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2020

K.V. Blankenbach, G. Bruno, E. Wondra, A.K. Spohner, N.J. Aster, H. Vienken, S. Trautmann, N. Ferreirós, T. Wieland, P. Bruni, D. Meyer Zu Heringdorf. The WD40 repeat protein, WDR36, orchestrates sphingosine kinase-1 recruitment and phospholipase C-β activation by G(q)-coupled receptors. Biochimica et biophysica acta. Molecular and cell biology of lipids. (2020)

https://doi.org/10.1016/j.bbalip.2020.158704

K.V. Blankenbach, R.F. Claas, N.J. Aster, A.K. Spohner, S. Trautmann, N. Ferreirós, J.L. Black, J.J.G. Tesmer, S. Offermanns, T. Wieland, D. Meyer Zu Heringdorf. Dissecting G(q/11)-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1. Cells. (2020)

https://doi.org/10.3390/cells9102201

F. Buljubasic, I. El-Battrawy, H. Lan, S.K. Lomada, A. Chatterjee, Z. Zhao, X. Li, R. Zhong, Q. Xu, M. Huang, Z. Liao, S. Lang, L. Cyganek, X. Zhou, T. Wieland, M. Borggrefe, I. Akin. Nucleoside Diphosphate Kinase B Contributes to Arrhythmogenesis in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy. Journal of clinical medicine. (2020)

https://doi.org/10.3390/jcm9020486

A. Chatterjee, R. Eshwaran, H. Huang, D. Zhao, M. Schmidt, T. Wieland, Y. Feng. Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency. International journal of molecular sciences. (2020)

https://doi.org/10.3390/ijms21103713

A. Chatterjee, R. Eshwaran, G. Poschet, S. Lomada, M. Halawa, K. Wilhelm, M. Schmidt, H.P. Hammes, T. Wieland, Y. Feng. Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity. Cells. (2020)

https://doi.org/10.3390/cells9102324

I. Felix, S.K. Lomada, H. Barth, T. Wieland. Bacillus anthracis' PA(63) Delivers the Tumor Metastasis Suppressor Protein NDPK-A/NME1 into Breast Cancer Cells, International journal of molecular. Sciences. (2020)

https://doi.org/10.3390/ijms21093295

B. Lemmer, M. Middeke. Insufficient reply by Hermida et al. to the critical comments to the MAPEC and HYGIA studies. Chronobiology international. (2020)

https://doi.org/10.1080/07420528.2020.1812901

B. Lemmer, M. Middeke. A commentary on the Spanish hypertension studies MAPEC and HYGIA. Chronobiology international. (2020)

https://doi.org/10.1080/07420528.2020.1761374

J. Lin, J. Hu, A. Schlotterer, J. Wang, M. Kolibabka, K. Awwad, N. Dietrich, K. Breitschopf, P. Wohlfart, A. Kannt, K. Lorenz, Y. Feng, R. Popp, S. Hoffmann, I. Fleming, H.P. Hammes. Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease. Theranostics. (2020)

https://doi.org/10.7150/thno.43154

2019

K. Aktories, P. Gierschik, D.M.Z. Heringdorf, M. Schmidt, G. Schultz, T. Wieland. cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs. Naunyn-Schmiedeberg's archives of pharmacology. (2019)

doi.org10.1007/s00210-019-01650-1

S. Brachs, J. Polack, M. Brachs, K. Jahn-Hofmann, R. Elvert, A. Pfenninger, F. Barenz, D. Margerie, K. Mai, J. Spranger, A. Kannt. Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance. Diabetes. (2019)

https://doi.org/10.2337/db18-0780

I. El-Battrawy, S. Albers, L. Cyganek, Z. Zhao, H. Lan, X. Li, Q. Xu, M. Kleinsorge, M. Huang, Z. Liao, R. Zhong, B. Rudic, J. Muller, H. Dinkel, S. Lang, S. Diecke, W.H. Zimmermann, J. Utikal, T. Wieland, M. Borggrefe, X. Zhou, I. Akin. A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes. EP Europace. (2019)

https://doi.org/10.1093/europace/euz122

I. El-Battrawy, J. Muller, Z. Zhao, L. Cyganek, R. Zhong, F. Zhang, M. Kleinsorge, H. Lan, X. Li, Q. Xu, M. Huang, Z. Liao, A. Moscu-Gregor, S. Albers, H. Dinkel, S. Lang, S. Diecke, W.H. Zimmermann, J. Utikal, T. Wieland, M. Borggrefe, X. Zhou, I. Akin. Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Frontiers in cell and developmental biology. (2019)

https://doi.org/10.3389/fcell.2019.00261

D. Gordin, H. Shah, T. Shinjo, R. St-Louis, W. Qi, K. Park, S.M. Paniagua, D.M. Pober, I.H. Wu, V. Bahnam, M.J. Brissett, L.J. Tinsley, J.M. Dreyfuss, H. Pan, Y. Dong, M.A. Niewczas, P. Amenta, T. Sadowski, A. Kannt, H.A. Keenan, G.L. King. Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy. Diabetes care. (2019)

https://doi.org/10.2337/dc18-2585

H. Huang, M. Kolibabka, R. Eshwaran, A. Chatterjee, A. Schlotterer, H. Willer, K. Bieback, H.P. Hammes, Y. Feng. Intravitreal injection of mesenchymal stem cells evokes retinal vascular damage in rats. FASEB journal. (2019)

https://doi.org/10.1096/fj.201901500R

L. Leinhos, J. Peters, S. Krull, L. Helbig, M. Vogler, M. Levay, G.J. van Belle, A.J. Ridley, S. Lutz, D.M. Katschinski, A. Zieseniss. Hypoxia suppresses myofibroblast differentiation by changing RhoA activity. Journal of cell science. (2019)

doi.org10.1242/jcs.223230

B. Lemmer. Caelius Aurelianus' textbook on medicine of the fifth century: rhythm in asthma, pain, and drug effects. Chronobiology international. (2019)

https://doi.org/10.1080/07420528.2019.1595639

B. Lemmer. No correlation between lunar and menstrual cycle - an early report by the french physician J. A. Murat in 1806. Chronobiology international. (2019)

https://doi.org/10.1080/07420528.2019.1583669

B. Lemmer. The physiologist Johann Autenrieth (1772-1835) at Tübingen University: early reports on biological rhythms and their use for medical lectures. Chronobiology international  2019)

https://doi.org/10.1080/07420528.2018.1550653

J. Qiu, S.J. Hauske, S. Zhang, A. Rodriguez-Nino, T. Albrecht, D.O. Pastene, J. van den Born, H. van Goor, S. Ruf, M. Kohlmann, M. Teufel, B.K. Kramer, H.P. Hammes, V. Peters, B.A. Yard, A. Kannt. Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity. Amino acids. (2019)

doi.org10.1007/s00726-018-2601-z

K. Sattler, I. El-Battrawy, Z. Zhao, C. Schrottenberg, G. Yucel, H. Lan, X. Li, S. Lang, W.H. Zimmermann, L. Cyganek, J. Utikal, T. Wieland, U. Ravens, K. Bieback, M. Borggrefe, X. Zhou, I. Akin. Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes. Scientific reports. (2019)

doi.org10.1038/s41598-019-42079-z

F.A. von Samson-Himmelstjerna, G. Freundt, J.T. Nitz, F. Stelter, M. Luedde, T. Wieland, N. Frey, H.J. Hippe. The orphan receptor GPRC5B modulates inflammatory and fibrotic pathways in cardiac fibroblasts and mice hearts. Biochemical and biophysical research communications. (2019)

https://doi.org/10.1016/j.bbrc.2019.05.038

X. Wang, M.R. Sommerfeld, K. Jahn-Hofmann, B. Cai, A. Filliol, H.E. Remotti, R.F. Schwabe, A. Kannt, I. Tabas. A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice. Hepatology communications. (2019)

https://doi.org/10.1002/hep4.1405

Z. Zhao, X. Li, I. El-Battrawy, H. Lan, R. Zhong, Q. Xu, M. Huang, Z. Liao, S. Lang, W.H. Zimmermann, L. Cyganek, T. Wieland, I. Akin, X.B. Zhou, M. Borggrefe. Drug Testing in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1. Clinical pharmacology and therapeutics. (2019)

https://doi.org/10.1002/cpt.1449

2018

Abu-Taha IH, Vettel C, Wieland T. Targeting altered Nme heterooligomerization in disease? Oncotarget. 2017 eCollection 2018

DOI: 10.18632/oncotarget.22716

Abu-Taha IH, Heijman J, Feng Y, Vettel C, Dobrev D, Wieland T. Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update. Lab Invest. 2018

DOI: 10.1038/labinvest.2017.103

Arnold C, Demirel E, Feldner A, Genové G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T. Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J. 2018

https://doi.org/10.1096/fj.201700384RR

Beck SC, Karlstetter M, Garcia Garrido M, Feng Y, Dannhausen K, Mühlfriedel R, Sothilingam V, Seebauer B, Berger W, Hammes HP, Seeliger MW, Langmann T. Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina. Sci Rep. 2018

DOI: 10.1038/s41598-018-24476-y

El-Battrawy I, Lan H, Cyganek L, Zhao Z, Li X, Buljubasic F, Lang S, Yücel G, Sattler K, Zimmermann WH, Utikal J, Wieland T, Ravens U, Borggrefe M, Zhou XB, Akin I. Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. J Am Heart Assoc. 2018  

DOI: 10.1161/JAHA.117.007394

El-Battrawy I, Zhao Z, Lan H, Cyganek L, Tombers C, Li X, Buljubasic F, Lang S, Tiburcy M, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou XB, Akin I. Electrical dysfunctions in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with an arrhythmogenic right ventricular cardiomyopathy. Europace. 2018 https://doi.org/10.1093/europace/euy042

El-Battrawy I, Zhao Z, Lan H, Li X, Yücel G, Lang S, Sattler K, Schünemann JD, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Bieback K, Bauer R, Ratte A, Pribe-Wolferts R, Rapti K, Nowak D, Wittig J, Thomas D, Most P, Katus HA, Ravens U, Schmidt C, Borggrefe M, Zhou XB, Müller OJ, Akin I. Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy. Circ Genom Precis Med. 2018

DOI: 10.1161/CIRCGEN.117.001893

El-Battrawy I, Zhao Z, Lan H, Schünemann JD, Sattler K, Buljubasic F, Patocskai B, Li X, Yücel G, Lang S, Nowak D, Cyganek L, Bieback K, Utikal J, Zimmermann WH, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes. Int J Cardiol. 2018

https://doi.org/10.1016/j.ijcard.2017.11.007

Jansen S, Gosens R, Wieland T, Schmidt M. Paving the Rho in cancer metastasis: Rho GTPases and beyond. Pharmacol Ther. 2018

https://doi.org/10.1016/j.pharmthera.2017.09.002

Lemmer B, Oster H. The Role of Circadian Rhythms in the Hypertension of Diabetes Mellitus and the Metabolic Syndrome. Current Hypertension Reports 2018

DOI: 10.1007/s11906-018-0843-5

Lemmer B. The physiologist Johann Autenrieth (1772-1835) at Tübingen University: early reports on biological rhythms and their use for medical lectures. Chronobiol Int. 2018

https://doi.org/10.1080/07420528.2018.1550653

Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM, Neuenschwander M, Oder A, Elkewedi M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukićević T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann E. An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. PLoS One. 2018 https://doi.org/10.1371/journal.pone.0191423

Shan S, Chatterjee A, Qiu Y, Hammes HP, Wieland T, Feng Y. O-GlcNAcylation of FoxO1 mediates nucleoside diphosphate kinase B deficiency induced endothelial damage. Sci Rep. 2018

DOI: 10.1038/s41598-018-28892-y

Schwab DM, Tilemann L, Bauer R, Heckmann M, Jungmann A, Wagner M, Burgis J, Vettel C, Katus HA, El-Armouche A, Müller OJ. AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload. Gene Ther. 2018

DOI: 10.1038/gt.2017.97

Tóth AD, Schell R, Lévay M, Vettel C, Theis P, Haslinger C, Alban F, Werhahn S, Frischbier L, Krebs-Haupenthal J, Thomas D, Gröne HJ, Avkiran M, Katus HA, Wieland T, Backs J. Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes. EMBO Mol Med. 2018

https://doi.org/10.15252/emmm.201708536

Qiu Y, Huang H, Chatterjee A, Teuma LD, Baumann FS, Hammes HP, Wieland T, Feng Y. Mediation of FoxO1 in Activated Neuroglia Deficient for Nucleoside Diphosphate Kinase B during Vascular Degeneration. Neuroglia 2018

https://doi.org/10.3390/neuroglia1010019

Zhao Z, Lan H, El-Battrawy I, Li X, Buljubasic F, Sattler K, Yücel G, Lang S, Tiburcy M, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Borggrefe M, Zhou XB, Akin I. Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells Int. 2018

https://doi.org/10.1155/2018/6067096

2017

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz C, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 2017 Feb 28;135(9):881-897

Beck SC, Feng Y, Sothilingam V, Garcia Garrido M, Tanimoto N, Acar N, Shan S, Seebauer B, Berger W, Hammes HP, Seeliger MW. Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease. PLoS One. 2017 Jun 2;12(6):e0178753.

Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 2017 May;10(5):e003840.

Garg J, Feng YX, Jansen SR, Friedrich J, Lezoualc'h F, Schmidt M, Wieland T. Catecholamines facilitate VEGF-dependent angiogenesis via β2-adrenoceptor-induced Epac1 and PKA activation. Oncotarget. 2017 Jul 4;8(27):44732-44748

Gross S, Devraj K, Feng Y, Macas J, Liebner S, Wieland T. Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation. J Cereb Blood Flow Metab. 2017 Jul;37(7):2471-2484.

Jansen S, Gosens R, Wieland T, Schmidt M. Paving the Rho in cancer metastasis: Rho GTPases and beyond. Pharmacol Ther. 2017 Sep 11. pii: S0163-7258(17)30236-X. doi: 10.1016/j.pharmthera.2017.09.002. [Epub ahead of print] Review.

Lemmer B, The Circadian Clock is Now Ticking Even in Stockholm - Nobel Prize in Medicine 2017. Dtsch Med Wochenschr. 2017 Dec;142(25):1897-1900.

Lemmer B, Signal Transduction and Chronopharmacology of Regulation of Circadian Cardiovascular Rhythms in Animal Models of Human Hypertension. Heart Fail Clin. 2017 Oct;13(4):739-757.

Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, Maier LS, Conti M, Wess J, El-Armouche A, Hasenfuß G, Nikolaev VO. Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4. Sci Rep. 2017 Nov 9;7(1):15222.

Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS One. 2017 Jul 31;12(7)

Vettel C, Lindner M, Dewenter M, Lorenz K, Schanbacher C, Riedel M, Lämmle S, Meinecke S, Mason FE, Sossalla S, Geerts A, Hoffmann M, Wunder F, Brunner FJ, Wieland T, Mehel H, Karam S, Lechêne P, Leroy J, Vandecasteele G, Wagner M, Fischmeister R, El-Armouche A. Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction. Circ Res. 2017 Jan 6;120(1):120-132.

Yücel G, Zhao Z, El-Battrawy I, Lan H, Lang S, Li X, Buljubasic F, Zimmermann WH, Cyganek L, Utikal J, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017 Jun 7;7(1):2935.

2016

El-Battrawy I, Lang S, Zhao Z, Akin I, Yücel G, Meister S, Patocskai B, Behnes M, Rudic B, Tülümen E, Liebe V, Tiburcy M, Dworacek J, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou XB. Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS One. 2016 Nov 9;11(11):e0166143

Jansen SR, Poppinga WJ, de Jager W, Lezoualc'h F, Cheng X, Wieland T, Yarwood SJ, Gosens R, Schmidt M. Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition. Oncotarget. 2016 Jul 19;7(29):46354-46370

Kannt A, Wieland T. Managing risks in drug discovery: reproducibility of published findings. Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):353-60

Lemmer B, Scholtze J, Schmitt J. Circadian rhythms in blood pressure, heart rate, hormones, and on polysomnographic parameters in severe obstructive sleep apnea syndrome patients: effect of continuous positive airway pressure. Blood Press Monit. 2016 Jun;21(3):136-43

Meinert C, Kohse F, Böhme I, Gembardt F, Tetzner A, Wieland T, Greenberg B, Walther T. Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells. Data Brief. 2016 Dec 8;10:354-363

Meinert C, Gembardt F, Böhme I, Tetzner A, Wieland T, Greenberg B, Walther T. Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7). J Proteomics. 2016 Jan 1;130:129-39

Qiu Y, Zhao D, Butenschön VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 2016 Feb;53(1):81-9 

Wirth L, Dorn F, Wege M, Zemlin M, Lemmer B, Gorbey S, Timmesfeld N, Maier RF. Effects of standardized acoustic stimulation in premature infants: a randomized controlled trial. J Perinatol. 2016 Jun;36(6):486-92

2007 -2015

Qiu Y, Zhao D, Butenschön VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 53:81-9, 2015.

Feng Y, Gross S, Wolf NM, Butenschön VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes HP, Wieland T. Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins. Arterioscler Thromb Vasc Biol. 34: 2292-300, 2014.

Busch S, Wu L, Feng Y, Gretz N, Hoffmann S, Hammes HP. Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit and the innate immunity systems. PLoS One, 9: e102013, 2014.

Busch S, Kannt A, Kolibabka M, Schlotterer A, Wang Q, Lin J, Feng Y, Hoffmann S, Gretz N, Hammes HP. Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration. PLoS One, 11;9(7), 2014.

Feng Y, Wang Y, Yang Z, Wu L, Hoffmann S, Wieland T, Gretz N, Hammes HP. Chronic hyperglycemia inhibits vasoregression in a transgenic model of retinal degeneration. Acta Diabetol, 51: 211-8, 2014.

Del Galdo S, Vettel C, Heringdorf DM, Wieland T. The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. Cell Signal. 25: 2478-2484, 2013.

Lutz S, Mohl M, Rauch J, Weber P, Wieland T. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Ia. Cell Signal. 25: 630-638, 2013.

Carbajo-Lozoya J, Lutz S, Feng Y, Kroll J, Hammes HP, Wieland T. Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium. Cell Signal. 24: 1261-1269, 2012.

Feng Y, Busch S, Gretz N, Hoffmann S, Hammes HP. Crosstalk in the retinal neurovascular unit - lessons for the diabetic retina. Exp Clin Endocrinol Diabetes, 120:199-201, 2012.

Hippe HJ, Wolf NM, Abu-Taha HI, Lutz S, Le Lay S, Just S, Rottbauer W, Katus HA, Wieland T. Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae. Naunyn Schmiedebergs Arch Pharmacol. 384: 461-472, 2011.

Hammes HP, Feng Y, Pfister F, Brownlee M. Diabetic retinopathy: targeting vasoregression. Diabetes, 60: 9-16, 2011.

Feng Y, Wang Y, Li L, Wu L, Hoffmann S, Gretz N, Hammes HP. Gene expression profiling of vasoregression in the retina--involvement of microglial cells. PLoS One, 17;6:e16865, 2011.

Wieland T, Hippe HJ, Ludwig K, Zhou XB, Korth M, Klumpp S. Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1. Methods Enzymol. 471: 379-402, 2010.

Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S. p63RhoGEF - a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. FASEB J. 24: 4865-4876, 2010.

Hippe HJ, Wolf NM, Abu-Taha I, Mehringer R, Just S, Lutz S, Niroomand F, Postel EH, Katus HA, Rottbauer W, Wieland T. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A. 106: 16269-16274, 2009.

Pfister F, Feng Y, vom Hagen F, Hoffmann S, Molema G, Hillebrands JL, Shani M, Deutsch U, Hammes HP. Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes, 57: 2495-502, 2008.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ. Structure of G?q-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science 318: 1923-1927, 2007.

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