarayanan, U., Beauchamp, J., Vogt, M., Zipf, D., Beiert, T., Mansuroglu, B., Dusend, V., Meininghaus. M., Schneider, L., Kalthof, B., Wiegert, J.S., König, G.M., Kostenis, E., Patejdl, R., Sasse, P. Selective optogenetic control of Gq signaling using human Neuropsin (hOPN5). In revision at Nat Commun 13, 1765
  6. Formozov, A., Chini, M., Dieter, A., Yang, W., Pöpplau, J., Hanganu-Opatz, I.L., Wiegert, J.S. Calcium imaging and electrophysiology of hippocampal activity under anesthesia and natural sleep in mice. Scientific Data 9
  7. Anisimova M., van Bommel B., Wiegert J.S., Mikhaylova M., Oertner T.G., Gee C.E. Spike-timing-dependent plasticity rewards synchrony rather than causality. Cerebral Cortex
  8. Pulin, M., Stockhausen, K.E., Masseck, O.A., Kubitschke, M., Busse, B., Wiegert, J.S., and Oertner, T.G. (2022). Improved two-photon imaging of GPCR-based optogenetic neurotransmitter sensors using orthogonally polarized excitation. Biomed Opt Express 13(2): 777-790.
  9. Imambocus, B.N., Zhou, F., Formozov, A., Wittich, A., Tenedini, F.M., Hu, C., Sauter, K., Varela, E.M., Herédia, F., Casimiro, A.P., Schlegel, P., Yang, C.H., Miguel-Aliaga, I., Wiegert, J.S., Pankratz, M.J., Gontijo, A.M., Cardona, A., Soba, P. (2022) Discrete escape responses are generated by neuropeptide-mediated circuit logic. Curr Biol 32 (1), 149-163.e8
  10. *Vierock, J., *Rodriguez-Rozada, S., Dieter, A., Pieper, F., Sims, R., Tenedini, F., Bergs, A.C.F., Bendifallah, I., Zhou, F., Zeitzschel, N., Ahlbeck, J., Augustin S., Sauter, K., Papagiakoumou, E., Gottschalk, A., Soba, P., Emiliani, V., Engel, A.K., Hegemann, P., Wiegert, J.S. (2021). BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons. Nat Commun, 12, 4527. DOI: 10.1038/s41467-021-24759-5. * equal contributions
  11. *Yang, W., *Chini, M., Poepplau, J.A., Formozov, A., Piechocinski, P., Rais, C., Morellini, F., Sporns, O., Hanganu-Opatz, I.L., Wiegert, J.S. (2021). Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. PLOS Biol 19(4): e3001146. DOI: 10.1371/journal.pbio.3001146, * equal contributions
  12. *Mahn, M., *Saraf-Sinik, I., *Patil, P., *Pulin, M., Bitton, E., Karalis, N., Bruentgens, F., Palgi, S., Gat, A., Dine, J., Wietek, J., Davidi, I., Levy, R., Litvin, A., Zhou, F., Sauter, K., Soba, P., Schmitz, D., Lüthi, A., Rost, B.R., Wiegert, J.S., Yizhar, O. (2021). Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin. Neuron 109 (10). DOI: 10.1016/j.neuron.2021.03.013 * equal contributions
  13. Westermann, L. M., Fleischhauer, L., Vogel, J., Jenei-Lanzl, Z., Floriano Ludwig, N., Schau, L., Morellini, F., Baranowsky, A., Yorgan, T. A., Di Lorenzo, G., Schweizer, M., de Souza Pinheiro, B., Guarany, N. R., Sperb-Ludwig, F., Visioli, F., Oliveira Silva, T., Soul, J., Hendrickx, G., Wiegert, J. S., Schwartz, I. V. D., Clausen-Schaumann, H., Zaucke, F., Schinke, T., Pohl, S. and Danyukova, T., (2020). Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma. Dis Model Mech, DOI: 10.1242/dmm.04642
  14. Perez-Alvarez, A., Fearey, B., Schulze, C., O'Toole, R.J., Moeyaert, B., Mohr, M.A., Arganda-Carreras, I., Yang, W., Wiegert, J.S., Schreiter, E.R., Gee, C.E., Hoppa, M.B., Oertner, T.G., (2020). Freeze-frame imaging of synaptic activity using SynTagMA. Nat Commun, 11(1): 2464, DOI: 10.1038/s41467-020-16315-4
  15. Oppermann, J., Fischer, P., Silapetere, A., Liepe, B., Rodriguez-Rozada, S., Flores-Uribe, J., Peter, E., Keidel, A., Vierock, J., Kaufmann, J., Broser, M., Luck, M., Bartl, F., Hildebrandt, P., Wiegert, J. S., Béjà, O., Hegemann, P.,  and Wietek, J., (2019). MerMAIDs: A novel family of metagenomically discovered, marine, anion-conducting and intensely desensitizing Channelrhodopsins. Nat Commun 10(1):3315, DOI: 10.1038/s41467-019-11322-6
  16. Binder, S., Molle, M., Lippert, M., Bruder, R., Aksamaz, S., Ohl, F., Wiegert, J.S., and Marshall, L. (2019). Monosynaptic hippocampal-prefrontal projections contribute to spatial memory consolidation in mice. J Neurosci DOI:10.1523/JNEUROSCI.2158-18.2019
  17. Dürst, C., Wiegert, J.S., Helassa, N. Kerruth, S., Coates, C., Schulze, C., Geeves, M., Török, K., Oertner, T. G. (2019). High-speed imaging of glutamate release with genetically encoded sensors. Nat Prot 14(5):1401-1424 DOI:10.1038/s41596-019-0143-9
  18. Wiegert, J.S., Pulin, M., Gee, C.E., Oertner, T. G. (2018). The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife e39151 DOI: 10.7554/eLife.39151
  19. Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. (2018). Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun 9(1):3949 DOI: 10.1038/s41467-018-06421-9
  20. Helassa, N., Dürst, C.D., Coates, C., Arif, U., Schulze, C., Wiegert, J.S., Geeves, M., Oertner, T.G., Török, K. (2018). Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses, Proc Natl Acad Sci USA 115(21), 5594-5599 DOI: 10.1073/pnas.1720648115
  21. Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F., Grimm, C., Oertner, T.G., Soba, P., Hegemann, P., Wiegert, J.S. (2017). Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep 7:14957 DOI: 10.1038/s41598-017-14330-y
  22. Bitzenhofer, S.H., Ahlbeck, J., Wolff, A. Wiegert, J.S., Gee, C.E., Oertner, T.G., Hanganu-Opatz, I.L. (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Commun 8:14563 DOI: 10.1038/ncomms14563
  23. Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T.G., Wiegert, J.S. (2015). An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep 5:14807 DOI: 10.1038/srep14807
  24. Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, J.S., Vetter, T., Oertner, T.G. (2015). Automated analysis of spine dynamics on live CA1 pyramidal cells. Med Image Anal 19(1), 87-97 DOI: 10.1016/
  25. Wietek, J.*, Wiegert, J.S.*, Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S., Vogt, A., Elstner, M., Oertner, T.G., Hegemann, P. (2014). Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412, *first 2 authors equally contributing DOI: 10.1126/science.1249375,
    Highlighted in Science, Science Signaling & Nature Methods
  26. Biermann, B., Sokoll, S., Klyueva, J., Missler, M., Wiegert, J.S., Sibarita, J.-B., Heine, M. (2014). Imaging of molecular surface dynamic in brain slices using single particle tracking. Nat Commun 5:3024 DOI: 10.1038/ncomms4024
  27. Wiegert, J.S. and Oertner, T. G. (2013). Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 110(47), E4510-E4519. DOI: 10.1073/pnas.1315926110
  28. Huber, D., Gutnisky, D.A., Peron, S., O'Connor, D.H., Wiegert, J.S., Tian, L., Oertner, T.G., Looger, L.L., and Svoboda, K. (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484, 473-478. DOI: 10.1038/nature11039
  29. Holbro, N., Grunditz, A., Wiegert, J.S., and Oertner, T.G. (2010). AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 107(36), 15975-15980. DOI: 10.1073/pnas.1004562107
  30. Wittmann, M. *, Queisser, G. *, Eder, A. *, Wiegert, J.S. *, Bengtson, C.P. *, Hellwig, A. *, Wittum, G., and Bading, H. (2009). Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci 29, 14687-14700. *first 6 authors equally contributing DOI: 10.1523/jneurosci.1160-09.2009
  31. Wiegert, J.S., Hofmann, F., Bading, H., and Bengtson, C.P. (2009). A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10, 124. DOI: 10.1186/1471-2202-10-124
  32. Wiegert, J.S., Bengtson, C.P., and Bading, H. (2007). Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem 282, 29621-29633. DOI: 10.1074/jbc.m701448200y

Peer reviewed review articles:

  1. Wiegert, J. S., Mahn, M., Prigge, M. Prinz, Y., Yizhar, O. (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 95 (3), 504-529 DOI: 10.1016/j.neuron.2017.06.050
  2. Wiegert, J.S. and Bading, H. (2011). Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49, 296-305. DOI: 10.1016/j.ceca.2010.11.009
  3. Queisser, G., Wiegert, J.S., Bading, H. (2011). Structural dynamics of the cell nucleus: basis for morphology modulation of nuclear calcium signaling and gene transcription. Nucleus 2(2), 1-7. DOI: 10.4161/nucl.2.2.15116

Other publications:

  1. Yizhar, O. & Wiegert, J. S. Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics. (2019). Trends Pharmacol Sci 40(6):362-364 DOI:10.1016/
  2. Wiegert, J.S., Gee, C.E., and Oertner, T. G. (2017). Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels. Cold Spring Harb Protoc​ 2017 (2) DOI: 10.1101/pdb.top089714
  3. Gee, C.E., Ohmert, I., Wiegert, J. S., and Oertner, T. G. (2017). Preparation of Slice Cultures from Rodent Hippocampus. Cold Spring Harb Protoc​ 2017 (2)
    DOI: 10.1101/pdb.prot094888
  4. Wiegert, J.S., Gee, C.E., and Oertner, T. G. (2017). Single-Cell Electroporation of Neurons. Cold Spring Harb Protoc​ 2017 (2) DOI: 10.1101/pdb.prot094904
  5. Wiegert, J.S., Gee, C.E., and Oertner, T. G. (2017). Viral Vector-Based Transduction of Slice Cultures. Cold Spring Harb Protoc​ 2017 (2) DOI: 10.1101/pdb.prot094896
  6. Wiegert, J.S. and Oertner, T.G. (2016). How (not) to silence long-range projections with light. Nat Neurosci 19, 527-528. DOI: 10.1038/nn.4270
  7. Wiegert, J.S. and Oertner, T.G. (2015). Neighborly synapses help each other out. Nat Neurosci 18, 326-327. DOI: 10.1038/nn.3955
  8. Wiegert, J.S. and Oertner, T. G. (2011). Shapeshifting for memory.  e-Neuroforum 2(1), 6-12. [REVIEW ARTICLE] DOI: 10.1007/s13295-011-0014-5

Preprints and submitted manuscripts:

  1. Bergs, A., Liewald, J., Liu, Q., Zeitzschel, N., Durmaz, H., Vierock, J., Bargmann, C., Hegemann, P., Wiegert, J.S., Gottschalk, A. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals. Preprint:
  2. Nicolas, C., Ju, A., Wu, Y., Delcasso, S., Eldirdiri, H., Supiot, L., Fornari, C., Jacky, D., Vérité, A., Masson, M., Rodriguez-Rozada, S., Wiegert, J.S., Beyeler, A. Linking valence and anxiety in a mouse insula-amygdala circuit. Preprint:
  3. Wissing, C., Maheu, M., Wiegert, J.S., and Dieter, A. (2022). Targeting Noradrenergic Neurons of the Locus Coeruleus: A Comparison of Model Systems and Strategies. Preprint:
  4. Formozov, A., Dieter, A., & Wiegert, J. S. (2022). A flexible and versatile system for multicolor fiber photometry and optogenetic manipulation. Preprint: