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PROF. DR. FALK KIEFER

ADDICTION RESEARCH, NEUROSCIENCE

The research interests of Prof. Kiefer focus on the development of novel treatments for addictive behaviours through an application of targeted psycho- and pharmacotherapies based on neuroimaging, genetics and neuroendocrinology in interaction with psychosocial and environmental factors.

NATIONAL AND INTERNATIONAL JOINT RESEARCH PROJECTS

DFG    SFB/TRR265:
Losing and regaining control over drug intake: from trajectories to mechanisms to interventions, Local Spokesperson, TP’s A03 Stress-related predictor profiles for craving and relapse in human addiction; C04 Modification of cue-reactivity by neurofeedback in human addiction, 2019-2023;

BMBF 01EE1460C, AERIAL:
Addiction: Early recognition and intervention across the lifespan. Local Spokesperson, TP 1, Development of neurobehavioral signatures and mechanism-based interventions for SUD in adolescents, TP6 Mechanisms of addiction: social exclusion, risk and resilience prediction, and adapted interventions, TP 7, Epigenetics and alcohol use disorders 2015-2020

EU      Horizon 2020 Sybil-AA:
Realtime fMRI neurofeedback in the treatment of alcohol use disorder

SELECTED PUBLICATIONS

Bach P, Koopmann A, Bumb JM, Vollstädt-Klein S, Reinhard I, Rietschel M, Witt SH, Wiedemann K, Kiefer F (2020) Leptin predicts cortical and subcortical gray matter volume recovery in alcohol dependent patients: A longitudinal structural magnetic resonance imaging study.  Horm Behav11;124:104749

Bach P, Koopmann A, Bumb JM, Zimmermann S, Bühler S, Reinhard I, Witt SH, Rietschel M, Vollstädt-Klein S, Kiefer F (2020) Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study. Eur Arch Psychiatry Clin Neurosci; doi: 10.1007/s00406-020-01115-0. Online ahead of print.

Dinter C, Hermann D, Heckmann J, Hill H, Reinhard I, Vollstädt-Klein S, Kirsch P, Kiefer F (2020) Reconsolidation impairment of reward memory by stimulating stress response. Addict Biol 25(1):e12712.

Ghrelin modulates mesolimbic reactivity to alcohol cues in alcohol-addicted subjects: a functional imaging study (2019) Koopmann A, Bach P, Schuster R, Bumb JM, Vollstädt-Klein S, Reinhard I, Rietschel M, Witt SH, Wiedemann K, Kiefer F. Addict Biol 24(5):1066-1076

Walters RK, Polimanti R, Johnson EC … Kiefer F…, Agerwal A (2018) Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci 12 :1656-1669. doi: 10.1038/s41593-018-0275-1.

Kiefer F, Kirsch M, Bach P, Hoffmann S, Reinhard I, Jorde A, von der Goltz C, Mann K, Loeber S, Vollstädt-Klein S (2015) Effects of D-cycloserine on extinction of mesolimbic cue-reactivity: a randomized, placebo-controlled trial. Psychopharmacol 232:2353-62

Jorde A, Bach P, Witt SH, Becker K, Reinhard I, Vollstädt-Klein S, Kirsch M, Hermann D, Charlet K, Beck A, Wimmer L, Frank J, Treutlein J, Spanagel R, Mann K, Walter H, Heinz A, Rietschel M, Kiefer F (2014) Genetic Variation in the Atrial Natriuretic Peptide Transcription Factor GATA4 Modulates Amygdala Responsiveness in Alcohol Dependence. Bio. Psychiatry 75(10):790-7

Grosshans M, Vollmert C, Vollstädt-Klein S, Tost H, Leber S, Bach P, Bühler M, von der Goltz , Mutschler J, Loeber S, Hermann D, Wiedemann K, Meyer-Lindenberg A, Kiefer F (2012) Association of leptin with food cue-induced activation in human reward pathways. Arch Gen Psychiat 69(5):529-37

Vollstädt-Klein S, Loeber S, Kirsch M, Bach P, Richter A, Fauth-Bühler M, von der Goltz C, Hermann D, Mann K, Kiefer F (2011) Effects of Cue-Exposure Treatment on Neural Cue Reactivity in Alcohol Dependence: A Randomized Trial. Biol Psychiatry 69(11):1060-6

Kiefer F, Jahn H, Tarnaske T, Helwig H, Briken P, Holzbach R, Kämpf P, Stracke R, Baehr M, Naber D, Wiedemann K (2003) Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study. Arch Gen Psychiat 60: 92-99

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