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Prof. Dr. Christian Schulz

IMMUNOPHARMACOLOGY

Myeloid cells play an important role as effectors cells of the innate immune system. In addition, they contribute to developmental processes, tissue homeostasis and organ physiology. We are researching differential functions of myeloid immune cells in health and diseases, specifically in inflammatory conditions related to a disturbed immune system, cardiovascular diseases and ageing. We interrogate intra- and extracellular signals that drive inflammatory processes, and promote tissue fibrosis and adverse remodeling after injury. This could lead to the development of novel therapeutic approaches in inflammatory diseases.

Funding

  • GRK2727
  • DFG-ANR “Ageing Immunity“
  • DFG Research Unit “Infinite”

Publications

Simats A, Zhang S, Messerer D, Chong F, Beşkardeş S, Chivukula AS, Cao J, Besson-Girard S, Montellano FA, Morbach C, Carofiglio O, Ricci A, Roth S, Llovera G, Singh R, Chen Y, Filser S, Plesnila N, Braun C, Spitzer H, Gokce O, Dichgans M, Heuschmann PU, Hatakeyama K, Beltrán E, Clauss S, Bonev B, Schulz C, Liesz A. Innate immune memory after brain injury drives inflammatory cardiac dysfunction. Cell. 2024 Jul 12:S0092-8674(24)00702-5. doi: 10.1016/j.cell.2024.06.028.

Weinberger T, Denise M, Joppich M, Fischer M, Garcia Rodriguez C, Kumaraswami K, Wimmler V, Ablinger S, Räuber S, Fang J, Liu L, Liu WH, Winterhalter J, Lichti J, Thomas L, Esfandyari D, Percin G, Matin S, Hidalgo A, Waskow C, Engelhardt S, Todica A, Zimmer R, Pridans C, Gomez Perdiguero E, Schulz C. Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia. Elife. 2024 May 22;12:RP89377. DOI: 10.7554/eLife.89377

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