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Inhalt
The role of the Innate immune system in inflammation resolution in patients with chronic inflammatory diseases
Our aim is to obtain a better understanding of the processes and environmental cues that regulate inflammation resolution. We hypothesise that dysregulation of these processes is at the heart of chronic inflammatory diseases e.g. vasculitis, rheumatoid arthritis and atherosclerosis. We aim to understand if and how resolution signals derived from the innate immune system crosstalk with the endothelium and the adaptive immune system to orchestrate regulation of the inflammatory process. Our research implements both leukocyte - and vascular biology with the intention to unravel regulation of tissue homeostasis in a contextual situation. As such we are making use of both in vitro and in vivo models of inflammation, and testing newly designed compounds for efficacy to counteract inflammation.
Publications
Lu YP, Wu HW, Zhu T, Li XT, Zuo J, Hasan AA, Reichetzeder C, Delic D, Yard B, Klein T, Krämer BK, Zhang ZY, Wang XH, Yin LH, Dai Y, Zheng ZH, Hocher B. Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy. Biomed Pharmacother. 2022 Dec; 156:113947. doi: 10.1016/j.biopha.2022.113947
Zhang S, Cui D, Tang M, Yang G, Yard B, Hu H, Wu Y, Zhang Q. Serum and urinary carnosinase-1 correlate with kidney function and inflammation. Amino Acids. 2022 Nov 1. doi: 10.1007/s00726-022-03206-9
Leikeim L, Li H, An L, Sticht C, Krämer BK, Yard B, Leipe J, Kälsch AI. Immunology. Adenosine signalling in T-cell activation favours development of IL-17 positive cells with suppressive properties. Immunology. 2022 Nov 14. doi: 10.1111/imm.13608.
An L, Michaeli J, Pallavi P, Breedijk A, Xu X, Dietrich N, Sigl M, Keese M, Nitschke K, Jarczyk J, Nuhn P, Krämer BK, Yard BA, Leipe J. Concurrent stimulation of monocytes with CSF1 and polarizing cytokines reveals phenotypic and functional differences with classical polarized macrophages. J Leukoc Biol. 2022 Sep;112(3):437-447. doi: 10.1002/JLB.3A0721-383R.
Li Y, Hemmersbach L, Krause B, Sitnikov N, Schlundt Née Göderz A, Pastene Maldonado DO, Schmalz HG, Yard B. Head-to-Head Comparison of Selected Extra- and Intracellular CO-Releasing Molecules on Their CO-Releasing and Anti-Inflammatory Properties. Chembiochem. 2022 Jan 5;23(1):e202100452. doi: 10.1002/cbic.202100452.
Krebs J, Hillenbrand A, Tsagogiorgas C, Patry C, Tönshoff B, Yard B, Beck G, Rafat N. Intravenous delivery of granulocyte-macrophage colony stimulating factor impairs survival in lipopolysaccharide-induced sepsis. PLoS One. 2019 Jun 20;14(6):e0218602
Pallavi P, Pretze M, Caballero J, Li Y, Hofmann BB, Stamellou E, Klotz S, Wängler C, Wängler B, Loesel R, Roth S, Theisinger B, Moerz H, Binzen U, Greffrath W, Treede RD, Harmsen MC, Krämer BK, Hafner M, Yard BA, Kälsch AI. Analyses of Synthetic N-Acyl Dopamine Derivatives Revealing Different Structural Requirements for Their Anti-inflammatory and Transient-Receptor-Potential-Channel-of-the-Vanilloid-Receptor-Subfamily-Subtype-1 (TRPV1)-Activating Properties. J Med Chem. 2018 Apr 12;61(7):3126-3137
Stamellou E, Storz D, Botov S, Ntasis E, Wedel J, Sollazzo S, Krämer BK, van Son W, Seelen M, Schmalz HG, Schmidt A, Hafner M, Yard BA. Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation. Redox Biol. 2014 Jun 5;2:739-48. doi:
Romanski S, Stamellou E, Jaraba JT, Storz D, Krämer BK, Hafner M, Amslinger S, Schmalz HG, Yard BA. Enzyme-triggered CO-releasing molecules (ET-CORMs): evaluation of biological activity in relation to their structure. Free Radic Biol Med. 2013 Dec;65:78-88.
Schnuelle P, Gottmann U, Hoeger S, Boesebeck D, Lauchart W, Weiss C, Fischereder M, Jauch KW, Heemann U, Zeier M, Hugo C, Pisarski P, Krämer BK, Lopau K, Rahmel A, Benck U, Birck R, Yard BA. Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized. JAMA. 2009 Sep 9;302(10):1067-75controlled trial
Kontextspalte
Contact
Prof. Dr. Benito Yard
V. Department of Medicine
Head of Nephrology Laboratory
Universitätsklinikum Mannheim
Theodor-Kutzer-Ufer 1-3
68167 Mannheim