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Publications

2021

Huang M, Fan X, Yang Z, Cyganek L, Li X, Yuecel G, Lan H, Li Y, Wendel A, Lang S, Bieback K, El-Battrawy I, Zhou X, Akin I, Borggrefe M. Alpha 1-adrenoceptor signalling contributes to toxic effects of catecholamine on electrical properties in cardiomyocytes. Europace. 2021 Feb 19:euab008. doi: 10.1093/europace/euab008.

Fiori A, Uhlig S, Klüter H, Bieback K Human Adipose Tissue-Derived Mesenchymal Stromal Cells Inhibit CD4+ T Cell Proliferation and Induce Regulatory T Cells as Well as CD127 Expression on CD4+CD25+ T Cells. Cells. 2021;10(1):58. doi: 10.3390/cells10010058. PMID: 33401501

2020

Torres Crigna A, Uhlig S, Elvers-Hornung S, Klüter H, Bieback K. Human Adipose Tissue-Derived Stromal Cells Suppress Human, but Not Murine Lymphocyte Proliferation, via Indoleamine 2,3-Dioxygenase Activity. Cells. 2020;9(11):2419. doi: 10.3390/cells9112419. PMID: 33167329

Torres-Crigna A, Fricke F, Nitschke K, Worts T, Erb U, Karremann M, Buschmann D, Elvers-Hornung S, Tucher C, Schiller M, Hausser i, Gebert j, Bieback K. Inter-Laboratory Comparison of Extracellular Vesicle Isolation Based on Ultracentrifugation. Transfusion Medicine and Hemotherapy , Volume 48, pp 48-59; doi:10.1159/000508712

Kremer H, Gebauer J, Elvers-Hornung S, Uhlig S, Hammes HP, Beltramo E, Steeb L, Harmsen MC, Sticht C, Klueter H, Bieback K, Fiori A. Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy. Front Cell Dev Biol. 2020;8:387. doi: 10.3389/fcell.2020.00387. eCollection 2020. PMID: 32582693

Melzak KA, Moreno-Flores S, Bieback K.Spicule movement on RBCs during echinocyte formation and possible segregation in the RBC membrane. Biochim Biophys Acta Biomembr. 2020;1862(10):183338. doi: 10.1016/j.bbamem.2020.183338. Epub 2020 May 30. PMID: 32485161

Melzak KA, Muth M, Kirschhöfer F, Brenner-Weiss G, Bieback K. Lipid ratios as a marker for red blood cell storage quality and as a possible explanation for donor gender differences in storage quality. Vox Sang. 2020;115(8):655-663. doi: 10.1111/vox.12924. Epub 2020 May 6. PMID: 32378231

Melzak KA Spouge JL, Boecker C, Kirschhöfer F, Brenner-Weiss G, Bieback K. Hemolysis Pathways during Storage of Erythrocytes and Inter-Donor Variability in Erythrocyte Morphology. Transfusion Medicine and Hemotherapy, Volume 48, pp 39-47; doi:10.1159/000508711

Gerhards C, Uhlig S, Etemad M, Christodoulou F, Bieback K, Klüter H, Bugert P. Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis. Platelets. 2020:1-8. doi: 10.1080/09537104.2020.1782868. Online ahead of print. PMID: 32619120

Fiori A, Hammes HP, Bieback K. Adipose-derived mesenchymal stromal cells reverse high glucose-induced reduction of angiogenesis in human retinal microvascular endothelial cells. Cytotherapy. 2020;22(5):261-275. doi: 10.1016/j.jcyt.2020.02.005. Epub 2020 Apr 1. PMID: 32247542

Rendra E, Scaccia E, Bieback K. Recent advances in understanding mesenchymal stromal cells. F1000Res. 2020;9:F1000 Faculty Rev-156. doi: 10.12688/f1000research.21862.1. eCollection 2020. PMID: 32148780

Uhlig S, Wuhrer A, Berlit S, Tuschy B, Sütterlin M, Bieback K.Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth. Strahlenther Onkol. 2020;196(4):398-404. doi: 10.1007/s00066-020-01586-z. Epub 2020 Feb 6. PMID: 32030446

Gamez C, Schneider-Wald B, Schuette A, Mack M, Hauk L, Khan AUM, Gretz N, Stoffel M, Bieback K, Schwarz ML Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results. PLoS One. 2020;15(1):e0227553. doi: 10.1371/journal.pone.0227553. eCollection 2020. PMID: 31923210

2019

Worst TS, Previti C, Nitschke K, Diessl N, Gross JC, Hoffmann L, Frey L, Thomas V, Kahlert C, Bieback K, Crigna AT, Fricke F, Porubsky S, Westhoff N, Hardenberg JV, Nuhn P, Erben P, Michel MS, Boutros M. miR-10a-5p and miR-29b-3p as Extracellular Vesicle-Associated Prostate Cancer Detection Markers. Cancers (Basel). 2019;12(1):43. doi: 10.3390/cancers12010043. PMID: 31877768

Fleming V, Hu X, Weller C, Weber R, Groth C, Riester Z, Hüser L, Sun Q, Nagibin V, Kirschning C, Bronte V, Utikal J, Altevogt P, Umansky V. Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling. Cancer Res. 2019;79(18):4715-4728. doi: 10.1158/0008-5472.CAN-19-0053. Epub 2019 Jul 23. PMID: 31337655

Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G.Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res. 2019;29(6):486-501. doi: 10.1038/s41422-019-0168-1. Epub 2019 Apr 25. PMID: 31024170

Wiatr M, Stump-Guthier C, Latorre D, Uhlig S, Weiss C, Ilonen J, Engelhardt B, Ishikawa H, Schwerk C, Schroten H, Tenenbaum T, Rudolph H. Distinct migratory pattern of naive and effector T cells through the blood-CSF barrier following Echovirus 30 infection. J Neuroinflammation. 2019;16(1):232. doi: 10.1186/s12974-019-1626-x. PMID: 31752904

Bieback K, Fernandez-Muñoz B, Pati S, Schäfer R. Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy. Transfusion. 2019;59(11):3448-3460. doi: 10.1111/trf.15483. Epub 2019 Aug 14. PMID: 31412158

Bieback K, Fernandez-Muñoz B, Pati S, Schäfer R. Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy. Cytotherapy. 2019;21(9):911-924. doi: 10.1016/j.jcyt.2019.06.006. Epub 2019 Jul 12. PMID: 31307904

Bieback K, Kuçi S, Schäfer R. Production and quality testing of multipotent mesenchymal stromal cell therapeutics for clinical use. Transfusion. 2019;59(6):2164-2173. doi: 10.1111/trf.15252. Epub 2019 Mar 18. PMID: 30882925

Sattler K, El-Battrawy I, Zhao Z, Schrottenberg C, Yücel G, Lan H, Li X, Lang S, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Ravens U, Bieback K, Borggrefe M, Zhou X, Akin I. Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes. Sci Rep. 2019;9(1):5651. doi: 10.1038/s41598-019-42079-z.

2018

Melzak KA, Uhlig S, Kirschhöfer F, Brenner-Weiss G, Bieback K. The Blood Bag Plasticizer Di-2-Ethylhexylphthalate Causes Red Blood Cells to Form Stomatocytes, Possibly by Inducing Lipid Flip-Flop. Transfus Med Hemother. 2018;45(6):413-422. doi: 10.1159/000490502. Epub 2018 Oct 30. PMID: 30574059

Bunse L, Pusch S, Bunse T, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Eisel J, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger MC, Harter PN, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende C, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hänggi D, Dorsch M, Suvà ML, Niemeyer BA, von Deimling A, Wick W, Platten M. Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nat Med. 2018;24(8):1192-1203. doi: 10.1038/s41591-018-0095-6. Epub 2018 Jul 9. PMID: 29988124

Netsch P, Elvers-Hornung S, Uhlig S, Klüter H, Huck V, Kirschhöfer F, Brenner-Weiß G, Janetzko K, Solz H, Wuchter P, Bugert P, Bieback K.Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine. Stem Cell Res Ther. 2018;9(1):184. doi: 10.1186/s13287-018-0936-8. PMID: 29973267

2017

Ovsiy I, Riabov V, Manousaridis I, Michel J, Moganti K, Yin S, Liu T, Sticht C, Kremmer E, Harmsen MC, Goerdt S, Gratchev A, Kzhyshkowska. IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration J. Sci Rep. 2017;7(1):16847. doi: 10.1038/s41598-017-17307-z.

El-Battrawy I, Zhao Z, Lan H, Schünemann JD, Sattler K, Buljubasic F, Patocskai B, Li X, Yücel G, Lang S, Nowak D, Cyganek L, Bieback K, Utikal J, Zimmermann WH, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes. Int J Cardiol. 2018;254:195-202. doi: 10.1016/j.ijcard.2017.11.007.

Völkening B , Schönig K , Kronenberg G , Bartsch D, Weber T. Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion. Glia. 2017;65(5):817-827.doi: 10.1002/glia.23128.

Yücel G, Zhao Z, El-Battrawy I, Lan H, Lang S, Li X, Buljubasic F, Zimmermann WH, Cyganek L, Utikal J, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017 Jun 7;7(1):2935. doi: 10.1038/s41598-017-03147-4.

2016

Sharma KR, Heckler K, Stoll SJ, Hillebrands JL, Kynast K, Herpel E, Porubsky S, Elger M, Hadaschik B, Bieback K, Hammes HP, Nawroth PP, Kroll J. ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Sci Rep. 2016;6:37172. doi: 10.1038/srep37172. PMID: 27849017

Riabov V, Yin S, Song B, Avdic A, Schledzewski K, Ovsiy I, Gratchev A, Llopis Verdiell M, Sticht C, Schmuttermaier C, Schönhaber H, Weiss C, Fields AP, Simon-Keller K, Pfister F, Berlit S, Marx A, Arnold B, Goerdt S, Kzhyshkowska J. Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model. Oncotarget. 2016;7(21):31097-110. doi: 10.18632/oncotarget.8857.

2015

Schedel A, Kaiser K, Uhlig S, Lorenz F, Sarin A, Starigk J, Hassmann D, Bieback K, Bugert P. Megakaryocytes and platelets express nicotinic acetylcholine receptors but nicotine does not affect megakaryopoiesis or platelet function. Platelets. 2016;27(1):43-50. doi: 10.3109/09537104.2015.1026803. Epub 2015 Apr 22. PMID: 25902378

Schäker K, Bartsch S, Patry C, Stoll SJ, Hillebrands JL, Wieland T, Kroll J. The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development. J Biol Chem. 2015;290(10):6408-18. doi: 10.1074/jbc.M114.633701

2013

Karagianni M, Brinkmann I, Kinzebach S, Grassl M, Weiss C, Bugert P, Bieback K. A comparative analysis of the adipogenic potential in human mesenchymal stromal cells from cord blood and other sources. Cytotherapy. 2013;15(1):76-88. doi: 10.1016/j.jcyt.2012.11.001.

Kuch V, Schreiber C, Thiele W, Umansky V, Sleeman JP.Tumor-initiating properties of breast cancer and melanoma cells in vivo are not invariably reflected by spheroid formation in vitro, but can be increased by long-term culturing as adherent monolayers. Int J Cancer. 2013;132(3):E94-105. doi: 10.1002/ijc.27785.

2011

Stoll SJ, Bartsch S, Augustin HG, Kroll J. The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. Circ Res. 2011;108(11):1367-77. doi: 10.1161/CIRCRESAHA.111.244095.

2010

Bieback K, Ha VA, Hecker A, Grassl M, Kinzebach S, Solz H, Sticht C, Klüter H, Bugert P. Altered gene expression in human adipose stem cells cultured with fetal bovine serum compared to human supplements. Tissue Eng Part A. 2010;16(11):3467-84. doi: 10.1089/ten.TEA.2009.0727

Maier P, Herskind C, Barzan D, Zeller WJ, Wenz F. SNAI2 as a novel radioprotector of normal tissue by gene transfer using a lentiviral bicistronic SIN vector. Radiat Res. 2010;173(5):612-9.doi: 10.1667/RR1952.1.

Barzan D, Maier P, Zeller WJ, Wenz F, Herskind C Overexpression of caveolin-1 in lymphoblastoid TK6 cells enhances proliferation after irradiation with clinically relevant doses. Strahlenther Onkol. 2010;186(2):99-106. doi: 10.1007/s00066-010-2029-1.

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