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Dr. Kai Doberstein | Prof. Dr. Marc Sütterlin

The focus of our laboratory is to develop a comprehensive understanding of the molecular factors that drive the development of ovarian cancer and to develop new therapeutic approaches. Research over the last decade has led to the paradigm shift, showing that serous ovarian cancers originate in the secretory cells of the fallopian tube (FT) and not in the ovary. We are studying how genetic factors and the microenvironment can trigger the dissemination and metastasization of precursor lesions to the ovary and the peritoneum. To study those mechanisms we perform comprehensive analysis of primary tumor samples that were isolated from different metastatic sides using 3D organoid models. Additionally, we use immortalized FT cell lines and co-culture models to study the dissemination process.





Prof. Dr. med. Frederik Marmé

Sektionsleitung Konservative Gynäkologische Onkologie
Experimentelle & Translationale Gynäkologische Onkologie
Medizinische Fakultät Mannheim
Universität Heidelberg

Universitätsmedizin Mannheim
Theodor-Kutzer-Ufer 1-3
68167 Mannheim

Phone +49 621 383-8215
Phone +49 621 383-3661