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Bajic, D., Niemann, A., Hillmer, A.-K., Mejias-Luque, R., Bluemel, S., Docampo, M. Funk, M. C., Tonin, E., Boutros, M., Schnabl, B., Busch, D. H., Miki, T., Schmid, R. M., van den Brink, M., Gerhard, M., Stein-Thoeringer, C. K. (2020). Gut microbiota derived propionate regulates the expression of Reg3 mucosal lectins and ameliorates experimental colitis in mice. J Crohns Colitis pii: jjaa065. doi: 10.1093/ecco-jcc/jjaa065.

Port., F., Strein, C., Stricker, M., Rauscher, B., Heigwer, F., Zhou, J., Beyersdörffer, C., Frei, J., Hess, A., Kern, K., Malamud, R., Pavlovic, B., Rädecke, K., Schmitt, L., Voos, L., Valentini, E., Boutros, M. (2020). A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. eLife 13:9. pii: e53865.

Zhou, J., Boutros, M. (2020). JNK-dependent intestinal barrier failure disrupts host-microbe homeostasis during tumorigenesis. Proceedings of the National Academy of Sciences pii: 201913976. doi: 10.1073/pnas.1913976117.

Imkeller, K., Ambrosi, G., Boutros, M., Huber, W. (2020). gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection. Genome Biology 21:53.

Laiouar S, Berns N, Brech A, Riechmann V. (2020) RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism. Curr Biol. 2020 Apr 6;30(7):1177-1188.e5. doi: 10.1016/j.cub.2020.01.048. Epub 2020 Feb 13. PMID: 32059769


Bageritz, J., Willnow, P., Valentini, E., Leible, S., Boutros, M., Teleman, A.A. (2019). Gene expression atlas of a developing tissue by single cell expression correlation analysis. Nature Methods 16:750-756.

Rad, R., Boutros, M. (2019). Functionalizing cancer genomes in the era of big data. Current Opinions in Genetics and Development 54:iii-vi.

Chaudhary, V., Hingole, S., Frei, J., Port, F., Strutt, D., Boutros, M. (2019). Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing. Development 146:dev174789.

Chaudhary, V., Boutros, M. (2019). Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium. PLoSGenetics 15:e1008351.

Herrmann, S., Zhan, T., Betge, J., Rauscher, B., Belle, S., Gutting, T., Schulte, N., Jesenofsky, R., Härtel, N., Gaiser, T., Hofheinz, R.D., Ebert, M.P., Boutros, M. (2019). Detection of mutational patterns in cell-free DNA of colorectal cancer by custom amplicon sequencing. Molecular Oncology 13:1669-1683.

Worst, T.S., Previti, C., Nitschke, K., Diessl, N., Gross, J.C., Hoffmann, L., Frey, L., Thomas, V., Kahlert, C., Bieback, K., Crigna, A.T., Fricke, F., Porubsky, S., Westhoff, N., Hardenberg, J.V., Nuhn, P., Erben, P., Michel, M.S., Boutros, M. (2019) miR-10a-5p and miR-29b-3p as Extracellular Vesicle-Associated Prostate Cancer Detection Markers. Cancers 12: pii: E43.

Zhan, T., Ambrosi, G., Wandmacher, A.M., Rauscher, B., Betge, J., Rindtorff, N., Häussler, R.S., Hinsenkamp, I., Bamberg, L., Hessling, B., Müller-Decker, K., Erdmann, G., Burgermeister, E., Ebert, M.P., Boutros, M. (2019). MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer. Nat Commun 10:2197

Henkel, L., Rauscher, B., Boutros, M. (2019). Context-dependent genetic interactions in cancer. Curr Opin Genet Dev 54:73-82

Nitschke, K., Erben, P., Waldbillig, F., Abdelhadi, A., Weis, C.A., Gottschalt, M., Wahby, S., Nuhn, P., Boutros, M., Michel, M.S., von Hardenberg, J., Worst, T.S. (2019). Clinical relevance of gene expression in localized and metastatic prostate cancer exemplified by FABP5. World J Urol. Epub ahead of print

Even, I., Reidenbach, S., Schlechter, T., Berns, N., Herold, R., Roth, W., Krunic, D., Riechmann, V., Hofmann, I. (2019). DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells. FEBS J 286:803-820


Heigwer, F., Scheeder, C., Miersch ,T., Schmitt, B., Blass, C., Pour Jamnani, M.V., Boutros, M. (2018). Time-resolved mapping of genetic interactions to model rewiring of signaling pathways. Elife 7. pii: e40174
Scheeder, C., Heigwer, F., Boutros, M. (2018). Machine learning and image-based profiling in drug discovery. Curr Opin Syst Biol 10:43-52

Tamirisa, S., Papagiannouli, F., Rempel, E., Ermakova, O., Trost, N., Zhou, J., Mundorf, J., Brunel, S., Ruhland, N., Boutros, M., Lohmann, J.U., Lohmann, I. (2018). Decoding the Regulatory Logic of the Drosophila Male Stem Cell System. Cell Rep 24:3072-3086

Mattila, J., Kokki, K., Hietakangas, V., Boutros, M. (2018). Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content. Dev Cell 47:112-121.e3

Trost, N., Rempel, E., Ermakova, O., Tamirisa, S., Pârcălăbescu, L., Boutros, M., Lohmann, J.U., Lohmann, I. (2018). WEADE: A workflow for enrichment analysis and data exploration. PLoS One 13:e0204016

Klingenberg, M., Groß, M., Goyal, A., Polycarpou-Schwarz, M., Miersch, T., Ernst, A.S., Leupold, J., Patil, N., Warnken, U., Allgayer, H., Longerich, T., Schirmacher, P., Boutros, M., Diederichs, S. (2018). The lncRNA CASC9 and RNA binding protein HNRNPL form a complex and co-regulate genes linked to AKT signaling. Hepatology 68:1817-1832

Kober, K.I., Cano, A., Géraud, C., Sipilä, K., Mobasseri, S.A., Philippeos, C., Pisco, A.O., Stannard, A., Martin, A., Salvador, F., Santos, V., Boutros, M., Rognoni, E., Watt, F.M. (2018). Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation. PLoS One 13:e0199679

Shen, J., Najafi, S., Stable, S., Fabian, J., Koeneke, E., Kolbinger, F.R., Wrobel, J.K., Meder, B., Distel, M., Heimburg, T., Sippl, W., Jung, M., Peterziel, H., Kranz, D., Boutros, M., Westermann, F., Witt, O., Oehme, I. (2018). A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment. Cell Death Differ 25:2053-2070

Dix, C.L., Matthews, H.K., Uroz, M., McLaren, S., Wolf, L., Heatley, N., Win, Z., Almada, P., Henriques, R., Boutros, M., Trepat, X., Baum, B. (2018). The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division. Dev Cell 45:132-45 e3

Zhan, T., Rindtorff, N., Betge, J., Ebert, M.P., Boutros, M. (2018). CRISPR/Cas9 for cancer research and therapy. Semin Cancer Biol pii: S1044-579X(17)30274-2

Heigwer, F., Port, F., Boutros, M. (2018). RNA Interference (RNAi) Screening in Drosophila. Genetics 208:853-74

Buljan, M., Blattmann, P., Aebersold, R., Boutros, M. (2018). Systematic characterization of pan-cancer mutation clusters. Mol Syst Biol 14:e7974

Glaeser, K., Urban, M., Fenech, E., Voloshanenko, O., Kranz, D., Lari, F., Christianson, J.C., Boutros, M. (2018). ERAD-dependent control of the Wnt secretory factor Evi. EMBO J 37

Rauscher, B., Heigwer, F., Henkel, L., Hielscher, T., Voloshanenko, O., Boutros, M. (2018). Toward an integrated map of genetic interactions in cancer cells. Mol Syst Biol 14:e7656

Voloshanenko, O., Schwartz, U., Kranz, D., Rauscher, B., Linnebacher, M., Augustin, I., Boutros, M. (2018). beta-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells. Sci Rep 8:3178

Leibing, T., Geraud, C., Augustin, I., Boutros, M., Augustin, H.G., Okun, J.G., Langhans, C.D., Zierow, J., Wohlfeil, S.A., Olsavszky, V., Schledzewski, K., Goerdt, S., Koch, P.S. (2018). Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology 68:707-722

Galata, C., Hirsch, D., Reindl, W., Post, S., Kienle, P., Boutros, M., Gaiser, T., Horisberger, K. (2017). Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn's Disease. J Clin Gastroenterol 52:635-640

Billmann, M., Chaudhary, V., ElMaghraby, M.F., Fischer, B., Boutros, M. (2018). Widespread Rewiring of Genetic Networks upon Cancer Signaling Pathway Activation. Cell Syst 6:52-64 e4

Dimitrov, B., Himmelreich, N., Hipgrave Ederveen, A.L., Lüchtenborg, C., Okun, J.O., Breuer, M., Hutter, A.-M., Carl, M., Guglielmi, L., Hellwig, A., Thiemann, K.C., Jost, M., Peters, V., Staufner, C., Hoffmann, G.F., Hackenberg, A., Paramasivam, N., Wiemann, S., Eils, R., Schlesner, M., Strahl, S., Brügger, B., Wuhrer, M., Korenke, G.C., and Thiel, C. (2018). Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolism as additional symptoms in a new patient with ATP6AP1-CDG. Molecular Genetics and Metabolism 123:364-374

Roussigné, M., Wei, L., Tsingos, E., Kuchling, F., Alkobtawi, M., Tsalavouta, M., Witbrodt, J.W., Carl, M., Blader, P., Wilson, S.W. (2018). Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signalling activity in leading cells. Proceedings of the National Academy of Sciences USA 115:E9812-E9821

Zielonka, M., Breuer, M., Okun, J. G., Carl, M., Hoffmann, G. F., Kölker, S. (2018). Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase. PlosOne 13:e0203707


Voloshanenko, O., Gmach, P., Winter, J., Kranz, D., Boutros, M. (2017). Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J 31:4832-44

Meyer, I.S., Jungmann, A., Dieterich, C., Zhang, M., Lasitschka, F., Werkmeister, S., Haas, J., Muller, O.J., Boutros, M., Nahrendorf, M., Katus, H.A., Hardt, S.E., Leuschner, F. (2017). The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction. EMBO Mol Med 9:1279-93

Menck, K., Sonmezer, C., Worst, T.S., Schulz, M., Dihazi, G.H., Streit, F., Erdmann, G., Kling, S., Boutros, M., Binder, C., Gross, J.C. (2017). Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane. J Extracell Vesicles 6:1378056

Larribere, L., Galach, M., Novak, D., Arevalo, K., Volz, H.C., Stark, H.J., Boukamp, P., Boutros, M., Utikal, J. (2017). An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs. Stem Cell Reports 9:1234-45

Merk, K., Breinig, M., Bottcher, R., Krebs, S., Blum, H., Boutros, M., Forstemann, K. (2017). Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks. PLoS Genet 13:e1006861

Notzold, L., Frank, L., Gandhi, M., Polycarpou-Schwarz, M., Gross, M., Gunkel, M., Beil, N., Erfle, H., Harder, N., Rohr, K., Trendel, J., Krijgsveld, J., Longerich, T., Schirmacher, P., Boutros, M., Erhardt, S., Diederichs, S. (2017). The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells. Sci Rep 7:2265

Rauscher, B., Valentini, E., Hardeland, U., Boutros, M. (2017). Phenotype Databases for Genetic Screens in Human Cells. J Biotechnol

Strassburger, K., Lorbeer, F.K., Lutz, M., Graf, F., Boutros, M., Teleman, A.A. (2017). Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs. Development 144:2529-38

Scheeder, C., Heigwer, F., Boutros, M. (2017). HTSvis: a web app for exploratory data analysis and visualization of arrayed high-throughput screens. Bioinformatics

Worst, T.S., von Hardenberg, J., Gross, J.C., Erben, P., Schnoelzer, M., Hausser, I., Bugert, P., Michel, M.S., Boutros, M. (2017). A database-augmented, exosome-based mass spectrometry approach exemplarily identifies circulating claudin 3 as biomarker in prostate cancer. Mol Cell Proteomics 16:998-1008


Billmann, M., Boutros, M. (2016). Methods for High-Throughput RNAi Screening in Drosophila Cells. Methods Mol Biol 1478:95-116 Link

Augustin, I., Dewi, D.L., Hundshammer, J., Rempel, E., Brunk, F., Boutros, M. (2016). Immune cell recruitment in teratomas is impaired by increased Wnt secretion. Stem Cell Res 17:607-15 Link

Billmann, M., Horn, T., Fischer, B., Sandmann, T., Huber, W., Boutros, M. (2016). A genetic interaction map of cell cycle regulators. Mol Biol Cell 27:1397-407 Link

Costanzo, M., VanderSluis, B., Koch, E.N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S.D., Pelechano, V., Styles, E.B., Billmann, M., van Leeuwen, J., van Dyk, N., Lin, Z.Y., Kuzmin, E., Nelson, J., Piotrowski, J.S., Srikumar, T., Bahr, S., Chen, Y., Deshpande, R., Kurat, C.F., Li, S.C., Li, Z., Usaj, M.M., Okada, H., Pascoe, N., San Luis, B.J., Sharifpoor, S., Shuteriqi, E., Simpkins, S.W., Snider, J., Suresh, H.G., Tan, Y., Zhu, H., Malod-Dognin, N., Janjic, V., Przulj, N., Troyanskaya, O.G., Stagljar, I., Xia, T., Ohya, Y., Gingras, A.C., Raught, B., Boutros, M., Steinmetz, L.M., Moore, C.L., Rosebrock, A.P., Caudy, A.A., Myers, C.L., Andrews, B., Boone, C. (2016). A global genetic interaction network maps a wiring diagram of cellular function. Science 353 pii: aaf1420 Link

Konotop, G., Bausch, E., Nagai, T., Turchinovich, A., Becker, N., Benner, A., Boutros, M., Mizuno, K., Kramer, A., Raab, M.S. (2016). Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization. Cancer Res 76:6690-6700 Link

Zhan, T., Boutros, M. (2016). Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells. Crit Rev Biochem Mol Biol 51:74-85 Link

Glaeser, K., Boutros, M., Gross, J.C. (2016). Biochemical Methods to Analyze Wnt Protein Secretion. Methods Mol Biol 1481:17-28 Link

Gilbert, D.F., Boutros, M. (2016). A Protocol for a High-Throughput Multiplex Cell Viability Assay. Methods Mol Biol 1470:75-84 Link

Tsokanos, F.F., Albert, M.A., Demetriades, C., Spirohn, K., Boutros, M., Teleman, A.A. (2016). eIF4A inactivates TORC1 in response to amino acid starvation. EMBO J35:1058-76 Link

Heigwer, F., Zhan, T., Breinig, M., Winter, J., Brugemann, D., Leible, S., Boutros, M. (2016). CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries. Genome Biol 17:55. Link

Moffa, G., Erdmann, G., Voloshanenko, O., Hundsrucker, C., Sadeh, M.J., Boutros, M., Spang, R. (2016). Refining Pathways: A Model Comparison Approach. PLoS One 11:e0155999. Link

Chatterjee, N., Tian, M., Spirohn, K., Boutros, M., Bohmann, D. (2016). Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein. PLoS Genet 12:e1006072. Link

Boutros, M., Niehrs, C. (2016). Sticking Around: Short-Range Activity of Wnt Ligands. Dev Cell 36:485-6. Link

Billmann, M., Horn, T., Fischer, B., Sandmann, T., Huber, W., Boutros, M. (2016). A genetic interaction map of cell cycle regulators. Mol Biol Cell Link

Lamiable, O., Kellenberger, C., Kemp, C., Troxler, L., Pelte, N., Boutros, M., Marques, J.T., Daeffler, L., Hoffmann, J.A., Roussel, A., Imler, J.L. (2016). Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila. Proc Natl Acad Sci U S A 113:698-703. Link

Li, X., Chatterjee, N., Spirohn, K., Boutros, M., Bohmann, D. (2016). Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Sci Rep 6:21455. Link

Schafer, M., Oeing, C.U., Rohm, M., Baysal-Temel, E., Lehmann, L.H., Bauer, R., Volz, H.C., Boutros, M., Sohn, D., Sticht, C., Gretz, N., Eichelbaum, K., Werner, T., Hirt, M.N., Eschenhagen, T., Muller-Decker, K., Strobel, O., Hackert, T., Krijgsveld, J., Katus, H.A., Berriel Diaz, M., Backs, J., Herzig, S. (2016). Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia. Mol Metab 5:67-78. Link

Scholz, B., Korn, C., Wojtarowicz, J., Mogler, C., Augustin, I., Boutros, M., Niehrs, C., Augustin, H.G. (2016). Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling. Dev Cell 36:79-93. Link

Winter, J., Breinig, M., Heigwer, F., Brugemann, D., Leible, S., Pelz, O., Zhan, T., Boutros, M. (2016). caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens. Bioinformatics 32:632-4. Link

Kopajtich, R., Murayama, K., Janecke, A.R., Haack, T.B., Breuer, M., Knisely, A.S.,Harting, I., Ohashi, T., Okazaki, Y., Watanabe, D., Tokuzawa, Y., Kotzaeridou, U., Kölker, S., Sauer, S., Carl, M., Straub, S., Entenmann, A., Gizewski, E., Feichtinger, R.G., Mayr, J.A., Lackner, K.,Strom, T.M., Meitinger, T., Müller, T., Ohtake, A., Hoffmann, G.F.,Prokisch, H., Staufner, C. (2016). Biallelic mutations in IARS, encoding cytosolic isoleucyl-tRNA synthetase, cause growth retardation with prenatal onset, intellectual disability, muscular hypotonia, and infantile hepatopathy. American Journal of Human Genetics, 99:414-422. Link

Beretta, C.A., Dross, N., Engel, U., and Carl, M. (2016). Tracking cells in GFP-transgenic zebrafish using the photoconvertible PSmOrange system. J. Vis. Exp. (108), e53604. Link


Boutros, M., Heigwer, F., Laufer, C. (2015). Microscopy-Based High-Content Screening. Cell 163:1314-25. Link

Breinig, M., Klein, F.A., Huber, W., Boutros, M. (2015). A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells. Mol Syst Biol 11:846. Link

Brunk, F., Augustin, I., Meister, M., Boutros, M., Kyewski, B. (2015). Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development. J Immunol 195:5261-71. Link

Zhan, T., Boutros, M. (2015). Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells. Crit Rev Biochem Mol Biol 1-12. Link

Erdmann, G., Suchanek, M., Horn, P., Graf, F., Volz, C., Horn, T., Zhang, X., Wagner, W., Ho, A.D., Boutros, M. (2015). Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening. Genome Medicine 7(1):46. Link

Betge, J., Kerr, G., Miersch, T., Leible, S., Erdmann, G., Galata, C.L., Zhan, T., Gaiser, T., Post, S., Ebert, M.P., Horisberger, K., Boutros, M. (2015). Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples. PLoS One 10(5):e0127146. Link

Tiebe, M., Lutz, M., De La Garza, A., Buechling, T., Boutros, M., Teleman, A.A. (2015). REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1. Developmental Cell 33(3):272-84. Link

Fischer, B., Sandmann, T., Horn, T., Billmann, M., Chaudhary, V., Huber, W., Boutros, M. (2015). A map of directional genetic interactions in a metazoan cell. Elife 4. Link

Khandelwal, N., Breinig, M., Speck, T., Michels, T., Kreutzer, C., Sorrentino, A., Sharma, A.K., Umansky, L., Conrad, H., Poschke, I., Offringa, R., König, R., Bernhard, H., Machlenkin, A., Boutros, M., Beckhove, P. (2015). A high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes. EMBO Molecular Medicine 7(4):450-63. Link

Guida, C., Altamura, S., Klein, F.A., Galy, B., Boutros, M., Ulmer, A.J., Hentze, M.W., Muckenthaler, M.U. (2015). A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia. Blood 125(14):2265-75. Link

Zhou, J., Florescu, S., Boettcher, A., Luo, L., Dutta, D., Kerr, G., Cai, Y., Edgar, B.A., Boutros, M. (2015). Dpp/Gbb signaling is required for normal intestinal regeneration during infection. Developmental Biology 399(2):189-203 Link


Berns, N., Woichansky, I., Friedrichsen, S., Kraft, N., Riechmann, V.  (2014) A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche. Jornal of Cell Science 127(12):2736-48 Link

Hüsken, U., Stickney, H.L., Gestri, G., Bianco, I.H., Faro, A., Young, R.M., Roussigne, M., Hawkins, T.A., Beretta, C.A., Brinkmann, I., Paolini A., Jacinto, R., Albadri, S., Dreosti, E., Tsalavouta, M., Schwarz, Q., Cavodeassi, F., Barth, A.K., Wen, L., Zhang, B., Blader, P., Yaksi, E., Poggi, L., Zigman, M., Lin, S., Wilson, S.W., and Carl, M. (2014). Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons. Current Biology 24(19):2217-2227 Link

Laufer, C., Fischer, B., Huber, W., Boutros, M. (2014). Measuring genetic interactions in human cells by RNAi and imaging. Nature Protocols 9(10):2341-2353 Link

Schmidt, E.E., Banos, M.S., Smith, J.A., Birmingham, A., Boutros, M., Shamu, C.E. (2014). Public Repositories for RNAi Screening Data. In: Frontiers in RNAi / Tripp, R.A., Karpilow, J.M., Bentham eBooks Link

Jankovics, F., Henn, L., Bujna, Á., Vilmos, P., Spirohn, K., Boutros, M., Erdélyi, M. (2014). Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. PLoS One 9(6):e98579 Link

Kumar, S., Žigman, M., Patel, T.R., Trageser, B., Gross, J.C., Rahm, K., Boutros, M., Gradl, D., Steinbeisser, H., Holstein, T., Stetefeld, J., Özbek, S. (2014). Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity. BMC Biol 12:44 Link

Korn, C., Scholz, B., Hu, J., Srivastava, K., Wojtarowicz, J., Arnsperger, T., Adams, R.H., Boutros, M., Augustin, H.G., Augustin, I. (2014). Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development 141(8):1757-66 » Link

Dross, N., Beretta, C.A., Bankhead, P., Carl, M., and Engel, U. (2014). Zebrafish Brain Development Monitored by Long-Term in Vivo Microscopy: A Comparison Between Laser Scanning Confocal and 2-Photon Microscopy. Book chapter in: Laser Scanning Microscopy and Quantitative Image Analysis of Neuronal Tissue, Springer Science » Link

Dreosti, E., Llopis, N.V., Carl, M., Yaksi E., Wilson, S.W. (2014). Left/right asymmetry is required for the habenulae to respond to both visual and olfactory stimuli. Current Biology 24(4):440-5 » Link

Mwafi, N., Beretta, C.A., Paolini, A., Carl, M. (2014). Divergent Wnt8a gene expression in teleosts. Plos One 9(1):e85303 » Link

Heigwer, F., Kerr, G., Boutros, M. (2014). E-CRISP: fast CRISPR target site identification. Nature Methods 11(2):122-3 » Link

Kranz, D., Boutros, M. (2014). A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. EMBO Journal 33(3):181-97 » Link

Mleczko-Sanecka, K., Roche, F., da Silva, A.R., Call, D., D'Alessio, F., Ragab, A., Lapinski, P.E., Ummanni, R., Korf, U., Oakes, C., Damm, G., D'Alessandro, L.A., Klingmüller, U., King, P.D., Boutros, M., Hentze, M.W., Muckenthaler, M.U. (2014). Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to the proliferative Ras/RAF and the nutrient-dependent mTOR signaling pathways. Blood 123(10):1574-85 » Link


Zhang, X., Boutros, M. (2013). A novel phenotypic dissimilarity method for image-based high-throughput screens. BMC Bioinformatics 14:336. » Link

Voloshanenko, O., Erdmann, G., Dubash, T.D., Augustin, I., Metzig, M., Moffa, G., Hundsrucker, C., Kerr, G., Sandmann, T., Anchang, B., Demir, K., Boehm, C., Leible, S., Ball, C.R., Glimm, H., Spang, R., Boutros, M. (2013). Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nature Communications 4:2610. » Link

Beretta, C.A., Dross, N., Bankhead, P., Carl, M. (2013). The ventral habenulae in zebrafish develop in prosomere 2 dependent on Tcf7l2 function. Neural Development 8:19. » Link

Demir, K., Kirsch, N., Beretta, C.A., Erdmann, G., Ingelfinger, D., Moro, E., Argenton, F., Carl, M., Niehrs, C., Boutros, M. (2013). RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Reports 4:1224-34. » Link

Börner, K., Niopek, D., Cotugno, G., Kaldenbach, M., Pankert, T., Willemsen, J., Zhang, X., Schürmann, N., Mockenhaupt, S., Serva, A., Hiet, M.S., Wiedtke, E., Castoldi, M., Starkuviene, V., Erfle, H., Gilbert, D.F., Bartenschlager, R., Boutros, M., Binder, M., Streetz, K., Kräusslich, H.G., Grimm, D. (2013). Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines. Nucleic Acids Research 41(21):e199.» Link

Heigwer, F., Kerr, G., Walther, N., Glaeser, K., Pelz, O., Breinig, M., Boutros, M. (2013). E-TALEN: a web tool to design TALENs for genome engineering. Nucleic Acids Research 41(20):e190. » Link

Hüsken, U., Carl, M. (2013). The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. Mechanisms of Development 130: 330-335. » Link

Fukuyama, H., Verdier, Y., Guan, Y., Makino-Okamura, C., Shilova, V., Liu, X., Maksoud, E., Matsubayashi, J., Haddad, I., Spirohn, K., Ono, K., Hetru, C., Rossier, J., Ideker, T., Boutros, M., Vinh, J., Hoffmann, J.A. (2013). Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge. Proceedings of the National Academy of Sciences of the United States of America110:10717-22. » Link

Augustin, I., Gross, J., Baumann, D., Korn, C., Kerr, G., Grigoryan, T., Mauch, C., Birchmeier, W., Boutros, M. (2013). Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis. The Journal of Experimental Medicine 210:1761-77. » Link

Serysheva, E., Berhane, H., Grumolato, L., Demir, K., Balmer, S., Bodak, M., Boutros, M., Aaronson, S., Mlodzik, M., Jenny, A. (2013). Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling. EMBO Reports 14:718-25 » Link

Laufer, C., Fischer, B., Billmann, M., Huber, W., Boutros, M. (2013). Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping. Nature Methods 10:427-31. » Link

Gross, J.C., Boutros, M. (2013). Secretion and extracellular space travel of Wnt proteins. Current Opinion in Genetics and Development 23(4):385-90. » Link

Horn, T., Boutros, M. (2013). Design of RNAi Reagents for Invertebrate Model Organisms and Human Disease Vectors. Methods in Molecular Biology 942:315-46. » Link

Schmidt, E.E., Pelz, O., Buhlmann, S., Kerr, G., Horn, T., Boutros, M. (2013). GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update. Nucleic Acids Research 41(Database issue):D1021-6. » Link

Kuhns, S., Schmidt, K.N., Reymann, J., Gilbert, D.F., Neuner, A., Hub, B., Carvalho, R., Wiedemann, P., Zentgraf, H., Erfle, H., Klingmüller, U., Boutros, M., Pereira, G. (2013). The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. The Journal of Cell Biology 200:505-22. » Link


Gomez, J.M., Wang, Y., Riechmann, V. (2012). Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. The Journal of Cell Biology 199:1131-43. » Link

Page, R.M., Münch, A., Horn, T., Kuhn, P.H., Colombo, A., Reiner, O., Boutros, M., Steiner, H., Lichtenthaler, S.F., Haass, C. (2012). Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. The Journal of Neuroscience 32:18204-14. » Link

Brechmann, M., Mock, T., Nickles, D., Kiessling, M., Weit, N., Breuer, R., Müller, W., Wabnitz, G., Frey, F., Nicolay, J.P., Booken, N., Samstag, Y., Klemke, C.D., Herling, M., Boutros, M., Krammer, P.H., Arnold, R. (2012). A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes. Immunity 37:697-708. » Link

Gross, J.C., Chaudhary, V., Bartscherer, K., Boutros, M. (2012). Active Wnt proteins are secreted on exosomes. Nature Cell Biology 14:1036-45. » Link

Stender, J.D., Pascual, G., Liu, W., Kaikkonen, M.U., Do, K., Spann, N.J., Boutros, M., Perrimon, N., Rosenfeld, M.G., Glass, C.K. (2012). Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20. Molecular Cell 48:28-38. » Link

Petrakis, S., Raskó, T., Russ, J., Friedrich, R.P., Stroedicke, M., Riechers, SP., Muehlenberg, K., Möller, A., Reinhardt, A., Vinayagam, A., Schaefer, M.H., Boutros, M., Tricoire, H., Andrade-Navarro, MA., Wanker, E.E. (2012). Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1. PLoS Genetics 8:e1002897. » Link

Demir, K., Boutros, M. (2012). Cell perturbation screens for target identification by RNAi. Methods in Molecular Biology 910:1-13. » Link

Icardi, L., Mori, R., Gesellchen, V., Eyckerman, S., De Cauwer, L., Verhelst, J., Vercauteren, K., Saelens, X., Meuleman, P., Leroux-Roels, G., De Bosscher, K., Boutros, M., Tavernier, J. (2012). The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America 109:12058-63. » Link

Nickles, D., Falschlehner, C., Metzig, M., Boutros, M. (2012). A genome-wide RNAi screen identifies CASP4 as a factor required for TNF-α signaling. Molecular and Cellular Biology 32:3372-81. » Link

McNabb, A., Scott, K., von Ochsenstein, E., Seufert, K., Carl, M. (2012). Don’t be afraid to set up your fish facility. Zebrafish 9:120-5. » Link

Erdmann, G., Volz, C., Boutros, M. (2012). Systematic approaches to dissect biological processes in stem cells by image-based screening. Biotechnology Journal 7:768-78. » Link

Falschlehner, C., Boutros, M. (2012). Innate immunity: regulation of caspases by IAP-dependent ubiquitylation. EMBO Journal 31:2750-2752. » Link

Beretta, C.A., Dross, N., Gutierrez-Triana, J.A., Ryu, S., Carl, M. (2012). Habenula circuit development: past, present and future. Frontiers in Neuroscience 6:51. » Link

Berns, N., Woichansky, I., Kraft, N., Hüsken, U., Carl, M., Riechmann, V. (2012). “Vacuum-assisted staining”: a simple and efficient method for screening in Drosophila. Development Genes and Evolution 222:113-118. » Link

Sandmann, T., Boutros, M. (2012). Screens, maps & networks: from genome sequences to personalized medicine. Current Opinion in Genetics and Development 22:36-44. » Link

Shamu, C.E., Wiemann, S., Boutros, M. (2012). On target: A public repository for large-scale RNAi experiments. Nature Cell Biology 14(2):115. » Link

Augustin, I., Goidts, V., Bongers, A., Kerr, G., Vollert, G., Radlwimmer, B., Hartmann, C., Herold-Mende, C., Reifenberger, G., von Deimling, A., Boutros, M. (2012). The Wnt secretion protein Evi/Gpr177 promotes glioma tumorigenesis. EMBO Molecular Medicine 4:38-51. >>Link


JayaNandanan, N., Gavis, E.R., Riechmann, V., Leptin, M. (2011). A genetic in vivo system to detect asymmetrically distributed RNA. EMBO Reports 12:1167-1174. » Link

Buechling, T., Boutros, M. (2011). Wnt signaling signaling at and above the receptor level. Current Topics in Developmental Biology 97:21-53. » Link

Gilbert, D.F., Erdmann, G., Zhang, X., Fritzsche, A., Demir, K., Jaedicke, A., Muehlenberg, K., Wanker, E.E., Boutros, M. (2011). A Novel Multiplex Cell Viability Assay for High-Throughput RNAi Screening. PLoS One 6:e28338. » Link

Horn, T., Boutros, M. (2011). Design of RNAi reagents for invertebrate model organisms and human disease vectors. Nature Precedings » Link

Glinka, A., Dolde, C., Kirsch, N., Huang, Y.L., Kazanskaya, O., Ingelfinger, D., Boutros, M., Cruciat, C.M., Niehrs, C. (2011). LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Reports 12:1055-61. » Link

Buechling, T., Chaudhary, V., Spirohn, K., Weiss, M., Boutros, M. (2011). p24 proteins are required for secretion of Wnt ligands. EMBO Reports 12:1265-72. » Link

Axelsson, E., Sandmann, T., Horn, T., Boutros, M., Huber, W., Fischer, B. (2011). Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. BMC Bioinformatics 12:342. » Link

Zacharogianni, M., Kondylis, V., Tang, Y., Farhan, H., Xanthakis, D., Fuchs, F., Boutros, M., Rabouille, C. (2011). ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. EMBO Journal 30:3684-700. » Link

Sandmann, T., Vogg, M.C., Owlarn, S., Boutros, M., Bartscherer, K. (2011). The head-regeneration transcriptome of the planarian Schmidtea mediterranea. Genome Biology 12:R76. » Link

Kondylis, V., Tang, Y., Fuchs, F., Boutros, M., Rabouille, C. (2011). Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. PLoS One 6:e17173. » Link

Metzig, M., Nickles, D., Boutros, M. (2011). Large-scale RNAi screens to dissect TNF and NF-κB signaling pathways. Advances in Experimental Medicine and Biology 691:131-9. » Link

Horn, T., Sandmann, T., Fischer, B., Axelsson, E., Huber, W., Boutros, M. (2011). Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nature Methods 8:341-6. » Link

Metzig, M., Nickles, D., Falschlehner, C., Lehmann-Koch, J., Straub, B.K., Roth, W., Boutros, M. (2011). An RNAi screen identifies USP2 as a factor required for TNF-α induced NF-κB signaling. International Journal of Cancer 129:607-18. » Link

Beretta, C.A., Brinkmann, I., Carl, M. (2011). All four zebrafish Wnt7 genes are expressed during early brain development. Gene Expression Patterns 11:277-284. » Link

Ragab, A., Buechling, T., Gesellchen, V., Spirohn, K., Boettcher, A.L., Boutros, M. (2011). Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells. EMBO Journal 30:1123-36. » Link

Liang, J., Fu, Y., Cruciat, C.M., Jia, S., Wang, Y., Tong, Z., Tao, Q., Ingelfinger, D., Boutros, M., Meng, A., Niehrs, C., Wu, W. (2011). Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation. Molecular and Cellular Biology 31:2577-90. » Link

Huhn, S., Ingelfinger, D., Bermejo, J.L., Bevier, M., Pardini, B., Naccarati, A., Steinke, V., Rahner, N., Holinski-Feder, E., Morak, M., Schackert, H.K., Görgens, H., Pox, C.P., Goecke, T., Kloor, M., Loeffler, M., Büttner, R., Vodickova, L., Novotny, J., Demir, K., Cruciat, C.M., Renneberg, R., Huber, W., Niehrs, C., Boutros, M., Propping, P., Vodièka, P., Hemminki, K., Försti, A. (2011). Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications. International Journal of Molecular Epidemiology and Genetics 2:36-50. » Link to PubMed

1995 - 2010


Gilboa, L., Boutros, M. (2010). Celebrating 100 years of Drosophila research. EMBO Reports 11:724-6. » Link

Müller, H., Schmidt, D., Steinbrink, S., Mirgorodskaya, E., Lehmann, V., Habermann, K., Dreher, F., Gustavsson, N., Kessler, T., Lehrach, H., Herwig, R., Gobom, J., Ploubidou, A., Boutros, M., Lange, B.M. (2010). Proteomic and functional analysis of the mitotic Drosophila centrosome. EMBO Journal 29:3344-57. » Link

Franz, A., Riechmann, V. (2010) Stepwise polarisation of the Drosophila follicular epithelium. Developmental Biology 338:136-147. » Link

Niehrs, C., Boutros., M. (2010). Trafficking, Acidification, and Growth Factors Signaling. Science Signaling 3:pe26. » Link

Buechling, T., Bartscherer, K., Ohkawara, B., Chaudhary, V., Spirohn, K., Niehrs, C., Boutros., M. (2010). Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Current Biology 20:1263-1268. » Link

Horn, T., Sandmann, T., Boutros., M. (2010). Design and evaluation of genome-wide libraries for RNAi screens. Genome Biology 11:R61. » Link

Fuchs, F., Pau, G., Kranz, D., Sklyar, O., Budjan, C., Steinbrink, S., Horn, T., Pedal, A., Huber, W., Boutros, M. (2010). Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Molecular Systems Biology 6:370. » Link

Leber, B., Maier, B., Fuchs, F., Chi, J., Riffel, P., Anderhub, S., Wagner, L., Ho, A.D., Salisbury, J.L., Boutros, M., Krämer, A. (2010). Proteins required for centrosome clustering in cancer cells. Science Translational Medicine 2:33ra38. » Link

Saj, A., Arziman, Z., Stempfle, D., van Belle, W., Sauder, U., Horn, T., Dürrenberger, M., Paro, R., Boutros, M., Merdes, G. (2010). A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Developmental Cell 18:862-76. » Link

Horn, T., Boutros, M. (2010). E-RNAi: a web application for the multi-species design of RNAi reagents - 2010 update. Nucleic Acids Research 38:W332-339. » Link » Website

Pelz., O., Gilsdorf, M., Boutros, M. (2010). web cellHTS2: A web application for the analysis of high-throughput screening data. BMC Bioinformatics 11:185. » Link  » Source

Gobert, V., Osman, D., Bras, S., Auge, B., Boube, M., Bourbon, H.M., Horn, T., Boutros, M., Haenlin, M., Waltzer, L. (2010). A genome-wide RNA interference screen identifies a differential role of the Mediator CDK8 module subunits for GATA/RUNX-activated transcription in Drosophila. Molecular and Cellular Biology 30:2837-48. » Link

Falschlehner, C., Steinbrink, S., Erdmann, G., Boutros, M. (2010). High-throughput RNAi screening to dissect cellular pathways: a how-to guide. Biotechnology Journal 5:368-76. » Link

Pau, G., Fuchs, F., Sklyar, O., Boutros, M., Huber, W. (2010). EBImage - an R package for image processing with applications to cellular phenotypes. Bioinformatics 26:979-81. » Link

Cruciat, C.M., Ohkawara, B., Acebron, S.P., Karaulanov, E., Reinhard, C., Ingelfinger, D., Boutros, M., Niehrs, C. (2010). Requirement of prorenin receptor an vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 327:459-63. » Link

Gilsdorf, M., Horn, T., Arziman, Z., Pelz, O., Kiner E., Boutros, M. (2010). GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 Update. Nucleic Acids Research 38:D448-52. » Link » Website

Kuttenkeuler, D., Pelte, N., Ragab, A., Gesellchen, V., Schneider, L., Blass, C., Axelsson, E., Huber, W., Boutros, M. (2010). A Large-Scale RNAi Screen Identifies Deaf1 as a Regulator of Innate Immune Responses in Drosophila. Journal of Innate Immunity 2:181-194. » Link

Mleczko-Sanecka, K., Casanovas, G., Ragab, A., Breitkopf, K., Muller, A., Boutros, M., Dooley, S., Hentze, M.W., Muckenthaler, M.U. (2010). SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood 115:2657-65. » Link


Davidson, G., Shen, J., Huang, Y.L., Su, Y., Karaulanov, E., Bartscherer, K., Hassler, C., Stannek, P., Boutros, M., Niehrs, C. (2009). Cell cycle control of Wnt receptor activation. Developmental Cell 17:788-99. » Link

Farfsing, A., Engel, F., Seiffert, M., Hartmann, E., Ott, G., Rosenwald, A., Stilgenbauer, S., Döhner, H., Boutros, M., Lichter, P., Pscherer, A. (2009). Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia. Leukemia 11:2018-26. » Link

Simons, M., Gault, W.J., Gotthardt, D., Rohatgi, R., Klein, T.J., Shao, Y., Lee, H.J., Wu, A.L., Fang, Y., Satlin, L.M., Dow, J.T., Chen, J., Zheng, J., Boutros, M., Mlodzik, M. (2009). Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nature Cell Biology 11:286-94. » Link

Wilkinson, C.J., Carl, M., Harris, W.A. (2009). Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos. BMC Cell Biology 10:17. » Link

Gauhar, Z., Sun, L.V., Hua, S., Mason, C.E., Fuchs, F., Li, T.R., Boutros, M., White, K.P. (2009) Genomic mapping of binding regions for the ecdysone receptor protein complex. Genome Research 19:1006-13. » Link

Adell, T., Saló, E., Boutros, M., Bartscherer, K. (2009). Smed-Evi/Wntless is required for b-catenin-dependent and -independent processes during planarian regeneration. Development 136:905-910. » Link


Bartscherer, K., Boutros, M. (2008). Regulation of Wnt protein secretion and its role in gradient formation. EMBO Reports 9:977-982. » Link

Steinbrink, S., Boutros, M. (2008). RNAi screening in cultured Drosophila cells. Methods in Molecular Biology 420:139-1353. » Link

Mueller P., Boutros M., Zeidler, M. (2008). Identification of JAK/STAT pathway regulators-Insights from RNAi screens. Seminars in Cell and Developmental Biology 19:360-9 » Link

Boutros, M., Ahringer, J. (2008). The art and design of genetic screens: RNA interference. Nature Reviews Genetics 9:554-566. » Link

Stielow, B., Sapetschig, A., Krueger, I., Kunert, N., Brehm, A., Boutros, M., Suske, G. (2008). Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen. Molecular Cell 29:742-754. » Link

Goto, A., Matsushita, K., Gesellchen, V., El Chamy L., Kuttenkeuler, D., Takeuchi, O., Hoffmann, J.A., Akira, S., Boutros, M., Reichhart, J.M. (2008). Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in Drosophila and mice. Nature Immunology 9:97-104. » Link

Wang, Y., Riechmann, V. (2008). Microtubule anchoring by cortical actin bundles prevents streaming of the oocyte cytoplasm. Mechanisms of Development 125:142-152. » Link

Bianco, I.H., Carl, M., Russell, C., Clark, J., Wilson, S.W. (2008). Brain asymmetry is encoded at the level of axon terminal morphology. Neural Development 3:9. » Link


Eulalio, A., Rehwinkel J., Stricker, M., Huntzinger, E., Yang, S.F., Doerks, T., Dorner, S., Bork, P., Boutros, M., Izaurralde, E. (2007). Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes and Development 21:2558-2570. » Link

Horn, T., Arziman, Z., Berger J., Boutros, M. (2007). GenomeRNAi: a database for cell-based RNAi phenotypes. Nucleic Acids Research 35:D492-7. » Link » Website

Carl, M., Bianco, I.H., Bajoghli, B., Aghaallaei, N., Czerny, T., Wilson, S.W. (2007). Wnt/Axin1/b-catenin signalling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries. Neuron 55: 393-405. » Link

Riechmann, V. (2007). Developmental Biology: Hippo prevents posterior patterning by preventing proliferation. Current Biology 17:R1006-1008. » Link

Wang, Y., Riechmann, V. (2007). The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis. Current Biology 17:1349-1355. » Link

Yokoi, H., Shimada, A., Carl, M., Takashima, S., Kobayashi, D., Narita, T., Jindo, T., Kimura, T., Kitagawa, T., Kage, T., Sawada, A., Naruse, K., Asakawa, S., Shimizu, N., Mitani, H., Shima, A., Tsutsumi, M., Hori, H., Wittbrodt, J., Saga, Y., Ishikawa, Y., Araki, K., Takeda, H. (2007). Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships. Developmental Biology 304:326-337. » Link

Hochmann, S., Aghaallaei, N., Bajoghli, B., Soroldoni, D., Carl, M., Czerny, T. (2007). Expression of marker genes during early ear development in medaka. Gene Expression Patterns 7:355-362. » Link


Boutros, M., Bras, L., Huber, W. (2006). Analysis of cell-based RNAi screens. Genome Biology, 7:R66. » Link

Echeverri C.J., Beachy, P.A., Baum, B., Boutros, M., Buchholz, F., Chanda, S.K., Downward, J., Ellenberg, J., Fraser, A.G., Hacohen, N., Hahn, W.C., Jackson, A.L., Kiger, A., Linsley, P.S., Lum, L., Ma, Y., Mathey-Prevot, B., Root, D.E., Sabatini, D.M., Taipale, J., Perrimon, N., Bernards, R. (2006). Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods 3:777-9. » Link

Bartscherer, K., Pelte, N., Ingelfinger, D., Boutros, M. (2006). Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125:523-33. » Link

Fuchs, F., Boutros, M. (2006). Cellular phenotyping by RNAi. Briefings in Functional Genomics and Proteomics 5:52-6. » Link


Gesellchen, V., Kuttenkeuler, D., Steckel, M., Pelte, N., Boutros, M. (2005). An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila. EMBO Reports 6:979-84. » Link

Muller, P., D. Kuttenkeuler, V. Gesellchen, M. Zeidler, M. Boutros. (2005). Identification of JAK/STAT signaling components by genome-wide RNAi. Nature 436:871-5. » Link

Arziman, Z., Horn, T., Boutros, M. (2005). E-RNAi: A web application to design optimized RNAi constructs. Nucleic Acids Research 33:W582-88. » Link

Armknecht, S., M. Boutros, A. Kiger, K. Nybakken, B. Mathey-Prevot, N. Perrimon. (2005). High-throughput RNA interference screens in Drosophila tissue culture cells. Methods in Enzymology 392:55-73. » Link

Choe, S. E., Boutros, M., Michelson, A.M., Church, G.M., Halfon, M.S. (2005). Preferred analysis methods for Affymetrix GeneChips revealed by a wholly-defined control dataset. Genome Biology 6:R16. » Link

Gestri, G., Carl, M., Appolloni, I., Wilson, S.W., Barsacchi, G., Andreazzoli, M. (2005). Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression. Development 132:2401-2413. » Link


Gesellchen, V., Boutros, M. (2004). Managing the genome: microRNAs in Drosophila. Differentiation 72:74-80. » Link

Kuttenkeuler D., Boutros, M. (2004). Genome-wide RNAi as a route to gene function in Drosophila. Briefings in Functional Genomics and Proteomics 3:168-76. » Link

Boutros, M., Kiger, A., Armknecht, S., Kerr, K., Hild, M., Koch, B., Haas S., Heidelberg FlyArray, Paro, R, Perrimon, N. (2004). Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303:832-835. » Link

Riechmann, V., Ephrussi, A. (2004). Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia. Development 131:5897-5907. » Link

Watanabe, T., Asaka, S., Kitagawa, D., Saito, K., Kurashige, R., Sasado, T., Morinaga, C., Suwa, H., Niwa, K., Henrich, T., Hirose, Y., Yasuoka, A., Yoda, H., Deguchi, T., Iwanami, N., Kunimatsu, S., Osakada, M., Loosli, F., Quiring, R., Carl, M., Grabher, C., Winkler, S., Del Bene, F., Wittbrodt, J., Abe, K., Takahama, Y., Takahashi, K., Katada, T., Nishina, H., Kondoh, H, Furutani-Seiki, M. (2004). Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria. Mechanisms of Development 121:791-802. » Link

Loosli, F., Del Bene, F., Quiring, R., Rembold, M., Martinez-Morales, J.-R., Carl, M., Grabher, C., Iquel, C., Krone, A., Wittbrodt, B., Winkler, S., Sasado, T., Morinaga, C., Suwa, H., Niwa, K., Henrich, T., Deguchi, T., Hirose, Y., Iwanami, N., Kunimatsu, S., Osakada, M., Watanabe, T., Yasuoka, A., Yoda, H., Winkler, C., Elmasri, H., Kondoh, H., Furutani-Seiki, M., Wittbrodt, J. (2004). Mutations affecting retina development in Medaka. Mechanisms of Development 121:703-714. » Link

Kitagawa, D., Watanabe, T., Saito, K., Asaka, S., Sasado, T., Morinaga, C., Suwa, H., Niwa, K., Yasuoka, A., Deguchi, T., Yoda, H., Hirose, Y., Henrich, T., Iwanami, N., Kunimatsu, S., Osakada, M., Winkler, C., Elmasri, H., Wittbrodt, J., Loosli, F., Quiring, R., Carl, M., Grabher, C., Winkler, S., Del Bene, F., Momoi, A., Katada, T., Nishina, H., Kondoh, H., Furutani-Seiki, M. (2004). Genetic dissection of the formation of the forebrain in Medaka, Oryzias latipes. Mechanisms of Development 121:673-685. » Link

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