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Despite their distinct functions, the nervous and vascular systems regulate each other function and share many more similarities and common principles than previously expected.
In our lab, we are interested in understanding (i) the signaling pathways and cellular mechanisms that angiogenic molecules exert in neuronal cells and (ii) the communication between the vascular and nervous systems during development. For this, we are using a combination of mouse genetics, organotypic cultures, cell biology, biochemistry and molecular biology approaches.
Determining how the vascular system, influence neuronal wiring will shed new light in the understanding of the molecular control of neuronal development and the possible causes of neurodevelopmental disorders. Research in this field may suggest new strategies to treat those disorders and to promote axon regeneration after injury or disease.