Our research group investigates immune mechanisms regulating metastasis, the most advanced and life-threatening stage of cancer. We focus on the dynamic interplay between adaptive and innate immunity, aiming to harness their interactions for innovative anticancer therapies.

Using colorectal liver metastases and metastatic melanoma models, we have uncovered distinct spatial architectures of innate lymphocytes and memory T cells within metastatic niches. These immune landscapes continuously evolve in response to both intrinsic tumor cues and in response to therapy, reshaping immune interactions in the tumor microenvironment.

By integrating cutting-edge multi-omic approaches, we seek to decode how these immune cell populations adapt to therapeutic pressure, influence disease progression, and shape metastatic outcomes. Our goal is to develop strategies to reprogram immune niches, enhance treatment efficacy and ultimately improve patient prognosis in metastatic cancer.