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Publications

  • 2014-2017

    Höfflin F, Jack A, Riedel C, Mack-Bucher J, Roos J, Corcelli C, Schultz C, Wahle P, Engelhardt M: Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex. Front Cell Neurosci; 2017 Nov 6

    Schlüter A, del Turco D, Deller T, Gutzmann A, Schultz C, Engelhardt M: Dynamic regulation of synaptopodin in the axon initial segment during visual cortex development. Cereb Cortex, 2017, 27

    Jamann N, Jordan M, Engelhardt M: Activity-dependent axonal plasticity in sensory systems. Neurosci, 2017, in press

    Costello JL, Castro IG, Schrader TA, Islinger M, Schrader M. Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle. 2017 Jun 3;16(11):1039-1045.

    Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, Manner A, Islinger M*, Schrader M*. 2017. ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. J Cell Biol. 216, 331-342. (*shared senior authorship)

    Costello JL, Castro IG, Camões F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp NA, Ribeiro D, Wilmanns M, Jedd G, Islinger M*, Schrader M*. (2017) Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. J Cell Sci. accepted for publication. (*shared senior authorship)

    Engelhardt M, Di Cristo G, Grabert J, Patz S, Maffei L, Berardi N, Wahle P: Leukemia inhibitory factor impairs structural and neurochemical development of rat visual cortex in vivo. Mol Cell Neurosci 2017; 79

    Peroxisomes are platforms for cytomegalovirus' evasion from the cellular immune response. 2016. Magalhães AC, Ferreira AR, Gomes S, Vieira M, Gouveia A, Valença I, Islinger M, Nascimento R, Schrader M, Kagan JC, Ribeiro D. Sci Rep. 16;6:26028.

    Kübler J, Kirschner S, Hartmann L, Welzel G, Engelhardt M, Herskind C, Veldwijk MR, Schultz C, Felix M, Glatting G, Maier P, Wenz F, Brockmann MA, Giordano FA (2016) The HIV-derived protein Vpr52-96 has anti-glioma activity in vitro and in vivo. Oncotarget. 2016 Jun 2. doi: 10.18632/oncotarget.9787.

    Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL 3rd, Wisniewski T, Woulfe JM, Yamada M, Dickson DW (2016) Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol. 2016 Jan;131(1):87-102. doi: 10.1007/s00401-015-1509-x. Epub 2015 Dec 10.

    Camões F*, Islinger M*, Guimarães S*, Kilaru S, Schuster M, Godinho L, Steinberg G, Schrader M. 2015. New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes, Biochim Biophys Acta, 1853, 111-125 (*shared first authorship)

    Schrader M, Godinho LF, Costello JL, Islinger M. 2015. The different facets of organelle interplay-an overview of organelle interactions. Front Cell Dev Biol.3, 56.

    Peroxisome-mitochondria interplay and disease. 2015. Schrader M, Costello J, Godinho LF, Islinger M. (2015) J Inherit Metab Dis. 38,681-702.

    Thome C, Kelly T, Yanez A, Schultz C, Engelhardt M, Cambridge SB, Both M, Draguhn A, Beck H, Egorov AV (2014) Axon-Carrying Dendrites Convey Privileged Synaptic Input in Hippocampal Neurons. Neuron. 2014 Sep 3. pii: S0896-6273(14)00688-6. doi: 10.1016/j.neuron.2014.08.013

    Gutzmann A, Ergül N, Grossmann R, Schultz C, Wahle P and Engelhardt M (2014) A period of structural plasticity at the axon initial segment in developing visual cortex. Front. Neuroanat. 8:11. doi: 10.3389/fnana.2014.00011

    Book Chapters

     

    Engelhardt M, Sobotzik J. Functional neuroanatomy of the spinal cord. In: Weidner N., Rupp R., Tansey K. (eds) Neurological Aspects of Spinal Cord Injury. Springer, Cham

    Manner A, Islinger M. Isolation of Peroxisomes from Rat Liver and Cultured Hepatoma Cells by Density Gradient Centrifugation. Methods Mol Biol. 2017;1595:1-11.

    Schrader TA, Islinger M, Schrader M. Detection and Immunolabeling of Peroxisomal Proteins. Methods Mol Biol. 2017;1595:113-130.

    Schultz C, Engelhardt M (2014) Anatomy of the hippocampal formation.Szabo K, Hennerici MG (eds): The Hippocampus in Clinical Neuroscience. Front Neurol Neurosci. Basel, Karger, 2014, vol 34, pp 6-17 (DOI:10.1159/000360925)

  • 2010-2013

    Hirth M, Rukwied R, Gromann A, Turnquist B, Weinkauf B, Francke K, Albrecht P, Rice F, Hägglöf B, Ringkamp M, Engelhardt M, Schultz C, Schmelz M, Obreja O (2013) Nerve growth factor induces sensitization of nociceptors without evidence for increased intraepidermal nerve fiber density. Pain. 154(11):2500-11.

    Engelhardt M, Vorwald S, Sobotzik JM, Bennett V, Schultz C (2013) Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. Brain Struct Funct. Brain Struct Funct. 218(4):1005-1

    Ahmed S, Wittenmayer N, Kremer T, Hoeber J, Akula AK, Urlaub H, Islinger M, Kirsch J, Dean C, Dresbach T (2013) Mover is a homomeric phospho-protein present on synaptic vesicles. PLoS ONE. 8 e63474.

    Bonekamp NA, Grille S, Cardoso MJ, Almeida M, Aroso M, Gomes S, Magalhaes AC, Ribeiro D, Islinger M, Schrader M. (2013) Self-Interaction of Human Pex11pβ during Peroxisomal Growth and Division. PLoS ONE. 8 e53424.
    Kashyap A, Zimmerman T, Ergül N, Bosserhoff A, Hartman U, Alla V, Bataille F, Galle PR, Strand S, Strand D (2012) The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis. Oncogene. 32(11):1396-407

    Buffington SA, Sobotzik JM, Schultz C, Rasband MN (2012) IκBα is not required for axon initial segment assembly. Mol Cell Neurosci. 15;50(1):1-9

    Engelhardt M, Tosha C, Lopes VS, Chen B, Nguyen, L, Nusinowitz S, Williams DS (2012) Functional and morphological analysis of the subretinal injection of retinal pigment epithelium cells. Vis Neurosci. 29(2): 83-93 (cover art)

    Rinn C, Aroso M, Prüssing J, Islinger M, Schrader M (2012) Modulating zymogen granule formation in pancreatic AR42J cells. Exp Cell Res. 318, 1855–1866.

    Nawrotzki R, Islinger M, Vogel I, Völkl A, Kirsch J (2012) Expression and distribution of gephyrin in non-neuronal tissues and cells. Histochem Cell Biol. 137, 471–482.

    Hundelt M, Fath T, Selle K, Oesterwind K, Jordan J, Schultz C, Götz J, von Engelhardt J, Monyer H, Lewejohann L, Sachser N, Bakota L, Brandt R (2011) Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiology of Aging. 32,991–1006

    Seidel K, den Dunnen WFA, Schultz C, Paulson H, Frank S, de Vos RA, Brunt ER,  Deller T, Kampinga HH, Rüb U (2010) Axonal inclusions in spinocerebellar ataxia type 3 (SCA3). Acta Neuropathol. 120 (4): 449-460

    Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, Hrabé de Angelis M and Dikic I (2010) CIN85 regulates dopamine receptor endocytosis and governs behavior in mice. EMBO J. 29, 2421-2432

    Moreno R, Sobotzik JM, Schultz C, Schmitz ML (2010) Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε. Nucleic Acids Res. 38 (18): 6029-6044

    Islinger M, Liebler S., Angermüller, S., Weber G, Li KW, Loos M, Eckerskorn C, Völkl A (2010) Peroxisomes from the heavy mitochondrial fraction: isolation by zonal free flow electrophoresis and quantitative mass spectrometrical characterization. J Prot Res. 9, 113–124.

    Review Articles

    Islinger M, Grille S, Fahimi HD, Schrader M (2012) The Peroxisome – an update on mysteries. Histochem Cell Biol. 137, 547–574.

    Schrader M, Bonekamp NA, Islinger M (2012) Fission and proliferation in peroxisomes. Biochim Biophys Acta. 1822, 1343–1357.

    Islinger M, Schrader M (2011) Quick Guide: Peroxisomes. Curr Biol. 21, R1–R2.

    Islinger M, Eckerskorn C, Völkl A (2010) Free flow electrophoresis in the proteomics era – a technique in flux. Electrophoresis. 31, 1754–1763.

    Islinger M, Cardoso MJ, Schrader M (2010) Be different – the diversity of peroxisomes in the animal kingdom. Biochim Biophys Acta. 1803, 881–897.

    Book Chapters

    Schrader M, Grille S, Fahimi HD, Islinger M (2013) Peroxisome interactions and cross-talk with other subcellular compartments in animal cells. In: del Rio LA (ed.): Subcell Biochem. vol. 69, Peroxisomes as a Cellular Source of Different Signalling Molecules, Springer Science + Business Media, p. 1 – 22.

    Bonekamp NA, Islinger M, Gómez Lazárow M, Schrader M (2012) Cytochemical detection of perox-isomes and mitochondria. In: Roth J. (ed.): Methods in Molecular Biology. vol. 931, Cell Imaging Techniques: Methods and Protocols (2nd edition), Humana Press Inc., Totowa, NJ, p. 467–482.

    Islinger M, Abdolzade-Bavil A Liebler S Weber G, Völkl A (2012) Assessing heterogeneity of peroxisomes - isolation of two subpopulations from rat liver. In: Josic D and Hixson DC (eds.): Methods in Molecular Biology. vol. 909. Liver proteomics, Humana Press Inc., Totowa, NJ, p. 83–96.

    Islinger M, Kirsch J, Angermüller S, Rotaru R, Abdolzade-Bavil A, Weber G (2011) Subcellular fractionation of brain tissue samples using Free Flow Electrophoresis. In: Li KW (ed.): Neuromethods. vol. 57, Neuroproteomics, Humana Press Inc., New York, p. 27–45.

  • 2005-2009

    Sobotzik JM, Sie JM, Politi C, Del Turco D, Bennett V, Deller T, Schultz C (2009) AnkyrinG is required to maintain axo-dendritic polarity in vivo. Proc Natl Acad Sci U S A. 106:17564-17569.

    Winkels R, Jedlicka P, Weise FK, Schultz C, Deller T, Schwarzacher SW (2009) Reduced excitability in the dentate gyrus network of betaIV-spectrin mutant mice in vivo. Hippocampus. 7: 677-686

    Jedlicka P, Schwarzacher SW, Winkels R, Kienzler F, Frotscher M, Bramham CR, Schultz C, Bas Orth C, Deller T (2009) Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus. 19:130-140.

    Bockhart V, Constantin CE, Haussler A, Wijnvoord N, Kanngiesser M, Myrczek T, Pickert G, Popp L, Sobotzik JM, Pasparakis M, Kuner R, Geisslinger G, Schultz C, Kress M, Tegeder I (2009) Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity. J Neurosci. 29:12919-12929.

    Islinger M, Li KW, Seitz J, Völkl A, Lüers GH (2009) Hitchhiking of Cu/Zn superoxide dismutase to peroxisomes — evidence for a natural piggyback import mechanism in mammals. Traffic. 10, 1721–1731.


    Politi C, Del Turco D, Sie JM, Golinski PA, Tegeder I, Deller T, Schultz C (2008) Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of Ranvier. Neuropathol Appl Neurobiol. 34:357-365.

    Engelhardt M, Di Cristo G, Wahle P, Berardi N, Maffei L (2007) Differential effects of NT-4, NGF and BDNF on development of neurochemical architecture and cell size regulation in rat visual cortex during the critical period. Eur J Neurosci. 25:529-540.

    Bas Orth C, Schultz C, Muller CM, Frotscher M, Deller T (2007) Loss of the cisternal organelle in the axon initial segment of cortical neurons in synaptopodin-deficient mice. J Comp Neurol. 504:441-449.

    Ghebremedhin E, Thal DR, Schultz C, Braak H, Deller T (2007) Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages. Acta Neuropathol. 114:359-363.

    Rub U, Seidel K, Ozerden I, Gierga K, Brunt ER, Schols L, de Vos RA, den Dunnen W, Schultz C, Auburger G, Deller T (2007) Consistent affection of the central somatosensory system in spinocerebellar ataxia type 2 and type 3 and its significance for clinical symptoms and rehabilitative therapy. Brain Res Rev. 53:235-249.

    Islinger M, Lüers GH, Li KW, Loos M, Völkl A (2007) Rat liver peroxisomes after fibrate treatment: a survey using quantitative mass spectrometry. J Biol Chem. 282, 23055–23069.

    Rub U, Brunt ER, Petrasch-Parwez E, Schols L, Theegarten D, Auburger G, Seidel K, Schultz C, Gierga K, Paulson H, van Broeckhoven C, Deller T, de Vos RA (2006) Degeneration of ingestion-related brainstem nuclei in spinocerebellar ataxia type 2, 3, 6 and 7. Neuropathol Appl Neurobiol. 32:635-649.

    Custer SK, Garden GA, Gill N, Rueb U, Libby RT, Schultz C, Guyenet SJ, Deller T, Westrum LE, Sopher BL, La Spada AR (2006) Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci. 9:1302-1311.

    Braak H, Rub U, Schultz C, Del Tredici K (2006) Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases. J Alzheimers. Dis 9:35-44.

    Schultz C, Konig HG, Del Turco D, Politi C, Eckert GP, Ghebremedhin E, Prehn JH, Kogel D, Deller T (2006) Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci. 33:68-80.

    John N, Krugel H, Frischknecht R, Smalla KH, Schultz C, Kreutz MR, Gundelfinger ED, Seidenbecher CI (2006) Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures. Mol Cell Neurosci. 31:774-784.

    Islinger M, Lüers GH, Zischka H, Üffing M, Völkl A (2006) Insights into the membrane proteome of rat liver peroxisomes: microsomal glutathione-S-transferase is shared by both sunbcellular compartments. Proteomics. 6, 804–816.

    Engelhardt M, Bogdhan U, Aigner L (2005) Adult retinal pigment epithelium cells express neural progenitor properties and the neuronal precursor protein doublecortin. Brain Res. 1040: 98-111.

    Rub U, Brunt ER, Gierga K, Seidel K, Schultz C, Schols L, Auburger G, Heinsen H, Ippel PF, Glimmerveen WF, Wittebol-Post D, Arai K, Deller T, de Vos RA (2005) Spinocerebellar ataxia type 7 (SCA7): first report of a systematic neuropathological study of the brain of a patient with a very short expanded CAG-repeat. Brain Pathol. 15:287-295.

    Thal DR, Capetillo-Zarate E, Schultz C, Rub U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E (2005) Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathol. 110:459-471.

    Bahn A, Ljubojevic M, Lorenz H, Schultz C, Ghebremedhin E, Ugele B, Sabolic I, Burckhardt G, Hagos Y (2005) Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites. Am J Physiol Cell Physiol. 289:C1075-1084.

    Gierga K, Burk K, Bauer M, Orozco Diaz G, Auburger G, Schultz C, Vuksic M, Schols L, de Vos RA, Braak H, Deller T, Rub U (2005) Involvement of the cranial nerves and their nuclei in spinocerebellar ataxia type 2 (SCA2). Acta Neuropathol. 109:617-631.

    Thal DR, Schultz C, Botez G, Del Tredici K, Mrak RE, Griffin WS, Wiestler OD, Braak H, Ghebremedhin E (2005) The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology. Neuropathol Appl Neurobiol. 31:270-279.

    Thees S, Hubbard GB, Winckler J, Schultz C, Rami A (2005) Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons. Restor Neurol Neurosci. 23:1-9.

    Rub U, Gierga K, Brunt ER, de Vos RA, Bauer M, Schols L, Burk K, Auburger G, Bohl J, Schultz C, Vuksic M, Burbach GJ, Braak H, Deller T (2005) Spinocerebellar ataxias types 2 and 3: degeneration of the pre-cerebellar nuclei isolates the three phylogenetically defined regions of the cerebellum. J Neural Transm. 112:1523-1545.

    Rub U, Del Turco D, Burk K, Diaz GO, Auburger G, Mittelbronn M, Gierga K, Ghebremedhin E, Schultz C, Schols L, Bohl J, Braak H, Deller T (2005) Extended pathoanatomical studies point to a consistent affection of the thalamus in spinocerebellar ataxia type 2. Neuropathol Appl Neurobiol. 31:127-140.

    Hollert H, Dürr M, Holtey-Weber R, Islinger M, Brack W, Färber H, Erdinger L, Braunbeck T (2005) Endocrine disruption of water and sediment extracts in a non-radioactive dot blot/RNAse protection-assay using isolated hepatocytes of rainbow trout. Environ Sci Pollut Res Int. 12, 347–360.

    Review Articles

    Angermüller S, Islinger M, Völkl A (2009) Peroxisomes and reactive oxygen species, a lasting challenge. Histochem Cell Biol. 131, 459-463.

    Rüb U,  Özerden I, Seidel K, Schultz C, Gierga K, Brunt ER, Schöls L, de Vos RAI, Dunnen WD, Deller T (2007) Consistent affection of the central somatosensory system in spinocerebellar ataxia type 2 and type 3 and its significance for clinical symptoms and rehabilitative therapy. Brain Res Rev. 53:235-49.

    Braak H, Rüb U, Schultz C, Del Tredici K (2006) Vulnerability of cortical neurons to Alzheimer`s and Parkinson`s diseases, J Alzheimers Dis. 9(3 Suppl):35-44

    Book Chapters

    Islinger M and Weber G (2008) Free Flow Isoelectric Focusing - A method for the separation of both hydrophilic and hydrophobic proteins of rat liver peroxisomes. In: Pflieger D and Rossier J (eds): Methods in Molecular Biology. vol. 432: Organelle Proteomics. Humana Press Inc., Totowa, NJ, p 199–215.

  • 2000-2004

    Engelhardt M, Wachs FP, Couillard-Despres S, Aigner L (2004) The neurogenic competence of progenitors from the postnatal rat retina in vitro. Exp Eye Res. 78:1025-1036.

    Rub U, Burk K, Schols L, Brunt ER, de Vos RA, Diaz GO, Gierga K, Ghebremedhin E, Schultz C, Del Turco D, Mittelbronn M, Auburger G, Deller T, Braak H (2004) Damage to the reticulotegmental nucleus of the pons in spinocerebellar ataxia type 1, 2, and 3. Neurology. 63:1258-1263.

    Rub U, Brunt ER, de Vos RA, Del Turco D, Del Tredici K, Gierga K, Schultz C, Ghebremedhin E, Burk K, Auburger G, Braak H (2004) Degeneration of the central vestibular system in spinocerebellar ataxia type 3 (SCA3) patients and its possible clinical significance. Neuropathol Appl Neurobiol.30:402-414.

    Schultz C, Ghebremedhin E, Del Tredici K, Rub U, Braak H (2004) High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe. Neurobiol Aging. 25:397-405.

    Conrad C, Vianna C, Schultz C, Thal DR, Ghebremedhin E, Lenz J, Braak H, Davies P (2004) Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. J Neurochem. 89:179-188.

    Weber G*, Islinger M*, Weber PJA, Eckerskorn C, Völkl A (2004) Efficient separation and analysis of peroxisomal membrane proteins using free flow isoelectric focussing (FF-IEF). Electrophoresis. 25, 1735–1747. (*both authors contributed equally to this work).
    Wachs FP, Couillard-Despres S, Engelhardt M, Wilhelm D, Ploetz S, Vroemen M, Kaesbauer J, Uyanik G, Klucken J, Karl C, Tebbing J, Svendsen C, Weidner N, Kuhn HG, Winkler J, Aigner L (2003) High efficacy and clonal growth and expansion of adult neural stem cells. Lab Invest. 83: 949-962.

    Wahle P, Di Cristo G, Schwerdtfeger G, Engelhardt M, Berardi N, Maffei L (2003) Differential effetcs of cortical neurotrophic factors on development of lateral geniculate nucleus and superior colliculus neurons: anterograde and retrograde actions. Development. 130: 311-322.

    Rub U, Schultz C, Del Tredici K, Gierga K, Reifenberger G, de Vos RA, Seifried C, Braak H, Auburger G (2003) Anatomically based guidelines for systematic investigation of the central somatosensory system and their application to a spinocerebellar ataxia type 2 (SCA2) patient. Neuropathol Appl Neurobiol. 29:418-433.

    Rub U, Del Turco D, Del Tredici K, de Vos RA, Brunt ER, Reifenberger G, Seifried C, Schultz C, Auburger G, Braak H (2003) Thalamic involvement in a spinocerebellar ataxia type 2 (SCA2) and a spinocerebellar ataxia type 3 (SCA3) patient, and its clinical relevance. Brain. 126:2257-2272.

    Rub U, Brunt ER, Gierga K, Schultz C, Paulson H, de Vos RA, Braak H (2003) The nucleus raphe interpositus in spinocerebellar ataxia type 3 (Machado-Joseph disease). J Chem Neuroanat. 25:115-127.

    Islinger M, Willimski D, Völkl A, Braunbeck T (2003) Effects of 17a-ethinylestradiol on the expression of three estrogen-responsive genes and cellular ultrastructure of liver and testes in male zebrafish. Aquat Toxicol. 62, 85–103.

    Rub U, de Vos RA, Brunt ER, Schultz C, Paulson H, Del Tredici K, Braak H (2002) Degeneration of the external cuneate nucleus in spinocerebellar ataxia type 3 (Machado-Joseph disease). Brain Res. 953:126-134.

    Rub U, de Vos RA, Schultz C, Brunt ER, Paulson H, Braak H (2002) Spinocerebellar ataxia type 3 (Machado-Joseph disease): severe destruction of the lateral reticular nucleus. Brain. 125:2115-2124.

    Ghebremedhin E, Schultz C, Thal DR, Del Tredici K, Rueb U, Braak H (2002) Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes. Neuropathol Appl Neurobiol. 28:308-313.

    Willwohl D, Kettner M, Braak H, Hubbard GB, Dick EJ, Jr., Cox AB, Schultz C (2002) Pallido-nigral spheroids in nonhuman primates: accumulation of heat shock proteins in astroglial processes. Acta Neuropathol. 103:276-280.

    Ghebremedhin E, Thal DR, Schultz C, Braak H (2002) Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains. Neurosci Lett. 320:25-28.

    Rub U, Del Tredici K, Schultz C, de Vos RA, Jansen Steur EN, Arai K, Braak H (2002) Progressive supranuclear palsy: neuronal and glial cytoskeletal pathology in the higher order processing autonomic nuclei of the lower brainstem. Neuropathol Appl Neurobiol. 28:12-22.

    Thal DR, Ghebremedhin E, Haass C, Schultz C (2002) UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain. Clin Neuropathol. 21:35-40.

    Rub U, Del Tredici K, Schultz C, Ghebremedhin E, de Vos RA, Jansen Steur E, Braak H (2002) Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology. Neurobiol Aging. 23:245-254.

    Islinger M, Yuan H, Völkl A, Braunbeck T (2002) Measurement of vitellogenin gene expression by RT-PCR as a tool to identify endocrine disruption in Japanese medaka (Oryzias latipes). Biomarkers. 7, 80–93.

    Braak H, Del Tredici K, Sandmann-Kiel D, Rub U, Schultz C (2001) Nerve cells expressing heat-shock proteins in Parkinson's disease. Acta Neuropathol. 102:449-454.

    Rub U, Del Tredici K, Schultz C, Thal DR, Braak E, Braak H (2001) The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology. Acta Neuropathol. 101:555-564.

    Rub U, Schultz C, Del Tredici K, Braak H (2001) Early involvement of the tegmentopontine reticular nucleus during the evolution of Alzheimer's disease-related cytoskeletal pathology. Brain Res. 908:107-112.

    Schultz C, Dick EJ, Cox AB, Hubbard GB, Braak E, Braak H (2001) Expression of stress proteins alpha B-crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys. Neurobiol Aging. 22:677-682.

    Ghebremedhin E, Schultz C, Thal DR, Rub U, Ohm TG, Braak E, Braak H (2001) Gender and age modify the association between APOE and AD-related neuropathology. Neurology. 56:1696-1701.

    Rub U, Del Tredici K, Schultz C, Buttner-Ennever JA, Braak H (2001) The premotor region essential for rapid vertical eye movements shows early involvement in Alzheimer's disease-related cytoskeletal pathology. Vision Res. 41:2149-2156.

    Schultz C, Hubbard GB, Tredici KD, Braak E, Braak H (2001) Tau pathology in neurons and glial cells of aged baboons. Adv Exp Med Biol. 487:59-69.

    Braak H, Del Tredici K, Schultz C, Braak E (2000) Vulnerability of select neuronal types to Alzheimer's disease. Ann N Y Acad Sci. 924:53-61.

    Schultz C, Hubbard GB, Rub U, Braak E, Braak H (2000) Age-related progression of tau pathology in brains of baboons. Neurobiol Aging. 21:905-912.

    Rub U, Del Tredici K, Schultz C, Thal DR, Braak E, Braak H (2000) The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nuclei. Neuropathol Appl Neurobiol. 26:553-567.

    Thal DR, Schultz C, Dehghani F, Yamaguchi H, Braak H, Braak E (2000) Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex. Acta Neuropathol. 100:608-617.

    Sassin I, Schultz C, Thal DR, Rub U, Arai K, Braak E, Braak H (2000) Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert. Acta Neuropathol. 100:259-269.

    Thal DR, Rub U, Schultz C, Sassin I, Ghebremedhin E, Del Tredici K, Braak E, Braak H (2000) Sequence of Abeta-protein deposition in the human medial temporal lobe. J Neuropathol Exp Neurol. 59:733-748.

    Schultz C, Dehghani F, Hubbard GB, Thal DR, Struckhoff G, Braak E, Braak H (2000) Filamentous tau pathology in nerve cells, astrocytes, and oligodendrocytes of aged baboons. J Neuropathol Exp Neurol. 59:39-52.

    Botez G, Schultz C, Ghebremedhin E, Bohl J, Braak E, Braak H (2000) [Clinical aspects of "argyrophilic grain disease"]. Nervenarzt. 71:38-43.

    Pawlowski S, Islinger M, Völkl A, Braunbeck T (2000) Temperature-dependent vitellogenin-mRNA expression in primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes at 14 and 18 °C. Toxicol In Vitro. 14, 531–540.

    Review Articles

    Schultz C, Braak E, Braak H (2001): Abnorme Phosphorylierung des Tau-Proteins im menschlichen und nicht menschlichen Zentralnervensystem. Neuroforum. 2/01:57-67.

    Braak H, Del Tredici K, Schultz C, Braak E (2000) Vulnerability of select neuronal types to Alzheimer´s disease. In: Khatchaturian ZS and Mesulam MM (Eds.) Alzheimer`s Disease: A compendium of current theories. Ann NY Acad Sci 924:53-61. Braak H, Braak E, Yilmazer D, Schultz C, de Vos RAI, Jansen ENH (1995) Nigral and extranigral pathology in Parkinson´s disease. J Neural Transm-Suppl. 46:15-31.

    Book Chapters

    Schultz C, Del Tredici K, Braak H (2003) Neuropathology of Alzheimer´s disease. in: Richter RW, Zoeller Richter B (eds.) Alzheimer’s Disease: A Physician’s Guide to Practical Management, Humana Press Inc., pp. 21-29.

    Schultz C,   del Tredici K, Rüb U, Braak E, Hubbard GB, Braak H (2002) The brain of the aging baboon: A nonhuman primate model for neuronal and glial tau pathology. In: Erwin JM, Hof, PR (eds.) Aging in Nonhuman Primates. Interdiscipl Top Gerontol. Karger, Basel Vol 31, pp. 118-129.

    Braak H, del Tredici K, Bratzke H, Bohl J, Schultz C (2002) Age-and disease-related changes of the human cerebral cortex: some implications for forensic medicine. In: Oehmichen M, Ritz-Timme S, Meissner C (eds.) Research in Legal Medicine /Rechtsmedizinische Forschungsergebnisse. Schmidt-Römhild, Lübeck Vol 27, pp. 145-159.

    Schultz C, Hubbard GB, Del Tredici K, Braak E, and Braak H (2001) Tau pathology in neurons and glial cells of aged baboons. in: Tolnay M, Probst A (eds.) Neuropathology and Genetics of Dementia, Kluwer Academic/Plenum Publishers, New York, pp. 59-69.

  • 1995-1999

    Schultz C, Ghebremedhin E, Braak E, Braak H (1999) Sex-dependent cytoskeletal changes of the human hypothalamus develop independently of Alzheimer's disease. Exp Neurol 160:186-193.

    Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H (1999) Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta. J Neuropathol Exp Neurol 58:210-216.

    Nagy Z, Hindley NJ, Braak H, Braak E, Yilmazer-Hanke DM, Schultz C, Barnetson L, King EM, Jobst KA, Smith AD (1999) The progression of Alzheimer's disease from limbic regions to the neocortex: clinical, radiological and pathological relationships. Dement Geriatr Cogn Disord 10:115-120.

    Nagy Z, Hindley NJ, Braak H, Braak E, Yilmazer-Hanke DM, Schultz C, Barnetson L, Jobst KA, Smith AD (1999) Relationship between clinical and radiological diagnostic criteria for Alzheimer's disease and the extent of neuropathology as reflected by 'stages': a prospective study. Dement Geriatr Cogn Disord 10:109-114.

    Islinger M, Pawlowski S, Hollert H, Völkl A, Braunbeck T (1999) Measurement of vitellogenin-mRNA expression in primary cultures of rainbow trout hepatocytes in a non-radioactive dot blot/RNAse protection-assay. Sci Total Environ 233, 109–122.

    Bieberstein U, Berbner T, Islinger M, Braunbeck T (1999) Immunohistochemical localization of vitellogenin in rainbow trout (Oncorhynchus mykiss) hepatocytes using immunofluorescence. Sci Total Environ 233, 67–75.

    Schultz C, Koppers D, Sassin I, Braak E, Braak H (1998) Cytoskeletal alterations in the human tuberal hypothalamus related to argyrophilic grain disease. Acta Neuropathol 96:596-602.

    Ghebremedhin E, Schultz C, Botez G, Rub U, Sassin I, Braak E, Braak H (1998) Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele. Acta Neuropathol 96:222-224.

    Ghebremedhin E, Schultz C, Braak E, Braak H (1998) High frequency of apolipoprotein E epsilon4 allele in young individuals with very mild Alzheimer's disease-related neurofibrillary changes. Exp Neurol 153:152-155.

    Nagy Z, Yilmazer-Hanke DM, Braak H, Braak E, Schultz C, Hanke J (1998) Assessment of the pathological stages of Alzheimer's disease in thin paraffin sections: a comparative study. Dement Geriatr Cogn Disord 9:140-144.

    Schultz C, Koppers D, Braak H, Braak E (1997) Cytoskeletal alterations in the aged human neurohypophysis. Neurosci Lett 237:93-96.

    Schultz C, Ghebremedhin E, Braak H, Braak E (1997) Neurofibrillary pathology in the human paraventricular and supraoptic nuclei. Acta Neuropathol 94:99-102.

    Nagy Z, Vatter-Bittner B, Braak H, Braak E, Yilmazer DM, Schultz C, Hanke J (1997) Staging of Alzheimer-type pathology: an interrater-intrarater study. Dement Geriatr Cogn Disord 8:248-251.

    Schultz C, Braak H, Braak E (1996) A sex difference in neurodegeneration of the human hypothalamus. Neurosci Lett 212:103-106.

    Braak H, Braak E, Yilmazer D, Schultz C, de Vos RA, Jansen EN (1995) Nigral and extranigral pathology in Parkinson's disease. J Neural Transm Suppl 46:15-31.

    Book Chapters

    Schultz C, Ghebremedhin E, Sassin I, Braak E, Braak H (1999) Abnormally phosphorylated tau protein in neurons and glial cells of aged baboons. in: Iqbal K, Swaab DF, Winblad B, Wisniewski HM (eds.) Alzheimer´s Disease and Related Disorders. John Wiley & Sons, West Sussex, England, pp. 179-185.

    Schultz C, Koppers D, Braak E, Braak H (1997) Neurofibrillary degeneration in hypophysiotrophic nuclei of the aging human hypothalamus. in: Korf H-W, Usadel K-H  (eds.) Neuroendocrinology: retrospect and perspectives. Springer, pp. 115-126.

    Schultz C (1997) Sex-dependent neurofibrillary pathology of the aging human hypothalamus. In: Press Book II, Lay-language summaries, Society for Neuroscience, 27 th Annual Meeting, New Orleans, La. October, pp. 25-30.

    Braak H, Braak E, Yilmazer D, Schultz C (1995) Age-related changes of the human cerebral cortex. in: Cruz-Sanchez FF et al. (eds.) Neuropathological Criteria for Brain Banking. IOS Press, pp. 15-19.

    Braak H, Braak E, Schultz C, Yilmazer D (1995) Staging of cortical pathology related to Alzheimer´s disease. in: Cruz-Sanchez FF et al. (eds.) Neuropathological Criteria for Brain Banking. IOS Press, pp. 31-34.

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