Sie befinden sich hier

Inhalt

FOR 2690 Project-related Publications, funded

(*FOR 2690 Project-related Publications, not funded)

2022

  • Pereira MP, Zeidler C, Ständer S. Improvement of chronic nodular prurigo with baricitinib. J Eur Acad Dermatol Venereol 2022, doi: 10.1111/jdv.17991.
  • Pereira MP, Görg M, Zeidler C, Ständer S. Periumbilical neuropathic pruritus in an infant: Presentation of a spinal intramedullary neoplasm. J Eur Acad Dermatol Venereol 2022; 36: e132-e133.
  • Gray N, Limberg MM, Bräuer AU, Raap U. (2022) Novel functions of S1P in chronic itchy and inflammatory skin diseases. J Eur Acad Dermatol Venereol. 2022 Mar;36(3):365-372. doi: 10.1111/jdv.17764. Epub 2021 Nov 12.

2021

  • Pereira MP, Zeidler C, Ständer S. Improvement of Chronic Kidney Disease-Associated Pruritus After Treatment With Intravenous Naloxone. JAMA Dermatol 2021; 157: 1380-1381.
  • Schneider S, Zeidler C, Pereira MP, Ständer S. One-third of chronic prurigo patients scratch automatically and in the absence of itch – a naturalistic study of 1142 patients. J Eur Acad Dermatol Venereol 2021, doi: 10.1111/jdv.17777.
  • Nau T, Rau V, Zeidler C, Ständer S, Pereira MP. Hand pruritus: clinical profile, functional impairment and disease-related burden. A prospective cohort study of 395 patients. Acta Derm Venereol 2021; 101: adv00562.
  • Pereira MP, Farcas A, Zeidler C, Ständer S. Chronic pruritus of unknown origin: Clinical profile and disease related burden. Acta Derm Venereol 2021; 101: adv00550.
  • Reinhart M, Koschmieder S, Ständer S, Pereira MP. Persistent erythema and aquagenic pruritus: A quiz. J Dtsch Dermatol Ges 2021, in press.
  • Pereira MP, Wiegmann H, Agelopoulos K, Ständer S. Neuropathic Itch: Routes to Clinical Diagnosis. Front Med (Lausanne) 2021; 8: 641746.
  • Ständer S, Sun YG, Schmelz M. Editorial: Pruritus Medicine. Front Med (Lausanne). 2021 Sep 28;8:763667.
  • Schmelz M. How Do Neurons Signal Itch? Front Med (Lausanne). 2021 Mar 15;8:643006.
  • Ruppenstein A, Limberg MM, Loser K, Kremer AE, Homey B, Raap U. Involvement of Neuro-Immune Interactions in Pruritus With Special Focus on Receptor Expressions. Front Med (Lausanne) 2021; 8: 627985
  • Solinski HJ, Rukwied R. Electrically Evoked Itch in Human Subjects. Front Med (Lausanne) 2021; 7: 627617.
  • Wolf K, Kühn H, Boehm F, Gebhardt L, Glaudo M, Agelopoulos K, Ständer S, Ectors P, Zahn D, Riedel YK, Thimm D, Müller CE, Kretschmann S, Kremer AN, Chien D, Limjunyawong N, Peng Q, Dong X, Kolkhir P, Scheffel J, Søgaard ML, Weigmann B, Neurath MF, Hawro T, Metz M, Fischer MJM, Kremer AE. A Group of Cationic Amphiphilic Drugs Activates MRGPRX2 and Induces Scratching Behavior in Mice. Journal of Allergy and Clinical Immunology 2021; S0091-6749(21)00229-3. Epub ahead of print.
  • Kühn H, Kolkhir P, Babina M, Düll M, Frischbutter S, Fok JS, Jiao Q, Metz M, Scheffel J, Wolf K, Kremer AE, Maurer M. Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies. Journal of Allergy and Clinical Immunology 2021; 147: 456–469.
  • Nemmer JM, Kuchner M, Datsi A, Oláh P, Julia V, Raap U, Homey B. (2021) Interleukin-31 Signaling Bridges the Gap Between Immune Cells, the Nervous System and Epithelial Tissues. Review Front Med (Lausanne). 2021 Feb 10;8:639097.doi: 10.3389/fmed.2021.639097 . eCollection 2021
  • Kleiner S, Rüdrich U, Gehring M, Loser K, Eiz-Vesper B, Noubissi Nzeteu G, Patsinakidis N, Meyer NH, Gibbs BF, Raap U (2021) Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte-stimulating hormone. J Allergy Clin Immunol. 2021 Jan 15;S0091-6749(21)00009-9.doi: 10.1016/j.jaci.2020.12.645 . Online ahead of print.
  • Klein A, Solinski HJ, Malewicz NM, Ieong HF, Sypek EI, Shimada SG, Hartke TV, Wooten M, Wu G, Dong X, Hoon MA, LaMotte RH, Ringkamp M. Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates. Elife. 2021 Apr 23;10:e64506*
  • Baumeister J, Chatain N, Sofias AM, Lammers T, Koschmieder S. Progression of Myeloproliferative Neoplasms (MPN): Diagnostic and Therapeutic Perspectives. Cells. 2021 Dec 16;10(12):3551*
  • Alvarez-Larrán A, Sant'Antonio E, Harrison C, Kiladjian JJ, Griesshammer M, Mesa R, Ianotto JC, Palandri F, Hernández-Boluda JC, Birgegård G, Nangalia J, Koschmieder S, Rumi E, Barbui T. Unmet clinical needs in the management of CALR-mutated essential thrombocythaemia: a consensus-based proposal from the European LeukemiaNet. Lancet Haematol. 2021 Sep;8(9):e658-e665*
  • Tillmann S, Olschok K, Schröder SK, Bütow M, Baumeister J, Kalmer M, Preußger V, Weinbergerova B, Kricheldorf K, Mayer J, Kubesova B, Racil Z, Wessiepe M, Eschweiler J, Isfort S, Brümmendorf TH, Becker W, Schemionek M, Weiskirchen R, Koschmieder S, Chatain N. The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR-ABL- and JAK2V617F-Positive MPN. Cancers (Basel). 2021 Aug 21;13(16):4210*
  • Gecht J, Tsoukakis I, Kricheldorf K, Stegelmann F, Klausmann M, Griesshammer M, Schulz H, Hollburg W, Göthert JR, Sockel K, Heidel FH, Gattermann N, Maintz C, Al-Ali HK, Platzbecker U, Hansen R, Hänel M, Parmentier S, Bommer M, Pahl HL, Lang F, Kirschner M, Isfort S, Brümmendorf TH, Döhner K, Koschmieder S. Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry. Cancers (Basel). 2021 Aug 13;13(16):4086*
  • Elbracht M, Meyer R, Kricheldorf K, Gezer D, Thomas E, Betz B, Kurth I, Teichmann LL, Brümmendorf TH, Germing U, Isfort S, Koschmieder S. Germline variants in DNA repair genes, including BRCA1/2, may cause familial myeloproliferative neoplasms. Blood Adv. 2021 Sep 14;5(17):3373-3376*
  • Olschok K, Han L, de Toledo MAS, Böhnke J, Graßhoff M, Costa IG, Theocharides A, Maurer A, Schüler HM, Buhl EM, Pannen K, Baumeister J, Kalmer M, Gupta S, Boor P, Gezer D, Brümmendorf TH, Zenke M, Chatain N, Koschmieder S. CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes. Stem Cell Reports. 2021 Nov 9;16(11):2768-2783*
  • Baumeister J, Maié T, Chatain N, Gan L, Weinbergerova B, de Toledo MAS, Eschweiler J, Maurer A, Mayer J, Kubesova B, Racil Z, Schuppert A, Costa I, Koschmieder S, Brümmendorf TH, Gezer D. Early and late stage MPN patients show distinct gene expression profiles in CD34<sup>+</sup> cells. Ann Hematol. 2021 Dec;100(12):2943-2956*
  • Rao TN, Hansen N, Stetka J, Luque Paz D, Kalmer M, Hilfiker J, Endele M, Ahmed N, Kubovcakova L, Rybarikova M, Hao-Shen H, Geier F, Beisel C, Dirnhofer S, Schroeder T, Brümmendorf TH, Wolf D, Koschmieder S, Skoda RC. JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality. Blood. 2021 Apr 22;137(16):2139-2151*
  • Toledo MAS, Gatz M, Sontag S, Gleixner KV, Eisenwort G, Feldberg K, Hamouda AEI, Kluge F, Guareschi R, Rossetti G, Sechi AS, Dufva OMJ, Mustjoki SM, Maurer A, Schüler HM, Goetzke R, Braunschweig T, Kaiser A, Panse J, Jawhar M, Reiter A, Hilberg F, Ettmayer P, Wagner W, Koschmieder S, Brümmendorf TH, Valent P, Chatain N, Zenke M. Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis. Blood. 2021 Apr 15;137(15):2070-2084*

2020

  • Rukwied R, Schnakenberg M, Solinski HJ, Schmelz M, Weisshaar E. Transcutaneous slowly depolarizing currents elicit pruritus in patients with atopic dermatitis. Acta Derm Venereol 2020; 100: 1–6.
  • Schmelz M, Ständer S. Pruritusmedizin – Austausch der Disziplinen [Pruritusmedicine-interdisciplinary exchange]. Hautarzt. 2020 Jul;71(7):485-486.
  • Ständer S, Schmelz M. Neuropathischer Pruritus [Neuropathic pruritus]. Schmerz. 2020 Dec;34(6):525-535.
  • Mettang T, Kremer AE. Brain teasers in pruritus—when laboratory tests will guide you. Hautarzt 2020; 71: 500–505.
  • Schmelz M. Pruritus - a long journey from neurophysiology to the clinic. Hautarzt 2020; 71: 487–492.
  • Rukwied R, Thomas C, Obreja O, Werland F, Kleggetveit IP, Jorum E, Carr RW, Namer B, Schmelz M. Slow depolarizing stimuli differentially activate mechanosensitive and silent C nociceptors in human and pig skin. Pain 2020; 161: 2119–2128.
  • Schmelz M. Pruritus – ein weiter Weg von der Neurophysiologie zur Klinik [Pruritus-a long journey from neurophysiology to the clinic]. Hautarzt. 2020Jul;71(7):487-492.
  • Kühn H, Kappes L, Wolf K, Gebhardt L, Neurath MF, Reeh P, Fischer MJM, Kremer AE. Complementary roles of murine NaV1.7, NaV1.8 and NaV1.9 in acute itch signalling. Sci Rep 2020; 10: 2326.
  • Guseva D, Rüdrich U, Kotnik N, Gehring M, Patsinakidis N, Agelopoulos K, Ständer S, Homey B, Kapp A, Gibbs BF, Ponimaskin E, Raap U. Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis. Clin Exp Allergy 2020; 50: 577–584.
  • Kremer AE, Mettang T, Weisshaar E. Non-dermatological challenges of chronic itch. Acta Dermato-Venereologica 2020; 100: 22–27.
  • Pereira MP, Derichs L, Meyer Zu Hörste G, Agelopoulos K, Ständer S. Generalized chronic itch induced by small-fibre neuropathy: clinical profile and proposed diagnostic criteria. J Eur Acad Dermatology Venereol 2020; 34: 1795–1802.
  • Pereira MP, Zeidler C, Storck M, Agelopoulos K, Philipp-Dormston WG, Zink A, Ständer S. Challenges in Clinical Research and Care in Pruritus. Acta Derm Venereol 2020; 100: adv00028.
  • Pogatzki-Zahn EM, Pereira MP, Cremer A, Zeidler C, Dreyer T, Riepe C, Wempe C, Lotts T, Segelcke D, Ringkamp M, Kremer AE, Agelopoulos K, Ständer S.. Peripheral Sensitization and Loss of Descending Inhibition Is a Hallmark of Chronic Pruritus. J Invest Dermatol 2020; 140: 203-211.e4.
  • Chatain N, Koschmieder S, Jost E. Role of Inflammatory Factors during Disease Pathogenesis and Stem Cell Transplantation in Myeloproliferative Neoplasms. Cancers (Basel). 2020 Aug 12;12(8):2250*
  • Gupta V, Wolleschak D, Hasselbalch H, Vannucchi AM, Koschmieder S, Cervantes F, Li Y, Dong T, Wroclawska M, Bharathy S, Harrison C. Safety and efficacy of the combination of sonidegib and ruxolitinib in myelofibrosis: a phase 1b/2 dose-finding study. Blood Adv. 2020 Jul 14;4(13):3063-3071*
  • Koschmieder S, Jost E, Cornelissen C, Müller T, Schulze-Hagen M, Bickenbach J, Marx G, Kleines M, Marx N, Brümmendorf TH, Dreher M. Favorable COVID-19 course despite significant comorbidities in a ruxolitinib-treated patient with primary myelofibrosis. Eur J Haematol. 2020 Nov;105(5):655-658*
  • Koschmieder S, Chatain N. Role of inflammation in the biology of myeloproliferative neoplasms. Blood Rev. 2020 Jul;42:100711*
  • Crodel CC, Jentsch-Ullrich K, Koschmieder S, Kämpfe D, Griesshammer M, Döhner K, Jost PJ, Wolleschak D, Isfort S, Stegelmann F, Jilg S, Hofmann V, Auteri G, Rachow T, Ernst P, Brioli A, von Lilienfeld-Toal M, Hochhaus A, Palandri F, Heidel FH. Frequency of infections in 948 MPN patients: a prospective multicenter patient-reported pilot study. Leukemia. 2020 Jul;34(7):1949-1953*
  • Koschmieder S. How I Manage Thrombotic/Thromboembolic Complications in Myeloproliferative Neoplasms. Hamostaseologie. 2020 Feb;40(1):47-53*
  • Baumeister J, Chatain N, Hubrich A, Maié T, Costa IG, Denecke B, Han L, Küstermann C, Sontag S, Seré K, Strathmann K, Zenke M, Schuppert A, Brümmendorf TH, Kranc KR, Koschmieder S, Gezer D. Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms. Leukemia. 2020 Apr;34(4):1062-1074*
  • Ma G, Gezer D, Herrmann O, Feldberg K, Schemionek M, Jawhar M, Reiter A, Brümmendorf TH, Koschmieder S, Chatain N. LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia. Mol Carcinog. 2020 Jan;59(1):87-103*

2019

  • ​Kremer AE. What are new treatment concepts in systemic itch? Experimental Dermatology 2019; 28: 1485–1492.
  • Yosipovitch G, Misery L, Proksch E, Metz M, Ständer S, Schmelz M. Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions. Acta Derm Venereol. 2019 Dec 1;99(13):1201-1209.
  • Agelopoulos K, Rülander F, Dangelmaier J, Lotts T, Osada N, Metze D, Luger TA, Loser K, Ständer S. Neurokinin 1 receptor antagonists exhibit peripheral effects in prurigo nodularis including reduced ERK1/2 activation. J Eur Acad Dermatology Venereol 2019; 33: 2371–2379.
  • Süer A, Soto Rey, I, Storck M, Pereira MP, Agelopoulos K, Ständer S, Dugas M, Bruland P. Standardbasierte vernetzte IT-Infrastruktur zur multizentrischen und multidisziplinären Verwaltung von Forschungsdaten – Integration im Rahmen der DFG-geförderten Forschergruppe „PruSearch. Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie. 64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS). Dortmund, 08.-11.09.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocAbstr. 179.
  • Kremer AE, Mettang T. Pruritus in systemic diseases: Common and rare etiologies. Internist 2019; 60: 814–820.Düll M, Kremer AE. Treatment of Pruritus Secondary to Liver Disease. Current Gastroenterology Reports 2019;21: 48.
  • Schmid Y, Navarini A, Thomas ZM, Pfleiderer B, Krähenbühl S, Mueller SM. Sex differences in the pharmacology of itch therapies—a narrative review. Current Opinion in Pharmacology 2019; 46: 122–142.
  • Pereira MP, Agelopoulos K, Köllner J, Neufang G, Schmelz M, Ständer S. Selective nerve fibre activation in patients with generalized chronic pruritus: Hint for central sensitization? Acta Derm Venereol 2019; 99: 1009–1015.
  • Schmelz Martin. Itch Processing in the Skin. Front Med 2019; 6: 167.
  • Gibbs BF, Patsinakidis N, Raap U. Role of the pruritic cytokine IL-31 in autoimmune skin diseases. Frontiers in Immunology 2019; 10: 1383
  • Hidding J, Agelopoulos K, Pereira MP, Conrad H, Hatt H, Lotts T, Osada N, Pogatzki-Zahn E, Schmelz M, Ständer S. Sensory qualities point to different structural and functional skin patterns in chronic pruritus patients. A translational explorative study. Acta Derm Venereol 2019; 99: 668–674.
  • Ständer Sonja. How to define chronic pruritus: Symptom or disease? Exp Dermatol 2019; 28: 1461–1465.
  • Steinhoff M, Oaklander AL, Szabó IL, Ständer S, Schmelz M. Neuropathic itch. Pain 2019; 160: S11–S16.
  • Robering JW, Gebhardt L, Wolf K, Kühn H, Kremer AE, Fischer MJM. Lysophosphatidic acid activates satellite glia cells and Schwann cells. Glia 2019; 67: 999–1012.
  • Baumann KY, Church MK, Clough GF, Quist SR, Schmelz M, Skov PS, Anderson CD, Tannert LK, Giménez-Arnau AM, Frischbutter S, Scheffel J, Maurer M. Skin microdialysis: Methods, applications and future opportunities - An EAACI position paper. Clinical and Translational Allergy 2019; 9: 24.
  • Tsianakas A, Nippe N, Hamper CM, Cordes AF, Zeidler C, Schmelz M, Ständer S. Exploratory study of intracutaneous histamine stimulation in patient populations with chronic pruritus. Acta Derm Venereol 2019; 99: 291–297.
  • Meyer NH, Kotnik N, Meyer V, Gibbs BF, Raap U (2019) The Complexity of Pruritus Requires a Variety of Treatment Strategies. Current Treatment Options in Allergy September 2019, Volume 6, Issue 3, pp 189–199.
  • Solinski HJ, Dranchak P, Oliphant E, Gu X, Earnest TW, Braisted J, Inglese J,Hoon MA. Inhibition of natriuretic peptide receptor 1 reduces itch in mice. SciTransl Med. 2019 Jul 10;11(500):eaav5464*
  • Solinski HJ, Kriegbaum MC, Tseng PY, Earnest TW, Gu X, Barik A, Chesler AT, Hoon MA. Nppb Neurons Are Sensors of Mast Cell-Induced Itch. Cell Rep. 2019 Mar 26;26(13):3561-3573.e4*
  • Rao TN, Hansen N, Hilfiker J, Rai S, Majewska JM, Leković D, Gezer D, Andina N, Galli S, Cassel T, Geier F, Delezie J, Nienhold R, Hao-Shen H, Beisel C, Di Palma S, Dimeloe S, Trebicka J, Wolf D, Gassmann M, Fan TW, Lane AN, Handschin C, Dirnhofer S, Kröger N, Hess C, Radimerski T, Koschmieder S, Čokić VP, Skoda RC. JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood. 2019 Nov 21;134(21):1832-1846*
  • Schubert C, Allhoff M, Tillmann S, Maié T, Costa IG, Lipka DB, Schemionek M, Feldberg K, Baumeister J, Brümmendorf TH, Chatain N, Koschmieder S. Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha. J Hematol Oncol. 2019 Apr 2;12(1):36*
  • Czech J, Cordua S, Weinbergerova B, Baumeister J, Crepcia A, Han L, Maié T, Costa IG, Denecke B, Maurer A, Schubert C, Feldberg K, Gezer D, Brümmendorf TH, Müller-Newen G, Mayer J, Racil Z, Kubesova B, Knudsen T, Sørensen AL, Holmström M, Kjær L, Skov V, Larsen TS, Hasselbalch HC, Chatain N, Koschmieder S.cJAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation. Leukemia. 2019 Apr;33(4):995-1010*

2018

  • Pereira MP, Mittal A, Ständer S. Current treatment strategies in refractory chronic pruritus. Current Opinion in Pharmacology 2018; 46: 1–6.
  • Steinhoff M, Schmelz M, Szabó IL, Oaklander AL. Clinical presentation, management, and pathophysiology of neuropathic itch. The Lancet Neurology 2018; 17: 709–720.
  • Meyer NH, Gibbs B, Schmelz M, Homey B, Raap U. Neurophysiologie des atopischen Pruritus. Hautarzt 2018; 69: 204–209.
  • Pereira MP, Agelopoulos K, Kremer AE, Schmelz M. Aktuelles zur Neurobiologie von Pruritus [New findings regarding the neurobiology of pruritus]. Hautarzt. 2018 Aug;69(8):620-625.
  • Huang J, Polgár E, Solinski HJ, Mishra SK, Tseng PY, Iwagaki N, Boyle KA, Dickie AC, Kriegbaum MC, Wildner H, Zeilhofer HU, Watanabe M, Riddell JS, Todd AJ, Hoon MA. Author Correction: Circuit dissection of the role of somatostatin in itch and pain. Nat Neurosci. 2018 Jun;21(6):894*
  • Couban S, Benevolo G, Donnellan W, Cultrera J, Koschmieder S, Verstovsek S, Hooper G, Hertig C, Tandon M, Dimier N, Malhi V, Passamonti F. A phase Ib study to assess the efficacy and safety of vismodegib in combination with ruxolitinib in patients with intermediate- or high-risk myelofibrosis. J Hematol Oncol. 2018 Sep 24;11(1):122*
  • Lubberich RK, Walenda T, Goecke TW, Strathmann K, Isfort S, Brümmendorf TH, Koschmieder S, Wagner W. Serum of myeloproliferative neoplasms stimulates hematopoietic stem and progenitor cells. PLoS One. 2018 May 31;13(5):e0197233*
  • Barbui T, Tefferi A, Vannucchi AM, Passamonti F, Silver RT, Hoffman R, Verstovsek S, Mesa R, Kiladjian JJ, Hehlmann R, Reiter A, Cervantes F, Harrison C, Mc Mullin MF, Hasselbalch HC, Koschmieder S, Marchetti M, Bacigalupo A, Finazzi G, Kroeger N, Griesshammer M, Birgegard G, Barosi G. Philadelphia chromosome-negative classical myeloproliferative neoplasms: revised management recommendations from European LeukemiaNet. Leukemia. 2018 May;32(5):1057-1069*

Kontextspalte