Sie befinden sich hier

Inhalt

Publications

Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M, Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, Remedios CD, Riechert E, Völkers M, Doroudgar S, Jungmann A, Bauer R, Yin X, Mayr M, Wollert KC, Pich A, Xiao H, Katus HA, Bauersachs J, Müller OJ, Heineke J. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. EMBO Mol Med. 2019 Aug 30:e10018. doi: 10.15252/emmm.201810018

Malek Mohammadi M, Abouissa A, Azizah I, Xie Y, Cordero J, Shirvani A, Gigina A, Engelhardt M, Trogisch FA, Geffers R, Dobreva G, Bauersachs J, Heineke J. Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation. JCI Insight. 2019 Jul 23;5. pii: 128336. doi: 10.1172/jci.insight.128336

Scharf GM, Kilian K, Cordero J, Wang Y, Grund A, Hofmann M, Froese N, Wang X, Kispert A, Kist R, Conway SJ, Geffers R, Wollert KC, Dobreva G, Bauersachs J, Heineke J. Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation. JCI Insight. 2019 Jul 16;5. pii: 126721. doi: 10.1172/jci.insight.126721

Kattih B, Elling LS, Weiss C, Bea M, Zwadlo C, Bavendiek U, Bauersachs J, Heineke J. Anti-androgenic therapy with finasteride in patients with chronic heart failure - a retrospective propensity score based analysis. Sci Rep. 2019 Jul 12;9(1):10139. doi: 10.1038/s41598-019-46640-8

Grund A, Szaroszyk M, Doppner JK, Malek Mohammadi M, Kattih B, Korf-Klingebiel M, Gigina A, Scherr M, Kensah G, Jara-Avaca M, Gruh I, Martin U, Wollert KC, Gohla A, Katus HA, Muller OJ, Bauersachs J, Heineke J. A gene therapeutic approach to inhibit calcium and integrin binding protein 1 ameliorates maladaptive remodelling in pressure overload. Cardiovasc Res. 2019;115:71-82. doi: 10.1093/cvr/cvy154

Froese N, Wang H, Zwadlo C, Wang Y, Grund A, Gigina A, Hofmann M, Kilian K, Scharf G, Korf-Klingebiel M, Melchert A, Signorini MER, Halloin C, Zweigerdt R, Martin U, Gruh I, Wollert KC, Geffers R, Bauersachs J, Heineke J. Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice. J Mol Cell Cardiol. 2018;122:114-124. doi: 10.1016/j.yjmcc.2018.08.011

Appari M*, Breitbart A*, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Müller OJ, Bauersachs J, Heineke J. C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure. Circ Res. 2017 Jan 6;120(1):66-77. doi: 10.1161/CIRCRESAHA.116.309398

Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J. The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol Med. 2017 Feb;9(2):265-279. doi: 10.15252/emmm.201606602

Grund A, Heineke J. Exercise makes the difference: Deconstructing physiological hypertrophy in swine. J Mol Cell Cardiol. 2015; 79C:89-91. doi: 10.1016/j.yjmcc.2014.11.001

Zwadlo C*, Schmidtmann E*, Szaroszyk M*, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J. Anti-androgenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction. Circulation. 2015 Mar 24;131(12):1071-81. doi: 10.1161/circulationaha.114.012066

Heineke J. Screening for novel calcium-binding proteins that regulate cardiac hypertrophy: CIB1 as an example. Methods Mol Biol. 2013;963:279-301. doi: 10.1007/978-1-62703-230-8_17

Breitbart A*, Scharf GM*, Duncker D*, Widera C, Gottlieb J, Vogel A, Schmidt S, Brandes G, Heuft HG, Lichtinghagen R, Kempf T, Wollert KC, Bauersachs J, Heineke J. Highly specific detection of myostatin prodomain by an immunoradiometric sandwich assay in serum of healthy individuals and patients. PLoS One. 2013 Nov 15;8(11):e80454. doi: 10.1371/journal.pone.0080454

Scharf G, Heineke J. Finding good biomarkers for sarcopenia. J Cachexia Sarcopenia Muscle. 2012 Sep;3(3):145-8. doi: 10.1007/s13539-012-0081-7

Heineke J. Wag the Dog: How Endothelial Cells Regulate Cardiomyocyte Growth. Arterioscler Thromb Vasc Biol. 2012;32:545-547. doi: 10.1161/ATVBAHA.111.242784

Heineke J, Ritter O. Cardiomyocyte calcineurin signaling in subcellular domains: From the sarcolemma to the nucleus and beyond. J Mol Cell Cardiol. 2011;52(1):62-73. doi: 10.1016/j.yjmcc.2011.10.018

Breitbart A, Auger-Messier M, Molkentin JD, Heineke J. Myostatin from the Heart - Local and Systemic Actions in Cardiac Failure and Muscle Wasting. Am J Physiol – Heart Circ Physiol. 2011 Jun;300(6):H1973-82. doi: 10.1152/ajpheart.00200.2011

Froese N*, Kattih B*, Breitbart A, Grund A, Geffers R, Molkentin JD, Kispert A, Wollert KC, Drexler H, and Heineke J. GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor {beta}/Activin Receptor-like Kinase 5 Signaling. J Biol Chem 2011; 286: 5680-5690. doi: 10.1074/jbc.M110.176925

Heineke J*§, Auger-Messier M*, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD§. CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010; 16 (8):872-879. doi: 10.1038/nm.2181

Heineke J*, Auger-Messier M*, Xu J, Sargent M, York A, Welle S, Molkentin JD. Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation.  Jan 26 2010; 121(3): 419-25. doi: 10.1161/CIRCULATIONAHA.109.882068

Heineke J, Wollert KC, Osinska H, Sargent MA, York AJ, Robbins J, Molkentin JD. Calcineurin protects the heart in a murine model of dilated cardiomyopathy. J Mol Cell Cardiol. 2010; 48(6):1080-1087. doi: 10.1016/j.yjmcc.2009.10.012

Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Cromblehol TM, Molkentin JD. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest. Nov 2007;117(11):3198-3210. doi: 10.1172/JCI32573

Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. Aug 2006;7(8):589-600. doi: 10.1038/nrm1983

Heineke J, Ruetten H, Willenbockel C, Gross SC, Naguib M, Schaefer A, Kempf T, Hilfiker-Kleiner D, Caroni P, Kraft T, Kaiser RA, Molkentin JD, Drexler H, Wollert KC. Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc Natl Acad Sci U S A. Feb 1 2005;102(5):1655-1660. doi: 10.1073/pnas.0405488102

Heineke J, Kempf T, Kraft T, Hilfiker A, Morawietz H, Scheubel RJ, Caroni P, Lohmann SM, Drexler H, Wollert KC. Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on cardiac myocyte hypertrophy. Circulation. Mar 18 2003;107(10):1424-1432. doi: 10.1161/01.cir.0000055319.94801.fc

Kontextspalte