Publications and Theses

2026

Schiller C, Lemmer M, Reitter S, Lehmann J, Fenzl K, Schott J. (2026).
QuAPPro: An R/shiny app for quantification and alignment of polysome profiles. 
BMC Bioinformatics,  https://doi.org/10.1186/s12859-026-06379-2

Wu CC, Naarmann-de Vries IS, Hartmann J, Nidoieva Z, Kopietz K, Marchand V, Özrendeci Z, Lindner D, Schelchshorn S, Flad S, Frye M, Papavasiliou FN, Schirmeister T, Stoecklin G, Schott J, Motorin Y, Tuorto F, Dieterich C, Helm M, Ruggieri A. (2026)
The two-step purification method ViREn identifies a single NSUN6-mediated 5-methylcytosine modification promoting dengue virus RNA genome turnover.
Nucleic Acids Res. 2026 Jan 14;54(2):gkag003. doi: 10.1093/nar/gkag003. PMID: 41562255

Grassl N, Suwala AK, Kessler T, Bunse L, Mildenberger I, Breckwoldt MO, Ratliff M, Brehmer S, Herold-Mende C, Etminan N, Wick W, Sahm F, Platten M, Sahm K.
Early distant progression in adult Histone-3 K27-altered diffuse midline gliomas.
J Neurooncol. 2026 Jan 13;176(2):166. doi: 10.1007/s11060-025-05238-z. PMID: 41528563

Fonseca Ó, Oliveira PJ, Muckenthaler MU, Moreira AC, Gomes MS.
Iron-related intercellular communication in the liver: Main players and mechanisms.
Eur J Clin Invest. 2026 Jan;56(1):e70168. doi: 10.1111/eci.70168. Epub 2026 Jan 7. PMID: 41502243

Huang Z, Liu Y, Wu Y, Zhang F, Yu L, Gao S, Wen W, Wang G, Su R, Xia P, Zhou Q, Bie Y, Hu P, Burgermeister E, Lan P, Wu X, Zhang H, Zhang F, El-Omar EM, Zuo T. Nat Metab. (2026)
Gut mucosal mycobiome profiling in Crohn's disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum.
Jan 7. doi: 10.1038/s42255-025-01420-9. Online ahead of print. PMID: 41501528

Herold, N., Bochem, J., Leyens, J., Wingerter, S., Forchhammer, S., Spreuer, J., Deseke, M., Yurttas, C., Nocerino, P., Antunes Dos Reis, R., Amaral, T., Wagner, N. B., Thiel, K., Soffel, D., Bieber, K., Terheyden, P., Wesch, D., Oberg, H. H., Sebens, S., Claassen, M., … Wistuba-Hamprecht, K. (2026).
Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma. 
Journal for immunotherapy of cancer, 14(1), e011224. doi: 10.1136/jitc-2024-011224

2025

Sievers, P., Arora, S., Hielscher, T., Savran, D., Schrimpf, D., Banan, R., Vonhören, D., Pusch, S., Sill, M., Appay, R., Wirsching, H.G., Hortobagyi, T., Dohmen, H., Acker, T., Kohlhof-Meinecke, P., Schweizer, L., Wefers, A.K., Harter, P.N., Hartmann, C., Beschorner, R., Schittenhelm, J., Behling, F., Tabatabai, G., Mawrin, C., Snuderl, M., Maas, S.L.N., Wesseling, P., Brandner, S., Korshunov, A., Ratliff, M., Krieg, S.M., Wick, W., Jones, D.T.W., Pfister, S.M., Holland, E.C., von Deimling, A., Szulzewsky, F., and Sahm, F. (2025).
Molecular signatures define BAP1-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes.
Neuro Oncol. 10.1093/neuonc/noaf105.

von Kries A, Garcés-Lázaro I, Balzasch B, Sticht C, Shaltiel IA, Boonekamp KE, Sams A, Burgermeister E, Betge J, Ebert M, Boutros M, Helming L, Stojanovic A, Cerwenka A, (2025).
Colorectal cancer organoids drive hypoxia, TGF-β, and patient-specific diversification of NK cell activation programs.
 J Immunother. Cancer. Dec 5;13(12):e012988. doi: 10.1136/jitc-2025-012988.

*Heine L, *Griffiths H, Hu H, Müller I, Kuhn S, Rudolph L, Rait X, Waldhuber A, Chen Y and Miethke T. (2025).
TIR-domain-containing protein C as modulator of innate immune checkpoints.
Sci Rep Nov 27;15(1):42562. doi: 10.1038/s41598-025-29677-w. *equal contribution

Wünnemann F, Sicklinger F, Bestak K, Nimo J, Thiemann T, Amrute JM, Nordbeck M, Hartmann N, Ibarra-Arellano MA, Tanevski J, Chazotte M, Heine C, Frey N, Lavine KJ, Coscia F, Saez-Rodriguez J, Leuschner F, Schapiro D. (2025).
Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium. 
Nat Cardiovasc Res. Oct;4(10):1345-1362. doi: 10.1038/s44161-025-00717-y. Epub 2025 Oct 3.

Dobbertin T, Schirmer L. (2025).
Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation.
Eur J Immunol. Dec;55(12):e70119. doi: 10.1002/eji.70119.

Huang Z, Liu Y, Wu Y, Zhang F, Yu L, Gao S, Wen W, Wang G, Su R, Xia P, Zhou Q, Bie Y, Hu P, Burgermeister E, Lan P, Wu X, Zhang H, Zhang F, El-Omar EM, Zuo T. Nat Metab. (2026)
Gut mucosal mycobiome profiling in Crohn's disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum.
Jan 7. doi: 10.1038/s42255-025-01420-9. Online ahead of print. PMID: 41501528

Chen B, Tang H, Zheng X, Xie F, Yu P, Lyu Y, Feng T, Wu J, Liu J, Xu Y, Cheung AHK, Fang C, Wang Z, Wang S, Cheung JCT, Dong Y, Tian R, Zhang Y, Lu C, Wong CC, Yu J, Wu WKK, Burgermeister E, Tong M, Zhang F, Kang W, Leung KT, To KF. Mol Cancer. (2025)
Spatial and functional dissection of cancer-associated fibroblasts-mediated immune modulation in H. pylori-associated gastric cancer.
Nov 6;24(1):282. doi: 10.1186/s12943-025-02490-9. PMID: 41194113

Xiao Q, Riedesser JE, Mulholland T, Li Z, Buchloh J, Albrecht P, Yang X, Li M, Venkatachalam N, Skabkina O, Klupsch A, Eichhorn E, Wang L, Belle S, Schulte N, Schmitz D, Froelich MF, Trikhirhisthit K, Valentini E, Boonekamp KE, Petersen Y, Miersch T, Burgermeister E, Herskind C, Veldwijk MR, Brochhausen C, Ihnatko R, Krijgsveld J, Kurth I, Zhu Y, Ma Y, Cao K, Boutros M, Ebert MP, Zhan T, Betge J. . (2025)
Combined MEK and PARP inhibition enhances radiation response in rectal cancer. 
Cell Rep Med. 2025 Aug 19;6(8):102284. doi: 10.1016/j.xcrm.2025.102284. Epub 2025 Aug 8. PMID: 40782795

Feng Z, Burgermeister E, Philips A, Zuo T, Wen W. (2025)
The gut virome in association with the bacteriome in gastrointestinal diseases and beyond: roles, mechanisms, and clinical applications.
Precis Clin Med. May 28;8(2):pbaf010. doi: 10.1093/pcmedi/pbaf010. eCollection 2025 Jun. PMID: 40520768

Baumeister T, Proaño-Vasco A, Metwaly A, Kleigrewe K, Kuznetsov A, Schömig LR, Borgmann M, Khiat M, Anand A, Strangmann J, Böttcher K, Haller D, Dunkel A, Somoza V, Reiter S, Meng C, Thimme R, Schmid RM, Patil DT, Burgermeister E, Huang Y, Sun Y, Wang HH, Wang TC, Abrams JA, Quante M . (2025)
Loss of FXR or Bile Acid-dependent Inhibition Accelerate Carcinogenesis of Gastroesophageal Adenocarcinoma.
Cell Mol Gastroenterol Hepatol. 2025;19(8):101505. doi: 10.1016/j.jcmgh.2025.101505. Epub 2025 Mar 24. PMID: 40139565

Zhan, T., Betge, J., Schulte, N., Dreikhausen, L., Hirth, M., Li, M., Weidner, P., Leipertz, A., Teufel, A., & Ebert, M. P. (2025).
Digestive cancers: mechanisms, therapeutics and management. 
Signal transduction and targeted therapy, 10(1), 24. doi: 10.1038/s41392-024-02097-4

Gierschek F, Schlueter J, Kühnel I, Feigl FF, Schmiedel D, Prüfer M, Buchinger L, Cerwenka A, Cappel C, Huenecke S, Köhl U, Wels WS, Ullrich E; (2024)
Empowering Natural Killer Cells to Combat Acute Myeloid Leukemia: Perspective on CAR-NK Cell Therapy.
Translational Oncology Consortium “NKfit4AML” sponsored by the German Cancer Aid.Transfus Med Hemother. Oct 1;52(1):42-60. doi: 10.1159/000540962. eCollection 2025 Feb.PMID: 39944413 .

Liu H, Tang Y, Singh A, Vong J, Cordero J, Mathes A, Gao R, Jia Y, Garvalov BK, Acker T, Poschet G, Hell R, Schneider MA, Heineke J, Wieland T, Barreto G, Cerwenka A, Potente M, Bibli SI, Savai R, Dobreva G. (2025)
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α.
Nat Commun. May 28;16(1):4929. doi: 10.1038/s41467-025-60223-4.PMID: 40436847 

Aubermann F, Seneca S, Hofman T, Garcés-Lázaro I, Ajmail K, Daubner K, Cerwenka A, Platzman I, Spatz JP. (2025)
Modular Droplet-Based Microfluidic Platform for Functional Phenotypic Screening of Natural Killer Cells.
Small Methods. Aug;9(8):e2500236. doi: 10.1002/smtd.202500236. Epub 2025 Apr 21.PMID: 40256918 

Wünnemann, F., Sicklinger, F., Bestak, K., Nimo, J., Thiemann, T., Amrute, J. M., Nordbeck, M., Hartmann, N., Ibarra-Arellano, M. A., Tanevski, J., Chazotte, M., Heine, C., Frey, N., Lavine, K. J., Coscia, F., Saez-Rodriguez, J., Leuschner, F., & Schapiro, D. (2025).
Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium.
Nature cardiovascular research, 4(10), 1345–1362. doi: 10.1038/s44161-025-00717-y

Krohn JB, Sprehe LK, Sicklinger F, Kawohl J, Hess C, Spieler A, Dihlmann S, Eis L, Gleissner CA, Katus HA, Frey N, Leuschner F. (2025)
CXCL4-Induced PBMCs Modulate Vascular Extracellular Matrix via Wnt5a-Dependent Matrix Metalloproteinase-7 and Calcifying Extracellular Vesicle Release. Arterioscler Thromb Vasc Biol..
Oct;45(10):1799-1817. doi: 10.1161/ATVBAHA.124.322067. Epub 2025 Aug 21. PMID: 40836918

Abooali, M., Schlichtner, S., Lei, X., Aliu, N., Ruggiero, S., Loges, S., Ziegler, M., Hertel, F., Volckmar, A. L., Stenzinger, A., Christopoulos, P., Thomas, M., Klenova, E., Meyer, N. H., Boussios, S., Heaton, N., Zen, Y., Zamalloa, A., Chokshi, S., Urbani, L., … Sumbayev, V. V. (2025).
Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment.
Cancer letters, 616, 217581. doi: 10.1016/j.canlet.2025.217581

Foerster LC, Kaya O, Wüst V, Danciu DP, Akcay V, Bekavac M, Ziegler KC, Stinchcombe N, Tang A, Kleber S, Tang JLY, Brunken J, Lois-Bermejo I, Gesteira-Perez N, Ma X, Sadik A, Le PU, Petrecca K, Opitz CA, Liu H, Wirtz CR, Goncalves A, Marciniak-Czochra A, Anders S, Martin-Villalba A. (2025)
Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression.
Nat Commun. 2025 Aug 6;16(1):7250. doi: 10.1038/s41467-025-62528-w. Erratum in: Nat Commun. 2025 Oct 17;16(1):9243. doi: 10.1038/s41467-025-65072-9. PMID: 40770193

Danciu DP, Klawe FZ, Kazarnikov A, Femmer L, Kostina E, Martin-Villalba A, Marciniak-Czochra A. (2025)
Unraveling regulatory feedback mechanisms in adult neurogenesis through mathematical modelling.
NPJ Syst Biol Appl. 2025 Jul 26;11(1):82. doi: 10.1038/s41540-025-00563-5. PMID: 40715178

Mertens, C., Reuter, D., Agarvas, A. R., Schenz, J., Winkelhausen, B., Hafner, A., Kahlert, C., Dietrich, M., Fiedler-Kalenka, M. O., Weigand, M. A., Muckenthaler, M. U., & Fischer, D. (2025).
Monocyte iron load correlates with immune suppression and sepsis severity: A longitudinal analysis.
The Journal of infection, 91(6), 106660. doi: 10.1016/j.jinf.2025.106660

Ruban Agarvas, A., Kopf, S., Lopes, T. J. S., Atkins, J. L., Thalmann, P., Fernández-Real, J. M., Nawroth, P., & Muckenthaler, M. U. (2025).
Iron biomarkers predict peripheral artery disease in females.
Atherosclerosis, 402, 119111. doi: 10.1016/j.atherosclerosis.2025.119111

Platten M. (2025).
Isocitrate dehydrogenase mutation and microenvironment in gliomas: do immunotherapy approaches matter?
Current opinion in neurology, 38(6), 706–710. doi: 10.1097/WCO.0000000000001426

Lindner K, Stange SR, Hlawatsch JB, Hamberger M, Boschert T, Tan CL, Hülsmeyer I, Sachse SM, Jünger S, Ernst A, Głatki O, Vinogradova S, Fleischhacker L, Eichmüller SB, Fröhling S, Hassel JC, Zörnig I, Lyu Y, Huang Z, Jäger D, Momburg F, Meyer M, Bunse L, Green EW, Platten M, Poschke I.
ESPEC-SUIT: a versatile and robust platform to identify and track antigen-specific T cell receptors in patients with cancer.
J Immunother Cancer. 2025 Sep 21;13(9):e012216. doi: 10.1136/jitc-2025-012216. PMID: 40983341

Wick W, Lanz LM, Wick A, Harting I, Dettmer S, Suwala AK, Ketter R, Tabatabai G, Seliger C, Glas M, Burger MC, Timmer M, Ringel FA, Mildenberger I, Schulz-Schaeffer WJ, Winkler F, König L, Herold-Mende C, Eisenmenger A, Pfister SM, Renovanz M, Bendszus M, Sahm F, Platten M, Kessler T.
Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N²M² umbrella trial.
Nat Med. 2025 Oct;31(10):3534-3541. doi: 10.1038/s41591-025-03928-9. Epub 2025 Sep 5. PMID: 40913172

Wischnewski, S., Rausch, H. W., Ikenaga, C., Leipe, J., Lloyd, T. E., & Schirmer, L. (2025).
Emerging mechanisms and therapeutics in inflammatory muscle diseases.
Trends in pharmacological sciences, 46(3), 249–263. doi: 10.1016/j.tips.2025.01.005

Kooistra, S. M., & Schirmer, L. (2025).
Multiple Sclerosis: Glial Cell Diversity in Time and Space.
Glia, 73(3), 574–590. doi: 10.1002/glia.24655

Aguzzi, E. A., Desai, R. A., Yang, Z., Davies, A. L., Mahad, D., Siow, B., Yenicelik, A. G., Desai, R., Giama, E., Almasri, A., Colman, M., Geywitz, C., Schirmer, L., Felts, P. A., & Smith, K. J. (2025).
A cause and protective treatment for acute and progressive disability and grey matter atrophy.
Brain : a journal of neurology, awaf465. Advance online publication. doi: 10.1093/brain/awaf465

Sparano C, Solís-Sayago D, Zangger NS, Rindlisbacher L, Van Hove H, Vermeer M, Westermann F, Mussak C, Rallo E, Dergun S, Litscher G, Xu Y, Bijnen M, Friedrich C, Greter M, Juranić Lisnić V, Becher B, Gasteiger G, Oxenius A, Tugues S.
Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells.
J Exp Med. 2025 Mar 3;222(3):e20240930. doi: 10.1084/jem.20240930. Epub 2024 Dec 18. PMID: 39692745

Vermeer, M., Sparano, C., Coianiz, N., Mayoux, M., Litscher, G., Fonseca, A., Dergun, S., Mussak, C., Rindlisbacher, L., Häne, P., Ducimetière, L., Wertheimer, T., Becher, B., Dieterich, L. C., & Tugues, S. (2025).
Tissue localization of natural killer cells dictates surveillance of lung metastasis.
Nature communications, 16(1), 9464. doi: 10.1038/s41467-025-64531-7

2024

Hofmann, A., Krajnc, N., Dal-Bianco, A., Riedl, C. J., Zrzavy, T., Lerma-Martin, C., Kasprian, G., Weber, C. E., Pezzini, F., Leutmezer, F., Rommer, P., Bsteh, G., Platten, M., Gass, A., Berger, T., Eisele, P., Magliozzi, R., Schirmer, L., & Hametner, S. (2023).
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis.
Acta neuropathologica, 146(5), 707–724. doi: 10.1007/s00401-023-02627-4

Lerma-Martin, C., Badia-I-Mompel, P., Ramirez Flores, R. O., Sekol, P., Schäfer, P. S. L., Riedl, C. J., Hofmann, A., Thäwel, T., Wünnemann, F., Ibarra-Arellano, M. A., Trobisch, T., Eisele, P., Schapiro, D., Haeussler, M., Hametner, S., Saez-Rodriguez, J., & Schirmer, L. (2024).
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions.
Nature neuroscience, 27(12), 2354–2365. doi: 10.1038/s41593-024-01796-z

Wischnewski, S., Thäwel, T., Ikenaga, C., Kocharyan, A., Lerma-Martin, C., Zulji, A., Rausch, H. W., Brenner, D., Thomas, L., Kutza, M., Wick, B., Trobisch, T., Preusse, C., Haeussler, M., Leipe, J., Ludolph, A., Rosenbohm, A., Hoke, A., Platten, M., Weishaupt, J. H., … Schirmer, L. (2024).
Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis.
Nature aging, 4(7), 969–983. doi: 10.1038/s43587-024-00645-9

Jeong, M., Cortopassi, F., See, J. X., De La Torre, C., Cerwenka, A., & Stojanovic, A. (2024). Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation. European journal of immunology, 54(7), e2250342. https://doi.org/10.1002/eji.202250342

Giordano FA, Layer JP, Leonardelli S, Friker LL, Turiello R, Corvino D, Zeyen T, Schaub C, Müller W, Sperk E, Schmeel LC, Sahm K, Oster C, Kebir S, Hambsch P, Pietsch T, Bisdas S, Platten M, Glas M, Seidel C, Herrlinger U, Hölzel M.
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial.
Nat Commun. 2024 May 28;15(1):4210. doi: 10.1038/s41467-024-48416-9. PMID: 38806504

Kremer LPM, Cerrizuela S, El-Sammak H, Al Shukairi ME, Ellinger T, Straub J, Korkmaz A, Volk K, Brunken J, Kleber S, Anders S, Martin-Villalba A.
DNA methylation controls stemness of astrocytes in health and ischaemia.
Nature. 2024 Oct;634(8033):415-423. doi: 10.1038/s41586-024-07898-9. Epub 2024 Sep 4. PMID: 39232166

Lorenzo JP, Molla L, Amro EM, Ibarra IL, Ruf S, Neber C, Gkougkousis C, Ridani J, Subramani PG, Boulais J, Harjanto D, Vonica A, Di Noia JM, Dieterich C, Zaugg JB, Papavasiliou FN.
APOBEC2 safeguards skeletal muscle cell fate through binding chromatin and regulating transcription of non-muscle genes during myoblast differentiation.
Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2312330121. doi: 10.1073/pnas.2312330121. Epub 2024 Apr 16. PMID: 38625936

Magg V, Manetto A, Kopp K, Wu CC, Naghizadeh M, Lindner D, Eke L, Welsch J, Kallenberger SM, Schott J, Haucke V, Locker N, Stoecklin G, Ruggieri A.
Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress.
Cell Rep. 2024 Apr 23;43(4):114069. doi: 10.1016/j.celrep.2024.114069. Epub 2024 Apr 10. PMID: 38602876.

Lehmann JA, Lindner D, Sung HM, Stoecklin G. (2024)
E3 ubiquitin ligase RNF10 promotes dissociation of stalled ribosomes and responds to ribosomal subunit imbalance.
Nat Commun. Nov 28;15(1):10350. doi: 10.1038/s41467-024-54411-x. PMID: 39609413

Simats A, Zhang S, Messerer D, Chong F, Beşkardeş S, Chivukula AS, Cao J, Besson-Girard S, Montellano FA, Morbach C, Carofiglio O, Ricci A, Roth S, Llovera G, Singh R, Chen Y, Filser S, Plesnila N, Braun C, Spitzer H, Gokce O, Dichgans M, Heuschmann PU, Hatakeyama K, Beltrán E, Clauss S, Bonev B, Schulz C, Liesz A. (2024) 
Innate immune memory after brain injury drives inflammatory cardiac dysfunction.
Cell. Aug 22;187(17):4637-4655.e26. doi: 10.1016/j.cell.2024.06.028. Epub 2024 Jul 22. PMID: 39043180

Wertheimer T, Zwicky P, Rindlisbacher L, Sparano C, Vermeer M, de Melo BMS, Haftmann C, Rückert T, Sethi A, Schärli S, Huber A, Ingelfinger F, Xu C, Kim D, Häne P, Fonseca da Silva A, Muschaweckh A, Nunez N, Krishnarajah S, Köhler N, Zeiser R, Oukka M, Korn T, Tugues S*#, Becher B*#.
IL-23 stabilizes an effector Treg cell program in the tumor microenvironment.
Nat Immunol. 2024 Mar;25(3):512-524. doi: 10.1038/s41590-024-01755-7. Epub 2024 Feb 14. PMID: 38356059. *equal contribution senior authorship, #corresponding author.

Yang, A. Y., Wistuba-Hamprecht, K., Greten, T. F., & Ruf, B. (2024).
Innate-like T cells in liver disease.
Trends in immunology, 45(7), 535–548. doi: 10.1016/j.it.2024.05.008

Ludwig N, Cucinelli S, Hametner S, Muckenthaler MU, Schirmer L.
Iron scavenging and myeloid cell polarization.
Trends Immunol. 2024 Jul 24:S1471-4906(24)00155-8. doi: 10.1016/j.it.2024.06.006. Online ahead of print.PMID: 39054114 Free article. Review.

Hofman T, Ng SW, Garcés-Lázaro I, Heigwer F, Boutros M, Cerwenka A.
IFNγ mediates the resistance of tumor cells to distinct NK cell subsets.
J Immunother Cancer. 2024 Jul 1;12(7):e009410. doi: 10.1136/jitc-2024-009410.PMID: 38955423 

Jeong M, Cortopassi F, See JX, De La Torre C, Cerwenka A, Stojanovic A.
Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation.
Eur J Immunol. 2024 Jul;54(7):e2250342. doi: 10.1002/eji.202250342. Epub 2024 Apr 9.PMID: 38593338

Lisa-Marie Rieckmann, Michael Spohn, Lisa Ruff, David Agorku, Lisa Becker, Alina Borchers, Jenny Krause, Roisin O’Reilly, Jurek Hille, Janna-Lisa Velthaus-Rusik, Niklas Beumer, Armin Günther, Lena Willnow, Charles D. Imbusch, Peter Iglauer, Ronald Simon, Sören Franzenburg, Hauke Winter, Michael Thomas, Carsten Bokemeyer, Nicola Gagliani, Christian F. Krebs, Martin Sprick, Olaf Hardt, Sabine Riethdorf, Andreas Trumpp, Nikolas H. Stoecklein, Sven Peine, Philipp Rosenstiel, Klaus Pantel, Sonja Loges & Melanie Janning.
Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells.
Mol Cancer 23, 93 (2024). https://doi.org/10.1186/s12943-024-01984-2

C.L. Tan, K. Lindner, T. Boschert, Z. Meng, A. Rodriguez Ehrenfried, A. De Roia, G. Haltenhof, A. Faenza, F. Imperatore, L. Bunse, J.M. Lindner, R.P. Harbottle, M. Ratliff, R. Offringa, I. Poschke, M. Platten and E.W. Green:
Tumor-reactive T-cell receptors are rapidly identified from lymphocyte scRNA-seq data.
Nature Biotechnology 2024, DOI: 10.1038/s41587-024-02161-y

Kilian M, Friedrich MJ, Lu KH, Vonhören D, Jansky S, Michel J, Keib A, Stange S, Hackert N, Kehl N, Hahn M, Habel A, Jung S, Jähne K, Sahm F, Betge J, Cerwenka A, Westermann F, Dreger P, Raab MS, Meindl-Beinker NM, Ebert M, Bunse L, Müller-Tidow C, Schmitt M, Platten M.
The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance
Sci Immunol. 2024 May 3;9(95):eadj7970. doi: 10.1126/sciimmunol.adj7970. Epub 2024 May 3. PMID: 38701193.

Natalie K Horvat, Sara Chocarro, Oriana Marques, Tobias A Bauer, Ruiyue Qiu, Alberto Diaz-Jimenez, Barbara Helm, Yuanyuan Chen, Stefan Sawall, Richard Sparla, Lu Su, Ursula Klingmüller, Matthias Barz, Matthias W Hentze, Rocío Sotillo, Martina U Muckenthaler.
Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment.
ACS Nano. 2024 Apr 16. doi: 10.1021/acsnano.3c08335. Online ahead of print PMID: 38626916 doi: 10.1021/acsnano.3c08335.

Weidner P, Saar D, Söhn M, Schroeder T, Yu Y, Zöllner FG, Ponelies N, Zhou X, Zwicky A, Rohrbacher FN, Pattabiraman VR, Tanriver M, Bauer A, Ahmed H, Ametamey SM, Riffel P, Seger R, Bode JW, Wade RC, Ebert MPA, Kragelund BB, Burgermeister E.
Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
Cancer Lett. 2024 Mar 8:216783. doi: 10.1016/j.canlet.2024.216783. Online ahead of print. PMID: 38462034.

Velásquez, S. Y., Baslar, G. E., Schulte, J., Fuderer, T., Lindner, H. A., & Coulibaly, A. (2024).
Downregulation of hypoxia inducible factor-1α in primary human natural killer cells using small interfering RNA delivery with ExPERT ATx by MaxCyte.
Current Protocols, 4, e987. doi: 10.1002/cpz1.987

Yu Y, Farooq MS, Eberhart Meessen S, Jiang Y, Kato D, Zhan T, Weiss C, Seger R, Kang W, Zhang X, Yu J, Ebert MPA, Burgermeister E.
Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ.
Cell Death Dis. 2024 Jan 4;15(1):7. doi: 10.1038/s41419-023-06371-1.

2023

Carvajal Ibañez D, Skabkin M, Hooli J, Cerrizuela S, Göpferich M, Jolly A, Volk K, Zumwinkel M, Bertolini M, Figlia G, Höfer T, Kramer G, Anders S, Teleman AA, Marciniak-Czochra A, Martin-Villalba A.
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle.
EMBO Mol Med. 2023 Apr 11;15(4):e16434. doi: 10.15252/emmm.202216434. Epub 2023 Jan 13. PMID: 36636818

Balzasch BM, Cerwenka A.(2023)
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Sung HM, Schott J, Boss P, Lehmann JA, Hardt MR, Lindner D, Messens J, Bogeski I, Ohler U, Stoecklin G.
Stress-induced nuclear speckle reorganization is linked to activation of immediate early gene splicing.
J Cell Biol. 2023 Dec 4;222(12):e202111151. doi: 10.1083/jcb.202111151. Epub 2023 Nov 13. PMID: 37956386

Kilian M*, Sheinin R*, Tan CL, Krämer C, Friedrich M, Kaminitz A, Sanghvi K, Lindner K, Chih YC, Cichon F, Richter B, Jung S, Jähne K, Ratliff M, Prins R, Etminan N, von Deimling A, Wick W, Madi A*, Bunse L*, Platten M*.
MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors.
Cancer Cell. 2023. 41(2):235-251.e9. doi: 10.1016/j.ccell.2022.12.007. Epub 2023 Jan 12. *equal contribution.

Krämer C*, Kilian M*, Chih YC, Kourtesakis A, Hoffmann DC, Boschert T, Koopmann P, Sanghvi K, De Roia A, Jung S, Jähne K, Day B, Shultz LD, Ratliff M, Harbottle R, Green EW, Will R, Wick W, Platten M, Bunse L.
NLGN4X TCR transgenic T cells to treat gliomas.
Neuro Oncol. 2024 Sep 16:noad172. doi: 10.1093/neuonc/noad172. Epub 2023 Sep 16. 

Zhao B, Kilian M, Bunse T, Platten M, Bunse L.
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Cancer Cell. 2023. 41(11):1829-1834. doi: 10.1016/j.ccell.2023.09.013. Epub 2023 Oct 19. Commentary

Papaioannou S, See JX, Jeong M, De La Torre C, Ast V, Reiners-Koch PS, Sati A, Mogler C, Platten M, Cerwenka A, Stojanovic A:
Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury.
Cell Rep. 2023 Aug 29;42(8):112836. doi: 10.1016/j.celrep.2023.112836. Epub 2023 Jul 19.PMID: 37471222

Burgermeister E.
Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy.
Int J Mol Sci. 2023 Sep 4;24(17):13661. doi: 10.3390/ijms241713661

Burgermeister E.
Mitogen-Activated Protein Kinase and Exploratory Nuclear Receptor Crosstalk in Cancer Immunotherapy.
Int J Mol Sci. 2023 Sep 26;24(19):14546. doi: 10.3390/ijms241914546.

2022

Lu K, Michel J, Kilian M, Aslan K, Qi H, Kehl N, Jung S, Sanghvi K, Lindner K, Zhang XW, Green EW, Poschke I, Ratliff M, Bunse T, Sahm F, von Deimling A, Wick W, Platten M, Bunse L*. T cell receptor dynamic and transcriptional determinants of T cell expansion in glioma-infiltrating T cells. Neuro-Oncol Adv. 2022. 4(1):vdac140 doi:10.1093/noajnl/vdac140 eCollection 2022 Jan-Dec.

Thomann AK, Wüstenberg T, Wirbel J, Knoedler LL, Thomann PA, Zeller G, Ebert MP, Lis S, Reindl W.
Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
BMC Med. 2022 Oct 17;20(1):366. doi: 10.1186/s12916-022-02550-7.

Hinsenkamp I, Köhler JP, Flächsenhaar C, Hitkova I, Meessen SE, Gaiser T, Wieland T, Weiss C, Röcken C, Mowat M, Quante M, Taxauer K, Mejias-Luque R, Gerhard M, Vogelmann R, Meindl-Beinker N, Ebert M, Burgermeister E.
Functional antagonism between CagA and DLC1 in gastric cancer.
Cell Death Discov. 2022 Aug 13;8(1):358. doi: 10.1038/s41420-022-01134-x.

Ebert MP, Meindl-Beinker NM, Gutting T, Maenz M, Betge J, Schulte N, Zhan T, Weidner P, Burgermeister E, Hofheinz R, Vogel A, Angermeier S, Bolling C, de Wit M, Jakobs R, Karthaus M, Stocker G, Thuss-Patience P, Leidig T, Gaiser T, Kather JN, Haertel N.
Second-line therapy with nivolumab plus ipilimumab for older patients with oesophageal squamous cell cancer (RAMONA): a multicentre, open-label phase 2 trial.
Lancet Healthy Longev. 2022 Jun;3(6):e417-e427. doi: 10.1016/S2666-7568(22)00116-7.

Betge J, Rindtorff N, Sauer J, Rauscher B, Dingert C, Gaitantzi H, Herweck F, Srour-Mhanna K, Miersch T, Valentini E, Boonekamp KE, Hauber V, Gutting T, Frank L, Belle S, Gaiser T, Buchholz I, Jesenofsky R, Härtel N, Zhan T, Fischer B, Breitkopf-Heinlein K, Burgermeister E, Ebert MP, Boutros M.
The drug-induced phenotypic landscape of colorectal cancer organoids.
Nat Commun. 2022 Jun 6;13(1):3135. doi: 10.1038/s41467-022-30722-9.

Lerma-Martin C, Badia-i-Mompel P, Ramirez Flores RO, Sekol P, Hofmann A, Thäwel T, Riedl CJ, Wünnemann F, Ibarra-Arellano MA, Trobisch T, Eisele P, Schapiro D, Haeussler M, Hametner S, Saez-Rodriguez J, Schirmer L.
Spatial cell type mapping of multiple sclerosis lesions.
bioRxiv preprint. 2022 Nov 3. doi: 10.1101/2022.11.03.514906