MI3 PUBLICATIONS

2025

Protocol for isolating and purifying murine liver sinusoidal endothelial cells for in vitro culture and functional assays. Papaioannou S, See JX, Baljkas T, Reiners-Koch P, Winkler M, Cerwenka A, Stojanovic A. STAR Protoc. 2025 Mar 21;6(1):103554. doi: 10.1016/j.xpro.2024.103554. Epub 2025 Jan 12. PMID: 39804772; PMCID: PMC11772955.

Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells. Sparano C, Solís-Sayago D, Zangger NS, Rindlisbacher L, Van Hove H, Vermeer M, Westermann F, Mussak C, Rallo E, Dergun S, Litscher G, Xu Y, Bijnen M, Friedrich C, Greter M, Juranić Lisnić V, Becher B, Gasteiger G, Oxenius A, Tugues S. J Exp Med. 2025 Mar 3;222(3):e20240930. doi: 10.1084/jem.20240930. Epub 2024 Dec 18. PMID: 39692745; PMCID: PMC11654236.

Multiple Sclerosis: Glial Cell Diversity in Time and Space. Kooistra SM, Schirmer L. Glia. 2025 Mar;73(3):574-590. doi: 10.1002/glia.24655. Epub 2024 Dec 24. PMID: 39719685; PMCID: PMC11784844.

ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation. Link F, Li Y, Zhao J, Munker S, Fan W, Nwosu ZC, Yao Y, Wang S, Huang C, Liebe R, Hammad S, Liu H, Shao C, Gao C, Sun B, Török NJ, Ding H, Ebert MP, Weng H, Ten Dijke P, Drasdo D, Dooley S, Wang S. Gut. 2025 Feb 6;74(3):424-439. doi: 10.1136/gutjnl-2024-333213. PMID: 39448254.

Interferential Current Stimulation Enhances Rectal Motor Activity: Insights from an Isolated Perfused Porcine Model. Martel R, Boettcher M, Klinke Petrowsky M, Hoyos NA, Herrmann I, Magerl W, Herrmann M. Eur J Pediatr Surg. 2025 Feb;35(1):60-70. doi: 10.1055/a-2482-5997. Epub 2024 Nov 25. PMID: 39587047.

Zn-doped CaP coating equips Ti implants with corrosion resistance, biomineralization, antibacterial and immunotolerant activities. Parau AC, Büyüksungur S, Li G, Liu Q, Badillo E, Blum L, Schmidt J, Pana I, Vitelaru C, Marinescu IM, Dinu M, Smuglov M, Schmuttermaier C, Tanir TE, Klüter H, Hasirci N, Kzhyshkowska J, Dragomir AV. J Adv Res. 2025 Jan 27:S2090-1232(25)00064-5. doi: 10.1016/j.jare.2025.01.045. Epub ahead of print. PMID: 39880075.

Aging platelets shift their hemostatic properties to inflammatory functions. Anjum A, Mader M, Mahameed S, Muraly A, Denorme F, Kliem FP, Rossaro D, Akgöl S, Di Fina L, Mulkers M, Laun LS, Li L, Kupper N, Yue K, Hoffknecht ML, Akhalkatsi A, Loew Q, Pircher J, Escaig R, Strasser EF, Wichmann C, Pekayvaz K, Nieswandt B, Schulz C, Robles MS, Kaiser R, Massberg S, Campbell RA, Nicolai L. Blood. 2025 Jan 22:blood.2024024901. doi: 10.1182/blood.2024024901. Epub ahead of print. PMID: 39841014.

Perinatal dysfunction of innate immunity in cystic fibrosis. Jaudas F, Bartenschlager F, Shashikadze B, Santamaria G, Reichart D, Schnell A, Stöckl JB, Degroote RL, Cambra JM, Graeber SY, Bähr A, Kartmann H, Stefanska M, Liu H, Naumann-Bartsch N, Bruns H, Berges J, Hanselmann L, Stirm M, Krebs S, Deeg CA, Blum H, Schulz C, Zawada D, Janda M, Caballero-Posadas I, Kunzelmann K, Moretti A, Laugwitz KL, Kupatt C, Saalmüller A, Fröhlich T, Wolf E, Mall MA, Mundhenk L, Gerner W, Klymiuk N. Sci Transl Med. 2025 Jan 22;17(782):eadk9145. doi: 10.1126/scitranslmed.adk9145. Epub 2025 Jan 22. PMID: 39841805.

3D Bioprinted Head and Neck Squamous Cell Carcinoma (HNSCC) Model Using Tunicate Derived Nanocellulose (NC) Bioink. Azhakesan A, Kern J, Mishra A, Selhuber-Unkel C, Affolter A, Gatenholm P, Rotter N, Bieback K. Adv Healthc Mater. 2025 Jan 13:e2403114. doi: 10.1002/adhm.202403114. Epub ahead of print. PMID: 39801216.

Urine miRNA signature as potential non-invasive diagnostic biomarker for Hirschsprung's disease. Sreepada A, Khasanov R, Elkrewi EZ, de la Torre C, Felcht J, Al Abdulqader AA, Martel R, Hoyos-Celis NA, Boettcher M, Wessel LM, Schäfer KH, Tapia-Laliena MÁ. Front Mol Neurosci. 2025 Jan 8;17:1504424. doi: 10.3389/fnmol.2024.1504424. PMID: 39872605; PMCID: PMC11770682.

2024

The Lymphatic Vascular System in Extracellular Vesicle-Mediated Tumor Progression. Lodha P, Acari A, Rieck J, Hofmann S, Dieterich LC. Cancers (Basel). 2024 Dec 2;16(23):4039. doi: 10.3390/cancers16234039. PMID: 39682225; PMCID: PMC11640020.

Targeting of TAMs: can we be more clever than cancer cells? Kzhyshkowska J, Shen J, Larionova I. Cell Mol Immunol. 2024 Dec;21(12):1376-1409. doi: 10.1038/s41423-024-01232-z. Epub 2024 Nov 8.

E3 ubiquitin ligase RNF10 promotes dissociation of stalled ribosomes and responds to ribosomal subunit imbalance. Lehmann JA, Lindner D, Sung HM, Stoecklin G. Nat Commun. 2024 Nov 28;15(1):10350. doi: 10.1038/s41467-024-54411-x. PMID: 39609413; PMCID: PMC11604940

Immunotherapy that improves response to chemotherapy in high-grade serous ovarian cancer. Elorbany S, Berlato C, Carnevalli LS, Maniati E, Barry ST, Wang J, Manchanda R, Kzhyshkowska J, Balkwill F. Nat Commun. 2024 Nov 22;15(1):10144. doi: 10.1038/s41467-024-54295-x.

Transcriptional pathways of terminal differentiation in high- and low-density blood granulocytes in sepsis. Guenther T, Coulibaly A, Velásquez SY, Schulte J, Fuderer T, Sturm T, Hahn B, Thiel M, Lindner HA. J Inflamm (Lond). 2024 Oct 21;21(1):40. doi: 10.1186/s12950-024-00414-w. PMID: 39434093; PMCID: PMC11492786.

Empowering Natural Killer Cells to Combat Acute Myeloid Leukemia: Perspective on CAR-NK Cell Therapy. Gierschek F, Schlueter J, Kühnel I, Feigl FF, Schmiedel D, Prüfer M, Buchinger L, Cerwenka A, Cappel C, Huenecke S, Köhl U, Wels WS, Ullrich E; Translational Oncology Consortium “NKfit4AML” sponsored by the German Cancer Aid. Transfus Med Hemother. 2024 Oct 1;52(1):42-60. doi: 10.1159/000540962. PMID: 39944413; PMCID: PMC11813277.

Titanium induces proinflammatory and tissue-destructive responses in primary human macrophages. Gudima A, Hesselbarth D, Li G, Riabov V, Michel J, Liu Q, Schmuttermaier C, Jiao Z, Sticht C, Jawhar A, Obertacke U, Klüter H, Vrana NE, Kzhyshkowska J. J Leukoc Biol. 2024 Oct 1;116(4):706-725. doi: 10.1093/jleuko/qiae072.

Novel multiphoton intravital imaging enables real-time study of Helicobacter pylori interaction with neutrophils and macrophages in the mouse stomach. Ishikawa-Ankerhold H, Busch B, Bader A, Maier-Begandt D, Dionisio F, Namineni S, Vladymyrov M, Harrison U, van den Heuvel D, Tomas L, Walzog B, Massberg S, Schulz C, Haas R. PLoS Pathog. 2024 Sep 30;20(9):e1012580. doi: 10.1371/journal.ppat.1012580. PMID: 39348445; PMCID: PMC11478878.

S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling. Özbay Kurt FG, Cicortas BA, Balzasch BM, De la Torre C, Ast V, Tavukcuoglu E, Ak C, Wohlfeil SA, Cerwenka A, Utikal J, Umansky V. J Immunother Cancer. 2024 Sep 11;12(9):e009552. doi: 10.1136/jitc-2024-009552. PMID: 39266214; PMCID: PMC11409250.

Protocol for isolating high-purity natural killer cells from peripheral blood of septic patients using magnetic cell separation. Coulibaly A, Sturm T, Schulte J, Lindner HA, Velásquez SY. STAR Protoc. 2024 Sep 20;5(3):103288. doi: 10.1016/j.xpro.2024.103288. Epub 2024 Sep 4. PMID: 39235937; PMCID: PMC11452915.

Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma. Larionova I, Iamshchikov P, Kazakova A, Rakina M, Menyalo M, Enikeeva K, Rafikova G, Sharifyanova Y, Pavlov V, Villert A, Kolomiets L, Kzhyshkowska J. Front Immunol. 2024 Sep 9;15:1414716. doi: 10.3389/fimmu.2024.1414716. eCollection 2024.

DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, Messerer D, Horn A, Shemer R, Jacqmarcq C, Picot A, Green JP, Schlegl C, Li X, Tomas L, Dutsch A, Liman TG, Endres M, Wernsdorf SR, Fürle C, Carofiglio O, Zhu J, Brough D; DEMDAS Study Group; Hornung V, Dichgans M, Vivien D, Schulz C, Dor Y, Tiedt S, Sager HB, Grosse GM, Liesz A. Nature. 2024 Sep;633(8029):433-441. doi: 10.1038/s41586-024-07803-4. Epub 2024 Aug 7. PMID: 39112714; PMCID: PMC11390481.

Inter- and Intra-donor variability in bone marrow-derived mesenchymal stromal cells: implications for clinical applications. Trivedi A, Lin M, Miyazawa B, Nair A, Vivona L, Fang X, Bieback K, Schäfer R, Spohn G, McKenna D, Zhuo H, Matthay MA, Pati S. Cytotherapy. 2024 Sep;26(9):1062-1075. doi: 10.1016/j.jcyt.2024.03.486. Epub 2024 Mar 30. PMID: 38852094.

Innate immune memory after brain injury drives inflammatory cardiac dysfunction. Simats A, Zhang S, Messerer D, Chong F, Beşkardeş S, Chivukula AS, Cao J, Besson-Girard S, Montellano FA, Morbach C, Carofiglio O, Ricci A, Roth S, Llovera G, Singh R, Chen Y, Filser S, Plesnila N, Braun C, Spitzer H, Gokce O, Dichgans M, Heuschmann PU, Hatakeyama K, Beltrán E, Clauss S, Bonev B, Schulz C, Liesz A. Cell. 2024 Aug 22;187(17):4637-4655.e26. doi: 10.1016/j.cell.2024.06.028. Epub 2024 Jul 22. PMID: 39043180.

Neutrophil extracellular traps characterize caseating granulomas. Zlatar L, Knopf J, Singh J, Wang H, Muñoz-Becerra M, Herrmann I, Chukwuanukwu RC, Eckstein M, Eichhorn P, Rieker RJ, Naschberger E, Burkovski A, Krenn V, Bilyy R, Butova T, Liskina I, Kalabukha I, Khmel O, Boettcher M, Schett G, Butov D, Tkachenko A, Herrmann M. Cell Death Dis. 2024 Jul 31;15(7):548. doi: 10.1038/s41419-024-06892-3. PMID: 39085192; PMCID: PMC11291884.

KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2. Bi S, Huang L, Chen Y, Hu Z, Li S, Wang Y, Huang B, Zhang L, Huang Y, Dai B, Du L, Tu Z, Wang Y, Xu D, Xu X, Sun W, Kzhyshkowska J, Wang H, Chen D, Wang F, Zhang S. Nat Commun. 2024 Jul 3;15(1):5602. doi: 10.1038/s41467-024-49930-6.

IFNγ mediates the resistance of tumor cells to distinct NK cell subsets. Hofman T, Ng SW, Garcés-Lázaro I, Heigwer F, Boutros M, Cerwenka A. J Immunother Cancer. 2024 Jul 1;12(7):e009410. doi: 10.1136/jitc-2024-009410. PMID: 38955423; PMCID: PMC11218003.

Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation. Jeong M, Cortopassi F, See JX, De La Torre C, Cerwenka A, Stojanovic A. Eur J Immunol. 2024 Jul;54(7):e2250342. doi: 10.1002/eji.202250342. Epub 2024 Apr 9. PMID: 38593338.

Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis. Wischnewski S, Thäwel T, Ikenaga C, Kocharyan A, Lerma-Martin C, Zulji A, Rausch HW, Brenner D, Thomas L, Kutza M, Wick B, Trobisch T, Preusse C, Haeussler M, Leipe J, Ludolph A, Rosenbohm A, Hoke A, Platten M, Weishaupt JH, Sommer CJ, Stenzel W, Lloyd TE, Schirmer L. Nat Aging. 2024 Jul;4(7):969-983. doi: 10.1038/s43587-024-00645-9. Epub 2024 Jun 4. PMID: 38834884; PMCID: PMC11257986.

Hyperglycemia amplifies TLR-mediated inflammatory response of M(IL4) macrophages to dyslipidemic ligands. Badillo-Garcia LE, Liu Q, Ziebner K, Balduff M, Sevastyanova T, Schmuttermaier C, Klüter H, Harmsen M, Kzhyshkowska J. J Leukoc Biol. 2024 Jun 28;116(1):197-204. doi: 10.1093/jleuko/qiae050.

Mortality Prediction by Kinetic Parameters of Lactate and S-Adenosylhomocysteine in a Cohort of Critically Ill Patients. Schoettler JJ, Brohm K, Mindt S, Jäger E, Hahn B, Fuderer T, Lindner HA, Schneider-Lindner V, Krebs J, Neumaier M, Thiel M, Centner FS. Int J Mol Sci. 2024 Jun 9;25(12):6391. doi: 10.3390/ijms25126391. PMID: 38928097; PMCID: PMC11204002.

Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries. Hypertension. Rios FJ, de Ciuceis C, Georgiopoulos G, Lazaridis A, Nosalski R, Pavlidis G, Tual-Chalot S, Agabiti-Rosei C, Camargo LL, Dąbrowska E, Quarti-Trevano F, Hellmann M, Masi S, Lopreiato M, Mavraganis G, Mengozzi A, Montezano AC, Stavropoulos K, Winklewski PJ, Wolf J, Costantino S, Doumas M, Gkaliagkousi E, Grassi G, Guzik TJ, Ikonomidis I, Narkiewicz K, Paneni F, Rizzoni D, Stamatelopoulos K, Stellos K, Taddei S, Touyz RM, Virdis A. 2024 Jun;81(6):1218-1232. doi: 10.1161/HYPERTENSIONAHA.123.22483. Epub 2024 Mar 21. PMID: 38511317.

Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia. Weinberger T, Denise M, Joppich M, Fischer M, Garcia Rodriguez C, Kumaraswami K, Wimmler V, Ablinger S, Räuber S, Fang J, Liu L, Liu WH, Winterhalter J, Lichti J, Thomas L, Esfandyari D, Percin G, Matin S, Hidalgo A, Waskow C, Engelhardt S, Todica A, Zimmer R, Pridans C, Gomez Perdiguero E, Schulz C. Elife. 2024 May 22;12:RP89377. doi: 10.7554/eLife.89377. PMID: 38775664; PMCID: PMC11111219.

Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells. Rieckmann LM, Spohn M, Ruff L, Agorku D, Becker L, Borchers A, Krause J, O'Reilly R, Hille J, Velthaus-Rusik JL, Beumer N, Günther A, Willnow L, Imbusch CD, Iglauer P, Simon R, Franzenburg S, Winter H, Thomas M, Bokemeyer C, Gagliani N, Krebs CF, Sprick M, Hardt O, Riethdorf S, Trumpp A, Stoecklein NH, Peine S, Rosenstiel P, Pantel K, Loges S, Janning M. Mol Cancer. 2024 May 8;23(1):93. doi: 10.1186/s12943-024-01984-2. PMID: 38720314; PMCID: PMC11077784.

The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance. Kilian M, Friedrich MJ, Lu KH, Vonhören D, Jansky S, Michel J, Keib A, Stange S, Hackert N, Kehl N, Hahn M, Habel A, Jung S, Jähne K, Sahm F, Betge J, Cerwenka A, Westermann F, Dreger P, Raab MS, Meindl-Beinker NM, Ebert M, Bunse L, Müller-Tidow C, Schmitt M, Platten M. Sci Immunol. 2024 May 3;9(95):eadj7970. doi: 10.1126/sciimmunol.adj7970. Epub 2024 May 3. PMID: 38701193.

The Dual Role of Neutrophil Extracellular Traps (NETs) in Sepsis and Ischemia-Reperfusion Injury: Comparative Analysis across Murine Models. Kiwit A, Lu Y, Lenz M, Knopf J, Mohr C, Ledermann Y, Klinke-Petrowsky M, Pagerols Raluy L, Reinshagen K, Herrmann M, Boettcher M, Elrod J. Int J Mol Sci. 2024 Mar 28;25(7):3787. doi: 10.3390/ijms25073787. PMID: 38612596; PMCID: PMC11011604.

Modelling of macrophage responses to biomaterials in vitro: state-of-the-art and the need for the improvement. Piatnitskaia S, Rafikova G, Bilyalov A, Chugunov S, Akhatov I, Pavlov V, Kzhyshkowska J. Front Immunol. 2024 Mar 26;15:1349461. doi: 10.3389/fimmu.2024.1349461. eCollection 2024.

Macrophage diversity in human cancers: New insight provided by single-cell resolution and spatial context. Rakina M, Larionova I, Kzhyshkowska J. Heliyon. 2024 Mar 21;10(7):e28332. doi: 10.1016/j.heliyon.2024.e28332. eCollection 2024 Apr 15. PMID: 38571605

ROS signaling in innate immunity via oxidative protein modifications. Manoharan RR, Prasad A, Pospíšil P, Kzhyshkowska J. Front Immunol. 2024 Mar 7;15:1359600. doi: 10.3389/fimmu.2024.1359600. eCollection 2024.

NLGN4X TCR transgenic T cells to treat gliomas. Krämer C, Kilian M, Chih YC, Kourtesakis A, Hoffmann DC, Boschert T, Koopmann P, Sanghvi K, De Roia A, Jung S, Jähne K, Day B, Shultz LD, Ratliff M, Harbottle R, Green EW, Will R, Wick W, Platten M, Bunse L. Neuro Oncol. 2024 Feb 2;26(2):266-278. doi: 10.1093/neuonc/noad172. PMID: 37715782; PMCID: PMC10836769.

Downregulation of Hypoxia Inducible Factor-1α in Primary Human Natural Killer Cells Using Small Interfering RNA Delivery with ExPERT ATx by MaxCyte. Velásquez SY, Baslar GE, Schulte J, Fuderer T, Lindner HA, Coulibaly A. Curr Protoc. 2024 Feb;4(2):e987. doi: 10.1002/cpz1.987. PMID: 38327104.

Dysregulation of CITED2 in abnormal lung development in the nitrofen rat model. Jank M, Schwartz J, Miyake Y, Ozturk Aptekmann A, Patel D, Boettcher M, Keijzer R. Pediatr Surg Int. 2024 Jan 30;40(1):43. doi: 10.1007/s00383-023-05607-7. PMID: 38291157.

Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert anti-apoptotic and anti-inflammatory effects in vitro and modulate mRNA expression in a cisplatin-induced kidney injury murine model. Rendra E, Crigna AT, Daniele C, Sticht C, Cueppers M, Kluth MA, Ganss C, Frank MH, Gretz N, Bieback K. Front Immunol. 2024 Jan 11;14:1228928. doi: 10.3389/fimmu.2023.1228928. PMID: 38274791; PMCID: PMC10808769.

Optimization of extracellular vesicles preparation from saliva of head and neck cancer patients. Tengler L, Tiedtke M, Schütz J, Bieback K, Uhlig S, Theodoraki MN, Nitschke K, Worst TS, Seiz E, Scherl C, Rotter N, Ludwig S. Sci Rep. 2024 Jan 10;14(1):946. doi: 10.1038/s41598-023-50610-6. PMID: 38200037; PMCID: PMC10781729.

Adipose Stromal Cell-Derived Secretome Attenuates Cisplatin-Induced Injury In Vitro Surpassing the Intricate Interplay between Proximal Tubular Epithelial Cells and Macrophages. Rendra E, Uhlig S, Moskal I, Thielemann C, Klüter H, Bieback K. Cells. 2024 Jan 9;13(2):121. doi: 10.3390/cells13020121. PMID: 38247813; PMCID: PMC10814170.

DNases improve effectiveness of antibiotic treatment in murine polymicrobial sepsis. Willemsen JF, Wenskus J, Lenz M, Rhode H, Trochimiuk M, Appl B, Pagarol-Raluy L, Börnigen D, Bang C, Reinshagen K, Herrmann M, Elrod J, Boettcher M. Front Immunol. 2024 Jan 8;14:1254838. doi: 10.3389/fimmu.2023.1254838. PMID: 38259485; PMCID: PMC10801052.

Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ. Yu Y, Farooq MS, Eberhart Meessen S, Jiang Y, Kato D, Zhan T, Weiss C, Seger R, Kang W, Zhang X, Yu J, Ebert MPA, Burgermeister E. Cell Death Dis. 2024 Jan 4;15(1):7. doi: 10.1038/s41419-023-06371-1. PMID: 38177114; PMCID: PMC10766976.

The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC Activation. Wang S, Link F, Han M, Chaudhary R, Asimakopoulos A, Liebe R, Yao Y, Hammad S, Dropmann A, Krizanac M, Rubie C, Feiner LK, Glanemann M, Ebert MPA, Weiskirchen R, Henis YI, Ehrlich M, Dooley S. Cell Mol Gastroenterol Hepatol. 2024;17(4):567-587. doi: 10.1016/j.jcmgh.2023.12.012. Epub 2023 Dec 27. PMID: 38154598; PMCID: PMC10883985.

2023

Pneumonia in the first week after polytrauma is associated with reduced blood levels of soluble herpes virus entry mediator. Schaefer N, Lindner HA, Hahn B, Schefzik R, Velásquez SY, Schulte J, Fuderer T, Centner FS, Schoettler JJ, Himmelhan BS, Sturm T, Thiel M, Schneider-Lindner V, Coulibaly A. Front Immunol. 2023 Dec 22;14:1259423. doi: 10.3389/fimmu.2023.1259423. PMID: 38187375; PMCID: PMC10770833.

Dual-Specificity Phosphatases in Regulation of Tumor-Associated Macrophage Activity. Patysheva MR, Prostakishina EA, Budnitskaya AA, Bragina OD, Kzhyshkowska JG. Int J Mol Sci. 2023 Dec 16;24(24):17542. doi: 10.3390/ijms242417542.

Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity. Groth C, Maric J, Garcés Lázaro I, Hofman T, Zhang Z, Ni Y, Keller F, Seufert I, Hofmann M, Neumann-Haefelin C, Sticht C, Rippe K, Urban S, Cerwenka A. Front Immunol. 2023 Dec 8;14:1287367. doi: 10.3389/fimmu.2023.1287367. PMID: 38143742; PMCID: PMC10739304.

Microenvironmental signals shaping NK-cell reactivity in cancer. Balzasch BM, Cerwenka A. Eur J Immunol. 2023 Dec;53(12):e2250103. doi: 10.1002/eji.202250103. Epub 2023 May 28. PMID: 37194594.

Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro. da Silva TB, Rendra E, David CAW, Bieback K, Cross MJ, Wilm B, Liptrott NJ, Murray P. Biomed Pharmacother. 2023 Nov;167:115624. doi: 10.1016/j.biopha.2023.115624. Epub 2023 Sep 30. PMID: 37783151.

Neutrophil extracellular traps and DNases orchestrate formation of peritoneal adhesions. Elrod J, Heuer A, Knopf J, Schoen J, Schönfeld L, Trochimiuk M, Stiel C, Appl B, Raluy LP, Saygi C, Zlatar L, Hosari S, Royzman D, Winkler TH, Lochnit G, Leppkes M, Grützmann R, Schett G, Tomuschat C, Reinshagen K, Herrmann M, Fuchs TA, Boettcher M. iScience. 2023 Oct 27;26(12):108289. doi: 10.1016/j.isci.2023.108289. PMID: 38034352; PMCID: PMC10682263.

Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality. Skovronova R, Scaccia E, Calcat-I-Cervera S, Bussolati B, O'Brien T, Bieback K. J Transl Med. 2023 Oct 16;21(1):723. doi: 10.1186/s12967-023-04602-9. PMID: 37840135; PMCID: PMC10577984.

Mitogen-Activated Protein Kinase and Exploratory Nuclear Receptor Crosstalk in Cancer Immunotherapy. Burgermeister E. Int J Mol Sci. 2023 Sep 26;24(19):14546. doi: 10.3390/ijms241914546. PMID: 37833991; PMCID: PMC10572424.

Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy. Burgermeister E. Int J Mol Sci. 2023 Sep 4;24(17):13661. doi: 10.3390/ijms241713661. PMID: 37686465; PMCID: PMC10488039.

Modulation of PD‑L1 expression by standard therapy in head and neck cancer cell lines and exosomes. Affolter A, Liebel K, Tengler L, Seiz E, Tiedtke M, Azhakesan A, Schütz J, Theodoraki MN, Kern J, Ruder AM, Fleckenstein J, Weis CA, Bieback K, Kramer B, Lammert A, Scherl C, Rotter N, Ludwig S. Int J Oncol. 2023 Sep;63(3):102. doi: 10.3892/ijo.2023.5550. Epub 2023 Jul 28. PMID: 37503786; PMCID: PMC10552694.

Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury. Papaioannou S, See JX, Jeong M, De La Torre C, Ast V, Reiners-Koch PS, Sati A, Mogler C, Platten M, Cerwenka A, Stojanovic A. Cell Rep. 2023 Aug 29;42(8):112836. doi: 10.1016/j.celrep.2023.112836. Epub 2023 Jul 19. PMID: 37471222.

Immunofluorescence Imaging of Neutrophil Extracellular Traps in Human and Mouse Tissues. Schöenfeld L, Appl B, Pagerols-Raluy L, Heuer A, Reinshagen K, Boettcher M. J Vis Exp. 2023 Aug 18;(198). doi: 10.3791/65272. Erratum in: J Vis Exp. 2023 Sep 29;(199). doi: 10.3791/6573. PMID: 37677039.

Queuosine-tRNA promotes sex-dependent learning and memory formation by maintaining codon-biased translation elongation speed Cirzi C, Dyckow J, Legrand C, Schott J, Guo W, Perez Hernandez D, Hisaoka M, Parlato R, Pitzer C, van der Hoeven F, Dittmar G, Helm M, Stoecklin G, Schirmer L, Lyko F, Tuorto F. EMBO J. 2023 Aug 23:e112507. doi: 10.15252/embj.2022112507. Epub ahead of print. PMID: 37609797

Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers. Rafikova G, Gilyazova I, Enikeeva K, Pavlov V, Kzhyshkowska J. Int J Mol Sci. 2023 Aug 14;24(16):12797. doi: 10.3390/ijms241612797.

S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study. Centner FS, Schoettler JJ, Brohm K, Mindt S, Jäger E, Hahn B, Fuderer T, Lindner HA, Schneider-Lindner V, Krebs J, Neumaier M, Thiel M. Int J Mol Sci. 2023 Aug 9;24(16):12600. doi: 10.3390/ijms241612600. PMID: 37628779; PMCID: PMC10454796.

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction. Bawamia B, Spray L, Wangsaputra VK, Bennaceur K, Vahabi S, Stellos K, Kharatikoopaei E, Ogundimu E, Gale CP, Keavney B, Maier R, Hancock H, Richardson G, Austin D, Spyridopoulos I. Geroscience. 2023 Aug;45(4):2689-2705. doi: 10.1007/s11357-023-00794-6. Epub 2023 Apr 22. PMID: 37086366; PMCID: PMC10122201.

Hepatocytes reprogram liver macrophages involving control of TGF-β activation, influencing liver regeneration and injury. Wolf SD, Ehlting C, Müller-Dott S, Poschmann G, Petzsch P, Lautwein T, Wang S, Helm B, Schilling M, Saez-Rodriguez J, Vucur M, Stühler K, Köhrer K, Tacke F, Dooley S, Klingmüller U, Luedde T, Bode JG. Hepatol Commun. 2023 Jul 24;7(8):e0208. doi: 10.1097/HC9.0000000000000208. PMID: 37486964; PMCID: PMC10368377.

Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation. Hammad S, Ogris C, Othman A, Erdoesi P, Schmidt-Heck W, Biermayer I, Helm B, Gao Y, Piorońska W, Holland CH, D'Alessandro LA, de la Torre C, Sticht C, Al Aoua S, Theis FJ, Bantel H, Ebert MP, Klingmüller U, Hengstler JG, Dooley S, Mueller NS. Cell Death Dis. 2023 Jul 12;14(7):414. doi: 10.1038/s41419-023-05855-4. PMID: 37438332; PMCID: PMC10338629.

Clinical ground truth in machine learning for early sepsis diagnosis. Lancet Digit Health. Lindner HA, Thiel M, Schneider-Lindner V. 2023 Jun;5(6):e338-e339. doi: 10.1016/S2589-7500(23)00070-5. PMID: 37236696.

Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction. Sopova K, Tual-Chalot S, Mueller-Hennessen M, Vlachogiannis NI, Georgiopoulos G, Biener M, Sachse M, Turchinovich A, Polycarpou-Schwarz M, Spray L, Maneta E, Bennaceur K, Mohammad A, Richardson GD, Gatsiou A, Langer HF, Frey N, Stamatelopoulos K, Heineke J, Duerschmied D, Giannitsis E, Spyridopoulos I, Stellos K. Front Immunol. 2023 Jun 22;14:1177467. doi: 10.3389/fimmu.2023.1177467. PMID: 37426649; PMCID: PMC10326041.

RNA-binding proteins in vascular inflammation and atherosclerosis. Sachse M, Tual-Chalot S, Ciliberti G, Amponsah-Offeh M, Stamatelopoulos K, Gatsiou A, Stellos K. Atherosclerosis. 2023 Jun;374:55-73. doi: 10.1016/j.atherosclerosis.2023.01.008. Epub 2023 Jan 17. PMID: 36759270.

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation. Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A, Gallo A, Drakos SG, Dimmeler S, Sperandio M, Soehnlein O, Stellos K. Immunity. 2023 May 9;56(5):979-997.e11. doi: 10.1016/j.immuni.2023.03.021. Epub 2023 Apr 25. PMID: 37100060.

Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach. Calcat-I-Cervera S, Rendra E, Scaccia E, Amadeo F, Hanson V, Wilm B, Murray P, O'Brien T, Taylor A, Bieback K. Stem Cell Res Ther. 2023 May 4;14(1):120. doi: 10.1186/s13287-023-03352-1. PMID: 37143116; PMCID: PMC10161493.

Endothelial dysfunction and immunothrombosis in sepsis. Maneta E, Aivalioti E, Tual-Chalot S, Emini Veseli B, Gatsiou A, Stamatelopoulos K, Stellos K. Front Immunol. 2023 Apr 4;14:1144229. doi: 10.3389/fimmu.2023.1144229. PMID: 37081895; PMCID: PMC10110956.

Tumor-activated neutrophils promote metastasis in breast cancer via the G-CSF-RLN2-MMP-9 axis. Sheng Y, Peng W, Huang Y, Cheng L, Meng Y, Kwantwi LB, Yang J, Xu J, Xiao H, Kzhyshkowska J, Wu Q. J Leukoc Biol. 2023 Mar 29;113(4):383-399. doi: 10.1093/jleuko/qiad004.

Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF. Larionova I, Kiselev A, Kazakova E, Liu T, Patysheva M, Iamshchikov P, Liu Q, Mossel DM, Riabov V, Rakina M, Sergushichev A, Bezgodova N, Vtorushin S, Litviakov N, Denisov E, Koshkin P, Pyankov D, Tsyganov M, Ibragimova M, Cherdyntseva N, Kzhyshkowska J. Front Immunol. 2023 Mar 7;14:1000497. doi: 10.3389/fimmu.2023.1000497. eCollection 2023.

FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression. Wang S, Feng R, Wang SS, Liu H, Shao C, Li Y, Link F, Munker S, Liebe R, Meyer C, Burgermeister E, Ebert M, Dooley S, Ding H, Weng H. Gut. 2023 Mar;72(3):549-559. doi: 10.1136/gutjnl-2022-326987. Epub 2022 Apr 20. PMID: 35444014.

Angiogenesis regulators S100A4, SPARC and SPP1 correlate with macrophage infiltration and are prognostic biomarkers in colon and rectal cancers. Kazakova E, Rakina M, Sudarskikh T, Iamshchikov P, Tarasova A, Tashireva L, Afanasiev S, Dobrodeev A, Zhuikova L, Cherdyntseva N, Kzhyshkowska J, Larionova I. Front Oncol. 2023 Feb 21;13:1058337. doi: 10.3389/fonc.2023.1058337. eCollection 2023.

Interaction of Ceramic Implant Materials with Immune System. Rafikova G, Piatnitskaia S, Shapovalova E, Chugunov S, Kireev V, Ialiukhova D, Bilyalov A, Pavlov V, Kzhyshkowska J. Int J Mol Sci. 2023 Feb 20;24(4):4200. doi: 10.3390/ijms24044200.

Immunosuppressive capacity of circulating MDSC predicts response to immune checkpoint inhibitors in melanoma patients. Petrova V, Groth C, Bitsch R, Arkhypov I, Simon SCS, Hetjens S, Müller V, Utikal J, Umansky V. Front Immunol. 2023 Feb 13;14:1065767. doi: 10.3389/fimmu.2023.1065767. PMID: 36860876; PMCID: PMC9968744.

Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns. Elrod J, Lenz M, Kiwit A, Armbrust L, Schönfeld L, Reinshagen K, Pagerols Raluy L, Mohr C, Saygi C, Alawi M, Rohde H, Herrmann M, Boettcher M. Front Immunol. 2023 Feb 7;14:1113948. doi: 10.3389/fimmu.2023.1113948. PMID: 36825027; PMCID: PMC9941538.

Midgut Volvulus Adds a Murine, Neutrophil-Driven Model of Septic Condition to the Experimental Toolbox. Elrod J, Kiwit A, Lenz M, Rohde H, Börnigen D, Alawi M, Mohr C, Pagerols Raluy L, Trochimiuk M, Knopf J, Reinshagen K, Herrmann M, Boettcher M. Cells. 2023 Jan 19;12(3):366. doi: 10.3390/cells12030366. PMID: 36766707; PMCID: PMC9913099.

PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse. Larionova I, Patysheva M, Iamshchikov P, Kazakova E, Kazakova A, Rakina M, Grigoryeva E, Tarasova A, Afanasiev S, Bezgodova N, Kiselev A, Dobrodeev A, Kostromitskiy D, Cherdyntseva N, Kzhyshkowska J. Front Immunol. 2023 Jan 17;13:1080501. doi: 10.3389/fimmu.2022.1080501. eCollection 2022.

Macrophage scavenger receptors: Tumor support and tumor inhibition. Kazakova E, Iamshchikov P, Larionova I, Kzhyshkowska J. Front Oncol. 2023 Jan 6;12:1096897. doi: 10.3389/fonc.2022.1096897. eCollection 2022.

Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization. Huang Z, Li Y, Park H, Ho M, Bhardwaj K, Sugimura N, Lee HW, Meng H, Ebert MP, Chao K, Burgermeister E, Bhatt AP, Shetty SA, Li K, Wen W, Zuo T. Gut Microbes. 2023 Jan-Dec;15(1):2237645. doi: 10.1080/19490976.2023.2237645. PMID: 37498052; PMCID: PMC10376922.

Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies. Neumaier M et al., Sci. Adv.9,eadg1812(2023). doi:10.1126/sciadv.adg18

A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program. de Fijter JW, Dreyer GJ, Mallat MJ, Budde K, Pratschke J, Klempnauer J, Zeier M, Arns W, Hugo C, Rump LC, Hauser I, Schenker P, Schiffer M, Grimm MO, Kliem V, Olbricht CJ, Pisarski P, Banas B, Suwelack B, Hakenberg O, Berlakovich G, Schneeberger S, van de Wetering J, Berger SP, Bemelman F, Kuypers D, Heidt S, Rahmel A, Claas F, Peeters P, Oberbauer R, Heemann U, Krämer BK. Kidney International (2023), doi: 10.1016/j.kint.2023.05.025

2022

Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis. Jauch AS, Wohlfeil SA, Weller C, Dietsch B, Häfele V, Stojanovic A, Kittel M, Nolte H, Cerwenka A, Neumaier M, Schledzewski K, Sticht C, Reiners-Koch PS, Goerdt S, Géraud C. Cancer Cell Int. 2022 Dec 10;22(1):398. doi: 10.1186/s12935-022-02800-x. PMID: 36496412; PMCID: PMC9741792.

Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression. Manta CP, Leibing T, Friedrich M, Nolte H, Adrian M, Schledzewski K, Krzistetzko J, Kirkamm C, David Schmid C, Xi Y, Stojanovic A, Tonack S, de la Torre C, Hammad S, Offermanns S, Krüger M, Cerwenka A, Platten M, Goerdt S, Géraud C. Circulation. 2022 Dec 6;146(23):1783-1799. doi: 10.1161/CIRCULATIONAHA.121.058615. Epub 2022 Nov 3. PMID: 36325910.

Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages. Alsina-Sanchis E, Mülfarth R, Moll I, Böhn S, Wiedmann L, Jordana-Urriza L, Ziegelbauer T, Zimmer E, Taylor J, De Angelis Rigotti F, Stögbauer A, Giaimo BD, Cerwenka A, Borggrefe T, Fischer A, Rodriguez-Vita J. Cancer Res. 2022 Dec 2;82(23):4414-4428. doi: 10.1158/0008-5472.CAN-22-0076. PMID: 36200806.

SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry. Matveeva O, Nechipurenko Y, Lagutkin D, Yegorov YE, Kzhyshkowska J. Front Immunol. 2022 Dec 1;13:1050478. doi: 10.3389/fimmu.2022.1050478. eCollection 2022.

A hierarchical regulatory network ensures stable albumin transcription under various pathophysiological conditions. Feng R, Kan K, Sticht C, Li Y, Wang S, Liu H, Shao C, Munker S, Niess H, Wang S, Meyer C, Liebe R, Ebert MP, Dooley S, Ding H, Weng H. Hepatology. 2022 Dec;76(6):1673-1689. doi: 10.1002/hep.32414. Epub 2022 Mar 7. PMID: 35257388.

Monocyte programming by cancer therapy. Patysheva M, Frolova A, Larionova I, Afanas'ev S, Tarasova A, Cherdyntseva N, Kzhyshkowska J. Front Immunol. 2022 Oct 20;13:994319. doi: 10.3389/fimmu.2022.994319. eCollection 2022.

Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD. Schroeder-Castagno M, Del Rio-Serrato A, Wilhelm A, Romero-Suárez S, Schindler P, Alvarez-González C, Duchow AS, Bellmann-Strobl J, Ruprecht K, Hastermann M, Grütz G, Wildemann B, Jarius S, Schmitz-Hübsch T, Paul F, Infante-Duarte C. J Neuroinflammation. 2022 Oct 1;19(1):239. doi: 10.1186/s12974-022-02600-0. PMID: 36183103; PMCID: PMC9526338.

ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7. Garcia-Gonzalez C, Dieterich C, Maroli G, Wiesnet M, Wietelmann A, Li X, Yuan X, Graumann J, Stellos K, Kubin T, Schneider A, Braun T. Circ Res. 2022 Sep 16;131(7):580-597. doi: 10.1161/CIRCRESAHA.122.320839. Epub 2022 Aug 24. PMID: 36000401.

HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling. J Immunother Cancer. Arkhypov I, Özbay Kurt FG, Bitsch R, Novak D, Petrova V, Lasser S, Hielscher T, Groth C, Lepper A, Hu X, Li W, Utikal J, Altevogt P, Umansky V. 2022 Sep;10(9):e005551. doi: 10.1136/jitc-2022-005551. PMID: 36113897; PMCID: PMC9486388.

Case Studies Exemplifying the Transition to Animal Component-free Cell Culture. Weber T, Wiest J, Oredsson S, Bieback K. Altern Lab Anim. 2022 Sep;50(5):330-338. doi: 10.1177/02611929221117999. Epub 2022 Aug 19. Erratum in: Altern Lab Anim. 2022 Dec 1:2611929221141160. doi: 10.1177/02611929221141160. PMID: 35983799.

Pooled human bone marrow-derived mesenchymal stromal cells with defined trophic factors cargo promote dermal wound healing in diabetic rats by improved vascularization and dynamic recruitment of M2-like macrophages. Willer H, Spohn G, Morgenroth K, Thielemann C, Elvers-Hornung S, Bugert P, Delorme B, Giesen M, Schmitz-Rixen T, Seifried E, Pfarrer C, Schäfer R, Bieback K. Front Immunol. 2022 Aug 19;13:976511. doi: 10.3389/fimmu.2022.976511. PMID: 36059533; PMCID: PMC9437960.

Functional antagonism between CagA and DLC1 in gastric cancer. Hinsenkamp I, Köhler JP, Flächsenhaar C, Hitkova I, Meessen SE, Gaiser T, Wieland T, Weiss C, Röcken C, Mowat M, Quante M, Taxauer K, Mejias-Luque R, Gerhard M, Vogelmann R, Meindl-Beinker N, Ebert M, Burgermeister E. Cell Death Discov. 2022 Aug 13;8(1):358. doi: 10.1038/s41420-022-01134-x. PMID: 35963849; PMCID: PMC9376073.

The gut virome: A new microbiome component in health and disease. Cao Z, Sugimura N, Burgermeister E, Ebert MP, Zuo T, Lan P. EBioMedicine. 2022 Jul;81:104113. doi: 10.1016/j.ebiom.2022.104113. Epub 2022 Jun 23. PMID: 35753153; PMCID: PMC9240800.

Biomarkers and 3D models predicting response to immune checkpoint blockade in head and neck cancer (Review). Affolter A, Kern J, Bieback K, Scherl C, Rotter N, Lammert A. Int J Oncol. 2022 Jul;61(1):88. doi: 10.3892/ijo.2022.5378. Epub 2022 Jun 1. PMID: 35642667; PMCID: PMC9183766.

Key Signature Genes of Early Terminal Granulocytic Differentiation Distinguish Sepsis From Systemic Inflammatory Response Syndrome on Intensive Care Unit Admission. Velásquez SY, Coulibaly A, Sticht C, Schulte J, Hahn B, Sturm T, Schefzik R, Thiel M, Lindner HA. Front Immunol. 2022 Jun 30;13:864835.

NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy. Garcés-Lázaro I, Kotzur R, Cerwenka A, Mandelboim O. Front Immunol. 2022 Jun 13;13:924775. doi: 10.3389/fimmu.2022.924775. PMID: 35769460; PMCID: PMC9234265.

Caspase-8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice. Tisch N, Mogler C, Stojanovic A, Luck R, Korhonen EA, Ellerkmann A, Adler H, Singhal M, Schermann G, Erkert L, Patankar JV, Karakatsani A, Scherr AL, Fuchs Y, Cerwenka A, Wirtz S, Köhler BC, Augustin HG, Becker C, Schmidt T, Ruiz de Almodóvar C. EMBO Mol Med. 2022 Jun 8;14(6):e14121. doi: 10.15252/emmm.202114121. Epub 2022 May 2. PMID: 35491615; PMCID: PMC9174885.

Potential Therapeutic Effects of Long-Term Stem Cell Administration: Impact on the Gene Profile and Kidney Function of PKD/Mhm (Cy/+) Rats. Nardozi D, Palumbo S, Khan AUM, Sticht C, Bieback K, Sadeghi S, Kluth MA, Keese M, Gretz N. J Clin Med. 2022 May 5;11(9):2601. doi: 10.3390/jcm11092601. PMID: 35566725; PMCID: PMC9102853.

Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis. Carai P, Papageorgiou AP, Van Linthout S, Deckx S, Velthuis S, Lutgens E, Wijnands E, Tschöpe C, Schmuttermaier C, Kzhyshkowska J, Jones EAV, Heymans S. J Mol Cell Cardiol. 2022 Apr;165:31-39. doi: 10.1016/j.yjmcc.2021.12.009. Epub 2021 Dec 28.

Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8. Walle T, Kraske JA, Liao B, Lenoir B, Timke C, von Bohlen Und Halbach E, Tran F, Griebel P, Albrecht D, Ahmed A, Suarez-Carmona M, Jiménez-Sánchez A, Beikert T, Tietz-Dahlfuß A, Menevse AN, Schmidt G, Brom M, Pahl JHW, Antonopoulos W, Miller M, Perez RL, Bestvater F, Giese NA, Beckhove P, Rosenstiel P, Jäger D, Strobel O, Pe'er D, Halama N, Debus J, Cerwenka A, Huber PE. Sci Adv. 2022 Mar 25;8(12):eabh4050. doi: 10.1126/sciadv.abh4050. Epub 2022 Mar 23. PMID: 35319989; PMCID: PMC8942354.

Human ILC3 Exert TRAIL-Mediated Cytotoxicity Towards Cancer Cells. Siegler JJ, Correia MP, Hofman T, Prager I, Birgin E, Rahbari NN, Watzl C, Stojanovic A, Cerwenka A. Front Immunol. 2022 Mar 1;13:742571. doi: 10.3389/fimmu.2022.742571. PMID: 35300331; PMCID: PMC8921484.

Effect of Early-Stage Human Breast Carcinoma on Monocyte Programming. Patysheva M, Larionova I, Stakheyeva M, Grigoryeva E, Iamshchikov P, Tarabanovskaya N, Weiss C, Kardashova J, Frolova A, Rakina M, Prostakishina E, Zhuikova L, Cherdyntseva N, Kzhyshkowska J. Front Oncol. 2022 Feb 14;11:800235. doi: 10.3389/fonc.2021.800235. eCollection 2021.

Dopamine D1/D5 Receptor Signaling Is Involved in Arrhythmogenesis in the Setting of Takotsubo Cardiomyopathy. Huang M, Yang Z, Li Y, Lan H, Cyganek L, Yuecel G, Lang S, Bieback K, El-Battrawy I, Zhou X, Borggrefe M, Akin I. Front Cardiovasc Med. 2022 Feb 4;8:777463. doi: 10.3389/fcvm.2021.777463. PMID: 35187102; PMCID: PMC8855058.

Hyperglycemia Induces Inflammatory Response of Human Macrophages to CD163-Mediated Scavenging of Hemoglobin-Haptoglobin Complexes. Matuschik L, Riabov V, Schmuttermaier C, Sevastyanova T, Weiss C, Klüter H, Kzhyshkowska J. Int J Mol Sci. 2022 Jan 26;23(3):1385. doi: 10.3390/ijms23031385.

The Promoter of the Immune-Modulating Gene TIR-Containing Protein C of the Uropathogenic Escherichia coli Strain CFT073 Reacts to the Pathogen's Environment. Hemberger J, Ittensohn J, Griffiths H, Keller M, Costina V, Albrecht S, Miethke T. Int J Mol Sci. 2022 Jan 20;23(3):1148. doi: 10.3390/ijms23031148.

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors Kilian M, Sheinin R, Tan CL, Krämer C, Friedrich M, Kaminitz A, Sanghvi K, Lindner K, Cichon F, Jung S, Jähne K, Ratliff M, Prins R, Deimling A, Wick W, Madi A, Bunse L, Platten M. bioRxiv 2022.06.10.495502; doi: 10.1101/2022.06.10.495502

Preferential translation of p53 target genes. Hisaoka M, Schott J, Bortecen T, Lindner D, Krijgsveld J, Stoecklin G. RNA Biology 2022;19:1,437-452.

Differential network testing reveals diverging dynamics of organ system interactions for survivors and non-survivors in intensive care medicine. Schefzik R, Boland L, Hahn B, Kirschning T, Lindner HA, Thiel M, Schneider-Lindner V. Frontiers in Physiology 2022;12:801622.

Ground truth labels challenge the validity of sepsis consensus definitions in critical illness. Lindner HA, Schamoni S, Kirschning T, Worm C, Hahn B, Centner F-S, Schoettler JJ, Hagmann M, Krebs J, Mangold D, Nitsch S, Riezler S, Thiel M, Schneider-Lindner V. Journal of Translational Medicine 2022; 20:27.

2021

Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density. Schott J, Reitter S, Lindner D, Grosser J, Bruer M, Shenoy A, Geiger T, Mathes A, Dobreva G, Stoecklin G.  Nat Methods. 2021 Sep 3. doi: 10.1038/s41592-021-01250-z. Epub ahead of print. PMID: 34480152.

Patient and Graft Survival After Dual Kidney Transplantation With Marginal Donors in Comparison to Matched Control Groups. Yazdani B, Marinez J, Krüger B, Kälsch AI, Jung M, Chen G, Leipe J, Benck U, Schnülle P, Nuhn P, Keese M, Schwenke K, Krämer BK. Transplant Proc. 2021 Aug 21:S0041-1345(21)00490-5. doi: 10.1016/j.transproceed.2021.07.016. Online ahead of print.

PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells. Gutting T, Hauber V, Pahl J, Klapproth K, Wu W, Dobrota I, Herweck F, Reichling J, Helm L, Schroeder T, Li B, Weidner P, Zhan T, Eckardt M, Betge J, Belle S, Sticht C, Gaiser T, Boutros M, Ebert MPA, Cerwenka A, Burgermeister E. Oncoimmunology. 2021 May 5;10(1):1906500. doi: 10.1080/2162402X.2021.1906500. PMID: 34026331

Regulation of Expression of the TIR-Containing Protein CGene of the Uropathogenic Escherichia coliStrain CFT073. Ittensohn J, Hemberger J, Griffiths H, Keller M, Albrecht S, Miethke T. Pathogens. 2021 May 1;10(5):549. doi: 10.3390/pathogens10050549. PMID: 34062817; PMCID: PMC8147327.

C-terminal and intact FGF23 in kidney transplant recipients and their associations with overall graft survival. Chu C, Elitok S, Zeng S, Xiong Y, Hocher CF, Hasan AA, Krämer BK, Hocher B. BMC Nephrol. 2021 Apr 8;22(1):125. doi: 10.1186/s12882-021-02329-7.

STAT3 governs the HIF-1α response in IL-15 primed human NK cells. Coulibaly A, Velásquez SY, Kassner N, Schulte J, Barbarossa MV, Lindner HA. Sci Rep. 2021 Mar 29;11(1):7023. doi: 10.1038/s41598-021-84916-0. PMID: 33782423.

A vaccine targeting mutant IDH1 in newly diagnosed glioma. Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W. Nature. 2021 Apr;592(7854):463-468. doi: 10.1038/s41586-021-03363-z. Epub 2021 Mar 24. PMID: 33762734; PMCID: PMC8046668.

A Comparative Transcriptome Analysis of Human and Porcine Choroid Plexus Cells in Response to Streptococcus suis Serotype 2 Infection Points to a Role of Hypoxia. Lauer AN, Scholtysik R, Beineke A, Baums CG, Klose K, Valentin-Weigand P, Ishikawa H, Schroten H, Klein-Hitpass L, Schwerk C. Front Cell Infect Microbiol. 2021 Mar 8;11:639620. doi: 10.3389/fcimb.2021.639620. PMID: 33763387; PMCID: PMC7982935.

Lung Protection vs. Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19. Lindner HA, Velásquez SY, Thiel M, Kirschning T. Front Immunol. 2021 Mar 3;12:602130. doi: 10.3389/fimmu.2021.602130. PMID: 33746948; PMCID: PMC7966717.

Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression. Groth C, Arpinati L, Shaul ME, Winkler N, Diester K, Gengenbacher N, Weber R, Arkhypov I, Lasser S, Petrova V, Augustin HG, Altevogt P, Utikal J, Fridlender ZG, Umansky V.  Cancers (Basel). 2021 Feb 10;13(4):726. doi: 10.3390/cancers13040726. PMID: 33578808.

Human Adipose Tissue-Derived Mesenchymal Stromal Cells Inhibit CD4+ T Cell Proliferation and Induce Regulatory T Cells as Well as CD127 Expression on CD4+CD25+ T Cells. Fiori A, Uhlig S, Klueter H, Bieback K. Cells. 2021 Jan 1;10(1):58. doi: 10.3390/cells10010058.

2020

Comparison of Infection Risks and Clinical Outcomes in Patients with and without SARS-CoV-2 Lung Infection under Renin-Angiotensin-Aldosterone-System Blockade - Systematic Review and Meta-Analysis.
Chu C, Zeng S, Hasan AA, Hocher CF, Kraemer BK, Hocher B. Br J Clin Pharmacol. 2020 Nov 20. doi: 10.1111/bcp.14660. Epub ahead of print. PMID: 33217033.

Human Adipose Tissue-Derived Stromal Cells Suppress Human, but Not Murine Lymphocyte Proliferation, via Indoleamine 2,3-Dioxygenase Activity. Torres Crigna A, Uhlig S, Elvers-Hornung S, Klueter H, Bieback K. Cells. 2020 Nov 5;9(11):2419. doi: 10.3390/cells9112419.

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses. Eiermann N, Haneke K, Sun Z, Stoecklin G, Ruggieri A. Viruses. 2020 Sep 4;12(9):984

Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy. Kremer H, Gebauer J, Elvers-Hornung S, Uhlig S, Hammes HP, Beltramo E, Steeb L, Harmsen MC, Sticht C, Klueter H, Bieback K, Fiori A. Front Cell Dev Biol. 2020 Jun 9;8:387. doi: 10.3389/fcell.2020.00387. eCollection 2020. 

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity.
Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A. Immunity. 2020 Jun 16;52(6):1075

CDK1 couples proliferation with protein synthesis.
Haneke K, Schott J, Lindner D, Hollensen AK, Damgaard CK, Mongis C, Knop M, Palm W, Ruggieri A, Stoecklin G. J Cell Biol. 2020 Mar 2;219(3):e201906147

Recent advances in understanding mesenchymal stromal cells.
Rendra E, Scaccia E, Bieback K. F1000Res. 2020 Feb 27;9:F1000 Faculty Rev-156

The heat's on: nuclear stress bodies signal intron retention.
Erhardt S, Stoecklin G. EMBO J. 2020 Feb 3;39(3):e104154

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells.
Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar Š, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M. Nat Immunol. 2020 Jul;21(7):766

Innate Cytokine Induced Early Release of IFNγ and CC Chemokines from Hypoxic Human NK Cells Is Independent of Glucose.
Velásquez SY, Himmelhan BS, Kassner N, Coulibaly A, Schulte J, Brohm K, Lindner HA. Cells. 2020 Mar 17;9(3):734

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.
Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP. Nutrients. 2020 Mar 24;12(3):871

Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy.
Kremer H, Gebauer J, Elvers-Hornung S, Uhlig S, Hammes HP, Beltramo E, Steeb L, Harmsen MC, Sticht C, Klueter H, Bieback K, Fiori A. Front Cell Dev Biol. 2020 Jun 9;8:387