Sie befinden sich hier

Inhalt

Prof. Dr. Christian Schulz

IMMUNOPHARMACOLOGY

Myeloid cells play an important role as effectors cells of the innate immune system. In addition, they contribute to developmental processes, tissue homeostasis and organ physiology. We are researching differential functions of myeloid immune cells in health and diseases, specifically in inflammatory conditions related to a disturbed immune system, cardiovascular diseases and ageing. We interrogate intra- and extracellular signals that drive inflammatory processes, and promote tissue fibrosis and adverse remodeling after injury. This could lead to the development of novel therapeutic approaches in inflammatory diseases.

Funding

  • GRK2727
  • DFG-ANR “Ageing Immunity“
  • DFG Research Unit “Infinite”

Publications

Anjum A, Mader M, Mahameed S, Muraly A, Denorme F, Kliem FP, Rossaro D, Akgöl S, Di Fina L, Mulkers M, Laun LS, Li L, Kupper N, Yue K, Hoffknecht ML, Akhalkatsi A, Loew Q, Pircher J, Escaig R, Strasser EF, Wichmann C, Pekayvaz K, Nieswandt B, Schulz C, Robles MS, Kaiser R, Massberg S, Campbell RA, Nicolai L. Aging platelets shift their hemostatic properties to inflammatory functions. Blood. 2025 Jan 22:blood.2024024901. doi: 10.1182/blood.2024024901.

Jaudas F, Bartenschlager F, Shashikadze B, Santamaria G, Reichart D, Schnell A, Stöckl JB, Degroote RL, Cambra JM, Graeber SY, Bähr A, Kartmann H, Stefanska M, Liu H, Naumann-Bartsch N, Bruns H, Berges J, Hanselmann L, Stirm M, Krebs S, Deeg CA, Blum H, Schulz C, Zawada D, Janda M, Caballero-Posadas I, Kunzelmann K, Moretti A, Laugwitz KL, Kupatt C, Saalmüller A, Fröhlich T, Wolf E, Mall MA, Mundhenk L, Gerner W, Klymiuk N. Perinatal dysfunction of innate immunity in cystic fibrosis. Sci Transl Med. 2025 Jan 22;17(782):eadk9145. doi: 10.1126/scitranslmed.adk9145.

Simats A, Zhang S, Messerer D, Chong F, Beşkardeş S, Chivukula AS, Cao J, Besson-Girard S, Montellano FA, Morbach C, Carofiglio O, Ricci A, Roth S, Llovera G, Singh R, Chen Y, Filser S, Plesnila N, Braun C, Spitzer H, Gokce O, Dichgans M, Heuschmann PU, Hatakeyama K, Beltrán E, Clauss S, Bonev B, Schulz C, Liesz A. Innate immune memory after brain injury drives inflammatory cardiac dysfunction. Cell. 2024 Aug 22;187(17):4637-4655.e26. doi: 10.1016/j.cell.2024.06.028. Epub 2024 Jul 22.

Ishikawa-Ankerhold H, Busch B, Bader A, Maier-Begandt D, Dionisio F, Namineni S, Vladymyrov M, Harrison U, van den Heuvel D, Tomas L, Walzog B, Massberg S, Schulz C, Haas R. Novel multiphoton intravital imaging enables real-time study of Helicobacter pylori interaction with neutrophils and macrophages in the mouse stomach. PLoS Pathog. 2024 Sep 30;20(9):e1012580. doi: 10.1371/journal.ppat.1012580. eCollection 2024 Sep.

Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, Messerer D, Horn A, Shemer R, Jacqmarcq C, Picot A, Green JP, Schlegl C, Li X, Tomas L, Dutsch A, Liman TG, Endres M, Wernsdorf SR, Fürle C, Carofiglio O, Zhu J, Brough D; DEMDAS Study Group; Hornung V, Dichgans M, Vivien D, Schulz C, Dor Y, Tiedt S, Sager HB, Grosse GM, Liesz A. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature. 2024 Sep;633(8029):433-441. doi: 10.1038/s41586-024-07803-4. Epub 2024 Aug 7.

Weinberger T, Denise M, Joppich M, Fischer M, Garcia Rodriguez C, Kumaraswami K, Wimmler V, Ablinger S, Räuber S, Fang J, Liu L, Liu WH, Winterhalter J, Lichti J, Thomas L, Esfandyari D, Percin G, Matin S, Hidalgo A, Waskow C, Engelhardt S, Todica A, Zimmer R, Pridans C, Gomez Perdiguero E, Schulz C. Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia. Elife. 2024 May 22;12:RP89377. doi: 10.7554/eLife.89377.

Kontextspalte

Nach obenDruckenImpressumDatenschutz