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PD Dr. Holger A. Lindner

Innate Immunity and sepsis

Innate immunity is the very first line of defense against infection. It is also triggered by severe sterile tissue injury. In either case, if they are not controlled, innate immune responses can promote systemic inflammation, organ dysfunction and long-term immunosuppression, and, thereby, can become the root cause of sepsis.

In the lab, we study changes in subpopulations of innate immune cells from patient blood and their immunometabolism under inflammatory conditions, including hypoxia, in vitro to gain insight into sepsis pathogenesis and discover predictive and diagnostic sepsis classifiers.


Velásquez SY, Coulibaly A, Sticht C, Schulte J, Hahn B, Sturm T, Schefzik R, Thiel M, Lindner HA.
Key signature genes of early terminal granulocytic differentiation distinguish sepsis from systemic inflammatory response syndrome on intensive care unit admission.
Front Immunol. 2022 Jun 30;13:864835. doi: 10.3389/fimmu.2022.864835

Coulibaly A, Velásquez SY, Kassner N, Schulte J, Barbarossa MV, Lindner HA.
STAT3 governs the HIF-1α response in IL-15 primed human NK cells.
Sci Rep. 2021 Mar 29;11(1):7023. doi: 10.1038/s41598-021-84916-0

Coulibaly A, Velásquez SY, Sticht C, Figueiredo AS, Himmelhan BS, Schulte J, Sturm T, Centner F-S, Schöttler JJ, Thiel M, Lindner HA.
AKIRIN1: a potential new reference gene in human natural killer cells and granulocytes in sepsis.
Int J Mol Sci. 2019;20(9):2290. doi: 10.3390/ijms20092290

Velásquez SY, Himmelhan BS, Kassner N, Coulibaly A, Schulte J, Brohm K, Lindner HA.
Innate Cytokine Induced Early Release of IFNγ and CC Chemokines from Hypoxic Human NK Cells Is Independent of Glucose.
Cells. 2020;9(3),pii: E734. doi: 10.3390/cells9030734

Coulibaly A, Bettendorf A, Kostina E, Figueiredo AS, Velásquez SY, Bock HG, Thiel M, Lindner HA, Barbarossa MV. Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models.
Front Immunol. 2019;10:2401. doi: 10.3389/fimmu.2019.02401