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Prof. Dr. Bernd Lenz

Addictive Behavior

We investigate the role of biological mechanisms, neurodevelopmental factors over the lifespan, and clinical aspects in the pathogenesis of addictive behaviors. To develop novel preventive and therapeutic strategies, the research group conducts in-depth mechanistic studies, large-scale longitudinal cohort studies, and clinical trials with a strong translational emphasis.

Selected national and international joint research projects

CRC / TRR265: Losing and Regaining Control over Drug Intake: From Trajectories to Mechanisms to Interventions. Subproject A08: Effects of longitudinal sex hormone variations on trajectories of losing and regaining control over alcohol use: Prediction, mechanisms, and treatment targets and Project S01 Central recruitment, imaging and biobanking. Project duration: 2019 - 2023

IMAC-Mind: Improving Mental Health and Reducing Addiction in Childhood and Adolescence through Mindfulness: Mechanisms, Prevention and Treatment. Subproject 3: Reducing stress and substance use in pregnant women to improve the children’s later mental health. Project duration: 2018 – 2022

Selected publications

  1. Sulphated dehydroepiandrosterone serum levels are reduced in women with alcohol use disorder and correlate negatively with craving: A sex-separated cross-sectional and longitudinal study.
    Weinland C, Mühle C, von Zimmermann C, Kornhuber J, Lenz B. Addict Biol. 2022 27(2):e13135.
  2. Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects.
    Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Tesch N, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Gulbins E, Lenz B, Schumann G, Kornhuber J, Müller CP. Mol Psychiatry. 2021 26(12):7403-7416.

  3. Oxytocin blood concentrations in alcohol use disorder: A cross-sectional, longitudinal, and sex-separated study.
    Lenz B, Weinland C, Bach P, Kiefer F, Grinevich V, Zoicas I, Kornhuber J, Mühle C. Eur Neuropsychopharmacol. 2021 51:55-67.
  4. Virtual reality: A powerful technology to provide novel insight into treatment mechanisms of addiction.
    Mazza M, Kammler-Sücker K, Leménager T, Kiefer F, Lenz B. Transl Psychiatry. 2021 11(1):617.
  5. Sex-dependent alcohol instrumentalization goals in non-addicted alcohol consumers versus patients with alcohol use disorder: Longitudinal change and outcome prediction.
    Müller CP, Mühle C, Kornhuber J, Lenz B. Alcohol Clin Exp Res. 2021 45(3):577-586.
  6. Progesterone serum levels correlate negatively with craving in female postmenopausal in-patients with alcohol use disorder: A sex- and menopausal status-separated study.
    Weinland C, Mühle C, Kornhuber J, Lenz B. Prog Neuropsychopharmacol Biol Psychiatry. 2021 (Aug 30):110278.
  7. Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD).
    Widder M, Mierzwa L, Schwerg L, Schecke H, Kornhuber J, Bouna-Pyrrou P, Bumb JM, Richter-Schmidinger T, Lenz B. Sci Rep. 2021 11(1):5233.
  8. The androgen model of suicide completion.
    Lenz B, Röther M, Bouna-Pyrrou P, Mühle C, Tektas OY, Kornhuber J. Prog Neurobiol. 2019 172:84-103.
  9. Body mass index and craving predict 24-month hospital readmissions of alcohol-dependent in-patients following withdrawal.
    Weinland C, Mühle C, Kornhuber J, Lenz B. Prog Neuropsychopharmacol Biol Psychiatry. 2019 90:300-307.
  10. Sex hormone activity in alcohol addiction: Integrating organizational and activational effects.
    Lenz B, Müller CP, Stoessel C, Sperling W, Biermann T, Hillemacher T, Bleich S, Kornhuber J. Prog Neurobiol. 2012 96(1):136-63.