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Prof. Dr. Benito Yard

The role of the Innate immune system in inflammation resolution in patients with chronic inflammatory diseases

Our aim is to obtain a better understand­ing of the processes and environmental cues that regulate inflamma­tion resolution. We hypothesise that dysregulation of these processes is at the heart of chronic inflammatory diseases e.g. vasculitis, rheumatoid arthritis and atherosclerosis. We aim to understand if and how resolution signals derived from the innate immune system crosstalk with the endothelium and the adaptive immune system to orchestrate regulation of the inflammatory process. Our research implements both leukocyte - and vascular biology with the intention to unravel regulation of tis­sue homeostasis in a contextual situation. As such we are making use of both in vitro and in vivo models of inflammation, and testing newly designed compounds for efficacy to counteract inflammation.

Publications

Krebs J, Hillenbrand A, Tsagogiorgas C, Patry C, Tönshoff B, Yard B, Beck G, Rafat N. Intravenous delivery of granulocyte-macrophage colony stimulating factor impairs survival in lipopolysaccharide-induced sepsis. PLoS One. 2019 Jun 20;14(6):e0218602

Pallavi P, Pretze M, Caballero J, Li Y, Hofmann BB, Stamellou E, Klotz S, Wängler C, Wängler B, Loesel R, Roth S, Theisinger B, Moerz H, Binzen U, Greffrath W, Treede RD, Harmsen MC, Krämer BK, Hafner M, Yard BA, Kälsch AI. Analyses of Synthetic N-Acyl Dopamine Derivatives Revealing Different Structural Requirements for Their Anti-inflammatory and Transient-Receptor-Potential-Channel-of-the-Vanilloid-Receptor-Subfamily-Subtype-1 (TRPV1)-Activating Properties. J Med Chem. 2018 Apr 12;61(7):3126-3137

Stamellou E, Storz D, Botov S, Ntasis E, Wedel J, Sollazzo S, Krämer BK, van Son W, Seelen M, Schmalz HG, Schmidt A, Hafner M, Yard BA. Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation Redox Biol. 2014 Jun 5;2:739-48. doi:

Romanski S, Stamellou E, Jaraba JT, Storz D, Krämer BK, Hafner M, Amslinger S, Schmalz HG, Yard BA. Enzyme-triggered CO-releasing molecules (ET-CORMs): evaluation of biological activity in relation to their structure. Free Radic Biol Med. 2013 Dec;65:78-88.

Schnuelle P, Gottmann U, Hoeger S, Boesebeck D, Lauchart W, Weiss C, Fischereder M, Jauch KW, Heemann U, Zeier M, Hugo C, Pisarski P, Krämer BK, Lopau K, Rahmel A, Benck U, Birck R, Yard BA. Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized. JAMA. 2009 Sep 9;302(10):1067-75controlled trial

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