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Projects

Work Package 1 – General Mechanisms

PhD SP1

Challenging the unifying hypothesis: Cellular dysfunction on multiple levels in situations of hyperglycemia despite normal glucose flux

PhD SP2

Targeting Angiopoietin-2 in diabetic complications

PhD SP3

Mechanism of hyperglycemic control of histone code in metabolic inflammation and microvascular complications

PhD SP4

Potassium channels in vascular tone regulation and small artery diabetic dysfunction

MD SP16

Hyperglycemia-evoked alterations in Ca2+ homeostasis and in Ca2+-dependent translational profiling in endothelial cells

Work Package 2 – Diabetic Retinopathy

MD SP5

Hyperglycemic memory–mechanisms relevant to the diabetic retina

PhD SP6

Impact of adipose-derived stem cells (ADSC) on diabetic and proliferative retinopathy

MD SP7

MicroRNA-induced microangiopathy in diabetes

Work Package 3 – Diabetic Nephropathy

PhD SP9

The function of the Rac1 regulator ELMO1 in the vasculature and in renal development under high glucose in zebrafish and in human diabetic nephropathy

PhD SP10

Association of the CD40 gene rs1883832 C/T polymorphism with hyperglycemia-induced diabetic micro- and macroangiopathy

PhD SP11

Sequestering of reactive carbonyl species (RCS) by carnosine ameliorates vascular damage in vitro and vivo

MD SP12

Increased renal carnosinase (CNDP1) expression depletes CNDP1 substrates and makes renal tissue more prone to hyperglycaemia mediated damage

MD SP17

The contribution of glomerular endothelial cells to hyperglycemia-induced glo-merular basement membrane thickening, and its effect on modified hyaluronan metabo-lism, inflammation and fibrosis during the development of diabetic nephropathy

Work Package 4 – Diabetic Neuropathy

Phd SP13

Altered cell-cell interaction in experimental diabetic neuropathy – translation of mouse to human

MD SP14

Diabetic thin fiber neuropathy - objective assessment and mechanisms

MD SP15

Identification of tissue specific changes within the nociceptive system in diabetic peripheral neuropathy – characterizing pain in zebra fish

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