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Prof. Dr. Tobias Banaschewski

The main research areas of the child and adolescent psychiatry are a) developmental trajectories of child and adolescent psychiatric disorders with associated risks and protective factors, b) their underlying etiological and neurobiological mechanisms, c) development of individualized treatment strategies, and d) development of evidence-based clinical guidelines. These research foci are mainly investigated within national and international research networks and multicenter studies. In the coming years, new longitudinal epidemiological cohort studies will be investigated in order to characterize disorder-specific and overarching pathophysiological mechanisms and their developmental trajectories. Of central interest are developmental aspects and developmental risks, multimodality, and ecological aspects of our longitudinal and clinical-translational studies.

These project research findings will help stratify the heterogeneity of disorders, provide specific diagnostic, prognostic, and treatment-related biomarkers, and promote more effective personalized approaches to prevention and treatment. Another research focus is the linkage between clinical treatment and research. To this end, the two innovative service models "Adolescent Center-Emotion Regulation" and "Adolescent Center-Psychosis" will be scientifically evaluated. In addition, we want to use the opportunity to integrate scientific evidence into the treatment of those affected, which is why it is important for us to contribute our expertise to the creation and regular updating of evidence-based S3 guidelines.

The five working groups of the department (Attention Deficit Hyperactivity Disorder (ADHD), Autism, Developmental Neurosciences in Psychiatry, Clinical Neurophysiology of Childhood and Adolescence, Clinical Psychopharmacology of Childhood and Adolescence) are strongly networked among each other, focusing on different topics and different methods.

Publications

Wong ICK, Banaschewski T, Buitelaar J, Cortese S, Döpfner M, Simonoff E, Coghill D; European ADHD Guidelines Group.
Emerging challenges in pharmacotherapy research on attention-deficit hyperactivity disorder-outcome measures beyond symptom control and clinical trials.
Lancet Psychiatry. 2019 Jun;6(6):528-537. doi: 10.1016/S2215-0366(19)30096-3.
PMID: 31122482.

Robert GH, Luo Q, Yu T, Chu C, Ing A, Jia T, Papadopoulos Orfanos D, Burke-Quinlan E, Desrivières S, Ruggeri B, Spechler P, Chaarani B, Tay N, Banaschewski T, Bokde ALW, Bromberg U, Flor H, Frouin V, Gowland P, Heinz A, Ittermann B, Martinot JL, Paillère Martinot ML, Nees F, Poustka L, Smolka MN, Vetter NC, Walter H, Whelan R, Conrod P, Barker T, Garavan H, Schumann G; IMAGEN Consortium.
Association of Gray Matter and Personality Development With Increased Drunkenness Frequency During Adolescence.
JAMA Psychiatry. 2019 Dec 18:e194063. doi: 10.1001/jamapsychiatry.2019.4063. Epub ahead of print.
PMID: 31851304; PMCID: PMC6990803.

Luo Q, Chen Q, Wang W, Desrivières S, Quinlan EB, Jia T, Macare C, Robert GH, Cui J, Guedj M, Palaniyappan L, Kherif F, Banaschewski T, Bokde ALW, Büchel C, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Paillère-Martinot ML, Nees F, Orfanos DP, Poustka L, Fröhner JH, Smolka MN, Walter H, Whelan R, Callicott JH, Mattay VS, Pausova Z, Dartigues JF, Tzourio C, Crivello F, Berman KF, Li F, Paus T, Weinberger DR, Murray RM,  Schumann G, Feng J; IMAGEN consortium.
Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents: A Voxelwise and Genome-Wide Association Study.
JAMA Psychiatry. 2019 Apr 1;76(4):435-445. doi: 10.1001/jamapsychiatry.2018.4126.
PMID: 30649180; PMCID: PMC6450291.

Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J, Ekström TJ, Bakalkin G, Schumann G; IMAGEN Consortium.
Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse.
Am J Psychiatry. 2019 Feb 1;176(2):146-155. doi: 10.1176/appi.ajp.2018.17121360. Epub 2018 Dec 11.
PMID: 30525907.

Hoogman M, Muetzel R, Guimaraes JP, Shumskaya E, Mennes M, Zwiers MP, Jahanshad N, Sudre G, Wolfers T, Earl EA, Soliva Vila JC, Vives-Gilabert Y, Khadka S, Novotny SE, Hartman CA, Heslenfeld DJ, Schweren LJS, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini TM, Rosa PGP, Zanetti MV, Malpas CB, Kohls G, von Polier GG, Seitz J, Biederman J, Doyle AE, Dale AM, van Erp TGM, Epstein JN, Jernigan TL, Baur-Streubel R, Ziegler GC, Zierhut KC, Schrantee A, Høvik MF, Lundervold AJ, Kelly C, McCarthy H, Skokauskas N, O'Gorman Tuura RL, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke KC, Christakou A, Vance A, Cercignani M, Gabel MC, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati IE, Tovar-Moll F, Fallgatter AJ, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, Coghill D, Plessen KJ, Kuntsi J, Mehta MA, Paloyelis Y, Harrison NA, Bellgrove MA, Silk TJ, Cubillo AI, Rubia K, Lazaro L, Brem S, Walitza S, Frodl T, Zentis M, Castellanos FX, Yoncheva YN, Haavik J, Reneman L, Conzelmann A, Lesch KP, Pauli P, Reif A, Tamm L, Konrad K, Oberwelland Weiss E, Busatto GF, Louza MR, Durston S, Hoekstra PJ, Oosterlaan J, Stevens MC, Ramos-Quiroga JA, Vilarroya O, Fair DA, Nigg JT, Thompson PM, Buitelaar JK, Faraone SV, Shaw P, Tiemeier H, Bralten J, Franke B.
Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.
Am J Psychiatry. 2019 Jul 1;176(7):531-542. doi: 10.1176/appi.ajp.2019.18091033. Epub 2019 Apr 24.
PMID: 31014101; PMCID: PMC6879185.

Quinlan EB, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Desrivières S, Flor H, Frouin V, Garavan H, Heinz A, Brühl R, Martinot JL, Paillère Martinot ML, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Smolka MN, Fröhner JH, Walter H, Whelan R, Schumann G; IMAGEN Consortium.
Identifying biological markers for improved precision medicine in psychiatry.
Mol Psychiatry. 2020 Feb;25(2):243-253. doi: 10.1038/s41380-019-0555-5. Epub 2019 Nov 1.
PMID: 31676814; PMCID: PMC6978138.

Cortese, S., Adamo, N., Del Giovane, C., Mohr-Jensen, C., Hayes, A. J., Carucci, S., Atkinson, L.Z., Tessari, L., Banaschewski, T., . . . Cipriani, A. (2018).
Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry, 5(9), 727-738. doi:10.1016/S2215-0366(18)30269-4

Barker ED, Ing A, Biondo F, Jia T, Pingault JB, Du Rietz E, Zhang Y, Ruggeri B, Banaschewski T, Hohmann S, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Sounga-Barke E, Bowling AB, Desrivières S, Flor H, Frouin V, Garavan H, Asherson P, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Nees F, Papadopoulos-Orfanos D, Poustka L, Smolka MN, Vetter NC, Walter H, Whelan R, Schumann G; IMAGEN Consortium.
Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?
Mol Psychiatry. 2019 Jun 21:10.1038/s41380-019-0444-y. doi: 10.1038/s41380-019-0444-y. Epub ahead of print.
PMID: 31227801.

Bartholdy S, O'Daly OG, Campbell IC, Banaschewski T, Barker G, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Paillère Martinot ML, Nees F, Orfanos DP, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Schmidt U; IMAGEN Consortium.
Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents.
Biol Psychiatry. 2019 Jun 1;85(11):956-965. doi: 10.1016/j.biopsych.2019.01.027. Epub 2019 Mar 25.
PMID: 31122340.

Ing A, Sämann PG, Chu C, Tay N, Biondo F, Robert G, Jia T, Wolfers T, Desrivières S, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Conrod P, Fadai T, Flor H, Frouin V, Garavan H, Spechler PA, Gowland P, Grimmer Y, Heinz A, Ittermann B, Kappel V, Martinot JL, Meyer-Lindenberg A, Millenet S, Nees F, van Noort B, Orfanos DP, Martinot MP, Penttilä J, Poustka L, Quinlan EB, Smolka MN, Stringaris A, Struve M, Veer IM, Walter H, Whelan R, Andreassen OA, Agartz I, Lemaitre H, Barker ED, Ashburner J, Binder E, Buitelaar J, Marquand A, Robbins TW, Schumann G; IMAGEN Consortium.
Identification of neurobehavioural symptom groups based on shared brain mechanisms.
Nat Hum Behav. 2019 Dec;3(12):1306-1318. doi: 10.1038/s41562-019-0738-8. Epub 2019 Oct 7.
PMID: 31591521.

National and international collaborative research projects

IMAGEN: Study to identify biological and environmental factors influencing adolescent risk behaviors

AERIAL (Early Recognition and Intervention Across the Lifespan): Study to explore new diagnostic and treatment options for addictive disorders

EU-AIMS-II: Identifying biomarkers for autism

ASD-Net: Study of the effect of oxytocin on social skills training in children and adolescents with autism spectrum disorders

ESCA-life: Study to investigate a stepped treatment program for children, adolescents, and adults with ADHD

MEHIRA (Mental Health in Refugees and Asylum Seekers): Tiered model of care to promote refugee mental health

Eat2BeNice: Study of the effect of diet and lifestyle on impulsive, compulsive, and externalizing behavior

IMAC-mind (Improving Mental Health and Reducing Addiction in Childhood and Adolescence through Mindfulness: Mechanisms, Prevention and Treatment): Study to improve mental health and reduce addiction risk in childhood and adolescence through mindfulness.

ADOPT (Affektive Dysregulation – Optimierung von Prävention und Therapie) The goal of the ADOPT study is to gain scientific insight into affective dysregulation.

PRIME (EU): Prevention and Remediation of Insulin Multimorbidity in Europe

STAR: Study evaluating internet-based therapeutic methods for adolescents with non-suicidal self-injurious behavior

MARS: Exploring the effect of risk and resilience on the social brain and antisocial behavior.

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