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MI3 PUBLICATIONS

2024

Immunotherapy that improves response to chemotherapy in high-grade serous ovarian cancer. Elorbany S, Berlato C, Carnevalli LS, Maniati E, Barry ST, Wang J, Manchanda R, Kzhyshkowska J, Balkwill F. Nat Commun. 2024 Nov 22;15(1):10144. doi: 10.1038/s41467-024-54295-x.

Targeting of TAMs: can we be more clever than cancer cells? Kzhyshkowska J, Shen J, Larionova I. Cell Mol Immunol. 2024 Dec;21(12):1376-1409. doi: 10.1038/s41423-024-01232-z. Epub 2024 Nov 8.

Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma. Larionova I, Iamshchikov P, Kazakova A, Rakina M, Menyalo M, Enikeeva K, Rafikova G, Sharifyanova Y, Pavlov V, Villert A, Kolomiets L, Kzhyshkowska J. Front Immunol. 2024 Sep 9;15:1414716. doi: 10.3389/fimmu.2024.1414716. eCollection 2024.

KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2. Bi S, Huang L, Chen Y, Hu Z, Li S, Wang Y, Huang B, Zhang L, Huang Y, Dai B, Du L, Tu Z, Wang Y, Xu D, Xu X, Sun W, Kzhyshkowska J, Wang H, Chen D, Wang F, Zhang S. Nat Commun. 2024 Jul 3;15(1):5602. doi: 10.1038/s41467-024-49930-6.

Modelling of macrophage responses to biomaterials in vitro: state-of-the-art and the need for the improvement. Piatnitskaia S, Rafikova G, Bilyalov A, Chugunov S, Akhatov I, Pavlov V, Kzhyshkowska J. Front Immunol. 2024 Mar 26;15:1349461. doi: 10.3389/fimmu.2024.1349461. eCollection 2024.

Macrophage diversity in human cancers: New insight provided by single-cell resolution and spatial context. Rakina M, Larionova I, Kzhyshkowska J. Heliyon. 2024 Mar 21;10(7):e28332. doi: 10.1016/j.heliyon.2024.e28332. eCollection 2024 Apr 15. PMID: 38571605

ROS signaling in innate immunity via oxidative protein modifications. Manoharan RR, Prasad A, Pospíšil P, Kzhyshkowska J. Front Immunol. 2024 Mar 7;15:1359600. doi: 10.3389/fimmu.2024.1359600. eCollection 2024.

Titanium induces proinflammatory and tissue-destructive responses in primary human macrophages. Gudima A, Hesselbarth D, Li G, Riabov V, Michel J, Liu Q, Schmuttermaier C, Jiao Z, Sticht C, Jawhar A, Obertacke U, Klüter H, Vrana NE, Kzhyshkowska J. J Leukoc Biol. 2024 Oct 1;116(4):706-725. doi: 10.1093/jleuko/qiae072.

Hyperglycemia amplifies TLR-mediated inflammatory response of M(IL4) macrophages to dyslipidemic ligands. Badillo-Garcia LE, Liu Q, Ziebner K, Balduff M, Sevastyanova T, Schmuttermaier C, Klüter H, Harmsen M, Kzhyshkowska J. J Leukoc Biol. 2024 Jun 28;116(1):197-204. doi: 10.1093/jleuko/qiae050.

E3 ubiquitin ligase RNF10 promotes dissociation of stalled ribosomes and responds to ribosomal subunit imbalance. Lehmann JA, Lindner D, Sung HM, Stoecklin G. Nat Commun. 2024 Nov 28;15(1):10350. doi: 10.1038/s41467-024-54411-x. PMID: 39609413; PMCID: PMC11604940

Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells. Rieckmann LM, Spohn M, Ruff L, Agorku D, Becker L, Borchers A, Krause J, O'Reilly R, Hille J, Velthaus-Rusik JL, Beumer N, Günther A, Willnow L, Imbusch CD, Iglauer P, Simon R, Franzenburg S, Winter H, Thomas M, Bokemeyer C, Gagliani N, Krebs CF, Sprick M, Hardt O, Riethdorf S, Trumpp A, Stoecklein NH, Peine S, Rosenstiel P, Pantel K, Loges S, Janning M. Mol Cancer. 2024 May 8;23(1):93. doi: 10.1186/s12943-024-01984-2. PMID: 38720314; PMCID: PMC11077784.

The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance. Kilian M, Friedrich MJ, Lu KH, Vonhören D, Jansky S, Michel J, Keib A, Stange S, Hackert N, Kehl N, Hahn M, Habel A, Jung S, Jähne K, Sahm F, Betge J, Cerwenka A, Westermann F, Dreger P, Raab MS, Meindl-Beinker NM, Ebert M, Bunse L, Müller-Tidow C, Schmitt M, Platten M. Sci Immunol. 2024 May 3;9(95):eadj7970. doi: 10.1126/sciimmunol.adj7970. Epub 2024 May 3. PMID: 38701193.

2023

Dual-Specificity Phosphatases in Regulation of Tumor-Associated Macrophage Activity. Patysheva MR, Prostakishina EA, Budnitskaya AA, Bragina OD, Kzhyshkowska JG. Int J Mol Sci. 2023 Dec 16;24(24):17542. doi: 10.3390/ijms242417542.

Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers. Rafikova G, Gilyazova I, Enikeeva K, Pavlov V, Kzhyshkowska J. Int J Mol Sci. 2023 Aug 14;24(16):12797. doi: 10.3390/ijms241612797.

Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF. Larionova I, Kiselev A, Kazakova E, Liu T, Patysheva M, Iamshchikov P, Liu Q, Mossel DM, Riabov V, Rakina M, Sergushichev A, Bezgodova N, Vtorushin S, Litviakov N, Denisov E, Koshkin P, Pyankov D, Tsyganov M, Ibragimova M, Cherdyntseva N, Kzhyshkowska J. Front Immunol. 2023 Mar 7;14:1000497. doi: 10.3389/fimmu.2023.1000497. eCollection 2023.

Angiogenesis regulators S100A4, SPARC and SPP1 correlate with macrophage infiltration and are prognostic biomarkers in colon and rectal cancers. Kazakova E, Rakina M, Sudarskikh T, Iamshchikov P, Tarasova A, Tashireva L, Afanasiev S, Dobrodeev A, Zhuikova L, Cherdyntseva N, Kzhyshkowska J, Larionova I. Front Oncol. 2023 Feb 21;13:1058337. doi: 10.3389/fonc.2023.1058337. eCollection 2023.

Interaction of Ceramic Implant Materials with Immune System. Rafikova G, Piatnitskaia S, Shapovalova E, Chugunov S, Kireev V, Ialiukhova D, Bilyalov A, Pavlov V, Kzhyshkowska J. Int J Mol Sci. 2023 Feb 20;24(4):4200. doi: 10.3390/ijms24044200.

Tumor-activated neutrophils promote metastasis in breast cancer via the G-CSF-RLN2-MMP-9 axis. Sheng Y, Peng W, Huang Y, Cheng L, Meng Y, Kwantwi LB, Yang J, Xu J, Xiao H, Kzhyshkowska J, Wu Q. J Leukoc Biol. 2023 Mar 29;113(4):383-399. doi: 10.1093/jleuko/qiad004.

PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse. Larionova I, Patysheva M, Iamshchikov P, Kazakova E, Kazakova A, Rakina M, Grigoryeva E, Tarasova A, Afanasiev S, Bezgodova N, Kiselev A, Dobrodeev A, Kostromitskiy D, Cherdyntseva N, Kzhyshkowska J. Front Immunol. 2023 Jan 17;13:1080501. doi: 10.3389/fimmu.2022.1080501. eCollection 2022.

Macrophage scavenger receptors: Tumor support and tumor inhibition. Kazakova E, Iamshchikov P, Larionova I, Kzhyshkowska J. Front Oncol. 2023 Jan 6;12:1096897. doi: 10.3389/fonc.2022.1096897. eCollection 2022.

SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry. Matveeva O, Nechipurenko Y, Lagutkin D, Yegorov YE, Kzhyshkowska J. Front Immunol. 2022 Dec 1;13:1050478. doi: 10.3389/fimmu.2022.1050478. eCollection 2022.

A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program. de Fijter JW, Dreyer GJ, Mallat MJ, Budde K, Pratschke J, Klempnauer J, Zeier M, Arns W, Hugo C, Rump LC, Hauser I, Schenker P, Schiffer M, Grimm MO, Kliem V, Olbricht CJ, Pisarski P, Banas B, Suwelack B, Hakenberg O, Berlakovich G, Schneeberger S, van de Wetering J, Berger SP, Bemelman F, Kuypers D, Heidt S, Rahmel A, Claas F, Peeters P, Oberbauer R, Heemann U, Krämer BK. Kidney International (2023), doi: 10.1016/j.kint.2023.05.025

2022

Monocyte programming by cancer therapy. Patysheva M, Frolova A, Larionova I, Afanas'ev S, Tarasova A, Cherdyntseva N, Kzhyshkowska J. Front Immunol. 2022 Oct 20;13:994319. doi: 10.3389/fimmu.2022.994319. eCollection 2022.

Effect of Early-Stage Human Breast Carcinoma on Monocyte Programming. Patysheva M, Larionova I, Stakheyeva M, Grigoryeva E, Iamshchikov P, Tarabanovskaya N, Weiss C, Kardashova J, Frolova A, Rakina M, Prostakishina E, Zhuikova L, Cherdyntseva N, Kzhyshkowska J. Front Oncol. 2022 Feb 14;11:800235. doi: 10.3389/fonc.2021.800235. eCollection 2021.

Hyperglycemia Induces Inflammatory Response of Human Macrophages to CD163-Mediated Scavenging of Hemoglobin-Haptoglobin Complexes. Matuschik L, Riabov V, Schmuttermaier C, Sevastyanova T, Weiss C, Klüter H, Kzhyshkowska J. Int J Mol Sci. 2022 Jan 26;23(3):1385. doi: 10.3390/ijms23031385.

Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis. Carai P, Papageorgiou AP, Van Linthout S, Deckx S, Velthuis S, Lutgens E, Wijnands E, Tschöpe C, Schmuttermaier C, Kzhyshkowska J, Jones EAV, Heymans S. J Mol Cell Cardiol. 2022 Apr;165:31-39. doi: 10.1016/j.yjmcc.2021.12.009. Epub 2021 Dec 28.

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors Kilian M, Sheinin R, Tan CL, Krämer C, Friedrich M, Kaminitz A, Sanghvi K, Lindner K, Cichon F, Jung S, Jähne K, Ratliff M, Prins R, Deimling A, Wick W, Madi A, Bunse L, Platten M.  bioRxiv 2022.06.10.495502; doi: 10.1101/2022.06.10.495502

HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling. Arkhypov I, Özbay Kurt FG, Bitsch R, Novak D, Petrova V, Lasser S, Hielscher T, Groth C, Lepper A, Hu X, Li W, Utikal J, Altevogt P, Umansky V. J Immunother Cancer. 2022 Sep;10(9):e005551. doi: 10.1136/jitc-2022-005551. PMID: 36113897; PMCID: PMC9486388.

Key Signature Genes of Early Terminal Granulocytic Differentiation Distinguish Sepsis From Systemic Inflammatory Response Syndrome on Intensive Care Unit Admission. Velásquez SY, Coulibaly A, Sticht C, Schulte J, Hahn B, Sturm T, Schefzik R, Thiel M, Lindner HA. Front Immunol. 2022 Jun 30;13:864835. 

Preferential translation of p53 target genes. Hisaoka M, Schott J, Bortecen T, Lindner D, Krijgsveld J, Stoecklin G. RNA Biology 2022; 19:1, 437-452.

Differential network testing reveals diverging dynamics of organ system interactions for survivors and non-survivors in intensive care medicine. Schefzik R, Boland L, Hahn B, Kirschning T, Lindner HA, Thiel M, Schneider-Lindner V. Frontiers in Physiology 2022; 12:801622.

​​​​​​​Ground truth labels challenge the validity of sepsis consensus definitions in critical illness. Lindner HA, Schamoni S, Kirschning T, Worm C, Hahn B, Centner F-S, Schoettler JJ, Hagmann M, Krebs J, Mangold D, Nitsch S, Riezler S, Thiel M, Schneider-Lindner V. Journal of Translational Medicine 2022; 20:27. 

The Promoter of the Immune-Modulating Gene TIR-Containing Protein C of the Uropathogenic Escherichia coli Strain CFT073 Reacts to the Pathogen's Environment. Hemberger J, Ittensohn J, Griffiths H, Keller M, Costina V, Albrecht S, Miethke T. Int J Mol Sci. 2022 Jan 20;23(3):1148. doi: 10.3390/ijms23031148.

2021

Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density. Schott J, Reitter S, Lindner D, Grosser J, Bruer M, Shenoy A, Geiger T, Mathes A, Dobreva G, Stoecklin G.  Nat Methods. 2021 Sep 3. doi: 10.1038/s41592-021-01250-z. Epub ahead of print. PMID: 34480152.

Patient and Graft Survival After Dual Kidney Transplantation With Marginal Donors in Comparison to Matched Control Groups. Yazdani B, Marinez J, Krüger B, Kälsch AI, Jung M, Chen G, Leipe J, Benck U, Schnülle P, Nuhn P, Keese M, Schwenke K, Krämer BK. Transplant Proc. 2021 Aug 21:S0041-1345(21)00490-5. doi: 10.1016/j.transproceed.2021.07.016. Online ahead of print.

PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells. Gutting T, Hauber V, Pahl J, Klapproth K, Wu W, Dobrota I, Herweck F, Reichling J, Helm L, Schroeder T, Li B, Weidner P, Zhan T, Eckardt M, Betge J, Belle S, Sticht C, Gaiser T, Boutros M, Ebert MPA, Cerwenka A, Burgermeister E. Oncoimmunology. 2021 May 5;10(1):1906500. doi: 10.1080/2162402X.2021.1906500. PMID: 34026331

Regulation of Expression of the TIR-Containing Protein CGene of the Uropathogenic Escherichia coliStrain CFT073. Ittensohn J, Hemberger J, Griffiths H, Keller M, Albrecht S, Miethke T. Pathogens. 2021 May 1;10(5):549. doi: 10.3390/pathogens10050549. PMID: 34062817; PMCID: PMC8147327.

C-terminal and intact FGF23 in kidney transplant recipients and their associations with overall graft survival. Chu C, Elitok S, Zeng S, Xiong Y, Hocher CF, Hasan AA, Krämer BK, Hocher B. BMC Nephrol. 2021 Apr 8;22(1):125. doi: 10.1186/s12882-021-02329-7.

STAT3 governs the HIF-1α response in IL-15 primed human NK cells. Coulibaly A, Velásquez SY, Kassner N, Schulte J, Barbarossa MV, Lindner HA. Sci Rep. 2021 Mar 29;11(1):7023. doi: 10.1038/s41598-021-84916-0. PMID: 33782423.

A vaccine targeting mutant IDH1 in newly diagnosed glioma. Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W. Nature. 2021 Apr;592(7854):463-468. doi: 10.1038/s41586-021-03363-z. Epub 2021 Mar 24. PMID: 33762734; PMCID: PMC8046668.

A Comparative Transcriptome Analysis of Human and Porcine Choroid Plexus Cells in Response to Streptococcus suis Serotype 2 Infection Points to a Role of Hypoxia. Lauer AN, Scholtysik R, Beineke A, Baums CG, Klose K, Valentin-Weigand P, Ishikawa H, Schroten H, Klein-Hitpass L, Schwerk C. Front Cell Infect Microbiol. 2021 Mar 8;11:639620. doi: 10.3389/fcimb.2021.639620. PMID: 33763387; PMCID: PMC7982935.

Lung Protection vs. Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19. Lindner HA, Velásquez SY, Thiel M, Kirschning T. Front Immunol. 2021 Mar 3;12:602130. doi: 10.3389/fimmu.2021.602130. PMID: 33746948; PMCID: PMC7966717.

Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression. Groth C, Arpinati L, Shaul ME, Winkler N, Diester K, Gengenbacher N, Weber R, Arkhypov I, Lasser S, Petrova V, Augustin HG, Altevogt P, Utikal J, Fridlender ZG, Umansky V.  Cancers (Basel). 2021 Feb 10;13(4):726. doi: 10.3390/cancers13040726. PMID: 33578808.

Human Adipose Tissue-Derived Mesenchymal Stromal Cells Inhibit CD4+ T Cell Proliferation and Induce Regulatory T Cells as Well as CD127 Expression on CD4+CD25+ T Cells. Fiori A, Uhlig S, Klueter H, Bieback K. Cells. 2021 Jan 1;10(1):58. doi: 10.3390/cells10010058.

2020

Comparison of Infection Risks and Clinical Outcomes in Patients with and without SARS-CoV-2 Lung Infection under Renin-Angiotensin-Aldosterone-System Blockade - Systematic Review and Meta-Analysis.
Chu C, Zeng S, Hasan AA, Hocher CF, Kraemer BK, Hocher B. Br J Clin Pharmacol. 2020 Nov 20. doi: 10.1111/bcp.14660. Epub ahead of print. PMID: 33217033.

Human Adipose Tissue-Derived Stromal Cells Suppress Human, but Not Murine Lymphocyte Proliferation, via Indoleamine 2,3-Dioxygenase Activity. Torres Crigna A, Uhlig S, Elvers-Hornung S, Klueter H, Bieback K. Cells. 2020 Nov 5;9(11):2419. doi: 10.3390/cells9112419.

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses. Eiermann N, Haneke K, Sun Z, Stoecklin G, Ruggieri A. Viruses. 2020 Sep 4;12(9):984

Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy. Kremer H, Gebauer J, Elvers-Hornung S, Uhlig S, Hammes HP, Beltramo E, Steeb L, Harmsen MC, Sticht C, Klueter H, Bieback K, Fiori A. Front Cell Dev Biol. 2020 Jun 9;8:387. doi: 10.3389/fcell.2020.00387. eCollection 2020. 

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity.
Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A. Immunity. 2020 Jun 16;52(6):1075

CDK1 couples proliferation with protein synthesis.
Haneke K, Schott J, Lindner D, Hollensen AK, Damgaard CK, Mongis C, Knop M, Palm W, Ruggieri A, Stoecklin G. J Cell Biol. 2020 Mar 2;219(3):e201906147

Recent advances in understanding mesenchymal stromal cells.
Rendra E, Scaccia E, Bieback K. F1000Res. 2020 Feb 27;9:F1000 Faculty Rev-156

The heat's on: nuclear stress bodies signal intron retention.
Erhardt S, Stoecklin G. EMBO J. 2020 Feb 3;39(3):e104154

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells.
Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar Š, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M. Nat Immunol. 2020 Jul;21(7):766

Innate Cytokine Induced Early Release of IFNγ and CC Chemokines from Hypoxic Human NK Cells Is Independent of Glucose.
Velásquez SY, Himmelhan BS, Kassner N, Coulibaly A, Schulte J, Brohm K, Lindner HA. Cells. 2020 Mar 17;9(3):734

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.
Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP. Nutrients. 2020 Mar 24;12(3):871

Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy.
Kremer H, Gebauer J, Elvers-Hornung S, Uhlig S, Hammes HP, Beltramo E, Steeb L, Harmsen MC, Sticht C, Klueter H, Bieback K, Fiori A. Front Cell Dev Biol. 2020 Jun 9;8:387

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