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Biochemistry

RNA Turnover & Translation

The activity of all eukaryotic genes is controlled in the nucleus at the level of transcription. In addition, gene expression is regulated at the posttranscriptional level in the cytoplasm through control of mRNA translation and degradation. Our lab examines molecular mechanisms by which mRNA decay and translation are controlled in mammalian cells.

Polysome profile analysis from macrophages during activation.

We investigate cis-acting RNA elements, trans-acting RNA-binding proteins and signaling pathways that specifically determine the fate of individual mRNAs. Our goal is to understand how the regulation of mRNA degradation and translation, both at the global level and at the level of individual mRNAs, contributes to innate immune activation, cellular differentiation and stress responses, and how the deregulation of posttranscriptional control participates in oncogenic transformation.

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