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PD Dr. Holger A. Lindner

innate Immunity and sepsis

Innate immunity is the very first line of defense against infection. If misguided, it can however also lead to systemic inflammation and organ dysfunction and become the root cause of sepsis. The goal of our research is to identify new strategies to diagnose and treat sepsis in the intensive care unit (ICU) by combining computational and laboratory investigation.

We found that an algorithmic description of the dynamics of systemic inflammation and machine learning in a comprehensive set of features in electronic medical records can identify sepsis onset in different groups of ICU patients.

In the lab, we study changes in populations of innate immune cells from patient blood and their immunometabolism under inflammatory conditions in vitro to gain a better process understanding of innate immune responses during sepsis and to discover new sepsis biomarkers.

Publications

Lindner HA, Balaban Ü, Sturm T, Weiß C, Thiel M, Schneider-Lindner V. An algorithm for systemic inflammatory response syndrome criteria-based prediction of sepsis in a polytrauma cohort. Crit Care Med. 2016;44(12):2199-2207

Schamoni S, Lindner HA, Schneider-Lindner V, Thiel M, Riezler S. Leveraging implicit expert knowledge for non-circular machine learning in sepsis prediction. Artif Intell Med. 2019;100. doi: 10.1016/j.artmed.2019.101725

Coulibaly A, Velásquez SY, Sticht C, Figueiredo AS, Himmelhan BS, Schulte J, Sturm T, Centner F-S, Schöttler JJ, Thiel M, Lindner HA. AKIRIN1: a potential new reference gene in human natural killer cells and granulocytes in sepsis. Int J Mol Sci. 2019;20(9):2290. doi: 10.3390/ijms20092290

Velásquez SY, Himmelhan BS, Kassner N, Coulibaly A, Schulte J, Brohm K, Lindner HA. Innate Cytokine Induced Early Release of IFNγ and CC Chemokines from Hypoxic Human NK Cells Is Independent of Glucose. Cells. 2020;9(3),pii: E734. doi: 10.3390/cells9030734

Coulibaly A, Bettendorf A, Kostina E, Figueiredo AS, Velásquez SY, Bock HG, Thiel M, Lindner HA, Barbarossa MV. Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models. Front Immunol. 2019;10:2401. doi: 10.3389/fimmu.2019.02401

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