Translational neurogenetics of psychiatric disorders

The research interests of Prof. Tost are neural mechanisms of genetic and environmental risk factors for mental illness, neurobiology of mood and psychosis spectrum disorders (schizophrenia, bipolar disorder, depression, autism), multimodal neuroimaging, neural plasticity, network connectivity, neuroimaging biomarkers for pharmacological challenge and therapy research.

National and international Joint Research Projects

DFG GRK 2350, TPB02 ACE and Stress Sensitivity: the Modulatory Role of the Social Environment, 04/2018-09/2022

BMBF: Removing language barriers in treating refugees, RELATER, WP3, 02/2019-01/2023

DFG SFB 1158/2nd FP, TPB04 Translational studies in pain chronicity: role of corticothalamostriatal pathway in stress-sensitisation and comorbidity development, 07/2019-06/2023

DFG TRR265, A04 Intense characterization of triggers, modifying factors and mechanisms at course transition points in human addiction, 07/2019-06/2023

Selected publications

Tost H, Reichert M, Braun U, Reinhard I, Peters R, Lautenbach S, Hoell A, Schwarz, Ph.D E, Ebner-Priemer U, Zipf A, Meyer-Lindenberg A. Neural correlates of individual differences in affective benefit of real-life urban green space exposure. Nat Neurosci. 2019 22(9):1389-1393. Epub 2019 Jul 29.

Tost H, Champagne FA, Meyer-Lindenberg A. Environmental influence in the brain, human welfare and mental health. Nat Neurosci. 2015 18(10):1421-31.

Stefansson H, Meyer-Lindenberg A, Steinberg S, Magnusdottir B, Morgen K, Arnarsdottir S, Bjornsdottir G, Walters GB, Jonsdottir G, Doyle OM, Tost H, Grimm O, Kristjansdottir S, Snorrason H, Davidsdottir SR, Gudmundsson LJ, Jonsson GF, Stefansdottir B, Helgadottir I, Haraldsson M, Jonsdottir B, Thygesen JH, Schwarz AJ, Didriksen M, Stensbøl TB, Brammer M, Kapur S, Halldorsson JG, Hreidarsson S, Saemundsen E, Sigurdsson E, Stefansson K. CNVs conferring risk of autism or schizophrenia affect cognition in controls. Nature. 2014 8(1):107-18. Epub 2013 Dec 18.

Tost H, Meyer-Lindenberg A. Puzzling over schizophrenia: Schizophrenia, social environment and the brain. Nat Med. 2012 18(2):211-3.

Lederbogen F, Kirsch P, Haddad L, Streit F, Tost H, Schuch P, Wüst S, Pruessner JC, Rietschel M, Deuschle M, Meyer-Lindenberg A. City living and urban upbringing affect neural social stress processing in humans. Nature. 2011 474(7352):498-501.

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