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Kirschstein T, Greffrath W, Büsselberg D, Treede R-D (1999) Inhibition of rapid heat responses in nociceptive primary sensory neurons of the rat by vanilloid receptor antagonists. J Neurophysiol 82:2853-2860.

Magerl W, Ali Z, Ellrich J, Meyer RA, Treede R-D (1999) C- and Ad-fiber components of heat-evoked cerebral potentials in healthy human subjects. Pain 82:127-137.

Rios M, Treede R, Lee J, Lenz FA (1999) Direct evidence of nociceptive input to human anterior cingulate gyrus and parasylvian cortex. Curr Rev Pain 3:256-264.

Spiegel J, Tintera J, Gawehn P, Stoeter P, Treede R-D (1999) Functional MRI of human primary somatosensory and motor cortex during median nerve stimulation. Clin Neurophysiol 110:47-52.

Treede R-D (1999) Physiologische Grundlagen des Knochenschmerzes. Osteologie 8:195-200.

Treede R-D (1999) Hitzeschmerz der Haut - Einfluss der a -Adrenorezeptoren. Schmerz 13:407-408.

Treede R-D (1999) Transduction and transmission properties of primary nociceptive afferents. Russ J Physiol 85:205-211.

Treede R-D, Kenshalo DR, Gracely RH, Jones AKP (1999) The cortical representation of pain. Pain 79:105-111.

Treede R-D, Vogel H, Rios M, Krauss G, Lesser RP, Lenz FA (1999) Pain related evoked potentials from parasylvian cortex in humans. Electroenceph Clin Neurophysiol Suppl.49:250-254.

Urban PP, Hansen C, Baumgärtner U, Fitzek S, Marx J, Fitzek C, Treede R-D, Hopf HC (1999) Abolished laser-evoked potentials and normal blink reflex in midlateral medullary infarction. J Neurol 246:347-352.

Ziegler EA, Magerl W, Meyer RA, Treede R-D (1999) Secondary hyperalgesia to punctate mechanical stimuli: Central sensitization to A-fibre nociceptor input. Brain 122:2245-2257.


Baumgärtner U, Vogel H, Ellrich J, Gawehn J, Stoeter P, Treede RD (1998) Brain electrical source analysis of primary cortical components of the tibial nerve somatosensory evoked potential using regional sources. Electroenceph Clin Neurophysiol 108:588-599.

Ellrich J, Treede R-D (1998) Convergence of nociceptive and non-nociceptive input onto spinal reflex pathways to the tibialis anterior muscle in man. Acta Physiol Scand 163:391-401.

Ellrich J, Treede R-D (1998) Characterization of blink reflex interneurons by activation of diffuse noxious inhibitory controls in man. Brain Res 803:161-168.

Ellrich J, Andersen OK, Treede R-D, Arendt-Nielsen L (1998) Convergence of nociceptive and non-nociceptive input onto the medullary dorsal horn in man. Neuroreport 9:3213-3217.

Ellrich J, Steffens H, Treede R-D, Schomburg ED (1998) The Hoffmann reflex of human plantar foot muscles. Muscle Nerve 21:732-738.

Magerl W, Wilk SH, Treede R-D (1998) Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans. Pain 74:257-268.

Treede R-D (1998) Pathophysiologie und Diagnostik von sensiblen Störungen bei Patienten mit sympathikusabhängigen Schmerzen. Schmerz 12:250-260.

Treede R-D (1998) Chronischer neuropathischer Schmerz: Klinik und Pathophysiologie beim Menschen. Tierlaboratorium 21:107-116.

Treede R-D, Magerl W, Baumgärtner U (1998) Laser evoked potentials for assessment of nociceptive pathways in humans. Towards a rational experimental and clinical use. Pain Forum 7:191-195.

Treede R-D, Meyer RA, Campbell JN (1998) Myelinated mechanically insensitive afferents from monkey hairy skin: heat response properties. J Neurophysiol 80:1082-1093.


Ellrich J, Hopf HC, Treede R-D (1997) Nociceptive masseter inhibitory reflexes evoked by laser radiant heat and electrical stimuli. Brain Res 764:214-220.

Kany C, Treede R-D (1997) Median and tibial nerve somatosensory evoked potentials: middle-latency components from the vicinity of the secondary somatosensory cortex in humans. Electroenceph Clin Neurophysiol 104:402-410.

Kirschstein T, Büsselberg D, Treede R-D (1997) Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons. Neurosci Lett 231:33-36.


Hansen C, Hopf HC, Treede R-D (1996) Paradoxical heat sensation in patients with multiple sclerosis. Evidence for a supraspinal integration of temperature sensation. Brain 119:1729-1736.

Hansen HC, Treede R-D, Lorenz J, Kunze K, Bromm B (1996) Recovery from brainstem lesions involving the nociceptive pathways: comparison of clinical findings with laser-evoked potentials. J Clin Neurophysiol 13:330-338.

Magerl W, Treede R-D (1996) Heat-evoked vasodilatation in human hairy skin: axon reflexes due to low-level activity of nociceptive afferents. J Physiol 497:837-848.

Magerl W, Koltzenburg M, Schmitz JM, Handwerker HO (1996) Asymmetry and time-course of cutaneous sympathetic reflex responses following sustained excitation of chemosensitive nociceptors in humans. J Autonom Nerv Syst 57:63-72.

Siedenberg R, Treede R-D (1996) Laser-evoked potentials: exogenous and endogenous components. Electroenceph Clin Neurophysiol 100:240-249.

Spiegel J, Hansen C, Treede R-D (1996) Laser-evoked potentials after painful hand and foot stimulation in humans: evidence for generation of the middle-latency component in the secondary somatosensory cortex. Neurosci Lett 216:179-182.

Treede R-D (1996) Assessment of thin-fiber and anterolateral-tract function with laser evoked potentials. In: Recent Advances in Clinical Neurophysiology (Kimura J, Shibasaki H eds), pp 323-327. Amsterdam: Elsevier Sci.

Treede R-D (1996) Funktionsprüfung der nozizeptiven Bahnen durch SEP nach schmerzhaften Laser-Hitzereizen. In: Evozierte Potentiale (Stöhr M, Dichgans J, Buettner UW, Hess CW, Altenmüller E eds), pp 655-676. Berlin-Heidelberg: Springer-Verlag.

Treede R-D (1996) Funktionsprüfung nozizeptiver Bahnen durch SEP nach schmerzhaften Laser-Reizen. Z EEG-EMG 27:16-18.


Cole JD, Merton WL, Barrett G, Katifi HA, Treede R-D (1995) Evoked potentials in a subject with a large-fibre sensory neuropathy below the neck. Can J Physiol Pharmacol 73:234-245.

Hansen C, Treede R-D (1995) Laser-evozierte Potentiale: Eine neue klinisch-neurophysiologische Untersuchungsmethode für die Schmerzbahnen. EEG-Labor 17:76-85.

Heyer G, Magerl W (1995) Skin reactions and sensations induced by intradermal injection of substance P into compound 48/80 pretreated skin. In: Wound Healing and Skin Physiology (Altmeyer P, Hoffmann K, El Gammal S, Hutchinson S eds), pp 335-344. Berlin-Heidelberg: Springer-Verlag.

Tillman D-B, Treede R-D, Meyer RA, Campbell JN (1995) Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: estimates of receptor depth and threshold. J Physiol 485:753-765.

Tillman D-B, Treede R-D, Meyer RA, Campbell JN (1995) Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: correlation with pain threshold in humans. J Physiol 485:767-774.

Treede R-D (1995) Peripheral acute pain mechanisms. Ann Med 27:213-216.

Treede R-D, Kunde V (1995) Middle-latency somatosensory evoked potentials after stimulation of the radial and median nerves: component structure and scalp topography. J Clin Neurophysiol 12:291-301.

Treede R-D, Magerl W (1995) Modern concepts of pain and hyperalgesia: beyond the polymodal C-nociceptor. News Physiol Sci 10:216-228.

Treede R-D, Lorenz J, Kunze K, Bromm B (1995) Assessment of nociceptive pathways with laser-evoked potentials in normal subjects and patients. In: Pain and the Brain: From Nociception to Cognition (Bromm B, Desmedt JE eds), pp 377-391. New York: Raven Press.

Treede R-D, Meyer RA, Raja SN, Campbell JN (1995) Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J Physiol 483:747-758.


Magerl W, Koltzenburg M, Meyer-Jürgens D, Handwerker HO (1994) The somatotopic organization of nociceptor-induced vascular response pattern reflects central nociceptive processing in humans. In: Proceedings of the 7th World Congress on Pain. Progress in Pain Research and Management, Vol. 2 (Gebhart GF, Hammond DL, Jensen TS eds), pp 843-856. Seattle: IASP Press.

Treede R-D (1994) Evoked potentials related to pain. In: Touch, Temperature, and Pain in Health and Disease: Mechanisms and Assessments. Progress in Pain Research and Management, Vol. 3 (Boivie J, Hansson P, Lindblom U eds), pp 473-489. Seattle: IASP Press.

Treede R-D (1994) Principles of central nervous system monitoring in humans. In: Central Nervous System Monitoring in Anesthesia and Intensive Care (Schulte am Esch J, Kochs E eds), pp 19-26. Berlin-Heidelberg-New York: Springer-Verlag.

Treede R-D, Meyer RA, Lesser RP (1994) Similarity of threshold temperatures for first pain sensation, laser-evoked potentials and nociceptor activation. In: Proceedings of the 7th World Congress on Pain. Progress in Pain Research and Management, Vol. 2 (Gebhart GF, Hammond DL, Jensen TS eds), pp 857-865. Seattle: IASP Press.


Kunde V, Treede R-D (1993) Topography of middle-latency somatosensory evoked potentials following painful laser stimuli and non-painful electrical stimuli. Electroenceph Clin Neurophysiol 88:280-289.

Tarkka IM, Treede R-D (1993) Equivalent electrical source analysis of pain-related somatosensory evoked potentials elicited by a CO2 laser. J Clin Neurophysiol 10:513-519.

Treede R-D, Cole JD (1993) Dissociated secondary hyperalgesia in a subject with a large-fibre sensory neuropathy. Pain 53:169-174.


Meyer RA, Raja SN, Treede R-D, Davis KD, Campbell JN (1992) Neural mechanisms of sympathetically maintained pain. In: Reflex Sympathetic Dystrophy: Pathophysiological Mechanisms and Clinical Implications (Jänig W, Schmidt RF eds), pp 57-66. Weinheim: Verlag Chemie.

Meyer RA, Treede R-D, Raja SN, Campbell JN (1992) Peripheral versus central mechanisms for secondary hyperalgesia. Is the controversy resolved? APS Journal 1:127-131.

Tarkka IM, Treede R-D, Bromm B (1992) Sensory and movement-related cortical potentials in nociceptive and auditory reaction time tasks. Acta Neurol Scand 86:359-364.

Treede R-D (1992) Vasodilator flare due to activation of superficial cutaneous afferents in humans: heat-sensitive versus histamine-sensitive fibers. Neurosci Lett 141:169-172.

Treede R-D, Davis KD, Campbell JN, Raja SN (1992) The plasticity of cutaneous hyperalgesia during sympathetic ganglion blockade in patients with neuropathic pain. Brain 115:607-621.

Treede R-D, Meyer RA, Raja SN, Campbell JN (1992) Peripheral and central mechanisms of cutaneous hyperalgesia. Prog Neurobiol 38:397-421.

Treede R-D, Hansen HC, Kunze K, Bromm B (1992) Neurophysiologische Beurteilung der Schmerzbahnen bei Patienten mit Hirnstammläsionen. In: Verhandlungen der Deutschen Gesellschaft für Neurologie, Vol. 7, 65. Jahrestagung Saarbrücken (Schimrigk K, Haaß A, Hamann G eds), pp 609-610.


Bromm B, Treede RD (1991). Laser-evoked cerebral potentials in the assessment of cutaneous pain sensitivity in normal subjects and patients. Rev Neurol (Paris). 1991;147(10):625-43.

Davis KD, Treede RD, Raja SN, Meyer RA, Campbell JN (1991). Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain. Pain. 1991 Dec;47(3):309-17.

Meyer RA, Davis KD, Cohen RH, Treede RD, Campbell JN (1991). Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey. Brain Res. 1991 Oct 11;561(2):252-61.

Meyer RA, Cohen RH, Davis KD, Treede RD, and Campbell JN (1991). Evidence for cutaneous afferents that are insensitive to mechanical stimuli. In: Proceedings of the VIth World Congress on Pain, edited by M. R. Bond, J. E. Charlton, and C. J. Woolf, Amsterdam:Elsevier Science Publishers, 1991, p. 71-75.

Raja SN, Treede RD, Davis KD, Campbell JN (1991). Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain. Anesthesiology. 1991 Apr;74(4):691-8.

Treede RD, Lankers J, Frieling A, Zangemeister WH, Kunze K, Bromm B (1991). Cerebral potentials evoked by painful, laser stimuli in patients with syringomyelia. Brain. 1991 Aug;114 ( Pt 4):1595-607.

Treede RD, Raja SN, Davis KD, Meyer RA, and Campbell JN (1991). Evidence that peripheral alpha-adrenergic receptors mediate sympathetically maintained pain. In: Proceedings of the Vth World Congress on Pain, edited by M. R. Bond, J. E. Charlton, and C. J. Woolf, Amsterdam:Elsevier Science Publishers, 1991, p. 377-382.

Treede RD and Bromm B (1991). Neurophysiological approaches to the study of spinothalamic tract function in humans. In: Pain and Central Nervous System Disease: The Central Pain Syndromes, edited by K. L. Casey, New York:Raven Press, 1991, p. 117-127.


Kochs E, Treede RD, Schulte am Esch J, Bromm B (1990). Modulation of pain-related somatosensory evoked potentials by general anesthesia. Anesth Analg. 1990 Sep;71(3):225-30.

Kochs E, Schulte am Esch J, Treede RD, and Bromm B (1990). Evoked cerebral responses to painful stimulation during general anesthesia. In: Advances in Pain Research and Therapy, Vol. 13, edited by S. Lipton, New York:Raven Press, 1990, p. 99-105.

Treede RD, Meyer RA, Davis KD, Campbell JN (1990). Intradermal injections of bradykinin or histamine cause a flare-like vasodilatation in monkey. Evidence from laser Doppler studies. Neurosci Lett. 1990 Jul 31;115(2-3):201-6.

Treede RD, Meyer RA, Campbell JN (1990). Comparison of heat and mechanical receptive fields of cutaneous C-fiber nociceptors in monkey. J Neurophysiol. 1990 Nov;64(5):1502-13.