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Inhalt

PhD SP04

Potassium channels in vascular tone regulation and small artery diabetic dysfunction

Supervisor (Mannheim): Rudolf Schubert
Co-Supervisor (Groningen): Hendrik Buikema
Graduate: n.n.

Project description

This project addresses the hypothesis that dysfunction of vascular smooth muscle potassium channels, in particular BK- and Kv7-channels, contributes to dysregulation of vascular tone in diabetes and related renal damage.

References

  1. *Schubert R, Lidington D, Bolz SS. Cardiovasc Res. 2008; 77 (1):8-18.
  2. Gollasch M. Br J Pharmacol. 2012; 165 (3):633-42.
  3. *Zavaritskaya O, Zhuravleva N, Schleifenbaum J, Gloe T, Devermann L, Kluge R, et al. Hypertension. 2013; 61 (1):151-9.
  4. Ungvari Z, Pacher P, Kecskemeti V, Papp G, Szollar L, Koller A. Cardiovasc Res. 1999; 43 (4):1018-28.
  5. Lee RM, Lu C, Su LY, Werstuck G, Gao YJ. J Hypertens. 2009; 27 (1):118-31.
  6. *Ochodnicky P, Henning RH, Buikema HJ, et al. Am J Physiol Renal Physiol. 2010; 298 (3):F625-F33.
  7. Sauve M, Hui SK, Dinh DD, Foltz WD, Momen A, Nedospasov SA, et al. Diabetes. 2016; 65 (7):1916-28.
  8. Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M. J Clin Invest. 2006; 116:1071-80.

* Own publications

Methods used

Diabetic rat models (STZ), myography on isolated intact arteries, membrane potential measurement with sharp microelectrodes, FURA-2 fluorimetry 

Collaboration Partners

  • Hendrik Buikema, Groningen
  • Hans-Peter Hammes, Mannheim
  • Wolfgang Greffrath, Mannheim
  • Aimo Kannt, Sanofi

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