Ruprecht-Karls-Universität Heidelberg Medizinische Fakultät Mannheim
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Curriculum Vitae

Heike Allgayer, MD, PhD

Full Professor, Director and Head
Dept. of Experimental Surgery - Cancer Metastasis
Medical Faculty Mannheim, Ruprecht Karls University Heidelberg,

Main Research Fields

# Metastasis research
# microRNAs in metastasis
#

Tumor-associated proteolysis

#

Translational metastasis research

#

Molecular staging of cancer

Education/ Training

1995 Medical Board Examination (MD), Medicine, Ludwig-Maximilians-University Munich
1996

Dr. med. (Medicine, Translational Research)  Ludwig-Maximilians-University Munich, with “summa cum laude”

1997 - 1999 Postdoctoral Fellow (Molecular Biology, Metastasis), MD Anderson Cancer Center, Houston/USA
1999

PhD, Molecular Biology, Graduate School of Biomedical Sciences (GSBS), MD Anderson Cancer Center, Houston/USA

1999 - 2001

Assistant Professor, Section Molecular Biology,  Dept. Surgery, Clinical Surgeon, Surgical Oncology, Ludwig-Maximilians-University Munich

2001

Priv.Doz. (Associate Professor), Experimental Surgery/Molecular Biology, Ludwig-Maximilians-University Munich

2003 Diploma in Medical Economics, Chur, Switzerland
2004

Surgical Board Exam, Munich/Germany

2004 - 2015

Full Professor and Head, Dept. of Experimental Surgery, Med. Faculty Mannheim, Univ. of Heidelberg, Molecular Oncology of Solid Tumors Unit, DKFZ Heidelberg

Since 2015

Full Professor and Head, Dept. of Experimental Surgery, Med. Faculty Mannheim, Univ. of Heidelberg; and Centre for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, University of Heidelberg

Positions and Employment

1996 - 1997

Medical Intern, Dept. Surgery, Klinikum Großhadern, Ludwig-Maximilians-University Munich

1997 – 1999

Fellow at the Dept. of Cancer Biology, MD Anderson Cancer Center, Houston, TX (Prof. Douglas D. Boyd, PhD, Principal Investigator, Prof. J.I. Fidler, Head)

1999 – 2004 Assistant, later Associate Professor, Molecular Oncology, PI of section Molecular Biology, in parallel: Resident, Dept. of Surgery, Klinikum Großhadern, Ludwig-Maximilians-University Munich
2004 - 2015 Full Professor and Head, Dept. Experimental Surgery, Medical Faculty Mannheim, University of Heidelberg, and Joint Professor, DKFZ (German Cancer Research Center) Heidelberg
Since 2015 Full Professor and Head, Dept. of Experimental Surgery, Med. Faculty Mannheim, Univ. of Heidelberg; and Centre for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, University of Heidelberg

Professional Memberships

Honors/Awards (Excerpt out of a total of 23 awards)

1986

1st Prize of the German Chemical Industry for the promotion of research youngsters

1997

Research fellowship of the Dr. Mildred Scheel Stiftung (Deutsche Krebshilfe), Bonn, Germany, for postdoctoral period, MD Anderson Cancer Center, Houston

1999 Rhone-Poulenc-Rorer-Award for Young Investigators of the American Association of Cancer Research (AACR), Philadelphia, USA
1999

Langenbeck Research Award of the German College of Surgeons

1999

1st Prize, Wolfgang Wilmanns Research Foundation for Innovative Concepts of Translational Cancer Research

2000 Otto-Goetze-Award for the best scientific lecture at the Year 2000-Congress of the Bavarian College of Surgeons
2000

1st Prize of the DPC-Biermann-Academy of Biomedical Sciences

2001

Ferdinand-Sauerbruch Research Award of the Berlin College of Surgeons
2002 Johann-Nepomuk-von-Nussbaum-Research Award of the Bavarian College of Surgeons
2002 Research Award of the Drs. Graute- und Graute-Oppermann-Foundation, Essen
2003 Johann-Georg-Zimmermann-Award for Extraordinary Merits in Cancer Research, University of Hannover
2003 Travel Award of the Japanese Society of Surgery
2004 Research Award of the Ingrid-zu-Solms Foundation for excellent achievements of Women in Science, Frankfurt, Germany
2005 Young Cancer Researcher Award Lecture of the EACR (European Association of Cancer Research)
2005 Research Award for high-potential young Full Professors, Alfried Krupp von Bohlen- and Halbach-Foundation, Essen, Germany (1 Mill. Euro, the second highest and most competitive Research Award in Germany)
2006 Hella-Bühler-Award, University of Heidelberg, Germany
2007 European Association for Cancer Research (EACR) First Annual Distinguished Lecture, Nottingham, UK
2008 Walter-Schulz Award, Munich, Germany
2013 Annual Lilly Oncology Lecture, Dresden 2013
2014/15 Inoviem Scientific Excellence Award, Inoviem Scientific, Strasbourg

Patent

Allgayer H, Leupold JH (2003): Tissue specific expression (PCT/EPO3/01671)

Publications

90 original articles, 30 reviews, 4 books, 18 contributions to books, amongst others

Total Impact Factor

according to actual Ifs 2015: ca. 620

The top original articles have been published in: Nature Medicine, J Biol Chem, Cancer Research, Journal of Clinical Oncology, Oncogene, and Clinical Cancer Research.
Most cited original article as Senior Author: Asangani I et al, Oncogene 2009 (currently 1224 citations, most cited original article of Oncogene 2009)

Top publications of last years

Mudduluru G*, Abba M*, Batliner J*, Patil N, Scharp M, Leupold JH, Oleksiuk O, Buchhalter I, Thiele W, Benner A, Sleeman J, Allgayer H:: A systematic approach to defining the microRNA landscape in metastasis. Cancer Research, in press 2015
Utikal J, Abba M, Novak D, Moniuszko M, Allgayer H (Invited Review): Function and Significance of MicroRNAs in benign and malignant Human Stem Cells. Seminars in Cancer Biology, 2015, in press
Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer,H: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008, 27, 2128-2136. (1224 citations, Most cited Original Article Oncogene 2009)
Mudduluru G, Ceppi P, Kumarswamy R, Scagliotti GV, Papotti M, Allgayer H: Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer. Oncogene 2011, 30, 2888-2899 (101 citations)
Nikolova DA, Asangani IA, NelsonLD, Hughes DP, Siwak DR, Mills GB, Harms A, Buchholz E, Pilz LR, Manegold C, Allgayer H: Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity. Cancer Res 2009, 69, 2461-2470 (23 citations)
Mudduluru G, Medved F, Grobholz R, Joste C, Gruber A, Leupold JH, Post S, Jansen A, Colburn NH, Allgayer H: Loss of Pdcd4 expression marks adenoma-carcinoma transition, correlates inversely with pAkt, and is a new and independent prognostic factor in resected colorectal cancer. Cancer 2007, 110:8, 1697-1707 (141 citations)
Heiss MM, Simon EH, Beyer BCM, Grützner KU, Tarabichi A, Babic R, Schildberg FW, Allgayer H: Minimal residual disease in gastric cancer: First evidence of an independent prognostic relevance of urokinase receptor gene expression by disseminated tumor cells in a large series of patients. The Journal of Clinical Oncology 2002, 20(8):2005-2016 (83 citations)
Leupold JH, Yang HS, Colburn NH, Asangani I, Post S, Allgayer H: Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Oncogene 2007, 26, 4550-62 (116 citations)
Maurer GD, Leupold JH, Schewe DM, Biller T, Kates RE, Hornung H-M, Lau-Werner U, Post S, Allgayer H: First analysis of specific transcriptional regulators as predictors of independent prognostic relevance in resected colorectal cancer. Clinical Cancer Research 2007, 13(4): 1123-1132 (38 citations)
Ceppi P, Mudduluru G, Regalla K, Rap I, Scagliotti GV, Papotti M, Allgayer H: Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small-cell lung cancer. Mol Cancer Res Sept 2010, 8(9): 1207-16 Highlight of the Issue, (166 citations)
Mesenguer S, Mudduluru G, Escamilla JM, Allgayer H*, Barrettino D*: MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 (SF2/ASF). Journal of Biological Chemistry 2011, 286(6), 4150-4164 (63 citations), *equal senior authorship
Regalla K, Mudduluru G, Ceppi P, Muppala S, Kozlowski M, Niklinski J, Papotti M, Allgayer H: MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. Int J Cancer J 2012 May 1;130(9):2044-53 (105 citations)
Heckmann D, Maier P, Laufs S, Li L, Wenz F, Zeller WJ, Fruehauf S, Allgayer H: The disparate twins: A comparative study of CXCR4 and CXCR7 in SDF-1-induced gene expression, invasion and chemosensitivity of colon cancer. Clin Cancer Res. 2014 Feb 1;20(3):604-16 (12 citations).
Patil N, Rasheed SAK, Abba M, Leupold JH, Schwarzbach M, Allgayer H: A mechanistic study on the metastasis inducing function of FUS-CHOP fusion protein in liposarcoma Running title: The role of FUS-CHOP in metastasis. Int J Cancer. 2014 Jun 15;134(12):2808-19 (1 citation).

Grant Support

Completed grant supports

2004

B. Braun Foundation, Melsungen

2004 Friedrich Baur Foundation Munich
2004

Research Funding Centocor, Malvern, USA, "Immunohistochemical and - cytochemical analysis of EMMPRIN and MCP-1 in material of gastrointestinal cancer patients"

2005

Wilhelm Sander Foundation, Munich, "Molecular Staging Simulation with Neural Networks", together with Prof. N. Harbeck und Dr. R. Kates, Munich
2005 Auguste Schaedel-Dantscher-Foundation, "Role of Pdcd4 tumor suppressor in invasion"
2005 RMerck, Darmstadt "Translational studies at resected patient tissues on Cetuximab response and resistance"
2006 Merck, Darmstadt "Preclinical project: molecular mechanisms of anti-metastasis of Cetuximab"
2006 Deutsche Forschungsgemeinschaft (DFG), "Molecular Staging of Cancer"
2006 National Cancer Institutes, USA, "Defining molecular risk groups in colorectal cancer"
2006 Daub Foundation, University of Heidelberg, "Advancing the chicken embryo (CAM) metastasis model"
2006 Novartis, Nürnberg, "Mechanisms of metastasis inhibition brought about by zoledronic acid"
2006 Eli Lilly, Indianapolis/USA, together with Prof. Christian Manegold, "Preclinical and translational studies on Enzastaurin and is action towards metastasis"
2006 Industrial Grant Support, Congress "Molecular Staging of Cancer", Eli Lilly, Merck, Novartis, and others
2006 Dr. Hella-Bühler-Foundation, Univ. of Heidelberg, "Molecular regulators of metastasis as individual clinical risk factors"
2007 Hector-Foundation, Weinheim, "Role of CXRC4 in colorectal cancer metastasis and therapy"
2008 Walter-Schulz-Foundation, Munich, "Studies on microRNAs and Pdcd4 in metastasis"
2008 Excellence Initiative "FRONTIER", University of Heidelberg, "FUS-CHOP as a regulator of invasion and metastasis in sarcoma"
2009 Bundesministerium für Bildung und Forschung (BMBF), "HaematoSys: Systems - Biology of the Haematopoetic System and Related Neoplasias"
2009 Apogenix, Heidelberg, "Analysis of APG101 for its effect on the migration and invasion of tumor cells"
2010 Grant Support of the University of Heidelberg Foundation, "Role of specific microRNAs in EMT"
2011 Swiss National Fonds, Bern, Switzerland, "Defining important miRs regulating metastasis"

Ongoing grant-supported projects

2005

Alfried Krupp von Bohlen und Halbach-Foundation, Essen (€ 1 Million); "Molecular tumor staging - translating molecular knowledge on metastasis into patient benefit"

2011

Deutsche Krebshilfe, Bonn, "Role of specific microRNAs in the regulation of carcinoma metastasis"

2011

German-Israeli Project Cooperation (DKFZ-MOST), "MicroRNA control of tissue invasion and inflammatory intestinal cancer"

2011

Complete Genomics, Inc., Mountain View, CA/USA, "Pilot studies on genome sequencing of resected metastases"

2012

Wilhelm Sander-Foundation, Munich, "The functional interplay between CD24, Src, miR-21, Pdcd4 and u-PAR and its impact on invasion and metastasis"

2012

"Verification of bacterial DNA-integration into tumor DNA in colorectal cancer", Heidelberg Initiative of Personalized Oncology (HIPO) Grant

2013

"Genome alterations defining the metastatistically relevant cancer cell", Heidelberg Initiative of Personalized Oncology (HIPO) Grant

2013

DAAD "GERLS" Stipend for Ahmed Atef Shoukry Sadik, for 3 years

2013

6th German-Israeli Cancer Research School, Stipend for Sara Laudato (DKFZ-MOST- Project)

2014

Erasmus Post-Doc-Scholarship of the Erasmus Mundus Action 2 Program for Aida Hajdarpasic for 10 months

2015

CSC Scholarship for Sha Guan for 12 months

2015

CSC Scholarship for Xue Cao for 12 months

2015

CSC Scholarship for Chan Zhou for 12 months

Total direct funding by competitive grant support for the H. Allgayer lab: ca. € 5.15 Mio

Ph.D. Degrees

2004

Denis Schewe, Dr. med. (summa cum laude)

2004

Erich Simon, Dr. med. (magna cum laude)

2005

Jörg Leupold, Dr. rer. nat. (magna cum laude)

2006

Bianca Beyer, Dr. med. (magna cum laude)

2008

Fabian Medved, Dr. med. (magna cum laude)

2008

Tobias Biller, Dr. med. (magna cum laude)

2008

Gabriele Maurer, Dr. med. (summa cum laude)

2009

Irfan Asangani, Dr. sc. hum. (summa cum laude)

2009

Giridhar Mudduluru, Dr. sc. hum. (summa cum laude)

2010

Kabeer Rasheed, Dr. sc. hum. (magna cum laude)

2010

Daniel Bürgy, Dr. med. (summa cum laude)

2011

Tina Fuchs, Dr. med. (magna cum laude)

2012

Nitin Patil, Dr. sc. hum. (summa cum laude)

2012

Alexandra Körner, Dr. sc. hum. (magna cum laude)

2013

Doreen Heckmann, Dr. sc. hum. (summa cum laude)

2013

Julia Rotert, Dr. med. (magna cum laude)

2014

Jonahunata G. W. Nesson, Dr. sc. hum. (cum laude)

2014

Santoshi Muppala, Dr. sc. hum. (magna cum laude)

2004

Erich Simon, Dr. med. (magna cum laude)

Habilitation

2013

Giridhar Mudduluru

Activities in the scientific community

Associate Editor, International Journal of Cancer (since 2008), RNA Biology (since 2014)
Editorial Board: Advances in Medical Sciences, Journal of Cellular and Molecular Medicine, Frontiers in Molecular and Cellular Oncology, The Open Surgical Oncology Journal, Frontiers in Pharmacology, Fokus Onkologie, Translational Gastrointestinal Cancer, PEER, Scientific Reports.
EACR Council Member as Representative of Germany (since 2007)
Reviewer for scientific journals: Clinical Cancer Research, Oncogene, Cancer Research, Oncology, Nature Communications, Molecular Cancer, Molecular and Cellular Biology (MCB), International Journal of Colorectal Disease, Gastroenterology, British Journal of Cancer, PLOS ONE, Cancer Letters, World Journal of Clinical Oncology, The Open Surgical Oncology Journal, Nucleic Acids Research, FEBS Journal, APMIS, Journal of Cellular and Molecular Medicine, Frontiers in Molecular and Cellular Oncology, Methods in Enzymology, European Journal of Surgical Research, Carcinogenesis, Cancer Genetics, Molecular Cancer Research, Molecular Cancer Therapeutics, Open Access Publishing London (OAPL) Ethics Committee, Naunyn-Schmiedeberg's Archives of Pharmacology, Molecular & Cellular Oncology, Molecular Oncology, Journal of Cancer Biology and Treatment (CBT), Experimental Cell Research, Annals of Oncology, Amino Acids, Scientific Reports, Breast Cancer Research, Oncotarget, Journal of Cellular and Molecular Medicine, Reviewer for the European Cancer Congress (ECCO 18 - ESMO 40).
Reviewer for funding agencies: Wilhelm Sander Foundation, Deutsche Krebshilfe (German Cancer Aid), Scientific Reviewer for the European Community (Vice Chair of EU Life Sciences Review 2008), German Israeli Foundation for Scientific Research and Development, Deutsche Forschungsgemeinschaft (DFG), Alexander-von-Humboldt Foundation, Scientific Selection Committee for the King Faisal International Prize, Riyadh/Saudi Arabia, Reviewer for the Swedish Academy of Sciences, Stockholm/Sweden, Association for International Cancer Research (AICR), Institut National du Cancer.
Member of the Award Selection Committee, Karl Heinz Beckurts-Stiftung, Garching (since 2013)
EACR Ambassador (since 2012)
Founder of the international meeting series "Molecular Staging of Cancer" (held since 2001)
Chair of the Fellows of the Ingrid-zu-Solms Foundation for excellent Women in Research, Medicine and Culture, Frankfurt/Main (since 2007)
MD Anderson Cancer Center - DKFZ Institutional Sister Alliance (supported initiation, continuous activities)
AACR Surgical Oncology Task Force, Member upon personal invitation by Dr. Margaret Foti, since 2013 (Heads: Dr. Monica Morrow, Sloan Kettering Cancer Center, Dr. Margaret Foti, AACR-CEO)
Member, International Advisory Committee, 7th International Conference on the Tumor Microenvironment: Progression, Therapy & Prevention, Tel Aviv, Israel, Oct 2015
Member, Selection Committee of the Mildred Scheel Lectureship (Deusche. Krebshilfe, Bonn, Germany))
Zurich Minds, Member upon personal invitation by Dr. Rolf Dobelli since 2014
Opponent at International PhD Defenses, e.g. Department of Translational Medicine, Malmö/Lund University

Director and Head:

Prof. Dr. med. Heike Allgayer, MD, PhD
Department of Experimental Surgery - Cancer Metastasis
Medical Faculty Mannheim
University of Heidelberg
Center for Biomedicine and Medical Technology Mannheim (CBTM)
Ludolf-Krehl-Straße 13-17
68167 Mannheim
Tel.: +49 (0)621/383-6876

Secretary
Dr. phil. Laura Said
Tel. +49 (0)621/383-6876
Fax: +49 (0)621/383-6878