These project research findings will help stratify the heterogeneity of disorders, provide specific diagnostic, prognostic, and treatment-related biomarkers, and promote more effective personalized approaches to prevention and treatment. Another research focus is the linkage between clinical treatment and research. To this end, the two innovative service models "Adolescent Center-Emotion Regulation" and "Adolescent Center-Psychosis" will be scientifically evaluated. In addition, we want to use the opportunity to integrate scientific evidence into the treatment of those affected, which is why it is important for us to contribute our expertise to the creation and regular updating of evidence-based S3 guidelines.

The five working groups of the department (Attention Deficit Hyperactivity Disorder (ADHD), Autism, Developmental Neurosciences in Psychiatry, Clinical Neurophysiology of Childhood and Adolescence, Clinical Psychopharmacology of Childhood and Adolescence) are strongly networked among each other, focusing on different topics and different methods.

Publications

1. Identifying biological markers for improved precision medicine in psychiatry.
   Quinlan EB, Banaschewski T, […], Schumann G; IMAGEN Consortium. (2020) Mol Psychiatry Feb;25(2):243-253.
2. Emerging challenges in pharmacotherapy research on attention-deficit hyperactivity disorder-outcome measures beyond symptom control and clinical trials.
   Wong ICK, Banaschewski T, Buitelaar J, Cortese S, Döpfner M, Simonoff E, Coghill D; European ADHD Guidelines Group. (2019) Lancet Psychiatry Jun;6(6):528-537.
3. Association of Gray Matter and Personality Development With Increased Drunkenness Frequency During Adolescence.
   Robert GH, Luo Q, Yu T, Chu C, Ing A, Jia T, Papadopoulos Orfanos D, Burke-Quinlan E, Desrivières S, Ruggeri B, Spechler P, Chaarani B, Tay N, Banaschewski T, […], Schumann G; IMAGEN Consortium. (2019) JAMA Psychiatry Dec 18:e194063.
4. Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents: A Voxelwise and Genome-Wide Association Study.
   Luo Q, Chen Q, Wang W, Desrivières S, Quinlan EB, Jia T, Macare C, Robert GH, Cui J, Guedj M, Palaniyappan L, Kherif F, Banaschewski T, […], Feng J; IMAGEN consortium. (2019) JAMA Psychiatry Apr 1;76(4):435-445.
5. Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse.
   Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, […], Schumann G; IMAGEN Consortium. (2019) Am J Psychiatry Feb 1;176(2):146-155.
6. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.
   Hoogman M, Muetzel R, Guimaraes JP, Shumskaya E, Mennes M, Zwiers MP, Jahanshad N, Sudre G, Wolfers T, Earl EA, Soliva Vila JC, Vives-Gilabert Y, Khadka S, Novotny SE, Hartman CA, Heslenfeld DJ, Schweren LJS, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini TM, Rosa PGP, Zanetti MV, Malpas CB, Kohls G, von Polier GG, Seitz J, Biederman J, Doyle AE, Dale AM, van Erp TGM, Epstein JN, Jernigan TL, Baur-Streubel R, Ziegler GC, Zierhut KC, Schrantee A, Høvik MF, Lundervold AJ, Kelly C, McCarthy H, Skokauskas N, O'Gorman Tuura RL, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke KC, Christakou A, Vance A, Cercignani M, Gabel MC, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati IE, Tovar-Moll F, Fallgatter AJ, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, […] Franke B. (2019) Am J Psychiatry Jul 1;176(7):531-542.
7. Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?
   Barker ED, Ing A, Biondo F, Jia T, Pingault JB, Du Rietz E, Zhang Y, Ruggeri B, Banaschewski T, […], Schumann G; IMAGEN Consortium. (2019) Mol Psychiatry Jun 21:10.1038/s41380-019-0444-y.
8. Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents.
   Bartholdy S, O'Daly OG, Campbell IC, Banaschewski T, […], Schmidt U; IMAGEN Consortium. (2019) Biol Psychiatry Jun 1;85(11):956-965.
9. Identification of neurobehavioural symptom groups based on shared brain mechanisms.
   Ing A, Sämann PG, Chu C, Tay N, Biondo F, Robert G, Jia T, Wolfers T, Desrivières S, Banaschewski T, […], Schumann G; IMAGEN Consortium. (2019) Nat Hum Behav Dec;3(12):1306-1318.
10. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis.
    Cortese S, Adamo N, Del Giovane C, Mohr-Jensen C, Hayes AJ, Carucci S, Atkinson, LZ, Tessari L., Banaschewski T, […], Cipriani A. (2018) Lancet Psychiatry 5(9), 727-738.

National and international collaborative research projects

IMAGEN: Study to identify biological and environmental factors influencing adolescent risk behaviors

AERIAL (Early Recognition and Intervention Across the Lifespan): Study to explore new diagnostic and treatment options for addictive disorders

EU-AIMS-II: Identifying biomarkers for autism

ASD-Net: Study of the effect of oxytocin on social skills training in children and adolescents with autism spectrum disorders

ESCA-life: Study to investigate a stepped treatment program for children, adolescents, and adults with ADHD

MEHIRA (Mental Health in Refugees and Asylum Seekers): Tiered model of care to promote refugee mental health

Eat2BeNice: Study of the effect of diet and lifestyle on impulsive, compulsive, and externalizing behavior

IMAC-mind (Improving Mental Health and Reducing Addiction in Childhood and Adolescence through Mindfulness: Mechanisms, Prevention and Treatment): Study to improve mental health and reduce addiction risk in childhood and adolescence through mindfulness.

ADOPT (Affektive Dysregulation – Optimierung von Prävention und Therapie) The goal of the ADOPT study is to gain scientific insight into affective dysregulation.

PRIME (EU): Prevention and Remediation of Insulin Multimorbidity in Europe

STAR: Study evaluating internet-based therapeutic methods for adolescents with non-suicidal self-injurious behavior

MARS: Exploring the effect of risk and resilience on the social brain and antisocial behavior.

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