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Selected publications

Hu J., Leisegang MS., Looso M., Drekolia MK., Wittig J., Mettner J., Karantanou C., Kyselova A., Dumbovic G., Li X., Li Y., Guenther S., John D., Siragusa M., Zukunft S., Oo JA., Wittig I., Hille S., Weigert A., Knapp S., Brandes RP., Müller OJ., Papapetropoulos A., Sigala F., Dobreva G., Kojonazarov B., Fleming I., Bibli SI.  Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence. Circ Res. 2023 Oct 27;133(10):842-857 

Drekolia MK., Karantanou C.,Wittig I., Li Y., Fuhrmann DC., Bruene B., Katsouda A., Hu J., Papapetropoulos A., Bibli SI. Loss of cardiac mitochondrial complex I persulfidation impairs NAD+ homeostasis in aging. Redox Biol 2023; 69:103014

Wittig J., Drekolia M-K., Kyselova A., Delgado Lagos F., Bochenek ML., Hu J., Scaefer K., Fleming I., Bibli SI. Endothelial dependent S-Sulfhydratioon of tissue factor pathway inhibitor regulates blood coagulation. Redox Biol 2022; 62:102694.  

Bibli SI., Hu J., Looso M., Weigert A., Ratiu C., Wittig J., Drekolia M-K., Tombor L., Randriamboavonjy V., Leisegang MS., Goymann P., Lagos FD., Fisslthaler B., Zukunft S., Kyselova A., Justo AFO., Heidler J., Tsilimigras D., Brandes RP., Dimmeler S., Papapetropoulos A., Knapp S., Offermanns S., Wittig I., Nishimura SL., Sigala F., Fleming I. Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function. Circulation 2021;143:935–948

Bibli SI., Hu J., Sigala F., Wittig I., Heidler J., Zukunft S., Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G., Chen C., Wang DW., Pfeilschifter J., Brandes RP., Szabo C., Papapetropoulos A., Fleming I. Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis. Circulation 2019.;139(1):101-114.    

Hu J*., Bibli SI*., Wittig J, Zukunft S, Lin J, Hammes HP, Popp R, Fleming I.. Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity. J Clin Invest 2019;129(12):5204–5218 (*Equally contributed)