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Schmitt N, Jann JC, Altrock E, Flach J, Danner J, Uhlig S, Streuer A, Knaflic A, Riabov V, Xu Q, Mehralivand A, Palme I, Nowak V, Oblander J, Weimer N, Haselmann V, Jawhar A, Darwich A, Weis CA, Marx A, Steiner L, Jawhar M, Metzgeroth G, Boch T, Nolte F, Hofmann WK, Nowak D. Preclinical evaluation of eltrombopag in a pdx model of myelodysplastic syndromes. Leukemia. 2022;36:236-247.10.1038/s41375-021-01327-w

Matuschik L, Riabov V, Schmuttermaier C, Sevastyanova T, Weiss C, Kluter H, Kzhyshkowska J. Hyperglycemia induces inflammatory response of human macrophages to cd163-mediated scavenging of hemoglobin-haptoglobin complexes. Int J Mol Sci. 2022;23.10.3390/ijms23031385

Gvaramia D, Kern J, Jakob Y, Tritschler H, Brenner RE, Breiter R, Kzhyshkowska J, Rotter N. Modulation of the inflammatory response to decellularized collagen matrix for cartilage regeneration. J Biomed Mater Res A. 2022;110:1021-1035.10.1002/jbm.a.37349


Wuhrer A, Uhlig S, Tuschy B, Berlit S, Sperk E, Bieback K, Sutterlin M. Wound fluid from breast cancer patients undergoing intraoperative radiotherapy exhibits an altered cytokine profile and impairs mesenchymal stromal cell function. Cancers (Basel). 2021;13.10.3390/cancers13092140

Torres Crigna A, Fricke F, Nitschke K, Worst T, Erb U, Karremann M, Buschmann D, Elvers-Hornung S, Tucher C, Schiller M, Hausser I, Gebert J, Bieback K. Inter-laboratory comparison of extracellular vesicle isolation based on ultracentrifugation. Transfus Med Hemother. 2021;48:48-59.10.1159/000508712

Silva-Bermudez LS, Sevastyanova TN, Schmuttermaier C, De La Torre C, Schumacher L, Kluter H, Kzhyshkowska J. Titanium nanoparticles enhance production and suppress stabilin-1-mediated clearance of gdf-15 in human primary macrophages. Front Immunol. 2021;12:760577.10.3389/fimmu.2021.760577

Poetz F, Corbo J, Levdansky Y, Spiegelhalter A, Lindner D, Magg V, Lebedeva S, Schweiggert J, Schott J, Valkov E, Stoecklin G. Rnf219 attenuates global mrna decay through inhibition of ccr4-not complex-mediated deadenylation. Nat Commun. 2021;12:7175.10.1038/s41467-021-27471-6

Melzak KA, Spouge JL, Boecker C, Kirschhofer F, Brenner-Weiss G, Bieback K. Hemolysis pathways during storage of erythrocytes and inter-donor variability in erythrocyte morphology. Transfus Med Hemother. 2021;48:39-47.10.1159/000508711

Kyjacova L, Saup R, Ronsch K, Wallbaum S, Dukowic-Schulze S, Foss A, Scherer SD, Rothley M, Neeb A, Grau N, Thiele W, Thaler S, Cremers N, Sticht C, Gretz N, Garvalov BK, Utikal J, Sleeman JP. Ier2-induced senescence drives melanoma invasion through osteopontin. Oncogene. 2021;40:6494-6512.10.1038/s41388-021-02027-6

Huang M, Yang Z, Li Y, Lan H, Cyganek L, Yuecel G, Lang S, Bieback K, El-Battrawy I, Zhou X, Borggrefe M, Akin I. Dopamine d1/d5 receptor signaling is involved in arrhythmogenesis in the setting of takotsubo cardiomyopathy. Front Cardiovasc Med. 2021;8:777463.10.3389/fcvm.2021.777463

Huang M, Fan X, Yang Z, Cyganek L, Li X, Yuecel G, Lan H, Li Y, Wendel A, Lang S, Bieback K, El-Battrawy I, Zhou X, Akin I, Borggrefe M. Alpha 1-adrenoceptor signalling contributes to toxic effects of catecholamine on electrical properties in cardiomyocytes. Europace. 2021;23:1137-1148.10.1093/europace/euab008

Gerhards C, Uhlig S, Etemad M, Christodoulou F, Bieback K, Kluter H, Bugert P. Expression of adp receptor p2y12, thromboxane a2 receptor and c-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis. Platelets. 2021;32:618-625.10.1080/09537104.2020.1782868

Fiori A, Uhlig S, Kluter H, Bieback K. Human adipose tissue-derived mesenchymal stromal cells inhibit cd4+ t cell proliferation and induce regulatory t cells as well as cd127 expression on cd4+cd25+ t cells. Cells. 2021;10.10.3390/cells10010058


Yin S, Wang N, Riabov V, Mossel DM, Larionova I, Schledzewski K, Trofimova O, Sevastyanova T, Zajakina A, Schmuttermaier C, Gratchev A, Flatley A, Kremmer E, Zavyalova M, Cherdyntseva N, Simon-Keller K, Marx A, Kluter H, Goerdt S, Kzhyshkowska J. Si-clp inhibits the growth of mouse mammary adenocarcinoma by preventing recruitment of tumor-associated macrophages. Int J Cancer. 2020;146:1396-1408.10.1002/ijc.32685

Uhlig S, Wuhrer A, Berlit S, Tuschy B, Sutterlin M, Bieback K. Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth. Strahlenther Onkol. 2020;196:398-404.10.1007/s00066-020-01586-z

Torres Crigna A, Uhlig S, Elvers-Hornung S, Kluter H, Bieback K. Human adipose tissue-derived stromal cells suppress human, but not murine lymphocyte proliferation, via indoleamine 2,3-dioxygenase activity. Cells. 2020;9.10.3390/cells9112419

Rendra E, Scaccia E, Bieback K. Recent advances in understanding mesenchymal stromal cells. F1000Res. 2020;9.10.12688/f1000research.21862.1

Mossel DM, Moganti K, Riabov V, Weiss C, Kopf S, Cordero J, Dobreva G, Rots MG, Kluter H, Harmsen MC, Kzhyshkowska J. Epigenetic regulation of s100a9 and s100a12 expression in monocyte-macrophage system in hyperglycemic conditions. Front Immunol. 2020;11:1071.10.3389/fimmu.2020.01071

Melzak KA, Muth M, Kirschhofer F, Brenner-Weiss G, Bieback K. Lipid ratios as a marker for red blood cell storage quality and as a possible explanation for donor gender differences in storage quality. Vox Sang. 2020;115:655-663.10.1111/vox.12924

Melzak KA, Moreno-Flores S, Bieback K. Spicule movement on rbcs during echinocyte formation and possible segregation in the rbc membrane. Biochim Biophys Acta Biomembr. 2020;1862:183338.10.1016/j.bbamem.2020.183338

Kremer H, Gebauer J, Elvers-Hornung S, Uhlig S, Hammes HP, Beltramo E, Steeb L, Harmsen MC, Sticht C, Klueter H, Bieback K, Fiori A. Pro-angiogenic activity discriminates human adipose-derived stromal cells from retinal pericytes: Considerations for cell-based therapy of diabetic retinopathy. Front Cell Dev Biol. 2020;8:387.10.3389/fcell.2020.00387

Haneke K, Schott J, Lindner D, Hollensen AK, Damgaard CK, Mongis C, Knop M, Palm W, Ruggieri A, Stoecklin G. Cdk1 couples proliferation with protein synthesis. J Cell Biol. 2020;219.10.1083/jcb.201906147

Gamez C, Schneider-Wald B, Schuette A, Mack M, Hauk L, Khan AUM, Gretz N, Stoffel M, Bieback K, Schwarz ML. Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results. PLoS One. 2020;15:e0227553.10.1371/journal.pone.0227553

Fiori A, Hammes HP, Bieback K. Adipose-derived mesenchymal stromal cells reverse high glucose-induced reduction of angiogenesis in human retinal microvascular endothelial cells. Cytotherapy. 2020;22:261-275.10.1016/j.jcyt.2020.02.005


Worst TS, Previti C, Nitschke K, Diessl N, Gross JC, Hoffmann L, Frey L, Thomas V, Kahlert C, Bieback K, Crigna AT, Fricke F, Porubsky S, Westhoff N, Hardenberg JV, Nuhn P, Erben P, Michel MS, Boutros M. Mir-10a-5p and mir-29b-3p as extracellular vesicle-associated prostate cancer detection markers. Cancers (Basel). 2019;12.10.3390/cancers12010043

Wiatr M, Stump-Guthier C, Latorre D, Uhlig S, Weiss C, Ilonen J, Engelhardt B, Ishikawa H, Schwerk C, Schroten H, Tenenbaum T, Rudolph H. Distinct migratory pattern of naive and effector t cells through the blood-csf barrier following echovirus 30 infection. J Neuroinflammation. 2019;16:232.10.1186/s12974-019-1626-x

Sattler K, El-Battrawy I, Zhao Z, Schrottenberg C, Yucel G, Lan H, Li X, Lang S, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Ravens U, Bieback K, Borggrefe M, Zhou X, Akin I. Serum of patients with acute myocardial infarction prevents inflammation in ipsc-cardiomyocytes. Sci Rep. 2019;9:5651.10.1038/s41598-019-42079-z

Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Gunther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G. Pioneering function of isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res. 2019;29:486-501.10.1038/s41422-019-0168-1

Fleming V, Hu X, Weller C, Weber R, Groth C, Riester Z, Huser L, Sun Q, Nagibin V, Kirschning C, Bronte V, Utikal J, Altevogt P, Umansky V. Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating pd-l1 via tlr4 signaling. Cancer Res. 2019;79:4715-4728.10.1158/0008-5472.CAN-19-0053

Bieback K, Kuci S, Schafer R. Production and quality testing of multipotent mesenchymal stromal cell therapeutics for clinical use. Transfusion. 2019;59:2164-2173.10.1111/trf.15252

Bieback K, Fernandez-Munoz B, Pati S, Schafer R. Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: A joint publication from the aabb and the international society for cell & gene therapy. Transfusion. 2019;59:3448-3460.10.1111/trf.15483


Rossnagl S, Ghura H, Groth C, Altrock E, Jakob F, Schott S, Wimberger P, Link T, Kuhlmann JD, Stenzl A, Hennenlotter J, Todenhofer T, Rojewski M, Bieback K, Nakchbandi IA. A subpopulation of stromal cells controls cancer cell homing to the bone marrow. Cancer Res. 2018;78:129-142.10.1158/0008-5472.CAN-16-3507

Netsch P, Elvers-Hornung S, Uhlig S, Kluter H, Huck V, Kirschhofer F, Brenner-Weiss G, Janetzko K, Solz H, Wuchter P, Bugert P, Bieback K. Human mesenchymal stromal cells inhibit platelet activation and aggregation involving cd73-converted adenosine. Stem Cell Res Ther. 2018;9:184.10.1186/s13287-018-0936-8

Melzak KA, Uhlig S, Kirschhofer F, Brenner-Weiss G, Bieback K. The blood bag plasticizer di-2-ethylhexylphthalate causes red blood cells to form stomatocytes, possibly by inducing lipid flip-flop. Transfus Med Hemother. 2018;45:413-422.10.1159/000490502

El-Battrawy I, Zhao Z, Lan H, Schunemann JD, Sattler K, Buljubasic F, Patocskai B, Li X, Yucel G, Lang S, Nowak D, Cyganek L, Bieback K, Utikal J, Zimmermann WH, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes. Int J Cardiol. 2018;254:195-202.10.1016/j.ijcard.2017.11.007

El-Battrawy I, Zhao Z, Lan H, Li X, Yucel G, Lang S, Sattler K, Schunemann JD, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Bieback K, Bauer R, Ratte A, Pribe-Wolferts R, Rapti K, Nowak D, Wittig J, Thomas D, Most P, Katus HA, Ravens U, Schmidt C, Borggrefe M, Zhou XB, Muller OJ, Akin I. Ion channel dysfunctions in dilated cardiomyopathy in limb-girdle muscular dystrophy. Circ Genom Precis Med. 2018;11:e001893.10.1161/CIRCGEN.117.001893

Bunse L, Pusch S, Bunse T, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Eisel J, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger MC, Harter PN, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende C, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hanggi D, Dorsch M, Suva ML, Niemeyer BA, von Deimling A, Wick W, Platten M. Suppression of antitumor t cell immunity by the oncometabolite (r)-2-hydroxyglutarate. Nat Med. 2018;24:1192-1203.10.1038/s41591-018-0095-6

Blattner C, Fleming V, Weber R, Himmelhan B, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, Utikal J, Karin N, Umansky V. Ccr5(+) myeloid-derived suppressor cells are enriched and activated in melanoma lesions. Cancer Res. 2018;78:157-167.10.1158/0008-5472.CAN-17-0348


Yucel G, Zhao Z, El-Battrawy I, Lan H, Lang S, Li X, Buljubasic F, Zimmermann WH, Cyganek L, Utikal J, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017;7:2935.10.1038/s41598-017-03147-4

Volkening B, Schonig K, Kronenberg G, Bartsch D, Weber T. Deletion of psychiatric risk gene cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion. Glia. 2017;65:817-827.10.1002/glia.23128

Ovsiy I, Riabov V, Manousaridis I, Michel J, Moganti K, Yin S, Liu T, Sticht C, Kremmer E, Harmsen MC, Goerdt S, Gratchev A, Kzhyshkowska J. Il-4 driven transcription factor foxq1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration. Sci Rep. 2017;7:16847.10.1038/s41598-017-17307-z

Horn S, Hughes MA, Schilling R, Sticht C, Tenev T, Ploesser M, Meier P, Sprick MR, MacFarlane M, Leverkus M. Caspase-10 negatively regulates caspase-8-mediated cell death, switching the response to cd95l in favor of nf-kappab activation and cell survival. Cell Rep. 2017;19:785-797.10.1016/j.celrep.2017.04.010


Sharma KR, Heckler K, Stoll SJ, Hillebrands JL, Kynast K, Herpel E, Porubsky S, Elger M, Hadaschik B, Bieback K, Hammes HP, Nawroth PP, Kroll J. Elmo1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Sci Rep. 2016;6:37172.10.1038/srep37172

Schedel A, Kaiser K, Uhlig S, Lorenz F, Sarin A, Starigk J, Hassmann D, Bieback K, Bugert P. Megakaryocytes and platelets express nicotinic acetylcholine receptors but nicotine does not affect megakaryopoiesis or platelet function. Platelets. 2016;27:43-50.10.3109/09537104.2015.1026803

Riabov V, Yin S, Song B, Avdic A, Schledzewski K, Ovsiy I, Gratchev A, Llopis Verdiell M, Sticht C, Schmuttermaier C, Schonhaber H, Weiss C, Fields AP, Simon-Keller K, Pfister F, Berlit S, Marx A, Arnold B, Goerdt S, Kzhyshkowska J. Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model. Oncotarget. 2016;7:31097-31110.10.18632/oncotarget.8857

Kubler J, Kirschner S, Hartmann L, Welzel G, Engelhardt M, Herskind C, Veldwijk MR, Schultz C, Felix M, Glatting G, Maier P, Wenz F, Brockmann MA, Giordano FA. The hiv-derived protein vpr52-96 has anti-glioma activity in vitro and in vivo. Oncotarget. 2016;7:45500-45512.10.18632/oncotarget.9787

El-Battrawy I, Tulumen E, Lang S, Akin I, Behnes M, Zhou X, Mavany M, Bugert P, Bieback K, Borggrefe M, Elmas E. Expression of inflammation-related intercellular adhesion molecules in cardiomyocytes in vitro and modulation by pro-inflammatory agents. In Vivo. 2016;30:213-217


Schaker K, Bartsch S, Patry C, Stoll SJ, Hillebrands JL, Wieland T, Kroll J. The bipartite rac1 guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development. J Biol Chem. 2015;290:6408-6418.10.1074/jbc.M114.633701

Kirschner S, Felix MC, Hartmann L, Bierbaum M, Maros ME, Kerl HU, Wenz F, Glatting G, Kramer M, Giordano FA, Brockmann MA. In vivo micro-ct imaging of untreated and irradiated orthotopic glioblastoma xenografts in mice: Capabilities, limitations and a comparison with bioluminescence imaging. J Neurooncol. 2015;122:245-254.10.1007/s11060-014-1708-7


Mavany M. Zell-adhäsionsmoleküle auf der oberfläche von kardiomyozyten. I. Medizinischen Klinik der Medizinischen Fakultät Mannheim; 2014.


Kuch V, Schreiber C, Thiele W, Umansky V, Sleeman JP. Tumor-initiating properties of breast cancer and melanoma cells in vivo are not invariably reflected by spheroid formation in vitro, but can be increased by long-term culturing as adherent monolayers. Int J Cancer. 2013;132:E94-105.10.1002/ijc.27785

Kinzebach S, Dietz L, Kluter H, Thierse HJ, Bieback K. Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells. BMC Cell Biol. 2013;14:48.10.1186/1471-2121-14-48

Karagianni M, Brinkmann I, Kinzebach S, Grassl M, Weiss C, Bugert P, Bieback K. A comparative analysis of the adipogenic potential in human mesenchymal stromal cells from cord blood and other sources. Cytotherapy. 2013;15:76-88.10.1016/j.jcyt.2012.11.001

Fuchs T, Puellmann K, Hahn M, Dollt C, Pechlivanidou I, Ovsiy I, Kzhyshkowska J, Gratchev A, Fleig J, Emmert A, Neumaier M, Beham AW, Kaminski WE. A second combinatorial immune receptor in monocytes/macrophages is based on the tcrgammadelta. Immunobiology. 2013;218:960-968.10.1016/j.imbio.2012.11.005

Dreher L, Elvers-Hornung S, Brinkmann I, Huck V, Henschler R, Gloe T, Kluter H, Bieback K. Cultivation in human serum reduces adipose tissue-derived mesenchymal stromal cell adhesion to laminin and endothelium and reduces capillary entrapment. Stem Cells Dev. 2013;22:791-803.10.1089/scd.2012.0051

Bieback K, Vinci M, Elvers-Hornung S, Bartol A, Gloe T, Czabanka M, Kluter H, Augustin H, Vajkoczy P. Recruitment of human cord blood-derived endothelial colony-forming cells to sites of tumor angiogenesis. Cytotherapy. 2013;15:726-739.10.1016/j.jcyt.2013.01.215


Guven S, Karagianni M, Schwalbe M, Schreiner S, Farhadi J, Bula S, Bieback K, Martin I, Scherberich A. Validation of an automated procedure to isolate human adipose tissue-derived cells by using the sepax(r) technology. Tissue Eng Part C Methods. 2012;18:575-582.10.1089/ten.TEC.2011.0617

Bieback K, Hecker A, Schlechter T, Hofmann I, Brousos N, Redmer T, Besser D, Kluter H, Muller AM, Becker M. Replicative aging and differentiation potential of human adipose tissue-derived mesenchymal stromal cells expanded in pooled human or fetal bovine serum. Cytotherapy. 2012;14:570-583.10.3109/14653249.2011.652809


Stoll SJ, Bartsch S, Augustin HG, Kroll J. The transcription factor hoxc9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. Circ Res. 2011;108:1367-1377.10.1161/CIRCRESAHA.111.244095

Gaebel R, Furlani D, Sorg H, Polchow B, Frank J, Bieback K, Wang W, Klopsch C, Ong LL, Li W, Ma N, Steinhoff G. Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration. PLoS One. 2011;6:e15652.10.1371/journal.pone.0015652

Dietz CT. Analyses of small rho-gtpases signaling molecules during vertebrate development and angiogenesis. Forschungsbereich Vaskuläre Biologie der Medizinischen Fakultät Mannheim, Ruprecht-Karls-Universität Heidelberg, und des Deutsches Krebsforschungszentrum, Heidelberg: Heidelberg University; 2011.


Maier P, Herskind C, Barzan D, Zeller WJ, Wenz F. Snai2 as a novel radioprotector of normal tissue by gene transfer using a lentiviral bicistronic sin vector. Radiat Res. 2010;173:612-619.10.1667/RR1952.1

Geok Choo S. Dysfunctional plasmacytoid dendritic cells but not nk cells in the peripheral blood of stage iv melanoma patients. clinical cooperation unit for Dermato-Oncology, German Cancer Research Center (DKFZ) and University Hospital Mannheim; 2010.

Bieback K, Ha VA, Hecker A, Grassl M, Kinzebach S, Solz H, Sticht C, Kluter H, Bugert P. Altered gene expression in human adipose stem cells cultured with fetal bovine serum compared to human supplements. Tissue Eng Part A. 2010;16:3467-3484.10.1089/ten.TEA.2009.0727

Barzan D, Maier P, Zeller WJ, Wenz F, Herskind C. Overexpression of caveolin-1 in lymphoblastoid tk6 cells enhances proliferation after irradiation with clinically relevant doses. Strahlenther Onkol. 2010;186:99-106.10.1007/s00066-010-2029-1


Goessler UR, Bugert P, Bieback K, Stern-Straeter J, Bran G, Sadick H, Hormann K, Riedel F. In vitro analysis of integrin expression in stem cells from bone marrow and cord blood during chondrogenic differentiation. J Cell Mol Med. 2009;13:1175-1184.10.1111/j.1582-4934.2008.00451.x

Germeyer A, Sharkey AM, Prasadajudio M, Sherwin R, Moffett A, Bieback K, Clausmeyer S, Masters L, Popovici RM, Hess AP, Strowitzki T, von Wolff M. Paracrine effects of uterine leucocytes on gene expression of human uterine stromal fibroblasts. Mol Hum Reprod. 2009;15:39-48.10.1093/molehr/gan075

Bieback K, Hecker A, Kocaomer A, Lannert H, Schallmoser K, Strunk D, Kluter H. Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow. Stem Cells. 2009;27:2331-2341.10.1002/stem.139