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Prof. Dr. Berhard Krämer

Innate immunity in renal transplantation and ischemia-reperfusion injury

My group has a long-standing interest in the role of innate immunity in renal transplantation. We found in renal transplant recipients an association of NOD2/CARD15 haplotypes, of the TLR system, i.e. TLR2, TLR3, and TLR9 on disorders, such as acute allograft rejection, cardiovascular and all-cause mortality, which may be considered as acute and/or chronic inflammation-driven. In addition we have shown that TLR4 may link podocytes with the innate immune system to mediate MPGN triggered by the deposition of immune complexes. Furthermore we are interested in the chemokine receptor/ligand system in renal transplantation and found CX3CR1, RANTES, SDF-1, MCP-1, and CCR5 to be associated with acute rejection and/or renal allograft survival. Our findings provide new targets for treatment or as a biomarker. 

Publications

Fischereder M, Luckow B, Hocher B, Wüthrich RP, Rothenpieler U, Schneeberger H, Panzer U, Stahl RA, Hauser IA, Budde K, Neumayer H, Krämer BK, Land W, Schlöndorff D. CC chemokine receptor 5 and renal-transplant survival. Lancet. 2001;357(9270):1758-61.

Krüger B, Schröppel B, Ashkan R, Marder B, Zülke C, Murphy B, Krämer BK, Fischereder M. A Monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation. J Am Soc Nephrol. 2002;13(10):2585-9.

Banas MC, Banas B, Hudkins KL, Wietecha TA, Iyoda M, Bock E, Hauser P, Pippin JW, Shankland SJ, Smith KD, Stoelcker B, Liu G, Gröne HJ, Krämer BK, Alpers CE. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol. 2008;19(4):704-13. Epub 2008 Feb 6.
Krüger B, Krick S, Dhillon N, Lerner SM, Ames S, Bromberg JS, Lin M, Walsh L, Vella J, Fischereder M, Krämer BK, Colvin RB, Heeger PS, Murphy BT, Schröppel B. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci U S A. 2009;106(9):3390-5.

Krüger B, Böger CA, Schröppel B, Obed A, Hoffmann U, Murphy BT, Fischereder M, Holler E, Banas B, Krämer BK. Impact of NOD2/CARD15 haplotypes on the outcome after kidney transplantation. Transpl Int. 2007;20(7):600-7.

Hoffmann U, Bergler T, Rihm M, Pace C, Krüger B, Jung B, Reinhold SW, Farkas S, Rümmele P, Krämer BK, Banas B. Impact of Toll-like receptor 2 expression in renal allograft rejection. Nephrol Dial Transplant. 2011;26(3):1080-7.

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