Angiorythms in Health and Disease

Research Focus

Mechanism-guided targeting of angiocrine signals to limit metastatic progression

Vascular endothelium instructs the formation of a conducive premetastatic niche to allow incoming malignant cells to colonize a distant organ. Interrogating crosstalk between endothelial cells and the rest of the stromal cells (immune and mesenchymal cells), we identify therapeutic vulnerabilities to limit metastatic progression.

Vascular rhythms in health and disease

Earth’s rotation imposes a daily day-night cycle generating physiological rhythms including awake-sleep and feeding-fasting, thereby necessitating endogenous circadian clock across all organs in our body. Taking a systems biology approach, we interrogate the influence of vascular rhythms on sustaining diurnally oscillatory homeostatic organ function and in pruning microenvironmental response to disease progression.