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PD Dr. sc. hum. biol. Walter Magerl

Im Zentrum unserer Arbeiten stehen Phänotypisierung von Patienten mit chronischen neuropathischen Schmerzen, mechanismenbasierte Klassifikation von Schmerzpatienten, Modellierung der Schmerzmechanismen in humanen Surrogatmodellen.

Sensibilitätsprofile von Patienten mit chronischen peripheren neuropathischen Schmerzen zeigen drei Phänotyp-Cluster (aus Baron et al. 2017)
Sensibilitätsprofile von Patienten mit chronischen peripheren neuropathischen Schmerzen zeigen drei Phänotyp-Cluster (aus Baron et al. 2017)

Auswahl aktueller Publikationen

  1. Sachau J, Bruckmueller H, Gierthmühlen J, Magerl W, May D, Binder A, Forstenpointner J, Koetting J, Maier C, Tölle TR, Treede RD, Berthele A, Caliebe A, Diesch C, Flor H, Huge V, Maihöfner C, Rehm S, Kersebaum D, Fabig SC, Vollert J, Rolke R, Stemmler S, Sommer C, Westermann A, Cascorbi I, Baron R. (2021) The serotonin receptor 2A (HTR2A) rs6313 variant is associated with higher ongoing pain and signs of central sensitization in neuropathic pain patients. Eur J Pain 25(3):595-611
  2. Enax-Krumova E, Attal N, Bouhassira D, Freynhagen R, Gierthmühlen J, Hansson P, Kuehler BM, Maier C, Sachau J, Segerdahl M, Tölle T, Treede RD, Ventzel L, Baron R, Vollert J (2021) Contralateral Sensory and Pain Perception Changes in Patients With Unilateral Neuropathy. Neurology 97(4):e389-e402.
  3. Forstenpointner J, Ruscheweyh R, Attal N, Baron R, Didier-Bouhassira, Enax-Krumova EK, Finnerup NB, Freynhagen R, Gierthmühlen J, Hansson P, Jensen TS, Maier C, Rice ASC, Segerdahl M, Tölle T, Treede R-D, Vollert J. (2021) No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy. Pain 162(3):718-727.
  4. Meyer-Frießem CH, Attal N, Baron R, Bouhassira D, Finnerup NB, Freynhagen R, Gierthmühlen J, Haanpaa M, Hansson P, Jensen TS, Kemp H, Kennedy D, Leffler A-S, Rice ASC, Segerdahl M, Serra J, Sindrup S, Sola R, Tölle T, Schuh-Hofer S, Treede R-D, Pogatzki-Zahn E, Maier C, Vollert J (2020). Pain thresholds and intensities of CRPS type I and neuropathic pain in respect to sex. Eur J Pain 24(6):1058-1071
  5. Gierthmühlen J, Schneider U, Seemann M, Freitag-Wolf S, Maihöfner C, Enax-Krumova EK, Azad S-C, Üceyler N, Birklein F, Maier C, Tölle T, Treede R-D, Baron R (2019) Can self-reported pain characteristics and bedside test be used for the assessment of pain mechanisms? An analysis of results of neuropathic pain questionnaires and quantitative sensory testing. Pain 160(9):2093-2104.
  6. Sachau J, Bruckmueller H, Gierthmühlen J, Magerl W, Kaehler M, Haenisch S, Binder A, Caliebe A, Maier C, Treede RD, Tölle T, Cascorbi I, Baron R. (2019) SIGMA-1 Receptor Gene Variants Affect the Somatosensory Phenotype in Neuropathic Pain Patients. J Pain 20(2):201-214.
  7. Vollert J, Magerl W, Baron R, Binder A, Enax-Krumova EK, Geisslinger G, Gierthmühlen J, Henrich F, Hüllemann P, Klein T, Lötsch J, Maier C, Oertel B, Schuh-Hofer S, Tölle TR, Treede RD (2018) Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. Pain 159(6):1090-1102
  8. Vollert J, Maier C, Attal N, Bennett DLH, Bouhassira D, Enax-Krumova EK, Finnerup NB, Freynhagen R, Gierthmühlen J, Haanpää J, Hansson P, Hüllemann P, Jensen TS, Magerl W, Ramirez JD, Rice ASC, Schuh-Hofer S, Segerdahl M, Serra J, Shillo PR, Sindrup S, Tesfaye S, Themistocleous AC, Tölle T, Treede R-D, Baron R (2017) Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations. Pain 158(8):1446-1455.
  9. Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice AS, Segerdahl M, Serra J, Sindrup S, Sommer C, Tölle T, Vollert J, Treede RD (2017) Peripheral Neuropathic Pain: A mechanism-related organizing principle based on sensory profiles. Pain 2016 Nov 3. [Epub ahead of print]
  10. Zhang J, Hoheisel U, Klein T, Magerl W, Mense S, Treede RD (2016) High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents. J Neurophysiol 115, 692-700
  11. Tesarz J, Eich W, Treede RD, Gerhardt A (2016) Altered pressure pain thresholds and increased wind-up in adult patients with chronic back pain with a history of childhood maltreatment: a quantitative sensory testing study. Pain 157: 1799-1809.
  12. Henrich F, Magerl W, Klein T, Greffrath W, Treede RD (2015) Capsaicin-sensitive C- and A-fibre nociceptors control long-term potentiation-like pain amplification in humans. Brain 138, 2505-2520.
  13. Caspani O, Reitz MC, Ceci A, Kremer A, Treede RD (2014) Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats. Pharmacol Biochem Behav 124, 290-296
  14. Hoheisel U, Reuter R, de Freitas MF, Treede RD, Mense S (2013) Injection of nerve growth factor into a low back muscle induces long-lasting latent hypersensitivity in rat dorsal horn neurons. Pain 154, 1953-1960
  15. Schuh-Hofer S, Wodarski R, Pfau DB, Caspani O, Magerl W, Kennedy JD, Treede RD (2013) One night of total sleep deprivation promotes a state of generalized hyperalgesia: a surrogate pain model to study the relationship of insomnia and pain. Pain 154, 1613-1621
  16. Michaux GP, Magerl W, Anton F, Treede RD (2012) Experimental characterization of the effects of acute stresslike doses of hydrocortisone in human neurogenic hyperalgesia models. Pain 153, 420-428.
  17. Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70: 1630-1635.
  18. Klein T, Magerl W, Hopf HC, Sandkühler J, Treede RD (2004) Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans. J Neurosci 24, 938-946

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