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The chicken embryo metastasis (CEM) or chorionallantoic membrane model (CAM) as an attractive and unique in vivo model to study specific steps of the metastatic cascade in cancer. More...
Since 1993, our group has been actively contributing to hypothesis generation on how the u-PAR works molecularly, how it is being regulated in malignant cells, and how this could contribute to a better understanding, diagnosis, therapy and classification of tumor diseases. More ...
Thus, to contribute to identifying metastatically relevant individual cells among heterogeneous tumor cell populations, our group initiated a highly interdisciplinary consortium of collaborators from biophysics and optical physics, light microscopy and bioimaging, and exosome biology to establish the first single-cell, single molecule superresolution microscopy for human microRNAs. The technology we presented recently is able to visualized single microRNA molecules within single fixed cells at a resolution up to 10-15nm. More ...
Recently, together with national and international collaborators, we extended out interest to decipher miRNA-driven molecular networks driving progression and metastasis and suggested a metastatically relevant network of miR-21, miR-34a, Pdcd4, Src, and PTEN. More ...
Systematic characterization of the genomic and molecular landscape of metastasis - the „Metastasome”
Recent activities of our department have been aiming at a more systematic characterization of the genetic and molecular landscape of human cancer metastases. More ...