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Focus of our vascular research is mainly on
- Evaluation of genetic polymorphisms using candidate gene and whole genome approaches with a focus on renal function, albuminuria/proteinuria, diabetic nephropathy, cardiovascular risk factors such as CRP, uric acid, blood pressure, lipids in conjunction with the group of Prof. W. März and Prof. B. Krüger in cooperation with Prof. Carsten Böger (Regensburg), Prof. Iris Heid (Regensburg), PD Anna Köttgen (Freiburg) and many others
- Evaluation and use of new techniques to measure/estimate renal function experimentally and in humans in conjunction with Prof. B. Yard, Dr. S. Klotz in cooperation with Prof. L. Schad, Prof. S. Schönberg and Prof. N. Gretz
- Studies dealing with diabetic nephropathy, especially the role of carnosine and carnosinase led by Prof. B. Yard (see presentation by Prof. Yard) and supported by Dr. S. Hauske, but also dealing with genetic polymorphisms (see point 1.) and the DIACORE study (PI in Mannheim B. Krämer) supported by PD A. Lammert
- Regulation of renal processes (i.e. chloride channels, potassium channels, RAAS, NFATs, SGK1) led by PD D. Heitzmann and PD W. Neuhofer
- Zimmer F, Zollner FG, Hoeger S, Klotz S, Tsagogiorgas C, Krämer BK, Schad LR. Quantitative renal perfusion measurements in a rat model of acute kidney injury at 3T: testing inter- and intramethodical significance of ASL and DCE-MRI. PloS One 8: e53849, 2013.
- Dörhofer L, Lammert A, Krane V, Gorski M, Banas B, Wanner C, Krämer BK, Heid IM, Böger CA, Group DS. Study design of DIACORE (DIAbetes COhoRtE) - a cohort study of patients with diabetes mellitus type 2. BMC Medical Genetics 14: 25, 2013.
- Hoeger S, Benck U, Petrov K, Waldherr R, Schnuelle P, Yard BA, Krämer BK, Göttmann U. Atorvastatin donor pre-treatment in a model of brain death and allogeneic kidney transplantation in rat. Ann Transplant 17: 79-85, 2012.
- Reinhold SW, Krüger B, Barner C, Zoicas F, Kammerl MC, Hoffmann U, Bergler T, Banas B, Krämer BK. Nephron-specific expression of components of the renin-angiotensin-aldosterone system in the mouse kidney. J Renin Angiotensin Aldosterone Syst 13: 46-55, 2012.
- Then C, Bergler T, Jeblick R, Jung B, Banas B, Krämer BK. Hypertonic stress promotes the upregulation and phosphorylation of zonula occludens 1. Nephron Physiol 119: p11-21, 2011.
- Ehret GB, et al., Krämer BK, et al., Lightstone L. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478: 103-9, 2011.
- Krüger B, Walberer A, Debler J, Böger CA, Farkas S, Reinhold SW, Obed A, Schlitt HJ, Fischereder M, Banas B, Krämer BK. Is inflammation prior to renal transplantation predictive for cardiovascular and renal outcomes? Atherosclerosis 210: 637-42, 2010.
- Köttgen A, Pattaro C, Böger CA, et al., Krämer BK, et al., Fox CS. New loci associated with kidney function and chronic kidney disease. Nat Genet 42: 376-84, 2010.
- Hausberg M, Tokmak F, Pavenstädt H, Krämer BK, Rump LC. Effects of moxonidine on sympathetic nerve activity in patients with end-stage renal disease.J Hypertens. 28: 1920-7, 2010.
- Bergler T, Stoelcker B, Jeblick R, Reinhold SW, Wolf K, Riegger GAJ, Krämer BK. High osmolality induces the kidney-specific chloride channel CLC-K1 by a serum and glucocorticoid-inducible kinase 1 MAPK pathway. Kidney Int 74: 1170-1177, 2008.
Bernhard Krämer, MD
Professor and ChairV. Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology)University Medical Centre and Medical Faculty MannheimHeidelberg University
Phone +49 621/383-3660