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Harrison's 21st edition 2022 online

The new edition is online new.

Access: Harrison’s Internal Medicine

In addition to access to the online readable full text (search within the book, adaptation to mobile devices, PDFs downloadable chapter by chapter, read-aloud mode with highlighting options), special features are available, including:

  • Chapter notes "Updated!" and "New!" compared to the 20th edition
  • Atlases (visual material in 16 chapters, Part 23)
  • Images can be saved as PowerPoint files
  • Videos (in the chapters and in Part 21)
  • 17 clinical procedure video tutorials (Part 24)
  • Review Questions (Quiz): start a self-selected number of questions as random selection or per speciality, the correct answers can already be displayed after each question.
  • Visual Cases: around 70 cases, each with two images and additional information: Input at "What is Image A/B?" and display of the answers.
  • Podcast with case discussions (Podclass).

These and other notes are available on our Books page, section E-Books.

Here is a part of the preface about new chapters:

"In the 21st edition, examples of new chapters include "Precision Medicine and Clinical Care," focusing on the ever-growing pool of "big data" used to provide individualized genotype-phenotype correlations; "Mechanisms of Regulation and Dysregulation of the Immune System," focusing on the extraordinary advances made over the past 5 years in understanding the complex and subtle mechanisms whereby the immune system is regulated and how perturbations in this regulation lead to disease states as well as targets for therapeutic intervention; new chapters on Alzheimer's disease and related conditions, with a special focus on vascular dementia, a common and treatable cause of cognitive loss; and a new chapter on marijuana and marijuana use disorders, as well as updated management guidelines for multiple sclerosis and the expanding array of other autoimmune nervous system diseases that can now be identified and treated.

Other new chapters include "Vaccine Opposition and Hesitancy," "Precision Medicine and Clinical Care," "Diagnosis: Reducing Errors and Improving Quality," "Approach to the Patient with Renal or Urinary Tract Disease," "Interventional Nephrology," "Health Effects of Climate Change," and "Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers." In addition, many chapters have new authors.

The chapter, "Vaccine Opposition and Hesitancy," provides an overview of the current antivaccination crisis, the issues involved, and specific strategies to utilize within the clinical setting to address the lack of confidence that many patients feel toward the health care system. The chapter, "Metabolomics," outlines an emerging and important new and sensitive approach to measuring perturbations within a system or patient that will likely become a routine part of the clinical armamentarium for diagnosing, monitoring, and treating disease."

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