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Cardiovascular Physiology

The blood supply of all organs has to be adjusted to different and permanently changing conditions at any time. However, adequate matching of blood supply to actual demand is often disturbed, in particular in widespread diseases of the circulatory system like hypertension and diabetes. Therefore, the mechanisms regulating blood supply are still an area of active research. Our group is studying these mechanisms with a focus and smooth muscle and endothelial cell function. This is presented in more detail in the section research.

In the Division of Cardiovascular Physiology we are investigating the role of different signaling molecules, in particular ion channels, in vascular smooth muscle cells and of mechanically induced signaling cascades in endothelial cells of different vascular beds. Special attention is paid to physiological regulation (myogenic and perivascular-fat dependent autoregulation, mechanical stimulus-induced signaling, functional remodeling of the vascular wall) and related pathophysiological processes (diabetes, hypertension, atherosclerosis). A broad spectrum of methods from the molecular and the cellular level up to the level of intact organs is employed.

Our staff is also actively involved in teaching of medical students in physiology in MARECUM. This includes stringent lecture courses on different topics of physiology. Seminars are based on an interactive dialog with the students to facilitate active learning. Practical courses are aimed to convey practical skills and advance scientific thinking. In the past years, several novel teaching concepts and methods have been implemented with the aim to widen the range of options for individual learning for the students.