Sie befinden sich hier

Inhalt

Publications

2018

Arnold, C., Demirel, E., Feldner, A., Genové, G., Zhang, H., Sticht, C., Wieland, T., Hecker, M., Heximer, S. & Korff, T. (2018) Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J., 32, 2021-2035

Zhao, Z., Lan, H., El-Battrawy, I., Li, X., Buljubasic, F., Sattler, K.  Yücel, G., Lang, S., Tiburcy, M., Zimmermann, W. H., Cyganek, L., Utikal , J., Wieland, T., Borggrefe, M., Zhou X.-B. & Akin, I. (2018) Ion channel expression and characterization in human induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Int, 2018, 6067096

Schrade, K,. Tröger, J., Eldahshan, A., Zühlke, K., Abdul Azeez, K. R., Elkins, J. M., Neuenschwander, M., Oder, A., Elkewedi, M., Jaksch, S., Andrae, K., Li, J., Fernandes, J., Müller, P. M., Grunwald, S., Marino, S. F., Vukićević, T., Eichhorst, J., Wiesner, B., Weber, M., Kapiloff, M., Rocks, O., Daumke, O., Wieland, T., Knapp, S., von Kries, J. P. & Klussmann, E. (2018) An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. PLoS One., 13, e0191423

El-Battrawy, I., Zhao, Z., Lan, H., Li, X., Yücel, G., Lang, S., Sattler, K., Schünemann, J. D., Zimmermann, W. H., Cyganek, L., Utikal, J., Wieland, T., Bieback, K., Bauer, R., Ratte, A., Pribe-Wolferts, R., Rapti, K., Nowak, D., Wittig, J., Thomas, D., Most, P., Katus, H. A., Ravens, U., Schmidt, C., Borggrefe, M., Zhou, X. B., Müller, O. J. & Akin, I. (2018) Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy. Circ Genom Precis Med., 11, e001893

El-Battrawy, I., Zhao, Z., Lan, H., Cyganek, L., Tombers, C., Li, X., Buljubasic, F., Lang, S., Tiburcy, M., Zimmermann, W. H., Utikal, J., Wieland, T., Borggrefe, M., Zhou, X. B. & Akin, I. (2018) Electrical dysfunctions in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with an arrhythmogenic right ventricular cardiomyopathy. Europace., doi: 10.1093/europace/euy042.

El-Battrawy, I., Lan, H., Cyganek, L., Zhao, Z., Li, X., Buljubasic, F., Lang, S., Yücel, G., Sattler, K., Zimmermann, W. H., Utikal, J., Wieland, T., Ravens, U., Borggrefe, M., Zhou, X. B. & Akin, I. (2018) Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. J Am Heart Assoc., 7, pii: e007394

Toth D. A., Schell R., Levay M., Vettel C., Theis P., Haslinger, C., Alban, F., Werhahn, S., Frischbier, L., Krebs-Haupenthal, J., Thomas, D., Gröne, H. J., Avkiran, M., Katus H. A., Wieland, T. & Backs, J. (2018) Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes. EMBO Mol. Med., DOI:10.15252/emmm.201708536

2017

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz C, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 2017 Feb 28;135(9):881-897

Beck SC, Feng Y, Sothilingam V, Garcia Garrido M, Tanimoto N, Acar N, Shan S, Seebauer B, Berger W, Hammes HP, Seeliger MW. Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease. PLoS One. 2017 Jun 2;12(6):e0178753.

Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 2017 May;10(5):e003840.

Garg J, Feng YX, Jansen SR, Friedrich J, Lezoualc'h F, Schmidt M, Wieland T. Catecholamines facilitate VEGF-dependent angiogenesis via β2-adrenoceptor-induced Epac1 and PKA activation. Oncotarget. 2017 Jul 4;8(27):44732-44748

Gross S, Devraj K, Feng Y, Macas J, Liebner S, Wieland T. Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation. J Cereb Blood Flow Metab. 2017 Jul;37(7):2471-2484.

Jansen S, Gosens R, Wieland T, Schmidt M. Paving the Rho in cancer metastasis: Rho GTPases and beyond. Pharmacol Ther. 2017 Sep 11. pii: S0163-7258(17)30236-X. doi: 10.1016/j.pharmthera.2017.09.002. [Epub ahead of print] Review.

Lemmer B, The Circadian Clock is Now Ticking Even in Stockholm - Nobel Prize in Medicine 2017. Dtsch Med Wochenschr. 2017 Dec;142(25):1897-1900.

Lemmer B, Signal Transduction and Chronopharmacology of Regulation of Circadian Cardiovascular Rhythms in Animal Models of Human Hypertension. Heart Fail Clin. 2017 Oct;13(4):739-757.

Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, Maier LS, Conti M, Wess J, El-Armouche A, Hasenfuß G, Nikolaev VO. Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4. Sci Rep. 2017 Nov 9;7(1):15222.

Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS One. 2017 Jul 31;12(7)

Vettel C, Lindner M, Dewenter M, Lorenz K, Schanbacher C, Riedel M, Lämmle S, Meinecke S, Mason FE, Sossalla S, Geerts A, Hoffmann M, Wunder F, Brunner FJ, Wieland T, Mehel H, Karam S, Lechêne P, Leroy J, Vandecasteele G, Wagner M, Fischmeister R, El-Armouche A. Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction. Circ Res. 2017 Jan 6;120(1):120-132.

Yücel G, Zhao Z, El-Battrawy I, Lan H, Lang S, Li X, Buljubasic F, Zimmermann WH, Cyganek L, Utikal J, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017 Jun 7;7(1):2935.

2016

El-Battrawy I, Lang S, Zhao Z, Akin I, Yücel G, Meister S, Patocskai B, Behnes M, Rudic B, Tülümen E, Liebe V, Tiburcy M, Dworacek J, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou XB. Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS One. 2016 Nov 9;11(11):e0166143

Jansen SR, Poppinga WJ, de Jager W, Lezoualc'h F, Cheng X, Wieland T, Yarwood SJ, Gosens R, Schmidt M. Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition. Oncotarget. 2016 Jul 19;7(29):46354-46370

Kannt A, Wieland T. Managing risks in drug discovery: reproducibility of published findings. Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):353-60

Lemmer B, Scholtze J, Schmitt J. Circadian rhythms in blood pressure, heart rate, hormones, and on polysomnographic parameters in severe obstructive sleep apnea syndrome patients: effect of continuous positive airway pressure. Blood Press Monit. 2016 Jun;21(3):136-43

Meinert C, Kohse F, Böhme I, Gembardt F, Tetzner A, Wieland T, Greenberg B, Walther T. Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells. Data Brief. 2016 Dec 8;10:354-363

Meinert C, Gembardt F, Böhme I, Tetzner A, Wieland T, Greenberg B, Walther T. Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7). J Proteomics. 2016 Jan 1;130:129-39

Qiu Y, Zhao D, Butenschön VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 2016 Feb;53(1):81-9 

Wirth L, Dorn F, Wege M, Zemlin M, Lemmer B, Gorbey S, Timmesfeld N, Maier RF. Effects of standardized acoustic stimulation in premature infants: a randomized controlled trial. J Perinatol. 2016 Jun;36(6):486-92

2007 -2015

Qiu Y, Zhao D, Butenschön VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 53:81-9, 2015.

Feng Y, Gross S, Wolf NM, Butenschön VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes HP, Wieland T. Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins. Arterioscler Thromb Vasc Biol. 34: 2292-300, 2014.

Busch S, Wu L, Feng Y, Gretz N, Hoffmann S, Hammes HP. Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit and the innate immunity systems. PLoS One, 9: e102013, 2014.

Busch S, Kannt A, Kolibabka M, Schlotterer A, Wang Q, Lin J, Feng Y, Hoffmann S, Gretz N, Hammes HP. Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration. PLoS One, 11;9(7), 2014.

Feng Y, Wang Y, Yang Z, Wu L, Hoffmann S, Wieland T, Gretz N, Hammes HP. Chronic hyperglycemia inhibits vasoregression in a transgenic model of retinal degeneration. Acta Diabetol, 51: 211-8, 2014.

Del Galdo S, Vettel C, Heringdorf DM, Wieland T. The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. Cell Signal. 25: 2478-2484, 2013.

Lutz S, Mohl M, Rauch J, Weber P, Wieland T. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Ia. Cell Signal. 25: 630-638, 2013.

Carbajo-Lozoya J, Lutz S, Feng Y, Kroll J, Hammes HP, Wieland T. Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium. Cell Signal. 24: 1261-1269, 2012.

Feng Y, Busch S, Gretz N, Hoffmann S, Hammes HP. Crosstalk in the retinal neurovascular unit - lessons for the diabetic retina. Exp Clin Endocrinol Diabetes, 120:199-201, 2012.

Hippe HJ, Wolf NM, Abu-Taha HI, Lutz S, Le Lay S, Just S, Rottbauer W, Katus HA, Wieland T. Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae. Naunyn Schmiedebergs Arch Pharmacol. 384: 461-472, 2011.

Hammes HP, Feng Y, Pfister F, Brownlee M. Diabetic retinopathy: targeting vasoregression. Diabetes, 60: 9-16, 2011.

Feng Y, Wang Y, Li L, Wu L, Hoffmann S, Gretz N, Hammes HP. Gene expression profiling of vasoregression in the retina--involvement of microglial cells. PLoS One, 17;6:e16865, 2011.

Wieland T, Hippe HJ, Ludwig K, Zhou XB, Korth M, Klumpp S. Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1. Methods Enzymol. 471: 379-402, 2010.

Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S. p63RhoGEF - a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. FASEB J. 24: 4865-4876, 2010.

Hippe HJ, Wolf NM, Abu-Taha I, Mehringer R, Just S, Lutz S, Niroomand F, Postel EH, Katus HA, Rottbauer W, Wieland T. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A. 106: 16269-16274, 2009.

Pfister F, Feng Y, vom Hagen F, Hoffmann S, Molema G, Hillebrands JL, Shani M, Deutsch U, Hammes HP. Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes, 57: 2495-502, 2008.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ. Structure of G?q-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science 318: 1923-1927, 2007.

Kontextspalte